Scott Kopetz

Scott Kopetz

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Scott Kopetz

Scott Kopetz

Publications by authors named "Scott Kopetz"

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Biomarker-guided therapy for colorectal cancer: strength in complexity.

Nat Rev Clin Oncol 2020 Jan 9;17(1):11-32. Epub 2019 Jul 9.

Department of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Division for Cancer Medicine, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41571-019-0241-1DOI Listing
January 2020

Mechanisms of Innate and Acquired Resistance to Anti-EGFR Therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies.

Clin Cancer Res 2019 Dec 1;25(23):6899-6908. Epub 2019 Jul 1.

Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891150PMC
December 2019

The BE GONE trial study protocol: a randomized crossover dietary intervention of dry beans targeting the gut microbiome of overweight and obese patients with a history of colorectal polyps or cancer.

BMC Cancer 2019 Dec 18;19(1):1233. Epub 2019 Dec 18.

Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1340, Houston, TX, TX 77030, USA.

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http://dx.doi.org/10.1186/s12885-019-6400-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921460PMC
December 2019

Development and Application of Duplex Sequencing Strategy for Cell-Free DNA-Based Longitudinal Monitoring of Stage IV Colorectal Cancer.

J Mol Diagn 2019 Nov 8;21(6):994-1009. Epub 2019 Aug 8.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854476PMC
November 2019

CTC analysis: an update on technological progress.

Transl Res 2019 Oct 11;212:14-25. Epub 2019 Jul 11.

Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19315244193013
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http://dx.doi.org/10.1016/j.trsl.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755047PMC
October 2019

Encorafenib, Binimetinib, and Cetuximab in V600E-Mutated Colorectal Cancer.

N Engl J Med 2019 10 30;381(17):1632-1643. Epub 2019 Sep 30.

From the University of Texas M.D. Anderson Cancer Center, Houston (S.K., V.M.); West Cancer Center and Research Institute, OneOncology, Germantown, TN (A. Grothey); Memorial Sloan Kettering Cancer Center, New York (R.Y., A.K.); University Hospital Gasthuisberg and University of Leuven, Leuven, Belgium (E.V.C., J. Dekervel); the Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (J. Desai, C.G.); National Cancer Center Hospital East, Kashiwa, Japan (T.Y.); Hammersmith Hospital, Division of Cancer, Imperial College London (H.W.), and the Sarah Cannon Research Institute and University College London Cancer Institute (H.-T.A.), London, and the Christie NHS Foundation Trust/National Institute for Health Research Manchester Biomedical Research Centre, Manchester (M.B.) - all in the United Kingdom; the University of Campania Luigi Vanvitelli, Naples (F.C.), and Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico, Padua (F.L., S.L.) - both in Italy; Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (Y.S.H., T.-W.K.); the Netherlands Cancer Institute, Amsterdam (N.S., J.H.M.S.); Oslo University Hospital, Oslo (T.K.G.); Hospital Gregorio Marañón, Madrid (P.G.-A., A.C.F.), and Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, UVic, IOB-Quiron, Barcelona (E.E., J.T.) - both in Spain; Odense University Hospital, Odense, Denmark (P.P., L.S.T.); Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia (S.O.); and Array BioPharma, Boulder, CO (A. Gollerkeri, C.K., K.M., M.P., J.C.-B., L.A., V.S.).

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http://dx.doi.org/10.1056/NEJMoa1908075DOI Listing
October 2019

Is the Patient Cured?

JAMA Oncol 2019 Oct 17. Epub 2019 Oct 17.

Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2019.3612DOI Listing
October 2019

Non-invasive genotyping of metastatic colorectal cancer using circulating cell free DNA.

Cancer Genet 2019 Sep 12;237:82-89. Epub 2019 Jun 12.

Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, 6565 MD Anderson Blvd., Houston, TX 77030, United States; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2019.06.004DOI Listing
September 2019

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research.

Cancers (Basel) 2019 Sep 6;11(9). Epub 2019 Sep 6.

