Scott Hultgren

Scott Hultgren

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Scott Hultgren

Publications by authors named "Scott Hultgren"

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Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence.

Elife 2019 08 20;8. Epub 2019 Aug 20.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St Louis, United States.

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http://dx.doi.org/10.7554/eLife.46677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701943PMC
August 2019

Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model.

Aesthet Surg J 2019 Jul 1. Epub 2019 Jul 1.

Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1093/asj/sjz190DOI Listing
July 2019

Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Sci Rep 2019 Jul 17;9(1):10393. Epub 2019 Jul 17.

Division of Plastic & Reconstructive Surgery, Washington University School of Medicine, Alvin J. Siteman Cancer Center, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1038/s41598-019-46535-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637124PMC
July 2019

Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae.

PLoS Pathog 2019 Jun 10;15(6):e1007671. Epub 2019 Jun 10.

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Klinikgatan, Lund, Sweden.

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http://dx.doi.org/10.1371/journal.ppat.1007671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557620PMC
June 2019

Reaching the End of the Line: Urinary Tract Infections.

Microbiol Spectr 2019 May;7(3)

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.

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http://dx.doi.org/10.1128/microbiolspec.BAI-0014-2019DOI Listing
May 2019

The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants.

Plast Reconstr Surg Glob Open 2019 Feb 8;7(2):e2037. Epub 2019 Feb 8.

Division of Plastic & Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Mo.

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http://dx.doi.org/10.1097/GOX.0000000000002037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416121PMC
February 2019

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design.

J Med Chem 2019 01 2;62(2):467-479. Epub 2019 Jan 2.

Department of Biochemistry and Molecular Biophysics , Washington University School of Medicine , St. Louis , Missouri 63110 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467771PMC
January 2019

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.

Nat Microbiol 2018 12 1;3(12):1362-1368. Epub 2018 Oct 1.

Department of Molecular Microbiology, Washington University in St Louis, St Louis, MO, USA.

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http://dx.doi.org/10.1038/s41564-018-0255-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258349PMC
December 2018

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.

PLoS Pathog 2018 12 13;14(12):e1007457. Epub 2018 Dec 13.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1007457
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http://dx.doi.org/10.1371/journal.ppat.1007457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292575PMC
December 2018

Manganese acquisition is essential for virulence of Enterococcus faecalis.

PLoS Pathog 2018 09 20;14(9):e1007102. Epub 2018 Sep 20.

Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147510PMC
September 2018

Differential Regulation of Genes following Binding to Mannose Receptors.

J Pathog 2018 22;2018:2897581. Epub 2018 May 22.

Center for Women's Infectious Disease Research, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1155/2018/2897581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987248PMC
May 2018

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.

Proc Natl Acad Sci U S A 2018 03 5;115(12):E2819-E2828. Epub 2018 Mar 5.

Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1720140115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866590PMC
March 2018

Precision antimicrobial therapeutics: the path of least resistance?

NPJ Biofilms Microbiomes 2018 27;4. Epub 2018 Feb 27.

2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110 USA.

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http://dx.doi.org/10.1038/s41522-018-0048-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829159PMC
February 2018

Narrowing the spectrum: the new frontier of precision antimicrobials.

Genome Med 2017 Dec 14;9(1):110. Epub 2017 Dec 14.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-017-0504-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729598PMC
December 2017

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection.

NPJ Biofilms Microbiomes 2017 6;3:28. Epub 2017 Nov 6.

Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.

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http://dx.doi.org/10.1038/s41522-017-0036-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673934PMC
November 2017

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions.

PLoS Negl Trop Dis 2017 May 22;11(5):e0005586. Epub 2017 May 22.

Molecular Microbiology and Microbial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0005586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456409PMC
May 2017

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.

Sci Adv 2017 Feb 10;3(2):e1601944. Epub 2017 Feb 10.

Center for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/sciadv.1601944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302871PMC
February 2017

One size doesn't fit all: unraveling the diversity of factors and interactions that drive urovirulence.

Ann Transl Med 2017 Jan;5(2):28

Department of Molecular Microbiology, Washington University, St. Louis, MO, USA;; Center for Women's Infectious Disease Research, Washington University, St. Louis, MO, USA.

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http://dx.doi.org/10.21037/atm.2016.12.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300855PMC
January 2017

The Catabolite Repressor Protein-Cyclic AMP Complex Regulates csgD and Biofilm Formation in Uropathogenic Escherichia coli.

