Scott Kopetz

Scott Kopetz

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Scott Kopetz

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100Publications

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Biomarker-guided therapy for colorectal cancer: strength in complexity.

Authors:
Anita Sveen Scott Kopetz Ragnhild A Lothe

Nat Rev Clin Oncol 2020 Jan 9;17(1):11-32. Epub 2019 Jul 9.

Department of Molecular Oncology, Institute for Cancer Research & K.G. Jebsen Colorectal Cancer Research Centre, Division for Cancer Medicine, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41571-019-0241-1DOI Listing
January 2020

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation.

Authors:
Ying-Nan Wang Yun-Xin Lu Jie Liu Ying Jin Hui-Chang Bi Qi Zhao Ze-Xian Liu Ying-Qin Li Jia-Jia Hu Hui Sheng Yi-Ming Jiang Chao Zhang Feng Tian Yang Chen Zhi-Zhong Pan Gong Chen Zhao-Lei Zeng Kai-Yan Liu Marcia Ogasawara Jin-Ping Yun Huai-Qiang Ju Jian-Xiong Feng Dan Xie Song Gao Wei-Hua Jia Scott Kopetz Rui-Hua Xu Feng Wang

Oncogene 2020 Jan 17;39(3):637-650. Epub 2019 Sep 17.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, China.

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http://dx.doi.org/10.1038/s41388-019-1004-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962094PMC
January 2020

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.

Authors:
Sangeeta Goswami Thomas Walle Andrew E Cornish Sreyashi Basu Swetha Anandhan Irina Fernandez Luis Vence Jorge Blando Hao Zhao Shalini Singh Yadav Martina Ott Ling Y Kong Amy B Heimberger John de Groot Boris Sepesi Michael Overman Scott Kopetz James P Allison Dana Pe'er Padmanee Sharma

Nat Med 2020 Jan 23;26(1):39-46. Epub 2019 Dec 23.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41591-019-0694-xDOI Listing
January 2020

Mechanisms of Innate and Acquired Resistance to Anti-EGFR Therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies.

Authors:
Christine M Parseghian Stefania Napolitano Jonathan M Loree Scott Kopetz

Clin Cancer Res 2019 Dec 1;25(23):6899-6908. Epub 2019 Jul 1.

Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891150PMC
December 2019

Validation of Microsatellite Instability Detection Using a Comprehensive Plasma-Based Genotyping Panel.

Authors:
Jason Willis Martina I Lefterova Alexander Artyomenko Pashtoon Murtaza Kasi Yoshiaki Nakamura Kabir Mody Daniel V T Catenacci Marwan Fakih Catalin Barbacioru Jing Zhao Marcin Sikora Stephen R Fairclough Hyuk Lee Kyoung-Mee Kim Seung Tae Kim Jinchul Kim Danielle Gavino Manuel Benavides Nir Peled Timmy Nguyen Mike Cusnir Ramez N Eskander Georges Azzi Takayuki Yoshino Kimberly C Banks Victoria M Raymond Richard B Lanman Darya I Chudova AmirAli Talasaz Scott Kopetz Jeeyun Lee Justin I Odegaard

Clin Cancer Res 2019 Dec 4;25(23):7035-7045. Epub 2019 Aug 4.

Guardant Health, Redwood City, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1324DOI Listing
December 2019

A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries.

Authors:
Omkara Lakshmi Veeranki Zhimin Tong Alicia Mejia Anuj Verma Riham Katkhuda Roland Bassett Tae-Beom Kim Jing Wang Wenhua Lang Barbara Mino Luisa Solis Charles Kingsley William Norton Ramesh Tailor Ji Yuan Wu Sunil Krishnan Steven H Lin Mariela Blum Wayne Hofstetter Jaffer Ajani Scott Kopetz Dipen Maru

Dis Model Mech 2019 12 17;12(12). Epub 2019 Dec 17.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

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http://dx.doi.org/10.1242/dmm.041004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918774PMC
December 2019

The BE GONE trial study protocol: a randomized crossover dietary intervention of dry beans targeting the gut microbiome of overweight and obese patients with a history of colorectal polyps or cancer.

Authors:
Xiaotao Zhang Gladys Browman Wesley Siu Karen M Basen-Engquist Samir M Hanash Kristi L Hoffman Pablo C Okhuysen Paul Scheet Joseph F Petrosino Scott Kopetz Carrie R Daniel

BMC Cancer 2019 Dec 18;19(1):1233. Epub 2019 Dec 18.

Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1340, Houston, TX, TX 77030, USA.

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http://dx.doi.org/10.1186/s12885-019-6400-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921460PMC
December 2019

Development and Application of Duplex Sequencing Strategy for Cell-Free DNA-Based Longitudinal Monitoring of Stage IV Colorectal Cancer.

Authors:
Saradhi Mallampati Stephanie Zalles Dzifa Y Duose Peter C Hu L Jeffrey Medeiros Ignacio I Wistuba Scott Kopetz Rajyalakshmi Luthra

J Mol Diagn 2019 Nov 8;21(6):994-1009. Epub 2019 Aug 8.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854476PMC
November 2019

Population pharmacokinetics and covariate analysis of Sym004, an antibody mixture against the epidermal growth factor receptor, in subjects with metastatic colorectal cancer and other solid tumors.

Authors:
Lene Alifrangis Rik Schoemaker Niels J Skartved Rikke Hald Clara Montagut Scott Kopetz Josep Tabernero Michael Kragh Janet R Wade

J Pharmacokinet Pharmacodyn 2019 Nov 2. Epub 2019 Nov 2.

Occams Coöperatie U.A., 1187 HE, Amstelveen, The Netherlands.

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http://dx.doi.org/10.1007/s10928-019-09663-2DOI Listing
November 2019

Mutation Status of , and is Superior to Mutation Status of Alone for Predicting Prognosis after Resection of Colorectal Liver Metastases.

Authors:
Yoshikuni Kawaguchi Scott Kopetz Timothy E Newhook Mario De Bellis Yun Shin Chun Ching-Wei D Tzeng Thomas A Aloia Jean-Nicolas Vauthey

Clin Cancer Res 2019 Oct 20;25(19):5843-5851. Epub 2019 Jun 20.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774854PMC
October 2019

CTC analysis: an update on technological progress.

Authors:
Izhar S Batth Abhisek Mitra Sierra Rood Scott Kopetz David Menter Shulin Li

Transl Res 2019 Oct 11;212:14-25. Epub 2019 Jul 11.

Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19315244193013
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http://dx.doi.org/10.1016/j.trsl.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755047PMC
October 2019

Encorafenib, Binimetinib, and Cetuximab in V600E-Mutated Colorectal Cancer.

Authors:
Scott Kopetz Axel Grothey Rona Yaeger Eric Van Cutsem Jayesh Desai Takayuki Yoshino Harpreet Wasan Fortunato Ciardiello Fotios Loupakis Yong Sang Hong Neeltje Steeghs Tormod K Guren Hendrik-Tobias Arkenau Pilar Garcia-Alfonso Per Pfeiffer Sergey Orlov Sara Lonardi Elena Elez Tae-Won Kim Jan H M Schellens Christina Guo Asha Krishnan Jeroen Dekervel Van Morris Aitana Calvo Ferrandiz L S Tarpgaard Michael Braun Ashwin Gollerkeri Christopher Keir Kati Maharry Michael Pickard Janna Christy-Bittel Lisa Anderson Victor Sandor Josep Tabernero

N Engl J Med 2019 10 30;381(17):1632-1643. Epub 2019 Sep 30.

