Scott M Dehm

Scott M Dehm

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Scott M Dehm

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PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer.

Cancer Res 2019 Nov 17;79(21):5668-5680. Epub 2019 Sep 17.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825593PMC
November 2019

Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer.

Clin Cancer Res 2019 Nov 15. Epub 2019 Nov 15.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1659DOI Listing
November 2019

A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities.

Nucleic Acids Res 2019 06;47(11):5634-5647

Northern Institute for Cancer Research, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkz286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582326PMC
June 2019

AR-Variant-Positive CTC: A Surrogate for a Surrogate for Taxane Therapy Outcome?

Clin Cancer Res 2019 03 27;25(6):1696-1698. Epub 2018 Dec 27.

Department of Medicine, University of Washington School of Medicine, Seattle, Washington.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3727DOI Listing
March 2019

Androgen Receptor Dependence.

Adv Exp Med Biol 2019 ;1210:333-350

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/978-3-030-32656-2_15DOI Listing
January 2019

Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.

Prostate 2018 11 15;78(15):1140-1156. Epub 2018 Jul 15.

Department of Anatomy and Cell Biology, UF Health Cancer Center and UF Genetics Institute, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1002/pros.23689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424568PMC
November 2018

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy.

Eur Urol 2018 11 23;74(5):562-572. Epub 2018 Jul 23.

Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Melbourne Urological Research Alliance (MURAL), Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351078PMC
November 2018

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Cell 2018 07 19;174(3):758-769.e9. Epub 2018 Jul 19.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA; Department of Radiation Oncology, UCSF, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425931PMC
July 2018

Indel detection from DNA and RNA sequencing data with transIndel.

BMC Genomics 2018 Apr 19;19(1):270. Epub 2018 Apr 19.

Masonic Cancer Center, University of Minnesota, 420 Delaware St SE, Minneapolis, MN, 55455, USA.

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https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12864-018-4671-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909256PMC
April 2018

Methods for Identifying and Quantifying mRNA Expression of Androgen Receptor Splicing Variants in Prostate Cancer.

Methods Mol Biol 2016 ;1443:165-77

Masonic Cancer Center and Department of Laboratory Medicine and Pathology, University of Minnesota Twin Cities, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/978-1-4939-3724-0_11DOI Listing
November 2017

Androgen Receptor Rearrangement and Splicing Variants in Resistance to Endocrine Therapies in Prostate Cancer.

Endocrinology 2017 06;158(6):1533-1542

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455.

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http://dx.doi.org/10.1210/en.2017-00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460940PMC
June 2017

Lessons from tissue compartment-specific analysis of androgen receptor alterations in prostate cancer.

J Steroid Biochem Mol Biol 2017 02 28;166:28-37. Epub 2016 Apr 28.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA; Department of Urology, University of Minnesota, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085889PMC
February 2017

Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

J Natl Cancer Inst 2016 May 11;108(5). Epub 2015 Dec 11.

Affiliations of authors:Cancer Research UK Cambridge Institute, University of Cambridge , Cambridge, UK (MA, CEM, NP, HIZ, AQ, AB, SM, BM, CE, SL, SW, VRZ, GS, RR, HM, AGL, CD, CT, AL, RS, JY, RS, JSC, JRG, ST, DEN); School of Medical Sciences, University of Aberdeen , Aberdeen, UK (FO, IJM); Department of Pathology, Addenbrooke's Hospital , Cambridge, UK (AYW, NS); Institute of Human Genetics, Jena University Hospital , Jena , Germany (ME, KL, WH, AB); Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Faculty of Health Sciences, University of Adelaide , Australia (LAS, WDT); Freemasons Foundation Centre for Men's Health, School of Medicine, Faculty of Health Sciences, University of Adelaide , Australia (LAS, WDT); Diatherix , Huntsville, AL (EG); Masonic Cancer Center, University of Minnesota , Minneapolis, MN (SMD); The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia , Vancouver BC , Canada (PSR); Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital , Oslo , Norway (IGM); Department of Cancer Prevention, Institute of Cancer Research and Department of Urology, Oslo University Hospital , Oslo , Norway (IGM); Prostate Cancer UK/Movember Centre of Excellence, Queens University , Belfast , UK (IGM); Department of Oncology, Addenbrooke's Hospital , Cambridge, UK (MA, DEN).