J Bacteriol 2016 12 18;198(24):3329-3334. Epub 2016 Nov 18.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1128/JB.00652-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116936PMC
December 2016

The unexplored relationship between urinary tract infections and the autonomic nervous system.

Auton Neurosci 2016 10 6;200:29-34. Epub 2015 Jun 6.

Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine in St. Louis, St. Louis, MO 63110-1010, United States; Center for Women's Infectious Disease Research, Washington University School of Medicine in St. Louis, St. Louis, MO 63110-1010, United States. Electronic address:

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http://dx.doi.org/10.1016/j.autneu.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670803PMC
October 2016

Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.

Cell Host Microbe 2016 Oct 22;20(4):482-492. Epub 2016 Sep 22.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294914PMC
October 2016

Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections.

MBio 2016 10 25;7(5). Epub 2016 Oct 25.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, Missouri, USA

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http://dx.doi.org/10.1128/mBio.01653-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080383PMC
October 2016

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease.

Nat Microbiol 2016 Oct 31;2:16196. Epub 2016 Oct 31.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nmicrobiol.2016.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308540PMC
October 2016

Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis.

MBio 2016 Apr 12;7(2):e00104-16. Epub 2016 Apr 12.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/mBio.00104-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959519PMC
April 2016

Adhesive Pili in UTI Pathogenesis and Drug Development.

Pathogens 2016 Mar 15;5(1). Epub 2016 Mar 15.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.3390/pathogens5010030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810151PMC
March 2016

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.

Cell 2016 Jan 24;164(1-2):269-278. Epub 2015 Dec 24.

Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London, WC1E 7HX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.11.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715182PMC
January 2016

Bacterial amyloid formation: structural insights into curli biogensis.

Trends Microbiol 2015 Nov 1;23(11):693-706. Epub 2015 Oct 1.

Structural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2015.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636965PMC
November 2015

Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice.

Pathog Dis 2015 Jul 4;73(5). Epub 2014 Dec 4.

Urology Institute, University Hospitals Case Medical Center and Department of Urology, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA

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http://dx.doi.org/10.1093/femspd/ftu004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444075PMC
July 2015

The pilus usher controls protein interactions via domain masking and is functional as an oligomer.

Nat Struct Mol Biol 2015 Jul 8;22(7):540-6. Epub 2015 Jun 8.

1] Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA. [2] Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1038/nsmb.3044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496297PMC
July 2015

Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders.

Cell Host Microbe 2015 Jul;18(1):1-2

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290729PMC
July 2015

Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli.

MBio 2015 Jun 30;6(4):e00820. Epub 2015 Jun 30.

Department of Molecular Microbiology and Microbial Pathogenesis and Center for Women's Infectious Disease Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/mBio.00820-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488945PMC
June 2015

Establishment and Characterization of UTI and CAUTI in a Mouse Model.

J Vis Exp 2015 Jun 23(100):e52892. Epub 2015 Jun 23.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine.

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http://dx.doi.org/10.3791/52892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544389PMC
June 2015

Urinary tract infections: epidemiology, mechanisms of infection and treatment options.

Nat Rev Microbiol 2015 May 8;13(5):269-84. Epub 2015 Apr 8.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA.

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http://www.nature.com/articles/nrmicro3432
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http://dx.doi.org/10.1038/nrmicro3432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457377PMC
May 2015

Impaired cytokine expression, neutrophil infiltration and bacterial clearance in response to urinary tract infection in diabetic mice.

Pathog Dis 2015 Apr 5;73(3). Epub 2015 Feb 5.

Urology Institute, University Hospitals Case Medical Center and Department of Urology, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA

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http://dx.doi.org/10.1093/femspd/ftv002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443837PMC
April 2015

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.

PLoS Pathog 2015 Apr 30;11(4):e1004818. Epub 2015 Apr 30.

Division of Pediatric Pharmacology & Drug Discovery, University of California, San Diego, La Jolla, California, United States of America; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America; Rady Children's Hospital, San Diego, California, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1004818
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http://dx.doi.org/10.1371/journal.ppat.1004818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415805PMC
April 2015

Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity.

MBio 2015 Mar 31;6(2). Epub 2015 Mar 31.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/mBio.00356-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453531PMC
March 2015

Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection.

Curr Opin Infect Dis 2015 Feb;28(1):97-105

aDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research bDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri cDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1097/QCO.0000000000000130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365976PMC
February 2015

Chaos controlled: discovery of a powerful amyloid inhibitor.

Mol Cell 2015 Feb;57(3):391-3

Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.031DOI Listing
February 2015

Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection.