Department of Genomic Medicine, UT MD Anderson cancer center, Houston, TX 77054, USA.

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http://dx.doi.org/10.3390/cancers11091321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770280PMC
September 2019

Genetic profiling as a clinical tool in advanced parathyroid carcinoma.

J Cancer Res Clin Oncol 2019 Aug 15;145(8):1977-1986. Epub 2019 Jul 15.

Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1461, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s00432-019-02945-9DOI Listing
August 2019

Prevalence of recurrent oncogenic fusion in mismatch repair-deficient colorectal carcinoma with hypermethylated MLH1 and wild-type BRAF and KRAS.

Mod Pathol 2019 07 5;32(7):1053-1064. Epub 2019 Feb 5.

Molecular Pathology Research Center, Department of Pathology, Peking Union Medical College Hospital, and Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/s41379-019-0212-1DOI Listing
July 2019

Evolving Strategies for the Management of BRAF-Mutant Metastatic Colorectal Cancer.

Oncology (Williston Park) 2019 06;33(6):206-11

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June 2019

Can Circulating Tumor DNA in Early-Stage Colorectal Cancer Be More Than a Prognostic Biomarker?

JAMA Oncol 2019 May 9. Epub 2019 May 9.

The University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2019.0503DOI Listing
May 2019

Ongoing and future directions in the management of metastatic colorectal cancer: Update on clinical trials.

J Surg Oncol 2019 Apr 10;119(5):642-652. Epub 2019 Mar 10.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/jso.25441DOI Listing
April 2019

Two phase I, pharmacokinetic, and pharmacodynamic studies of DFP-10917, a novel nucleoside analog with 14-day and 7-day continuous infusion schedules.

Invest New Drugs 2019 02 18;37(1):76-86. Epub 2018 Apr 18.

Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s10637-018-0602-0
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http://dx.doi.org/10.1007/s10637-018-0602-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521838PMC
February 2019

New therapies and insights into the changing landscape of colorectal cancer.

Authors:
Scott Kopetz

Nat Rev Gastroenterol Hepatol 2019 02;16(2):79-80

University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41575-018-0100-zDOI Listing
February 2019

Back to the Colorectal Cancer Consensus Molecular Subtype Future.

Curr Gastroenterol Rep 2019 Jan 30;21(2). Epub 2019 Jan 30.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard--Unit 0426, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11894-019-0674-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622456PMC
January 2019

Phase II study of DFP-10917, a deoxycytidine analog, given by 14-day continuous intravenous infusion for chemotherapy-refractory advanced colorectal cancer.

Invest New Drugs 2018 10 13;36(5):895-902. Epub 2018 Jun 13.

Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10637-018-0615-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136955PMC
October 2018

Circulating Tumor DNA-Defined Minimal Residual Disease in Solid Tumors: Opportunities to Accelerate the Development of Adjuvant Therapies.

J Clin Oncol 2018 Oct 30:JCO2018789032. Epub 2018 Oct 30.

Arvind Dasari, The University of Texas MD Anderson Cancer Center, Houston, TX; Axel Grothey, The University of Tennessee West Cancer Center, Memphis, TN; and Scott Kopetz, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2018.78.9032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286158PMC
October 2018

Bioactive lipid metabolism in platelet "first responder" and cancer biology.

Cancer Metastasis Rev 2018 09;37(2-3):439-454

Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1007/s10555-018-9755-8DOI Listing
September 2018

The Addition of Bevacizumab to Oxaliplatin-Based Chemotherapy: Impact Upon Hepatic Sinusoidal Injury and Thrombocytopenia.

J Natl Cancer Inst 2018 08;110(8):888-894

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1093/jnci/djx288DOI Listing
August 2018

Nivolumab in the treatment of microsatellite instability high metastatic colorectal cancer.