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http://jnci.oxfordjournals.org/content/108/5/djv371.full.pdf
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv37
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http://dx.doi.org/10.1093/jnci/djv371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849803PMC
May 2016

Clonal origin and spread of metastatic prostate cancer.

Endocr Relat Cancer 2016 Apr 21;23(4):R207-17. Epub 2016 Mar 21.

Masonic Cancer CenterUniversity of Minnesota, Minneapolis, MN, USA Department of Laboratory Medicine and PathologyUniversity of Minnesota, Minneapolis, MN, USA Department of UrologyUniversity of Minnesota, Minneapolis, MN, USA

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http://dx.doi.org/10.1530/ERC-16-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895916PMC
April 2016

Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies.

Nucleic Acids Res 2015 Jul 23;43(12):5880-97. Epub 2015 Apr 23.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55905, USA Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55905, USA

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http://dx.doi.org/10.1093/nar/gkv262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499120PMC
July 2015

Constitutive activity of the androgen receptor.

Adv Pharmacol 2014 ;70:327-66

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-417197-8.00011-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277179PMC
January 2015

Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer.

Endocr Relat Cancer 2014 Aug 23;21(4):T87-T103. Epub 2014 May 23.

Departments of Molecular Genetics and MedicineDuke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USADepartment of MedicineDuke Cancer Institute, Duke University, Durham, North Carolina, USAMasonic Cancer CenterUniversity of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USADepartment of Laboratory Medicine and PathologyUniversity of Minnesota, Minneapolis, Minnesota, USADepartments of Molecular Genetics and MedicineDuke University, 213 Research Dr, 0045 CARL Building, Durham, North Carolina 27710, USADepartment of MedicineDuke Cancer Institute, Duke University, Durham, North Carolina, USAMasonic Cancer CenterUniversity of Minnesota Masonic Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USADepartment of Laboratory Medicine and PathologyUniversity of Minnesota, Minneapolis, Minnesota, USA

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http://dx.doi.org/10.1530/ERC-13-0470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277180PMC
August 2014

SHEAR: sample heterogeneity estimation and assembly by reference.

BMC Genomics 2014 Jan 29;15:84. Epub 2014 Jan 29.

Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1186/1471-2164-15-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007568PMC
January 2014

Test-firing ammunition for spliceosome inhibition in cancer.

Authors:
Scott M Dehm

Clin Cancer Res 2013 Nov 4;19(22):6064-6. Epub 2013 Oct 4.

Author's Affiliation: Masonic Cancer Center and Department of Laboratory Medicine and Pathology, University of Minnesota, Twin Cities.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839097PMC
November 2013

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer.

Proc Natl Acad Sci U S A 2013 Oct 7;110(43):17492-7. Epub 2013 Oct 7.

Masonic Cancer Center, Graduate Program in Molecular, Cellular, and Developmental Biology and Genetics, and Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1308587110
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http://dx.doi.org/10.1073/pnas.1308587110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808622PMC
October 2013

mRNA splicing variants: exploiting modularity to outwit cancer therapy.

Authors:
Scott M Dehm

Cancer Res 2013 Sep 22;73(17):5309-14. Epub 2013 Aug 22.

Department of Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766449PMC
September 2013

FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants.

Prostate 2013 Jul 6;73(10):1017-27. Epub 2013 Feb 6.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1002/pros.22649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915545PMC
July 2013

Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression.

Horm Cancer 2013 Apr 10;4(2):61-9. Epub 2013 Jan 10.

Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1007/s12672-013-0131-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957092PMC
April 2013

Androgen receptor gene rearrangements: new perspectives on prostate cancer progression.

Curr Drug Targets 2013 Apr;14(4):441-9

Graduate Program in Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN 55455, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957184PMC
http://dx.doi.org/10.2174/1389450111314040005DOI Listing
April 2013

Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines.