Proc Natl Acad Sci U S A 2015 Feb 9;112(8):E871-80. Epub 2015 Feb 9.

Departments of Molecular Microbiology and Microbial Pathogenesis and Center for Women's Infections Disease Research, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1500374112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345586PMC
February 2015

Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection.

PLoS Pathog 2015 Jan 8;11(1):e1004599. Epub 2015 Jan 8.

Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287616PMC
January 2015

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG.

Nature 2014 Dec 14;516(7530):250-3. Epub 2014 Sep 14.

1] Structural and Molecular Microbiology, Structural Biology Research Center, VIB, Pleinlaan 2, 1050 Brussels, Belgium [2] Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.

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http://dx.doi.org/10.1038/nature13768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268158PMC
December 2014

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.

MBio 2014 Dec 30;6(1):e02304-14. Epub 2014 Dec 30.

Department of Molecular Biology, Umeå University, Umeå, Sweden Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden

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http://dx.doi.org/10.1128/mBio.02304-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281921PMC
December 2014

Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis.

EBioMedicine 2014 Nov 24;1(1):46-57. Epub 2014 Oct 24.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ebiom.2014.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457352PMC
November 2014

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.

MBio 2014 Oct 28;5(6):e02038. Epub 2014 Oct 28.

Department of Molecular Microbiology and Microbial Pathogenesis and Center for Women's Infectious Disease Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/mBio.02038-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217179PMC
October 2014

EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice.

Sci Transl Med 2014 Sep;6(254):254ra127

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.

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http://dx.doi.org/10.1126/scitranslmed.3009384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365981PMC
September 2014

Significance of the D-serine-deaminase and D-serine metabolism of Staphylococcus saprophyticus for virulence.

Infect Immun 2013 Dec 30;81(12):4525-33. Epub 2013 Sep 30.

Department of Medical Microbiology, Ruhr-University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1128/IAI.00599-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837983PMC
December 2013

Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis.

Proc Natl Acad Sci U S A 2013 Dec 4;110(50):20230-5. Epub 2013 Nov 4.

Interdisciplinary Graduate School and School of Biological Sciences, Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 637551.

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http://dx.doi.org/10.1073/pnas.1319066110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864318PMC
December 2013

Molecular basis of usher pore gating in Escherichia coli pilus biogenesis.

Proc Natl Acad Sci U S A 2013 Dec 2;110(51):20741-6. Epub 2013 Dec 2.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110.

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http://dx.doi.org/10.1073/pnas.1320528110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870681PMC
December 2013

From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections.

Curr Urol Rep 2013 Oct;14(5):448-56

Department of Molecular Microbiology and Microbial Pathogenesis; Center for Women's Infectious Disease Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8230, Saint Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11934-013-0354-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797163PMC
October 2013

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.

J Bacteriol 2013 Oct 2;195(19):4484-95. Epub 2013 Aug 2.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/JB.00451-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807452PMC
October 2013

Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor.

Proc Natl Acad Sci U S A 2013 Oct 23;110(41):16592-7. Epub 2013 Sep 23.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.

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http://dx.doi.org/10.1073/pnas.1315320110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799328PMC
October 2013

Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation.

Proc Natl Acad Sci U S A 2013 Sep 3;110(39):15530-7. Epub 2013 Sep 3.

Center for Women's Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.

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http://dx.doi.org/10.1073/pnas.1315203110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785778PMC
September 2013

Escherichia coli biofilms have an organized and complex extracellular matrix structure.

MBio 2013 Sep 10;4(5):e00645-13. Epub 2013 Sep 10.

Center for Women's Infectious Diseases Research, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/mBio.00645-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774191PMC
September 2013

Urinary tract infection as a preventable cause of pregnancy complications: opportunities, challenges, and a global call to action.

Glob Adv Health Med 2013 Sep;2(5):59-69

Departments of Molecular Microbiology, Obstetrics and Gynecology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St Louis, Missouri, United States.

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http://journals.sagepub.com/doi/10.7453/gahmj.2013.061
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http://dx.doi.org/10.7453/gahmj.2013.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833562PMC
September 2013

Estrogen and recurrent UTI: what are the facts?

Sci Transl Med 2013 Jun;5(190):190fs23

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006423DOI Listing
June 2013

Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes.

Infect Immun 2013 May 4;81(5):1606-17. Epub 2013 Mar 4.

Divison of Pediatric Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/IAI.00021-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648019PMC
May 2013

Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.

Cold Spring Harb Perspect Med 2013 Apr 1;3(4):a010306. Epub 2013 Apr 1.