From the University of Texas M.D. Anderson Cancer Center, Houston (S.K., V.M.); West Cancer Center and Research Institute, OneOncology, Germantown, TN (A. Grothey); Memorial Sloan Kettering Cancer Center, New York (R.Y., A.K.); University Hospital Gasthuisberg and University of Leuven, Leuven, Belgium (E.V.C., J. Dekervel); the Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (J. Desai, C.G.); National Cancer Center Hospital East, Kashiwa, Japan (T.Y.); Hammersmith Hospital, Division of Cancer, Imperial College London (H.W.), and the Sarah Cannon Research Institute and University College London Cancer Institute (H.-T.A.), London, and the Christie NHS Foundation Trust/National Institute for Health Research Manchester Biomedical Research Centre, Manchester (M.B.) - all in the United Kingdom; the University of Campania Luigi Vanvitelli, Naples (F.C.), and Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico, Padua (F.L., S.L.) - both in Italy; Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (Y.S.H., T.-W.K.); the Netherlands Cancer Institute, Amsterdam (N.S., J.H.M.S.); Oslo University Hospital, Oslo (T.K.G.); Hospital Gregorio Marañón, Madrid (P.G.-A., A.C.F.), and Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, UVic, IOB-Quiron, Barcelona (E.E., J.T.) - both in Spain; Odense University Hospital, Odense, Denmark (P.P., L.S.T.); Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia (S.O.); and Array BioPharma, Boulder, CO (A. Gollerkeri, C.K., K.M., M.P., J.C.-B., L.A., V.S.).

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http://dx.doi.org/10.1056/NEJMoa1908075DOI Listing
October 2019

Is the Patient Cured?

Authors:
Harry B Burke Scott Kopetz

JAMA Oncol 2019 Oct 17. Epub 2019 Oct 17.

Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2019.3612DOI Listing
October 2019

Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer.

Authors:
Shailesh Mahesh Advani Pragati Shailesh Advani Derek W Brown Stacia M DeSantis Krittiya Korphaisarn Helena M VonVille Jan Bressler David S Lopez Jennifer S Davis Carrie R Daniel Amir Mehrvarz Sarshekeh Dejana Braithwaite Michael D Swartz Scott Kopetz

BMC Cancer 2019 Oct 17;19(1):964. Epub 2019 Oct 17.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 0426, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s12885-019-6144-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796359PMC
October 2019

Medical Oncologists' Perspectives on How the Results of the IDEA Collaboration Impact the Adjuvant Treatment of Stage III Colon Cancer.

Authors:
Irene S Yu Allan A L Pereira Michael Lee Kritti Korphaisarn John Marshall Eva Segelov Chris O'Callaghan Howard J Lim Scott Kopetz Jonathan M Loree

Oncologist 2019 Oct 22. Epub 2019 Oct 22.

BC Cancer, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1634/theoncologist.2019-0553DOI Listing
October 2019

Evaluating for Pseudoprogression in Colorectal and Pancreatic Tumors Treated With Immunotherapy.

Authors:
Christine M Parseghian Madhavi Patnana Priya Bhosale Kenneth R Hess Ya-Chen Tina Shih Bumyang Kim Scott Kopetz Michael J Overman Gauri R Varadhachary Milind Javle Aung Naing Sarina Piha-Paul David Hong Hung Le Vivek Subbiah Shubham Pant

J Immunother 2018 Jul/Aug;41(6):284-291

Investigational Cancer Therapeutics.

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http://Insights.ovid.com/crossref?an=00002371-900000000-9948
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http://dx.doi.org/10.1097/CJI.0000000000000222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028046PMC
September 2019

Conditional Recurrence-Free Survival after Resection of Colorectal Liver Metastases: Persistent Deleterious Association with RAS and TP53 Co-Mutation.

Authors:
Yoshikuni Kawaguchi Heather A Lillemoe Elena Panettieri Yun Shin Chun Ching-Wei D Tzeng Thomas A Aloia Scott Kopetz Jean-Nicolas Vauthey

J Am Coll Surg 2019 Sep 2;229(3):286-294.e1. Epub 2019 May 2.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703951PMC
September 2019

Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma.

Authors:
Krittiya Korphaisarn Van Morris Jenifer S Davis Michael J Overman David R Fogelman Bryan K Kee Arvind Dasari Kanwal P S Raghav Imad Shureiqi Metha Trupti Robert A Wolff Cathy Eng David G Menter Stanley Hamilton Scott Kopetz

Br J Cancer 2019 Sep 13;121(6):505-510. Epub 2019 Aug 13.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41416-019-0548-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738104PMC
September 2019

Non-invasive genotyping of metastatic colorectal cancer using circulating cell free DNA.

Authors:
Xuemei Shi Dzifa Y Duose Meenakshi Mehrotra Michael A Harmon Peter Hu Ignacio I Wistuba Scott Kopetz Rajyalakshmi Luthra

Cancer Genet 2019 Sep 12;237:82-89. Epub 2019 Jun 12.

Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, 6565 MD Anderson Blvd., Houston, TX 77030, United States; Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2019.06.004DOI Listing
September 2019

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research.

Authors:
Akira Inoue Angela K Deem Scott Kopetz Timothy P Heffernan Giulio F Draetta Alessandro Carugo

Cancers (Basel) 2019 Sep 6;11(9). Epub 2019 Sep 6.

Department of Genomic Medicine, UT MD Anderson cancer center, Houston, TX 77054, USA.

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http://dx.doi.org/10.3390/cancers11091321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770280PMC
September 2019

Refining the Use of Adjuvant Oxaliplatin in Clinical Stage II or III Rectal Adenocarcinoma.

Authors:
Ofer Margalit Ronac Mamtani Scott Kopetz Yu-Xiao Yang Yaacov R Lawrence Samir Abu-Gazala Kim A Reiss Talia Golan Naama Halpern Dan Aderka Bruce Giantonio Einat Shacham-Shmueli Ben Boursi

Oncologist 2019 Aug 29;24(8):e671-e676. Epub 2019 Jan 29.

Department of Oncology, Sheba Medical Center, Tel-Hashomer, Israel.

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http://dx.doi.org/10.1634/theoncologist.2018-0333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693732PMC
August 2019

Genetic profiling as a clinical tool in advanced parathyroid carcinoma.

Authors:
Merve Kutahyalioglu Ha T Nguyen Lily Kwatampora Callisia Clarke Angelica Silva Eiman Ibrahim Steven G Waguespack Maria E Cabanillas Camilo Jimenez Mimi I Hu Steven I Sherman Scott Kopetz Russell Broaddus Ramona Dadu Kacey Wanland Michelle Williams Mark Zafereo Nancy Perrier Naifa L Busaidy

J Cancer Res Clin Oncol 2019 Aug 15;145(8):1977-1986. Epub 2019 Jul 15.

Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1461, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s00432-019-02945-9DOI Listing
August 2019

Disparity of Race Reporting and Representation in Clinical Trials Leading to Cancer Drug Approvals From 2008 to 2018.