Cancer Res 2013 Jan 1;73(2):483-9. Epub 2012 Nov 1.

Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549016PMC
January 2013

Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer.

Adv Urol 2012 22;2012:781459. Epub 2012 Aug 22.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1155/2012/781459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432332PMC
September 2012

Alternatively spliced androgen receptor variants.

Endocr Relat Cancer 2011 Oct 20;18(5):R183-96. Epub 2011 Sep 20.

Department of Laboratory Medicine and Pathology, Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1530/ERC-11-0141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235645PMC
October 2011

Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression.

Cancer Res 2011 Mar 19;71(6):2108-17. Epub 2011 Jan 19.

Department of Electrical and Computer Engineering, Masonic Cancer Center, University of Minnesota, Twin Cities, Minnesota 55455, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-1998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059379PMC
March 2011

Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.

Cancer Res 2009 Oct 29;69(20):8102-10. Epub 2009 Sep 29.

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947560PMC
October 2009

Induction of FLIP expression by androgens protects prostate cancer cells from TRAIL-mediated apoptosis.

Prostate 2008 Nov;68(15):1696-706

Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1002/pros.20844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574904PMC
November 2008

Androgen receptor structural and functional elements: role and regulation in prostate cancer.

Mol Endocrinol 2007 Dec 17;21(12):2855-63. Epub 2007 Jul 17.

Departments of Urology and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1210/me.2007-0223DOI Listing
December 2007

Androgen induction of the androgen receptor coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancer.

Cancer Res 2007 Nov;67(21):10592-9

Department of Urology Research/Biochemistry, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1917DOI Listing
November 2007

Selective role of an NH2-terminal WxxLF motif for aberrant androgen receptor activation in androgen depletion independent prostate cancer cells.

Cancer Res 2007 Oct;67(20):10067-77

Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1267DOI Listing
October 2007

Molecular regulation of androgen action in prostate cancer.

J Cell Biochem 2006 Oct;99(2):333-44

Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1002/jcb.20794DOI Listing
October 2006

The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter.

Gene 2006 Sep 5;379:68-78. Epub 2006 May 5.

Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, SK, Canada.

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http://dx.doi.org/10.1016/j.gene.2006.04.015DOI Listing
September 2006

Ligand-independent androgen receptor activity is activation function-2-independent and resistant to antiandrogens in androgen refractory prostate cancer cells.

J Biol Chem 2006 Sep 25;281(38):27882-93. Epub 2006 Jul 25.

Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.M605002200DOI Listing
September 2006

p300 regulates androgen receptor-independent expression of prostate-specific antigen in prostate cancer cells treated chronically with interleukin-6.

Cancer Res 2005 Jul;65(13):5965-73

Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2837DOI Listing
July 2005

Regulation of androgen receptor signaling in prostate cancer.

Expert Rev Anticancer Ther 2005 Feb;5(1):63-74

Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA.

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http://www.tandfonline.com/doi/full/10.1586/14737140.5.1.63
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http://dx.doi.org/10.1586/14737140.5.1.63DOI Listing
February 2005

Regulation of alternative SRC promoter usage in HepG2 hepatocellular carcinoma cells.

Gene 2004 Aug;337:141-50

Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Canada.

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http://dx.doi.org/10.1016/j.gene.2004.04.021DOI Listing
August 2004

SRC gene expression in human cancer: the role of transcriptional activation.

Biochem Cell Biol 2004 Apr;82(2):263-74

Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1139/o03-077DOI Listing
April 2004

SRC proximal and core promoter elements dictate TAF1 dependence and transcriptional repression by histone deacetylase inhibitors.

Mol Cell Biol 2004 Mar;24(6):2296-307

Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC355838PMC
http://dx.doi.org/10.1128/mcb.24.6.2296-2307.2004DOI Listing
March 2004

The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases.

Oncogene 2002 Sep;21(41):6340-7

Department of Biochemistry, University of Saskatchewan, Saskatoon SK, Canada S7N 5E5.

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http://dx.doi.org/10.1038/sj.onc.1205787DOI Listing
September 2002