Scott K Durum

Scott K Durum

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Scott K Durum

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New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.

Leukemia 2020 Jan 22;34(1):35-49. Epub 2019 Aug 22.

Cytokines and Immunity Section, Cancer and Inflammation Program (CIP), National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD, USA.

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http://dx.doi.org/10.1038/s41375-019-0531-8DOI Listing
January 2020

Flip the coin: IL-7 and IL-7R in health and disease.

Nat Immunol 2019 12 19;20(12):1584-1593. Epub 2019 Nov 19.

Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.

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http://dx.doi.org/10.1038/s41590-019-0479-xDOI Listing
December 2019

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.

Leukemia 2019 09 8;33(9):2155-2168. Epub 2019 Mar 8.

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal.

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http://dx.doi.org/10.1038/s41375-019-0434-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733707PMC
September 2019

Cytokine Tuning of Intestinal Epithelial Function.

Front Immunol 2018 5;9:1270. Epub 2018 Jun 5.

Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2018.01270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996247PMC
August 2019

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.

Leukemia 2018 08 15;32(8):1795-1882. Epub 2018 Feb 15.

Cytokines and Immunity Section, Cancer and Inflammation Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD, USA.

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http://dx.doi.org/10.1038/s41375-017-0001-0DOI Listing
August 2018

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Cell Signal 2018 07 24;47:131-141. Epub 2018 Mar 24.

Cancer and Inflammation Program, CCR, NCI, NIH, Bldg 560, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2018.03.008DOI Listing
July 2018

Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations.

Oncotarget 2018 Apr 27;9(32):22605-22617. Epub 2018 Apr 27.

Cytokines and Immunity Section, Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.25194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978251PMC
April 2018

Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.

Inflamm Bowel Dis 2017 11;23(11):1983-1995

*Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland; †School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Scotland, United Kingdom; ‡Pathology/Histotechnology Laboratory, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland; and §Intrexon Actobiotics N.V., Zwijnaarde, Belgium.

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http://dx.doi.org/10.1097/MIB.0000000000001274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796760PMC
November 2017

Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity.

J Immunol 2017 03 18;198(5):2182-2190. Epub 2017 Jan 18.

Priority Research Centre for Healthy Lungs, Department of Microbiology and Immunology, School of Pharmacy and Biomedical Sciences, Faculty of Health and Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales 2308, Australia;

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http://dx.doi.org/10.4049/jimmunol.1601480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367520PMC
March 2017

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice.

J Vis Exp 2017 01 25(119). Epub 2017 Jan 25.

Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health;

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http://dx.doi.org/10.3791/54710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352292PMC
January 2017

Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature.

Inflamm Bowel Dis 2016 09;22(9):2255-64

*Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland; and †School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000000818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992429PMC
September 2016

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment.

Blood 2016 07 6;128(4):473-8. Epub 2016 Jun 6.

Cytokines and Immunity Section, Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, MD;

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http://dx.doi.org/10.1182/blood-2016-03-679209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965903PMC
July 2016

IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice.

Front Immunol 2015 19;6:662. Epub 2016 Jan 19.

Cancer and Inflammation Program, Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Frederick, MD , USA.

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http://dx.doi.org/10.3389/fimmu.2015.00662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717188PMC
February 2016

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets.

Nat Immunol 2015 Mar 26;16(3):306-17. Epub 2015 Jan 26.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/ni.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372143PMC
March 2015

IL-7 and TSLP receptors: twisted sisters.

Authors:
Scott K Durum

Blood 2014 Jul;124(1):4-5

NATIONAL INSTITUTES OF HEALTH NATIONAL CANCER INSTITUTE.

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http://dx.doi.org/10.1182/blood-2014-05-574327DOI Listing
July 2014

Adaptive immunity to murine skin commensals.

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):E2977-86. Epub 2014 Jul 7.

Laboratory of Immunoregulation and

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http://dx.doi.org/10.1073/pnas.1401820111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115524PMC
July 2014

Targeting interleukins for the treatment of inflammatory bowel disease-what lies beyond anti-TNF therapy?

Inflamm Bowel Dis 2014 Feb;20(2):389-97

*National Cancer Institute, Laboratory of Molecular Immunoregulation, Cancer & Inflammation Program, Frederick, MD; †Department of Internal Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1097/01.MIB.0000437616.37000.41DOI Listing
February 2014

Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice.