Authors:
Jonathan M Loree Seerat Anand Arvind Dasari Joseph M Unger Anirudh Gothwal Lee M Ellis Gauri Varadhachary Scott Kopetz Michael J Overman Kanwal Raghav

JAMA Oncol 2019 Aug 15:e191870. Epub 2019 Aug 15.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2019.1870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696743PMC
August 2019

Correction: A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.

Authors:
Natalia Paez Arango Lauren Brusco Kenna R Mills Shaw Ken Chen Agda Karina Eterovic Vijaykumar Holla Amber Johnson Beate Litzenburger Yekaterina B Khotskaya Nora Sanchez Ann Bailey Xiaofeng Zheng Chacha Horombe Scott Kopetz Carol J Farhangfar Mark Routbort Russell Broaddus Elmer V Bernstam John Mendelsohn Gordon B Mills Funda Meric-Bernstam

Oncotarget 2019 Aug 27;10(50):5254. Epub 2019 Aug 27.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.27176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718259PMC
August 2019

Prevalence of recurrent oncogenic fusion in mismatch repair-deficient colorectal carcinoma with hypermethylated MLH1 and wild-type BRAF and KRAS.

Authors:
Jing Wang Yuting Yi Yi Xiao Lin Dong Li Liang Lianghong Teng Jian Ming Ying Tao Lu Yuanyuan Liu Yanfang Guan Junyi Pang Lianrui Zhou Junliang Lu Zhiwen Zhang Xiaoding Liu Xiaolong Liang Xuan Zeng Xin Yi Weixun Zhou Xuefeng Xia Ling Yang Jianjun Zhang Scott Kopetz P Andrew Futreal Huanwen Wu Zhiyong Liang

Mod Pathol 2019 07 5;32(7):1053-1064. Epub 2019 Feb 5.

Molecular Pathology Research Center, Department of Pathology, Peking Union Medical College Hospital, and Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/s41379-019-0212-1DOI Listing
July 2019

Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma.

Authors:
Zhimin Tong Alicia Mejia Omkara Veeranki Anuj Verma Arlene M Correa Rashmi Dokey Viren Patel Luisa Maren Solis Barbara Mino Riham Kathkuda Jaime Rodriguez-Canales Steven H Lin Sunil Krishnan Scott Kopetz Mariela Blum Jaffer A Ajani Wayne L Hofstetter Dipen M Maru

Ther Adv Med Oncol 2019 25;11:1758835919864850. Epub 2019 Jul 25.

Division of Pathology and Laboratory Medicine, Unit 085, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.

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http://dx.doi.org/10.1177/1758835919864850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659187PMC
July 2019

Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma.

Authors:
Omkara Lakshmi Veeranki Zhimin Tong Rashmi Dokey Alicia Mejia Jianhu Zhang Yawei Qiao Pankaj Kumar Singh Riham Katkhuda Barbara Mino Ramesh Tailor Jaime Rodriguez Canales Roland Bassett Jaffer Ajani Ji Yuan Wu Scott Kopetz Mariela Blum Wayne Hofstetter Michael Tetzlaff Sunil Krishnan Steven H Lin Dipen Maru

Oncotarget 2019 Jul 23;10(45):4703-4718. Epub 2019 Jul 23.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.27095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659793PMC
July 2019

Clinical and molecular characterization of early-onset colorectal cancer.

Authors:
Alexandra N Willauer Yusha Liu Allan A L Pereira Michael Lam Jeffrey S Morris Kanwal P S Raghav Van K Morris David Menter Russell Broaddus Funda Meric-Bernstam Andrea Hayes-Jordan Winston Huh Michael J Overman Scott Kopetz Jonathan M Loree

Cancer 2019 Jun 11;125(12):2002-2010. Epub 2019 Mar 11.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncr.31994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583775PMC
June 2019

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study.

Authors:
Eric Van Cutsem Sanne Huijberts Axel Grothey Rona Yaeger Pieter-Jan Cuyle Elena Elez Marwan Fakih Clara Montagut Marc Peeters Takayuki Yoshino Harpreet Wasan Jayesh Desai Fortunato Ciardiello Ashwin Gollerkeri Janna Christy-Bittel Kati Maharry Victor Sandor Jan H M Schellens Scott Kopetz Josep Tabernero

J Clin Oncol 2019 Jun 20;37(17):1460-1469. Epub 2019 Mar 20.

6 Vall d'Hebron Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://ascopubs.org/doi/10.1200/JCO.18.02459
Publisher Site
http://dx.doi.org/10.1200/JCO.18.02459DOI Listing
June 2019

Evolving Strategies for the Management of BRAF-Mutant Metastatic Colorectal Cancer.

Authors:
Hey Min Lee Van Morris Stefania Napolitano Scott Kopetz

Oncology (Williston Park) 2019 06;33(6):206-11

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June 2019

Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases.

Authors:
Yun Shin Chun Guillaume Passot Suguru Yamashita Maliha Nusrat Panagiotis Katsonis Jonathan M Loree Claudius Conrad Ching-Wei D Tzeng Lianchun Xiao Thomas A Aloia Cathy Eng Scott E Kopetz Olivier Lichtarge Jean-Nicolas Vauthey

Ann Surg 2019 05;269(5):917-923

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1097/SLA.0000000000002450DOI Listing
May 2019

Can Circulating Tumor DNA in Early-Stage Colorectal Cancer Be More Than a Prognostic Biomarker?

Authors:
Van Morris Arvind Dasari Scott Kopetz

JAMA Oncol 2019 May 9. Epub 2019 May 9.

The University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2019.0503DOI Listing
May 2019

Ongoing and future directions in the management of metastatic colorectal cancer: Update on clinical trials.

Authors:
Shailesh Advani Scott Kopetz

J Surg Oncol 2019 Apr 10;119(5):642-652. Epub 2019 Mar 10.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/jso.25441DOI Listing
April 2019

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.

Authors:
Wenting Liao Michael J Overman Adam T Boutin Xiaoying Shang Di Zhao Prasenjit Dey Jiexi Li Guocan Wang Zhengdao Lan Jun Li Ming Tang Shan Jiang Xingdi Ma Peiwen Chen Riham Katkhuda Krittiya Korphaisarn Deepavali Chakravarti Andrew Chang Denise J Spring Qing Chang Jianhua Zhang Dipen M Maru Dean Y Maeda John A Zebala Scott Kopetz Y Alan Wang Ronald A DePinho

Cancer Cell 2019 04 21;35(4):559-572.e7. Epub 2019 Mar 21.

Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467776PMC
April 2019

Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy.

Authors:
Niki M Zacharias Argentina Ornelas Jaehyuk Lee Jingzhe Hu Jennifer S Davis Nasir Uddin Shivanand Pudakalakatti David G Menter Jose A Karam Christopher G Wood Ernest T Hawk Scott Kopetz Eduardo Vilar Pratip K Bhattacharya Steven W Millward

Angew Chem Int Ed Engl 2019 Mar 20;58(13):4179-4183. Epub 2019 Feb 20.

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.

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http://dx.doi.org/10.1002/anie.201812759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467058PMC
March 2019

Two phase I, pharmacokinetic, and pharmacodynamic studies of DFP-10917, a novel nucleoside analog with 14-day and 7-day continuous infusion schedules.

