Publications by authors named "Scott J Hultgren"

200 Publications

Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections.

Authors:
Timothy J Straub Wen-Chi Chou Abigail L Manson Henry L Schreiber Bruce J Walker Christopher A Desjardins Sinéad B Chapman Kerrie L Kaspar Orsalem J Kahsai Elizabeth Traylor Karen W Dodson Meredith A J Hullar Scott J Hultgren Christina Khoo Ashlee M Earl

BMC Microbiol 2021 Feb 18;21(1):53. Epub 2021 Feb 18.

Infectious Disease & Microbiome Program, Broad Institute, 415 Main Street, Cambridge, MA, 02142, USA.

View Article and Find Full Text PDF
February 2021

A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.

Authors:
Lisa K McLellan Michael R McAllaster Arthur S Kim Ľubomíra Tóthová Patrick D Olson Jerome S Pinkner Allyssa L Daugherty Teri N Hreha James W Janetka Daved H Fremont Scott J Hultgren Herbert W Virgin David A Hunstad

PLoS Pathog 2021 Jan 29;17(1):e1009314. Epub 2021 Jan 29.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America.

View Article and Find Full Text PDF
January 2021

Adaptation of Arginine Synthesis among Uropathogenic Branches of the Escherichia coli Phylogeny Reveals Adjustment to the Urinary Tract Habitat.

Authors:
Michael E Hibbing Karen W Dodson Vasilios Kalas Swaine L Chen Scott J Hultgren

mBio 2020 09 29;11(5). Epub 2020 Sep 29.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA

View Article and Find Full Text PDF
September 2020

Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies.

Authors:
Roger D Klein Scott J Hultgren

Nat Rev Microbiol 2020 04 18;18(4):211-226. Epub 2020 Feb 18.

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.

View Article and Find Full Text PDF
April 2020

High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration.

Authors:
Jennifer N Walker Ana L Flores-Mireles Aaron J L Lynch Chloe Pinkner Michael G Caparon Scott J Hultgren Alana Desai

World J Urol 2020 Sep 2;38(9):2237-2245. Epub 2019 Dec 2.

Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, 4960 Children's Place, Box 8242, St. Louis, MO, 63110-1093, USA.

View Article and Find Full Text PDF
September 2020

Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence.

Authors:
Lu Yu Valerie P O'Brien Jonathan Livny Denise Dorsey Nirmalya Bandyopadhyay Marco Colonna Michael G Caparon Elisha DO Roberson Scott J Hultgren Thomas J Hannan

Elife 2019 08 20;8. Epub 2019 Aug 20.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St Louis, United States.

View Article and Find Full Text PDF
August 2019

Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Authors:
Jennifer N Walker Blake M Hanson Chloe L Pinkner Shelby R Simar Jerome S Pinkner Rajiv Parikh Mark W Clemens Scott J Hultgren Terence M Myckatyn

Sci Rep 2019 07 17;9(1):10393. Epub 2019 Jul 17.

Division of Plastic & Reconstructive Surgery, Washington University School of Medicine, Alvin J. Siteman Cancer Center, Saint Louis, Missouri, USA.

View Article and Find Full Text PDF
July 2019

Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model.

Authors:
Jennifer N Walker Louis H Poppler Chloe L Pinkner Scott J Hultgren Terence M Myckatyn

Aesthet Surg J 2020 04;40(5):516-528

Washington University School of Medicine, St Louis, MO.

View Article and Find Full Text PDF
April 2020

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes.

Authors:
Gisela Di Venanzio Ana L Flores-Mireles Juan J Calix M Florencia Haurat Nichollas E Scott Lauren D Palmer Robert F Potter Michael E Hibbing Laura Friedman Bin Wang Gautam Dantas Eric P Skaar Scott J Hultgren Mario F Feldman

Nat Commun 2019 06 24;10(1):2763. Epub 2019 Jun 24.

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, 63110, USA.

View Article and Find Full Text PDF
June 2019

Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae.

Authors:
Ines Ambite Daniel S C Butler Christoph Stork Jenny Grönberg-Hernández Bela Köves Jaroslaw Zdziarski Jerome Pinkner Scott J Hultgren Ulrich Dobrindt Björn Wullt Catharina Svanborg

PLoS Pathog 2019 06 10;15(6):e1007671. Epub 2019 Jun 10.