Future Oncol 2018 08 23;14(18):1869-1874. Epub 2018 Feb 23.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.2217/fon-2017-0696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088272PMC
August 2018

Genome-wide Discovery and Identification of a Novel miRNA Signature for Recurrence Prediction in Stage II and III Colorectal Cancer.

Clin Cancer Res 2018 08 7;24(16):3867-3877. Epub 2018 Mar 7.

Center for Gastrointestinal Research, Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute and Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-3236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095767PMC
August 2018

RAS Mutation is Associated with Unsalvageable Recurrence Following Hepatectomy for Colorectal Cancer Liver Metastases.

Ann Surg Oncol 2018 Aug 21;25(8):2457-2466. Epub 2018 May 21.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-018-6517-3DOI Listing
August 2018

SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases.

Eur J Surg Oncol 2018 05 7;44(5):684-692. Epub 2018 Mar 7.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2018.02.247DOI Listing
May 2018

Untying the gordion knot of targeting MET in cancer.

Cancer Treat Rev 2018 May 26;66:95-103. Epub 2018 Apr 26.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372183005
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http://dx.doi.org/10.1016/j.ctrv.2018.04.008DOI Listing
May 2018

How should BRAF V600E-mutated colorectal cancer be treated?

Authors:
Scott Kopetz

Clin Adv Hematol Oncol 2018 May;16(5):333-335

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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May 2018

Correction to: Accelerating Therapeutic Development through Innovative Trial Design in Colorectal Cancer.

Curr Treat Options Oncol 2018 04 23;19(5):25. Epub 2018 Apr 23.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard-Unit 0426, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s11864-018-0537-x
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http://dx.doi.org/10.1007/s11864-018-0537-xDOI Listing
April 2018

Platelet Metabolism and Other Targeted Drugs; Potential Impact on Immunotherapy.

Front Oncol 2018 20;8:107. Epub 2018 Apr 20.

Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

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http://dx.doi.org/10.3389/fonc.2018.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919962PMC
April 2018

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer.

J Clin Oncol 2018 03 20;36(8):773-779. Epub 2018 Jan 20.

Michael J. Overman and Scott Kopetz, University of Texas MD Anderson Cancer Center, Houston, TX; Sara Lonardi, Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico, Padova; Fabio Gelsomino, University Hospital of Modena, Modena; Massimo Aglietta, Institute for Cancer Research and Treatment of Candiolo, University of Torino Medical School, Turin, Italy; Ka Yeung Mark Wong, Sydney Medical School, University of Sydney, Sydney, New South Wales; Andrew Hill, Tasman Oncology Research, Ltd., Southport, Queensland, Australia; Heinz-Josef Lenz, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA; Michael A. Morse, Duke University Medical Center, Durham, NC; Eric Van Cutsem, University Hospitals Gasthuisberg Leuven and Katholieke Universiteit Leuven, Leuven; Alain Hendlisz, Institut Jules Bordet; Bart Neyns, Universitair Ziekenhuis Brussel, Brussels; Jean-Marie Ledeine, Bristol-Myers Squibb, Braine-L'Alleud, Belgium; Ray McDermott, St Vincent's University Hospital and Cancer Trials Ireland, Dublin, Ireland; Michael B. Sawyer, Cross Cancer Institute and University of Alberta, Edmonton, Alberta, Canada; Magali Svrcek and Thierry André, Hopital Saint Antoine, Assistance Publique Hôpitaux de Paris and Sorbonne Universités, Université Pierre et Marie Curie, Paris, France; and Rebecca A. Moss, Z. Alexander Cao, and Shital Kamble, Bristol-Myers Squibb, Princeton, NJ.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.9901
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http://dx.doi.org/10.1200/JCO.2017.76.9901DOI Listing
March 2018

Impact of Prior Hepatectomy History on Local Tumor Progression after Percutaneous Ablation of Colorectal Liver Metastases.

J Vasc Interv Radiol 2018 03 1;29(3):395-403.e1. Epub 2018 Feb 1.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler St., Unit 1471, Houston, TX 77030.