Authors:
Kamalesh Sankhala Chris H Takimoto Alain C Mita Henry Xiong Jordi Rodón Amir Mehrvarz Sarshekeh K Burns Kenzo Iizuka Scott Kopetz

Invest New Drugs 2019 02 18;37(1):76-86. Epub 2018 Apr 18.

Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s10637-018-0602-0
Publisher Site
http://dx.doi.org/10.1007/s10637-018-0602-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521838PMC
February 2019

Loss of muscle mass during preoperative chemotherapy as a prognosticator for poor survival in patients with colorectal liver metastases.

Authors:
Masayuki Okuno Claire Goumard Scott Kopetz Eduardo A Vega Katharina Joechle Takashi Mizuno Ching-Wei D Tzeng Yun Shin Chun Jeffrey E Lee Jean-Nicolas Vauthey Thomas A Aloia Claudius Conrad

Surgery 2019 02 6;165(2):329-336. Epub 2018 Sep 6.

Department of Surgical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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February 2019

New therapies and insights into the changing landscape of colorectal cancer.

Authors:
Scott Kopetz

Nat Rev Gastroenterol Hepatol 2019 02;16(2):79-80

University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41575-018-0100-zDOI Listing
February 2019

Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer.

Authors:
Andreas Varkaris Anastasia Katsiampoura Jennifer S Davis Neeraj Shah Michael Lam Rosa Lizeth Frias Cristina Ivan Masayoshi Shimizu Jeffrey Morris David Menter Michael Overman Hai Tran John Heymach Yun Shin Chun Jean-Nicolas Vauthey George Calin Scott Kopetz

Br J Cancer 2019 02 14;120(3):340-345. Epub 2019 Jan 14.

Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41416-018-0360-y
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353894PMC
February 2019

DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway.

Authors:
Liana Adam F Anthony San Lucas Richard Fowler Yao Yu Wenhui Wu Yulun Liu Huamin Wang David Menter Michael T Tetzlaff Joe Ensor Ganiraju Manyam Stefan T Arold Chad Huff Scott Kopetz Paul Scheet Michael J Overman

Clin Cancer Res 2019 01 23;25(2):641-651. Epub 2018 Oct 23.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335167PMC
January 2019

Back to the Colorectal Cancer Consensus Molecular Subtype Future.

Authors:
David G Menter Jennifer S Davis Bradley M Broom Michael J Overman Jeffrey Morris Scott Kopetz

Curr Gastroenterol Rep 2019 Jan 30;21(2). Epub 2019 Jan 30.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard--Unit 0426, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11894-019-0674-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622456PMC
January 2019

Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer.

Authors:
Jonathan M Loree Ann M Bailey Amber M Johnson Yao Yu Wenhui Wu Christopher A Bristow Jennifer S Davis Kenna R Shaw Russell Broaddus Kimberly C Banks Richard B Lanman Funda Meric-Bernstam Michael J Overman Scott Kopetz Kanwal Raghav

J Natl Cancer Inst 2018 12;110(12):1409-1417

Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1093/jnci/djy067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292791PMC
December 2018

Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics.

Authors:
Maliha Khan Jonathan M Loree Shailesh M Advani Jing Ning Wen Li Allan A L Pereira Michael Lam Kanwal Raghav Van K Morris Russell Broaddus Dipen Maru Michael J Overman Scott Kopetz

Clin Colorectal Cancer 2018 12 17;17(4):e699-e709. Epub 2018 Jul 17.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588353PMC
December 2018

TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling.

Authors:
Youn-Sang Jung Sohee Jun Moon Jong Kim Sung Ho Lee Han Na Suh Esther M Lien Hae-Yun Jung Sunhye Lee Jie Zhang Jung-In Yang Hong Ji Ji Yuan Wu Wenqi Wang Rachel K Miller Junjie Chen Pierre D McCrea Scott Kopetz Jae-Il Park

Nat Cell Biol 2018 12 29;20(12):1421-1433. Epub 2018 Oct 29.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41556-018-0219-8
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261670PMC
December 2018

Phase II study of DFP-10917, a deoxycytidine analog, given by 14-day continuous intravenous infusion for chemotherapy-refractory advanced colorectal cancer.

Authors:
Amir Mehrvarz Sarshekeh Henry Q Xiong Kenzo Iizuka Howard S Hochster Scott Kopetz

Invest New Drugs 2018 10 13;36(5):895-902. Epub 2018 Jun 13.

Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10637-018-0615-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136955PMC
October 2018

Clinical, Pathological, and Molecular Characteristics of CpG Island Methylator Phenotype in Colorectal Cancer: A Systematic Review and Meta-analysis.

Authors:
Shailesh M Advani Pragati Advani Stacia M DeSantis Derek Brown Helena M VonVille Michael Lam Jonathan M Loree Amir Mehrvarz Sarshekeh Jan Bressler David S Lopez Carrie R Daniel Michael D Swartz Scott Kopetz

Transl Oncol 2018 Oct 30;11(5):1188-1201. Epub 2018 Jul 30.

Division of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080640PMC
October 2018

Circulating Tumor DNA-Defined Minimal Residual Disease in Solid Tumors: Opportunities to Accelerate the Development of Adjuvant Therapies.

Authors:
Arvind Dasari Axel Grothey Scott Kopetz

J Clin Oncol 2018 Oct 30:JCO2018789032. Epub 2018 Oct 30.

Arvind Dasari, The University of Texas MD Anderson Cancer Center, Houston, TX; Axel Grothey, The University of Tennessee West Cancer Center, Memphis, TN; and Scott Kopetz, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2018.78.9032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286158PMC
October 2018

Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group.

Authors:
Kaitlyn K H Goey Halfdan Sørbye Bengt Glimelius Richard A Adams Thierry André Dirk Arnold Jordan D Berlin György Bodoky Aimery de Gramont Eduardo Díaz-Rubio Cathy Eng Alfredo Falcone Axel Grothey Volker Heinemann Howard S Hochster Richard S Kaplan Scott Kopetz Roberto Labianca Christopher H Lieu Neal J Meropol Timothy J Price Richard L Schilsky Hans-Joachim Schmoll Einat Shacham-Shmueli Qian Shi Alberto F Sobrero John Souglakos Eric Van Cutsem John Zalcberg Martijn G H van Oijen Cornelis J A Punt Miriam Koopman

Eur J Cancer 2018 09 22;100:35-45. Epub 2018 Jun 22.

Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.05.010DOI Listing
September 2018

Bioactive lipid metabolism in platelet "first responder" and cancer biology.

Authors:
Preeti Kanikarla-Marie Scott Kopetz Ernest T Hawk Steven W Millward Anil K Sood Paolo Gresele Michael Overman Kenneth Honn David G Menter

Cancer Metastasis Rev 2018 09;37(2-3):439-454

Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1007/s10555-018-9755-8DOI Listing
September 2018

The Addition of Bevacizumab to Oxaliplatin-Based Chemotherapy: Impact Upon Hepatic Sinusoidal Injury and Thrombocytopenia.

Authors:
Michael J Overman Renata Ferrarotto Kanwal Raghav Binsah George Wei Qiao Karime K Machado Leonard B Saltz Thibault Mazard J N Vauthey Paulo M Hoff Brian Hobbs Evelyn M Loyer Scott Kopetz

J Natl Cancer Inst 2018 08;110(8):888-894

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1093/jnci/djx288DOI Listing
August 2018

Nivolumab in the treatment of microsatellite instability high metastatic colorectal cancer.