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Klinikgatan, Lund, Sweden.

View Article and Find Full Text PDF
June 2019

Reaching the End of the Line: Urinary Tract Infections.

Authors:
Kevin O Tamadonfar Natalie S Omattage Caitlin N Spaulding Scott J Hultgren

Microbiol Spectr 2019 05;7(3)

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.

View Article and Find Full Text PDF
May 2019

Chemical disarming of isoniazid resistance in .

Authors:
Kelly Flentie Gregory A Harrison Hasan Tükenmez Jonathan Livny James A D Good Souvik Sarkar Dennis X Zhu Rachel L Kinsella Leslie A Weiss Samantha D Solomon Miranda E Schene Mette R Hansen Andrew G Cairns Martina Kulén Torbjörn Wixe Anders E G Lindgren Erik Chorell Christoffer Bengtsson K Syam Krishnan Scott J Hultgren Christer Larsson Fredrik Almqvist Christina L Stallings

Proc Natl Acad Sci U S A 2019 05 6;116(21):10510-10517. Epub 2019 May 6.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110;

View Article and Find Full Text PDF
May 2019

Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis.

Authors:
Jennifer N Walker Chloe L Pinkner Aaron J L Lynch Sarah Ortbal Jerome S Pinkner Scott J Hultgren Terence M Myckatyn

Aesthet Surg J 2020 02;40(3):281-295

Washington University School of Medicine, St. Louis, MO.

View Article and Find Full Text PDF
February 2020

The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants.

Authors:
Jennifer N Walker Chloe L Pinkner Jerome S Pinkner Scott J Hultgren Terence M Myckatyn

Plast Reconstr Surg Glob Open 2019 Feb 8;7(2):e2037. Epub 2019 Feb 8.

Division of Plastic & Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Mo.

View Article and Find Full Text PDF
February 2019

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.

Authors:
Valerie P O'Brien Denise A Dorsey Thomas J Hannan Scott J Hultgren

PLoS Pathog 2018 12 13;14(12):e1007457. Epub 2018 Dec 13.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.

View Article and Find Full Text PDF
December 2018

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design.

Authors:
Amarendar Reddy Maddirala Roger Klein Jerome S Pinkner Vasilios Kalas Scott J Hultgren James W Janetka

J Med Chem 2019 01 2;62(2):467-479. Epub 2019 Jan 2.

Department of Biochemistry and Molecular Biophysics , Washington University School of Medicine , St. Louis , Missouri 63110 , United States.

View Article and Find Full Text PDF
January 2019

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.

Authors:
Natalie S Omattage Zengqin Deng Jerome S Pinkner Karen W Dodson Fredrik Almqvist Peng Yuan Scott J Hultgren

Nat Microbiol 2018 12 1;3(12):1362-1368. Epub 2018 Oct 1.

Department of Molecular Microbiology, Washington University in St Louis, St Louis, MO, USA.

View Article and Find Full Text PDF
December 2018

Manganese acquisition is essential for virulence of Enterococcus faecalis.

Authors:
Cristina Colomer-Winter Ana L Flores-Mireles Shannon P Baker Kristi L Frank Aaron J L Lynch Scott J Hultgren Todd Kitten José A Lemos

PLoS Pathog 2018 09 20;14(9):e1007102. Epub 2018 Sep 20.

Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, United States of America.

View Article and Find Full Text PDF
September 2018

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.

Authors:
Roger D Klein Qin Shu Zachary T Cusumano Kanna Nagamatsu Nathaniel C Gualberto Aaron J L Lynch Chao Wu Wenjie Wang Neha Jain Jerome S Pinkner Gaya K Amarasinghe Scott J Hultgren Carl Frieden Matthew R Chapman

mBio 2018 07 17;9(4). Epub 2018 Jul 17.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA

View Article and Find Full Text PDF
July 2018

Differential Regulation of Genes following Binding to Mannose Receptors.

Authors:
William R Schwan Michael T Beck Chia S Hung Scott J Hultgren

J Pathog 2018 22;2018:2897581. Epub 2018 May 22.

Center for Women's Infectious Disease Research, Washington University, St. Louis, MO 63110, USA.

View Article and Find Full Text PDF
May 2018

Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis.