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http://dx.doi.org/10.1016/j.jvir.2017.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818310PMC
March 2018

Accelerating Therapeutic Development through Innovative Trial Design in Colorectal Cancer.

Curr Treat Options Oncol 2018 02 27;19(2):11. Epub 2018 Feb 27.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard-Unit 0426, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11864-018-0524-2DOI Listing
February 2018

Integrated safety summary for trifluridine/tipiracil (TAS-102).

Anticancer Drugs 2018 01;29(1):89-96

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1097/CAD.0000000000000554DOI Listing
January 2018

Individualized Treatment Sequencing Selection Contributes to Optimized Survival in Patients with Rectal Cancer and Synchronous Liver Metastases.

Ann Surg Oncol 2017 Dec 19;24(13):3857-3864. Epub 2017 Sep 19.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-017-6089-7DOI Listing
December 2017

Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment.

Am J Cancer Res 2017 1;7(12):2587-2599. Epub 2017 Dec 1.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterTX 77030, Houston, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752698PMC
December 2017

Platelet microparticles: small payloads with profound effects on tumor growth.

Noncoding RNA Investig 2017 Nov 17;1. Epub 2017 Nov 17.

Departments of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.21037/ncri.2017.11.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583804PMC
November 2017

BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer.

J Clin Oncol 2017 Aug 9;35(23):2624-2630. Epub 2017 May 9.

Jeremy C. Jones, Lindsay A. Renfro, Ben Y. Zhang, Pashtoon M. Kasi, Jesse S. Voss, Alexis D. Leal, Joleen M. Hubbard, Benjamin R. Kipp, Robert R. McWilliams, and Axel Grothey, Mayo Clinic, Rochester, MN; Humaid O. Al-Shamsi, Scott Kopetz, and Robert A. Wolff, The University of Texas MD Anderson Cancer Center, Houston, TX; and Alexa B. Schrock, Andrew Rankin, James Sun, Jeffrey Ross, and Siraj M. Ali, Foundation Medicine, Cambridge, MA.

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http://ascopubs.org/doi/10.1200/JCO.2016.71.4394
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http://dx.doi.org/10.1200/JCO.2016.71.4394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549454PMC
August 2017

Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer.

Genome Res 2017 08 25;27(8):1287-1299. Epub 2017 May 25.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gr.209973.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538546PMC
August 2017

Recent developments in the treatment of metastatic colorectal cancer.

Ther Adv Med Oncol 2017 Aug 29;9(8):551-564. Epub 2017 Jun 29.

Division of Gastrointestinal Medical Oncology, The University of Texas, MD Anderson Cancer Center, Unit 426, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1177/1758834017714997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524248PMC
August 2017

Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.

PLoS Pathog 2017 Jul 13;13(7):e1006440. Epub 2017 Jul 13.

Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509344PMC
July 2017

Targeting -Mutant Colorectal Cancer: Progress in Combination Strategies.

Cancer Discov 2017 06;7(6):558-560

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458523PMC
June 2017

Platelets, circulating tumor cells, and the circulome.

Cancer Metastasis Rev 2017 06;36(2):235-248

Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Unit 426, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10555-017-9681-1DOI Listing
June 2017

The potential role of platelets in the consensus molecular subtypes of colorectal cancer.

Cancer Metastasis Rev 2017 06;36(2):273-288

Department of Gastrointestinal Medical Oncology, M. D. Anderson Cancer, Unit 0426, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s10555-017-9678-9
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http://dx.doi.org/10.1007/s10555-017-9678-9DOI Listing
June 2017

Platelet "first responders" in wound response, cancer, and metastasis.

Cancer Metastasis Rev 2017 06;36(2):199-213

Bioactive Lipids Research Program, Department of Pathology, Wayne State University, 431 Chemistry Bldg, 5101 Cass Avenue, Detroit, MI, 48202, USA.

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http://dx.doi.org/10.1007/s10555-017-9682-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709140PMC
June 2017