Authors:
Amir Mehrvarz Sarshekeh Michael J Overman Scott Kopetz

Future Oncol 2018 08 23;14(18):1869-1874. Epub 2018 Feb 23.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.2217/fon-2017-0696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088272PMC
August 2018

Genome-wide Discovery and Identification of a Novel miRNA Signature for Recurrence Prediction in Stage II and III Colorectal Cancer.

Authors:
Raju Kandimalla Feng Gao Takatoshi Matsuyama Toshiaki Ishikawa Hiroyuki Uetake Naoki Takahashi Yasuhide Yamada Carlos Becerra Scott Kopetz Xin Wang Ajay Goel

Clin Cancer Res 2018 08 7;24(16):3867-3877. Epub 2018 Mar 7.

Center for Gastrointestinal Research, Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute and Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095767PMC
August 2018

Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.

Authors:
Kyle Chang Melissa W Taggart Laura Reyes-Uribe Ester Borras Erick Riquelme Reagan M Barnett Guido Leoni F Anthony San Lucas Maria T Catanese Federica Mori Maria G Diodoro Y Nancy You Ernest T Hawk Jason Roszik Paul Scheet Scott Kopetz Alfredo Nicosia Elisa Scarselli Patrick M Lynch Florencia McAllister Eduardo Vilar

JAMA Oncol 2018 08;4(8):1085-1092

Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2018.1482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087485PMC
August 2018

RAS Mutation is Associated with Unsalvageable Recurrence Following Hepatectomy for Colorectal Cancer Liver Metastases.

Authors:
Masayuki Okuno Claire Goumard Scott Kopetz Eduardo A Vega Katharina Joechle Takashi Mizuno Kiyohiko Omichi Ching-Wei D Tzeng Yun Shin Chun Jean-Nicolas Vauthey Claudius Conrad

Ann Surg Oncol 2018 Aug 21;25(8):2457-2466. Epub 2018 May 21.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-018-6517-3DOI Listing
August 2018

The somatic mutation landscape of premalignant colorectal adenoma.

Authors:
Shu-Hong Lin Gottumukkala S Raju Chad Huff Yuanqing Ye Jian Gu Jiun-Sheng Chen Michelle A T Hildebrandt Han Liang David G Menter Jeffery Morris Ernest Hawk John R Stroehlein Andrew Futreal Scott Kopetz Lopa Mishra Xifeng Wu

Gut 2018 07 12;67(7):1299-1305. Epub 2017 Jun 12.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1136/gutjnl-2016-313573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031265PMC
July 2018

Comparison of early radiological predictors of outcome in patients with colorectal cancer with unresectable hepatic metastases treated with bevacizumab.

Authors:
Thibault Mazard Piyaporn Boonsirikamchai Michael J Overman Mohamed A Asran Haesun Choi Delise Herron Cathy Eng Dipen M Maru Marc Ychou Jean-Nicolas Vauthey Evelyne M Loyer Scott Kopetz

Gut 2018 06 30;67(6):1095-1102. Epub 2017 Oct 30.

Department of Digestive Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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June 2018

SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases.

Authors:
Takashi Mizuno Jordan M Cloyd Diego Vicente Kiyohiko Omichi Yun Shin Chun Scott E Kopetz Dipen Maru Claudius Conrad Ching-Wei D Tzeng Steven H Wei Thomas A Aloia Jean-Nicolas Vauthey

Eur J Surg Oncol 2018 05 7;44(5):684-692. Epub 2018 Mar 7.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2018.02.247DOI Listing
May 2018

Untying the gordion knot of targeting MET in cancer.

Authors:
Kanwal Raghav Ann Marie Bailey Jonathan M Loree Scott Kopetz Vijaykumar Holla Timothy Anthony Yap Fang Wang Ken Chen Ravi Salgia David Hong

Cancer Treat Rev 2018 May 26;66:95-103. Epub 2018 Apr 26.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372183005
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May 2018

How should BRAF V600E-mutated colorectal cancer be treated?

Authors:
Scott Kopetz

Clin Adv Hematol Oncol 2018 May;16(5):333-335

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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May 2018

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.

Authors:
Clara Montagut Guillem Argilés Fortunato Ciardiello Thomas T Poulsen Rodrigo Dienstmann Michael Kragh Scott Kopetz Trine Lindsted Cliff Ding Joana Vidal Jenifer Clausell-Tormos Giulia Siravegna Francisco J Sánchez-Martín Klaus Koefoed Mikkel W Pedersen Michael M Grandal Mikhail Dvorkin Lucjan Wyrwicz Ana Rovira Antonio Cubillo Ramon Salazar Françoise Desseigne Cristina Nadal Joan Albanell Vittorina Zagonel Salvatore Siena Guglielmo Fumi Giuseppe Rospo Paul Nadler Ivan D Horak Alberto Bardelli Josep Tabernero

JAMA Oncol 2018 Apr 12;4(4):e175245. Epub 2018 Apr 12.

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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http://dx.doi.org/10.1001/jamaoncol.2017.5245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885274PMC
April 2018

Correction to: Accelerating Therapeutic Development through Innovative Trial Design in Colorectal Cancer.

Authors:
Michael Lam Jonathan M Loree Allan Andresson Lima Pereira Yun Shin Chun Scott Kopetz

Curr Treat Options Oncol 2018 04 23;19(5):25. Epub 2018 Apr 23.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard-Unit 0426, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s11864-018-0537-x
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April 2018

Platelet Metabolism and Other Targeted Drugs; Potential Impact on Immunotherapy.

Authors:
Preeti Kanikarla-Marie Michael Lam Alexey V Sorokin Michael J Overman Scott Kopetz David G Menter

Front Oncol 2018 20;8:107. Epub 2018 Apr 20.

Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

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http://dx.doi.org/10.3389/fonc.2018.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919962PMC
April 2018

Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes.

Authors:
Jonathan M Loree Allan A L Pereira Michael Lam Alexandra N Willauer Kanwal Raghav Arvind Dasari Van K Morris Shailesh Advani David G Menter Cathy Eng Kenna Shaw Russell Broaddus Mark J Routbort Yusha Liu Jeffrey S Morris Rajyalakshmi Luthra Funda Meric-Bernstam Michael J Overman Dipen Maru Scott Kopetz

Clin Cancer Res 2018 03 27;24(5):1062-1072. Epub 2017 Nov 27.

Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844818PMC
March 2018

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer.

Authors:
Michael J Overman Sara Lonardi Ka Yeung Mark Wong Heinz-Josef Lenz Fabio Gelsomino Massimo Aglietta Michael A Morse Eric Van Cutsem Ray McDermott Andrew Hill Michael B Sawyer Alain Hendlisz Bart Neyns Magali Svrcek Rebecca A Moss Jean-Marie Ledeine Z Alexander Cao Shital Kamble Scott Kopetz Thierry André

J Clin Oncol 2018 03 20;36(8):773-779. Epub 2018 Jan 20.