Authors:
Jiangchuan Shen Brenna J C Walsh Ana Lidia Flores-Mireles Hui Peng Yifan Zhang Yixiang Zhang Jonathan C Trinidad Scott J Hultgren David P Giedroc

ACS Chem Biol 2018 06 17;13(6):1610-1620. Epub 2018 May 17.

Department of Chemistry , Indiana University , Bloomington , Indiana 47405-7102 , United States.

View Article and Find Full Text PDF
June 2018

Precision antimicrobial therapeutics: the path of least resistance?

Authors:
Caitlin N Spaulding Roger D Klein Henry L Schreiber James W Janetka Scott J Hultgren

NPJ Biofilms Microbiomes 2018 27;4. Epub 2018 Feb 27.

2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110 USA.

View Article and Find Full Text PDF
February 2018

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.

Authors:
Vasilios Kalas Michael E Hibbing Amarendar Reddy Maddirala Ryan Chugani Jerome S Pinkner Laurel K Mydock-McGrane Matt S Conover James W Janetka Scott J Hultgren

Proc Natl Acad Sci U S A 2018 03 5;115(12):E2819-E2828. Epub 2018 Mar 5.

Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110;

View Article and Find Full Text PDF
March 2018

Narrowing the spectrum: the new frontier of precision antimicrobials.

Authors:
Alexandra E Paharik Henry L Schreiber Caitlin N Spaulding Karen W Dodson Scott J Hultgren

Genome Med 2017 Dec 14;9(1):110. Epub 2017 Dec 14.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

View Article and Find Full Text PDF
December 2017

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection.

Authors:
Wei Xu Ana L Flores-Mireles Zachary T Cusumano Enzo Takagi Scott J Hultgren Michael G Caparon

NPJ Biofilms Microbiomes 2017 6;3:28. Epub 2017 Nov 6.

Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.

View Article and Find Full Text PDF
November 2017

Catheterization alters bladder ecology to potentiate infection of the urinary tract.

Authors:
Jennifer N Walker Ana L Flores-Mireles Chloe L Pinkner Henry L Schreiber Matthew S Joens Alyssa M Park Aaron M Potretzke Tyler M Bauman Jerome S Pinkner James A J Fitzpatrick Alana Desai Michael G Caparon Scott J Hultgren

Proc Natl Acad Sci U S A 2017 10 25;114(41):E8721-E8730. Epub 2017 Sep 25.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110;

View Article and Find Full Text PDF
October 2017

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Authors:
Caitlin N Spaulding Roger D Klein Ségolène Ruer Andrew L Kau Henry L Schreiber Zachary T Cusumano Karen W Dodson Jerome S Pinkner Daved H Fremont James W Janetka Han Remaut Jeffrey I Gordon Scott J Hultgren

Nature 2017 06 14;546(7659):528-532. Epub 2017 Jun 14.

Department of Molecular Microbiology, Washington University in St Louis, St Louis, Missouri 63110, USA.

View Article and Find Full Text PDF
June 2017

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions.

Authors:
Alaullah Sheikh Rasheduzzaman Rashu Yasmin Ara Begum F Matthew Kuhlman Matthew A Ciorba Scott J Hultgren Firdausi Qadri James M Fleckenstein

PLoS Negl Trop Dis 2017 May 22;11(5):e0005586. Epub 2017 May 22.

Molecular Microbiology and Microbial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

View Article and Find Full Text PDF
May 2017

Bacterial virulence phenotypes of and host susceptibility determine risk for urinary tract infections.

Authors:
Henry L Schreiber Matt S Conover Wen-Chi Chou Michael E Hibbing Abigail L Manson Karen W Dodson Thomas J Hannan Pacita L Roberts Ann E Stapleton Thomas M Hooton Jonathan Livny Ashlee M Earl Scott J Hultgren

Sci Transl Med 2017 03;9(382)

Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA.

View Article and Find Full Text PDF
March 2017

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.

Authors:
Vasilios Kalas Jerome S Pinkner Thomas J Hannan Michael E Hibbing Karen W Dodson Alex S Holehouse Hao Zhang Niraj H Tolia Michael L Gross Rohit V Pappu James Janetka Scott J Hultgren

Sci Adv 2017 Feb 10;3(2):e1601944. Epub 2017 Feb 10.

Center for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article and Find Full Text PDF
February 2017