Gastroenterology 2014 Jan 9;146(1):210-221.e13. Epub 2013 Oct 9.

Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085130143
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http://dx.doi.org/10.1053/j.gastro.2013.09.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920828PMC
January 2014

Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines.

Cytokine Growth Factor Rev 2013 Dec 27;24(6):485-501. Epub 2013 Oct 27.

Laboratory of Molecular Immunoregulation, Frederick, MD 21702, USA; Department of Medicine and Aging Sciences, University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2013.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390295PMC
December 2013

The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.

Biochim Biophys Acta 2012 Oct 21;1823(10):1877-93. Epub 2012 Jun 21.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2012.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432704PMC
October 2012

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

BMC Immunol 2012 Aug 16;13:46. Epub 2012 Aug 16.

Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1186/1471-2172-13-46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496569PMC
August 2012

The human IL-7 receptor gene: deletions, polymorphisms and mutations.

Semin Immunol 2012 Jun 17;24(3):225-30. Epub 2012 Mar 17.

Laboratory of Gene Therapy and Primary Immunodeficiency, San Raffaele Telethon Institute for Gene Therapy, Milan, Italy.

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http://dx.doi.org/10.1016/j.smim.2012.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326362PMC
June 2012

Detection of nuclear and membrane antigens by liquid-based cytology following long-term storage of d1 cells, karpas cells, and peripheral blood mononuclear cells.

Ann Clin Lab Sci 2011 ;41(4):353-9

Department of Oncology and Experimanetal Medicine, Section of Cytopathology "G. d'Annunzio" University of Chieti-Pescara Via dei Vestini, 66100 Chieti Scalo, Italy.

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April 2012

Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.

Exp Hematol 2010 Dec 8;38(12):1143-56. Epub 2010 Sep 8.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL 32827, USA.

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http://dx.doi.org/10.1016/j.exphem.2010.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010876PMC
December 2010

Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease.

Neurochem Res 2010 Jun 14;35(6):940-6. Epub 2009 Nov 14.

Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1007/s11064-009-0091-9DOI Listing
June 2010

Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.

Mol Cell Biol 2010 Feb 23;30(3):590-600. Epub 2009 Nov 23.

Section of Cytokines and Immunity, National Cancer Institute, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1128/MCB.01006-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812241PMC
February 2010

Live from the liver: hepatocyte IL-7.

Immunity 2009 Mar;30(3):320-1

Laboratory of Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/j.immuni.2009.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326359PMC
March 2009

The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.

J Leukoc Biol 2008 Oct 23;84(4):973-80. Epub 2008 Jul 23.

Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick, Frederick, MD 21701, USA.

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http://dx.doi.org/10.1189/jlb.1107778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538590PMC
October 2008

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

Blood 2008 Oct 29;112(8):3283-92. Epub 2008 Jul 29.

Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-02-13
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http://dx.doi.org/10.1182/blood-2008-02-137414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569178PMC
October 2008

IL-7 induces myelopoiesis and erythropoiesis.

J Immunol 2007 Feb;178(3):1553-63

Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.4049/jimmunol.178.3.1553DOI Listing
February 2007

Interleukin-7 receptor expression: intelligent design.

Nat Rev Immunol 2007 Feb;7(2):144-54

Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 560, Room 31-71, Frederick, Maryland 21702-1201, USA.

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http://dx.doi.org/10.1038/nri2023DOI Listing
February 2007

Role of the intracellular domain of IL-7 receptor in T cell development.

J Immunol 2007 Jan;178(1):228-34

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.4049/jimmunol.178.1.228DOI Listing
January 2007

Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations.

J Leukoc Biol 2006 Sep 22;80(3):538-45. Epub 2006 Jun 22.

Laboratory of Immunology, National Eye Institute, NIH, Building 10, 10 Center Drive, Bethesda, MD 20892-1857, USA.

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http://dx.doi.org/10.1189/jlb.1205719DOI Listing
September 2006

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

J Exp Med 2006 Mar 21;203(3):573-82. Epub 2006 Feb 21.

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Frederick, MD 21702, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20051520
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http://dx.doi.org/10.1084/jem.20051520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118250PMC
March 2006

Stat5a/b are essential for normal lymphoid development and differentiation.