Michael J. Overman and Scott Kopetz, University of Texas MD Anderson Cancer Center, Houston, TX; Sara Lonardi, Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico, Padova; Fabio Gelsomino, University Hospital of Modena, Modena; Massimo Aglietta, Institute for Cancer Research and Treatment of Candiolo, University of Torino Medical School, Turin, Italy; Ka Yeung Mark Wong, Sydney Medical School, University of Sydney, Sydney, New South Wales; Andrew Hill, Tasman Oncology Research, Ltd., Southport, Queensland, Australia; Heinz-Josef Lenz, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA; Michael A. Morse, Duke University Medical Center, Durham, NC; Eric Van Cutsem, University Hospitals Gasthuisberg Leuven and Katholieke Universiteit Leuven, Leuven; Alain Hendlisz, Institut Jules Bordet; Bart Neyns, Universitair Ziekenhuis Brussel, Brussels; Jean-Marie Ledeine, Bristol-Myers Squibb, Braine-L'Alleud, Belgium; Ray McDermott, St Vincent's University Hospital and Cancer Trials Ireland, Dublin, Ireland; Michael B. Sawyer, Cross Cancer Institute and University of Alberta, Edmonton, Alberta, Canada; Magali Svrcek and Thierry André, Hopital Saint Antoine, Assistance Publique Hôpitaux de Paris and Sorbonne Universités, Université Pierre et Marie Curie, Paris, France; and Rebecca A. Moss, Z. Alexander Cao, and Shital Kamble, Bristol-Myers Squibb, Princeton, NJ.

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March 2018

Impact of Prior Hepatectomy History on Local Tumor Progression after Percutaneous Ablation of Colorectal Liver Metastases.

Authors:
Bruno C Odisio Suguru Yamashita Steven Y Huang Scott E Kopetz Kamran Ahrar Takashi Mizuno Claudius Conrad Thomas A Aloia Yun Shin Chun Sanjay Gupta Jean-Nicolas Vauthey

J Vasc Interv Radiol 2018 03 1;29(3):395-403.e1. Epub 2018 Feb 1.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler St., Unit 1471, Houston, TX 77030.

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http://dx.doi.org/10.1016/j.jvir.2017.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818310PMC
March 2018

Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer.

Authors:
John H Strickler Jonathan M Loree Leanne G Ahronian Aparna R Parikh Donna Niedzwiecki Allan Andresson Lima Pereira Matthew McKinney W Michael Korn Chloe E Atreya Kimberly C Banks Rebecca J Nagy Funda Meric-Bernstam Richard B Lanman AmirAli Talasaz Igor F Tsigelny Ryan B Corcoran Scott Kopetz

Cancer Discov 2018 02 1;8(2):164-173. Epub 2017 Dec 1.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809260PMC
February 2018

Accelerating Therapeutic Development through Innovative Trial Design in Colorectal Cancer.

Authors:
Michael Lam Jonathan M Loree Allan Anderson Lima Pereira Yun Shin Chun Scott Kopetz

Curr Treat Options Oncol 2018 02 27;19(2):11. Epub 2018 Feb 27.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard-Unit 0426, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11864-018-0524-2DOI Listing
February 2018

Detection of somatic mutations in cell-free DNA in plasma and correlation with overall survival in patients with solid tumors.

Authors:
Meenakshi Mehrotra Rajesh R Singh Sanam Loghavi Dzifa Yawa Duose Bedia A Barkoh Carmen Behrens Keyur P Patel Mark J Routbort Scott Kopetz Russell R Broaddus L Jeffrey Medeiros Ignacio I Wistuba Rajyalakshmi Luthra

Oncotarget 2018 02 24;9(12):10259-10271. Epub 2017 Oct 24.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://www.oncotarget.com/fulltext/21982
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828199PMC
February 2018

First-in-human trial of the PI3Kβ-selective inhibitor SAR260301 in patients with advanced solid tumors.

Authors:
Philippe L Bédard Michael A Davies Scott Kopetz Dejan Juric Geoffrey I Shapiro Jason J Luke Anna Spreafico Bin Wu Christelle Castell Corinne Gomez Sylvaine Cartot-Cotton Florent Mazuir Michel Dubar Sandrine Micallef Brigitte Demers Keith T Flaherty

Cancer 2018 01 4;124(2):315-324. Epub 2017 Oct 4.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/cncr.31044
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January 2018

Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers.

Authors:
Lino Möhrmann Helen J Huang David S Hong Apostolia M Tsimberidou Siqing Fu Sarina A Piha-Paul Vivek Subbiah Daniel D Karp Aung Naing Anne Krug Daniel Enderle Tina Priewasser Mikkel Noerholm Erez Eitan Christine Coticchia Georg Stoll Lisa-Marie Jordan Cathy Eng E Scott Kopetz Johan Skog Funda Meric-Bernstam Filip Janku

Clin Cancer Res 2018 01 19;24(1):181-188. Epub 2017 Oct 19.

Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754253PMC
January 2018

Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

Authors:
Guillaume Passot Bradford J Kim Olivier Glehen Reza J Mehran Scott E Kopetz Diane Goere Michael J Overman Marc Pocard Frédéric Marchal Claudius Conrad Thomas A Aloia Jean-Nicolas Vauthey Yun Shin Chun

Ann Surg Oncol 2018 Jan 25;25(1):179-187. Epub 2017 Oct 25.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-017-6141-7DOI Listing
January 2018

Integrated safety summary for trifluridine/tipiracil (TAS-102).

Authors:
Alfredo Falcone Atsushi Ohtsu Eric Van Cutsem Robert J Mayer Michele Buscaglia Johanna C Bendell Scott Kopetz Paul Bebeau Takayuki Yoshino

Anticancer Drugs 2018 01;29(1):89-96

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1097/CAD.0000000000000554DOI Listing
January 2018

Individualized Treatment Sequencing Selection Contributes to Optimized Survival in Patients with Rectal Cancer and Synchronous Liver Metastases.

Authors:
Claudius Conrad Jean-Nicolas Vauthey Okuno Masayuki Rahul A Sheth Suguru Yamashita Guillaume Passot Christina E Bailey Daria Zorzi Scott Kopetz Thomas A Aloia Y Nancy You

Ann Surg Oncol 2017 Dec 19;24(13):3857-3864. Epub 2017 Sep 19.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1245/s10434-017-6089-7DOI Listing
December 2017

Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.

Authors:
Callisia N Clarke Michael S Lee Wei Wei Ganiraju Manyam Zhi-Qin Jiang Yiling Lu Jeffrey Morris Bradley Broom David Menter Eduardo Vilar-Sanchez Kanwal Raghav Cathy Eng George J Chang Iris Simon Rene Bernards Michael Overman Gordon B Mills Dipen Maru Scott Kopetz

Ann Surg Oncol 2017 Dec 21;24(13):4051-4058. Epub 2017 Sep 21.

Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063735PMC
December 2017

Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment.

Authors:
Krittiya Korphaisarn Chao-Kai Chou Wei-Ya Xia Callisia N Clarke Riham Katkhuda Jennifer S Davis Kanwal Ps Raghav Hsin-Wei Liao Ji-Yuan Wu David G Menter Dipen M Maru Mien-Chie Hung Scott Kopetz

Am J Cancer Res 2017 1;7(12):2587-2599. Epub 2017 Dec 1.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterTX 77030, Houston, USA.

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December 2017

Platelet microparticles: small payloads with profound effects on tumor growth.