Department of Molecular Microbiology and Microbial Pathogenesis, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110-1010, USA.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a010306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683961PMC
April 2013

Structural and energetic basis of folded-protein transport by the FimD usher.

Nature 2013 Apr;496(7444):243-6

Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London WC1E 7HX, UK.

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http://dx.doi.org/10.1038/nature12007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673227PMC
April 2013

Dissection of pilus tip assembly by the FimD usher monomer.

J Mol Biol 2013 Mar 4;425(5):958-67. Epub 2013 Jan 4.

Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London WC1E 7HX, UK.

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http://dx.doi.org/10.1016/j.jmb.2012.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650583PMC
March 2013

Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections.

Infect Immun 2013 Jan 6;81(1):329-39. Epub 2012 Nov 6.

Department of Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, Saint Louis, Missouri, USA.

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http://iai.asm.org/lookup/doi/10.1128/IAI.00856-12
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http://dx.doi.org/10.1128/IAI.00856-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536162PMC
January 2013

Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli.

Infect Immun 2012 Dec 17;80(12):4186-94. Epub 2012 Sep 17.

Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/IAI.00684-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497425PMC
December 2012

The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket.

J Bacteriol 2012 Dec 21;194(23):6390-7. Epub 2012 Sep 21.

Washington University Department of Pathology and Immunology, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/JB.06651-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497488PMC
December 2012

Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors.

J Bacteriol 2012 Nov 14;194(22):6195-205. Epub 2012 Sep 14.

Department of Molecular Microbiology & Microbial Pathogenesis, Washington University in Saint Louis School of Medicine, St Louis, Missouri, USA.

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http://jb.asm.org/cgi/doi/10.1128/JB.01012-12
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http://dx.doi.org/10.1128/JB.01012-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486386PMC
November 2012

Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific.

J Infect Dis 2012 Nov 21;206(10):1589-96. Epub 2012 Sep 21.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, United Kingdom.

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https://academic.oup.com/jid/article-lookup/doi/10.1093/infd
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http://dx.doi.org/10.1093/infdis/jis554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475635PMC
November 2012

Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics.

Virulence 2012 Nov 15;3(7):592-4. Epub 2012 Nov 15.

Department of Molecular Microbiology and Center for Womens' Infectious Disease Research, Washington University in St. Louis, St. Louis, MO, USA.

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http://www.tandfonline.com/doi/abs/10.4161/viru.22364
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http://dx.doi.org/10.4161/viru.22364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545937PMC
November 2012

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.

MBio 2012 24;3(4):e00177-12. Epub 2012 Jul 24.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/mBio.00177-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419518PMC
October 2012

Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.

Antimicrob Agents Chemother 2012 Sep 25;56(9):4738-45. Epub 2012 Jun 25.

Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St. Louis, Missouri, USA,.

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http://dx.doi.org/10.1128/AAC.00447-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421856PMC
September 2012

Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.

Infect Immun 2012 Aug 4;80(8):2826-34. Epub 2012 Jun 4.

Department of Molecular Microbiology & Microbial Pathogenesis, Washington University in Saint Louis School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/IAI.00283-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434567PMC
August 2012

Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine.

Proc Natl Acad Sci U S A 2012 Jun 29;109(24):9563-8. Epub 2012 May 29.

Department of Molecular Microbiology, Center for Women's Infectious Diseases Research, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1207085109
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http://dx.doi.org/10.1073/pnas.1207085109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386062PMC
June 2012

What does it take to stick around? Molecular insights into biofilm formation by uropathogenic Escherichia coli.

Virulence 2012 May 1;3(3):231-3. Epub 2012 May 1.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, MO, USA.

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http://www.tandfonline.com/doi/abs/10.4161/viru.19763
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http://dx.doi.org/10.4161/viru.19763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442832PMC
May 2012

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

J Med Chem 2012 Apr 13;55(8):3945-59. Epub 2012 Apr 13.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, USA.

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http://pubs.acs.org/doi/10.1021/jm300165m
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375398PMC
April 2012

The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.

Proc Natl Acad Sci U S A 2012 Apr 9;109(17):6502-7. Epub 2012 Apr 9.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1204161109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340089PMC
April 2012

Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.

J Am Chem Soc 2012 Mar 23;134(9):3938-41. Epub 2012 Feb 23.

Department of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, USA.

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http://pubs.acs.org/doi/10.1021/ja2091917
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http://dx.doi.org/10.1021/ja2091917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325780PMC
March 2012