Proc Natl Acad Sci U S A 2006 Jan 17;103(4):1000-5. Epub 2006 Jan 17.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0507350103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1327727PMC
January 2006

The adaptive immune response in neonatal cerebral white matter damage.

Ann Neurol 2005 Dec;58(6):821-8

Neuroepidemiology Unit, Children's Hospital Boston, 1 Autumn Street, Boston, MA 02215-5349, USA.

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http://doi.wiley.com/10.1002/ana.20662
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http://dx.doi.org/10.1002/ana.20662DOI Listing
December 2005

Cell biology of IL-7, a key lymphotrophin.

Cytokine Growth Factor Rev 2005 Aug-Oct;16(4-5):513-33

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USA.

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http://dx.doi.org/10.1016/j.cytogfr.2005.05.004DOI Listing
October 2005

Cytokine-driven cell cycling is mediated through Cdc25A.

J Cell Biol 2005 Jun 31;169(5):755-63. Epub 2005 May 31.

University of Central Florida, BioMolecular Science Center, Orlando, FL 32628, USA.

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http://dx.doi.org/10.1083/jcb.200409099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171622PMC
June 2005

Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival.

J Biol Chem 2004 Jul 30;279(28):29160-6. Epub 2004 Apr 30.

Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702-1201, USA.

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http://dx.doi.org/10.1074/jbc.M401656200DOI Listing
July 2004

Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.

Mol Cell Biol 2004 Jul;24(14):6501-13

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702-1201, USA.

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http://dx.doi.org/10.1128/MCB.24.14.6501-6513.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC434255PMC
July 2004

IL-7 induces tyrosine phosphorylation of clathrin heavy chain.

Cell Signal 2004 Feb;16(2):281-6

Laboratory of Molecular Immunoregulation, CCR, National Cancer Institute, National Institutes of Health, Room 31-71, Building 560, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/s0898-6568(03)00138-4DOI Listing
February 2004

Interleukin-7 induces MUC1.

Cancer Biol Ther 2003 Mar-Apr;2(2):194-5

Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, NIH Frederick, Maryland USA.

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http://dx.doi.org/10.4161/cbt.2.2.351DOI Listing
October 2003

Death and Baxes: mechanisms of lymphotrophic cytokines.

Immunol Rev 2003 Jun;193:48-57

BioMolecular Science Center, Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL, USA.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00050.xDOI Listing
June 2003

Bcl11: sibling rivalry in lymphoid development.

Authors:
Scott K Durum

Nat Immunol 2003 Jun;4(6):512-4

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http://dx.doi.org/10.1038/ni0603-512DOI Listing
June 2003

Characterization of an interleukin-7-dependent thymic cell line derived from a p53(-/-) mouse.

J Immunol Methods 2003 Mar;274(1-2):177-84

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/s0022-1759(02)00513-6DOI Listing
March 2003

Lymphocide: cytokines and the control of lymphoid homeostasis.

Nat Rev Immunol 2002 Nov;2(11):817-30

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702-1201, USA.

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http://www.nature.com/articles/nri931
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http://dx.doi.org/10.1038/nri931DOI Listing
November 2002

Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.

Immunity 2002 Nov;17(5):561-73

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute - Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/s1074-7613(02)00450-8DOI Listing
November 2002

The role of cytokines in lymphocyte homeostasis.

Biotechniques 2002 Oct;Suppl:40-5

Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute-Frederick, MD 21702-1201, USA.

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October 2002

IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases.

Cell Signal 2002 Sep;14(9):761-9

Laboratory of Molecular Immunoregulation, National Cancer Institute, National Institute of Health, Building 560, Room 31-71, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/s0898-6568(02)00026-8DOI Listing
September 2002

Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax.

Blood 2002 Jul;100(1):217-23

Laboratory of Leukocyte Biology,and SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1182/blood.v100.1.217DOI Listing
July 2002

Trophic Factor Withdrawal Induces a Novel Pathway: p38 MAPK Activates NHE1 Resulting in Intracellular Alkalinization, an Early Step in Apoptosis.

ScientificWorldJournal 2001 1;1:93. Epub 2001 Dec 1.

Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1100/tsw.2001.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084262PMC
December 2001