Authors:
David G Menter Preeti Kanikarla-Marie Michael Lam Jennifer S Davis Scott Kopetz

Noncoding RNA Investig 2017 Nov 17;1. Epub 2017 Nov 17.

Departments of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.21037/ncri.2017.11.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583804PMC
November 2017

Global and targeted serum metabolic profiling of colorectal cancer progression.

Authors:
Yin Long Beatriz Sanchez-Espiridion Moubin Lin Lindsey White Lopa Mishra Gottumakkala S Raju Scott Kopetz Cathy Eng Michelle A T Hildebrandt David W Chang Yuanqing Ye Dong Liang Xifeng Wu

Cancer 2017 Oct 22;123(20):4066-4074. Epub 2017 Jun 22.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cncr.30829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626581PMC
October 2017

Clinical utility of circulating cell-free DNA in advanced colorectal cancer.

Authors:
Allan A Lima Pereira Maria Pia Morelli Michael Overman Bryan Kee David Fogelman Eduardo Vilar Imad Shureiqi Kanwal Raghav Cathy Eng Shanequa Manuel Shadarra Crosby Robert A Wolff Kimberly Banks Richard Lanman AmirAli Talasaz Scott Kopetz Van Morris

PLoS One 2017 29;12(8):e0183949. Epub 2017 Aug 29.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183949PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574560PMC
October 2017

Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers.

Authors:
Chan-Young Ock Jun-Eul Hwang Bhumsuk Keam Sang-Bae Kim Jae-Jun Shim Hee-Jin Jang Sarang Park Bo Hwa Sohn Minse Cha Jaffer A Ajani Scott Kopetz Keun-Wook Lee Tae Min Kim Dae Seog Heo Ju-Seog Lee

Nat Commun 2017 10 19;8(1):1050. Epub 2017 Oct 19.

Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1038/s41467-017-01018-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648801PMC
October 2017

Can Microsatellite Status of Colorectal Cancer Be Reliably Assessed after Neoadjuvant Therapy?

Authors:
Jennifer B Goldstein William Wu Ester Borras Gita Masand Amanda Cuddy Maureen E Mork Sarah A Bannon Patrick M Lynch Miguel Rodriguez-Bigas Melissa W Taggart Ji Wu Paul Scheet Scott Kopetz Y Nancy You Eduardo Vilar

Clin Cancer Res 2017 Sep 18;23(17):5246-5254. Epub 2017 May 18.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035875PMC
September 2017

Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer.

Authors:
Filip Janku Shile Zhang Jill Waters Li Liu Helen J Huang Vivek Subbiah David S Hong Daniel D Karp Siqing Fu Xuyu Cai Nishma M Ramzanali Kiran Madwani Goran Cabrilo Debra L Andrews Yue Zhao Milind Javle E Scott Kopetz Rajyalakshmi Luthra Hyunsung J Kim Sante Gnerre Ravi Vijaya Satya Han-Yu Chuang Kristina M Kruglyak Jonathan Toung Chen Zhao Richard Shen John V Heymach Funda Meric-Bernstam Gordon B Mills Jian-Bing Fan Neeraj S Salathia

Clin Cancer Res 2017 Sep 23;23(18):5648-5656. Epub 2017 May 23.

Illumina, Inc., San Diego, California.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600825PMC
September 2017

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.

Authors:
Michael J Overman Ray McDermott Joseph L Leach Sara Lonardi Heinz-Josef Lenz Michael A Morse Jayesh Desai Andrew Hill Michael Axelson Rebecca A Moss Monica V Goldberg Z Alexander Cao Jean-Marie Ledeine Gregory A Maglinte Scott Kopetz Thierry André

Lancet Oncol 2017 09 19;18(9):1182-1191. Epub 2017 Jul 19.

Hôpital Saint Antoine, Assistance Publique Hôpitaux de Paris and Sorbonne Universités, UMPC Paris 06, Paris, France.

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http://dx.doi.org/10.1016/S1470-2045(17)30422-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207072PMC
September 2017

BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer.

Authors:
Jeremy C Jones Lindsay A Renfro Humaid O Al-Shamsi Alexa B Schrock Andrew Rankin Ben Y Zhang Pashtoon M Kasi Jesse S Voss Alexis D Leal James Sun Jeffrey Ross Siraj M Ali Joleen M Hubbard Benjamin R Kipp Robert R McWilliams Scott Kopetz Robert A Wolff Axel Grothey

J Clin Oncol 2017 Aug 9;35(23):2624-2630. Epub 2017 May 9.

Jeremy C. Jones, Lindsay A. Renfro, Ben Y. Zhang, Pashtoon M. Kasi, Jesse S. Voss, Alexis D. Leal, Joleen M. Hubbard, Benjamin R. Kipp, Robert R. McWilliams, and Axel Grothey, Mayo Clinic, Rochester, MN; Humaid O. Al-Shamsi, Scott Kopetz, and Robert A. Wolff, The University of Texas MD Anderson Cancer Center, Houston, TX; and Alexa B. Schrock, Andrew Rankin, James Sun, Jeffrey Ross, and Siraj M. Ali, Foundation Medicine, Cambridge, MA.

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http://ascopubs.org/doi/10.1200/JCO.2016.71.4394
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http://dx.doi.org/10.1200/JCO.2016.71.4394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549454PMC
August 2017

Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer.

Authors:
Marco L Leung Alexander Davis Ruli Gao Anna Casasent Yong Wang Emi Sei Eduardo Vilar Dipen Maru Scott Kopetz Nicholas E Navin

Genome Res 2017 08 25;27(8):1287-1299. Epub 2017 May 25.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gr.209973.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538546PMC
August 2017

Impact of Recurrence and Salvage Surgery on Survival After Multidisciplinary Treatment of Rectal Cancer.

Authors:
Naruhiko Ikoma Y Nancy You Brian K Bednarski Miguel A Rodriguez-Bigas Cathy Eng Prajnan Das Scott Kopetz Craig Messick John M Skibber George J Chang

J Clin Oncol 2017 Aug 28;35(23):2631-2638. Epub 2017 Jun 28.

All authors: The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.72.1464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549457PMC
August 2017

Recent developments in the treatment of metastatic colorectal cancer.

Authors:
Jonathan M Loree Scott Kopetz

Ther Adv Med Oncol 2017 Aug 29;9(8):551-564. Epub 2017 Jun 29.

Division of Gastrointestinal Medical Oncology, The University of Texas, MD Anderson Cancer Center, Unit 426, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1177/1758834017714997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524248PMC
August 2017

Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature.

Authors:
Krittiya Korphaisarn Jonathan M Loree Van Nguyen Ryanne Coulson Vijaykumar Holla Beate C Litzenburger Ken Chen Gordon B Mills Dipen M Maru Funda Meric-Bernstan Kenna R Mills Shaw Scott Kopetz

Oncotarget 2017 Aug 3;8(34):57882-57888. Epub 2017 Jun 3.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://www.oncotarget.com/fulltext/18357
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http://dx.doi.org/10.18632/oncotarget.18357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593691PMC
August 2017

Modeling of Patient-Derived Xenografts in Colorectal Cancer.

Authors:
Anastasia Katsiampoura Kanwal Raghav Zhi-Qin Jiang David G Menter Andreas Varkaris Maria P Morelli Shanequa Manuel Ji Wu Alexey V Sorokin Bahar Salimian Rizi Christopher Bristow Feng Tian Susan Airhart Mingshan Cheng Bradley M Broom Jeffrey Morris Michael J Overman Garth Powis Scott Kopetz

Mol Cancer Ther 2017 07 3;16(7):1435-1442. Epub 2017 May 3.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562363PMC
July 2017

Study of Preanalytic and Analytic Variables for Clinical Next-Generation Sequencing of Circulating Cell-Free Nucleic Acid.

Authors:
Meenakshi Mehrotra Rajesh R Singh Wei Chen Richard S P Huang Alaa A Almohammedsalim Bedia A Barkoh Crystal M Simien Marcos Hernandez Carmen Behrens Keyur P Patel Mark J Routbort Russell R Broaddus L Jeffrey Medeiros Ignacio I Wistuba Scott Kopetz Rajyalakshmi Luthra

J Mol Diagn 2017 07 12;19(4):514-524. Epub 2017 May 12.

Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.03.003DOI Listing
July 2017

Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.

Authors:
Ritesh Kumar Jennifer L Herold Deborah Schady Jennifer Davis Scott Kopetz Margarita Martinez-Moczygemba Barbara E Murray Fang Han Yu Li Evelyn Callaway Robert S Chapkin Wan-Mohaiza Dashwood Roderick H Dashwood Tia Berry Chris Mackenzie Yi Xu

PLoS Pathog 2017 Jul 13;13(7):e1006440. Epub 2017 Jul 13.

Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509344PMC
July 2017

A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.

Authors:
Natalia Paez Arango Lauren Brusco Kenna R Mills Shaw Ken Chen Agda Karina Eterovic Vijaykumar Holla Amber Johnson Beate Litzenburger Yekaterina B Khotskaya Nora Sanchez Ann Bailey Xiaofeng Zheng Chacha Horombe Scott Kopetz Carol J Farhangfar Mark Routbort Russell Broaddus Elmer V Bernstam John Mendelsohn Gordon B Mills Funda Meric-Bernstam

Oncotarget 2017 Jun;8(26):41806-41814

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.16018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522029PMC
June 2017

FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.

Authors:
Krittiya Korphaisarn Van Karlyle Morris Michael J Overman David R Fogelman Bryan K Kee Kanwal Pratap Singh Raghav Shanequa Manuel Imad Shureiqi Robert A Wolff Cathy Eng David Menter Stanley R Hamilton Scott Kopetz Arvind Dasari

Oncotarget 2017 Jun;8(24):39268-39279

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.16848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503612PMC
June 2017

Targeting -Mutant Colorectal Cancer: Progress in Combination Strategies.

Authors:
Raghav Sundar David S Hong Scott Kopetz Timothy A Yap

Cancer Discov 2017 06;7(6):558-560

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458523PMC
June 2017

Platelets, circulating tumor cells, and the circulome.

Authors:
Preeti Kanikarla-Marie Michael Lam David G Menter Scott Kopetz

Cancer Metastasis Rev 2017 06;36(2):235-248

Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Unit 426, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10555-017-9681-1DOI Listing
June 2017

The potential role of platelets in the consensus molecular subtypes of colorectal cancer.

Authors:
Michael Lam Jason Roszik Preeti Kanikarla-Marie Jennifer S Davis Jeffrey Morris Scott Kopetz David G Menter

Cancer Metastasis Rev 2017 06;36(2):273-288

Department of Gastrointestinal Medical Oncology, M. D. Anderson Cancer, Unit 0426, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s10555-017-9678-9
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June 2017

Platelet "first responders" in wound response, cancer, and metastasis.

Authors:
David G Menter Scott Kopetz Ernest Hawk Anil K Sood Jonathan M Loree Paolo Gresele Kenneth V Honn

Cancer Metastasis Rev 2017 06;36(2):199-213

Bioactive Lipids Research Program, Department of Pathology, Wayne State University, 431 Chemistry Bldg, 5101 Cass Avenue, Detroit, MI, 48202, USA.

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http://dx.doi.org/10.1007/s10555-017-9682-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709140PMC
June 2017

N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration.

Authors:
Isidore Rigoutsos Sang Kil Lee Su Youn Nam Simone Anfossi Barbara Pasculli Martin Pichler Yi Jing Cristian Rodriguez-Aguayo Aristeidis G Telonis Simona Rossi Cristina Ivan Tina Catela Ivkovic Linda Fabris Peter M Clark Hui Ling Masayoshi Shimizu Roxana S Redis Maitri Y Shah Xinna Zhang Yoshinaga Okugawa Eun Jung Jung Aristotelis Tsirigos Li Huang Jana Ferdin Roberta Gafà Riccardo Spizzo Milena S Nicoloso Anurag N Paranjape Maryam Shariati Aida Tiron Jen Jen Yeh Raul Teruel-Montoya Lianchun Xiao Sonia A Melo David Menter Zhi-Qin Jiang Elsa R Flores Massimo Negrini Ajay Goel Menashe Bar-Eli Sendurai A Mani Chang Gong Liu Gabriel Lopez-Berestein Ioana Berindan-Neagoe Manel Esteller Scott Kopetz Giovanni Lanza George A Calin

Genome Biol 2017 05 24;18(1):98. Epub 2017 May 24.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1186/s13059-017-1224-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442648PMC
May 2017

Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma.

Authors:
Zhimin Tong Devkumar Chatterjee Defeng Deng Omkara Veeranki Alicia Mejia Jaffer A Ajani Wayne Hofstetter Steven Lin Sushovan Guha Scott Kopetz Sunil Krishnan Dipen Maru

Oncotarget 2017 Apr;8(17):28696-28710

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.18632/oncotarget.15645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438684PMC
April 2017

First-in-human trial of multikinase VEGF inhibitor regorafenib and anti-EGFR antibody cetuximab in advanced cancer patients.

Authors:
Vivek Subbiah Muhammad Rizwan Khawaja David S Hong Behrang Amini Jiang Yungfang Hui Liu Adrienne Johnson Alexa B Schrock Siraj M Ali James X Sun David Fabrizio Sarina Piha-Paul Siqing Fu Apostolia M Tsimberidou Aung Naing Filip Janku Daniel D Karp Michael Overman Cathy Eng Scott Kopetz Funda Meric-Bernstam Gerald S Falchook

JCI Insight 2017 Apr 20;2(8). Epub 2017 Apr 20.

Drug Development Program, Sarah Cannon Research Institute at HealthONE, Presbyterian/St. Luke's Medical Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1172/jci.insight.90380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396533PMC
April 2017

Preoperative radiation dose escalation for rectal cancer using a concomitant boost strategy improves tumor downstaging without increasing toxicity: A matched-pair analysis.

Authors:
Jillian R Gunther Awalpreet S Chadha Ui Sup Shin In Ja Park Kiran V Kattepogu Jonathan D Grant David C Weksberg Cathy Eng Scott E Kopetz Prajnan Das Marc E Delclos Harmeet Kaur Dipen M Maru John M Skibber Miguel A Rodriguez-Bigas Y Nancy You Sunil Krishnan George J Chang

Adv Radiat Oncol 2017 Jul-Sep;2(3):455-464. Epub 2017 Apr 12.

Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.adro.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605486PMC
April 2017