Scott Hughes

Scott Hughes

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Scott Hughes

Scott Hughes

Publications by authors named "Scott Hughes"

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Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs.

Bioorg Med Chem 2019 Jun 22;27(12):2466-2479. Epub 2019 Feb 22.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896193017
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http://dx.doi.org/10.1016/j.bmc.2019.02.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561380PMC
June 2019

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.

ACS Chem Biol 2019 Mar 22;14(3):361-368. Epub 2019 Feb 22.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee, James Black Centre , Dow Street , Dundee DD1 5EH , United Kingdom.

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http://pubs.acs.org/doi/10.1021/acschembio.9b00092
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http://dx.doi.org/10.1021/acschembio.9b00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423499PMC
March 2019

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.

Essays Biochem 2017 11 8;61(5):505-516. Epub 2017 Nov 8.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.

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http://dx.doi.org/10.1042/EBC20170041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869862PMC
November 2017

Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.

PLoS One 2016 4;11(5):e0154862. Epub 2016 May 4.

Department of Biochemistry and Molecular Biology, Tulane School of Medicine, New Orleans, LA 70112, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154862PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856263PMC
July 2017

Medications for Chronic Asthma.

Am Fam Physician 2016 Sep;94(6):454-62

Offutt Air Force Base Family Medicine Residency, Offutt Air Force Base, NE, USA.

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September 2016

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.

ACS Infect Dis 2016 09 3;2(9):627-641. Epub 2016 Aug 3.

Department of Biochemistry and Molecular Biology, Tulane School of Medicine , New Orleans, Louisiana 70112, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00090DOI Listing
September 2016

High-throughput method for simultaneous quantification of N, C and S stable isotopes and contents in organics and soils.

Rapid Commun Mass Spectrom 2016 08;30(15):1743-53

Center for Stable Isotope Biogeochemistry, 1140 Valley Life Science Building, University of California at Berkeley, Berkeley, CA, 94720, USA.

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http://dx.doi.org/10.1002/rcm.7605DOI Listing
August 2016

Lack of Evidence for Plague or Anthrax on the New York City Subway.

Cell Syst 2015 Jul 29;1(1):4-5. Epub 2015 Jul 29.

Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.

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http://dx.doi.org/10.1016/j.cels.2015.07.008DOI Listing
July 2015

Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281.

Cell Signal 2015 May 26;27(5):1008-18. Epub 2015 Feb 26.

Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada; Department of Physiology and Pharmacology, Western University, London N6A 5C1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.02.023DOI Listing
May 2015

Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus.

Proteins 2014 Jul 18;82(7):1542-8. Epub 2014 Feb 18.

Department of Pharmacology, University of Toronto, Toronto, Ontario, M5G 1L7.

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http://dx.doi.org/10.1002/prot.24524DOI Listing
July 2014

Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses.

PLoS One 2013 6;8(9):e72205. Epub 2013 Sep 6.

Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America ; Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072205PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765159PMC
June 2014

Active surveillance for low-risk prostate cancer in African American men: a multi-institutional experience.

Urology 2014 Feb 26;83(2):364-8. Epub 2013 Nov 26.

Detroit Medical Center, Michigan State University College of Osteopathic Medicine, Detroit, MI. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2013.09.038DOI Listing
February 2014

Identification of cysteines involved in the effects of methanethiosulfonate reagents on human equilibrative nucleoside transporter 1.

Mol Pharmacol 2011 Oct 26;80(4):735-46. Epub 2011 Jul 26.

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.

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http://molpharm.aspetjournals.org/content/80/4/735.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.111.07
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http://dx.doi.org/10.1124/mol.111.072587DOI Listing
October 2011

Modeling extreme mass ratio inspirals within the effective-one-body approach.

Phys Rev Lett 2010 Mar 5;104(9):091102. Epub 2010 Mar 5.

Department of Physics, Princeton University, Princeton, New Jersey 08544, USA.

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https://link.aps.org/doi/10.1103/PhysRevLett.104.091102
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http://dx.doi.org/10.1103/PhysRevLett.104.091102DOI Listing
March 2010

Heterotopic ossification--a complication of elbow arthroscopy: a case report.

J Shoulder Elbow Surg 2010 Jan;19(1):e1-5

Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jse.2009.04.015DOI Listing
January 2010

Osteogenic intraocular melanoma in an alpaca (Vicugna pacos).

J Vet Diagn Invest 2009 Jan;21(1):171-3

Gribbles Veterinary, Palmerston North, New Zealand.

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http://dx.doi.org/10.1177/104063870902100132DOI Listing
January 2009

Structural flexibility of laparoscopic instruments: implication for the design of virtual reality simulators.

Stud Health Technol Inform 2005 ;111:201-3

Surgical Skills Centre at Mt. Sinai Hospital, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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August 2005

Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans.

J Appl Physiol (1985) 2005 Jun 10;98(6):1985-90. Epub 2005 Feb 10.

Exercise Metabolism Research Group, Dept. of Kinesiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1.

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http://www.physiology.org/doi/10.1152/japplphysiol.01095.200
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http://dx.doi.org/10.1152/japplphysiol.01095.2004DOI Listing
June 2005

Gravitational radiation reaction and inspiral waveforms in the adiabatic limit.

Phys Rev Lett 2005 Jun 7;94(22):221101. Epub 2005 Jun 7.

Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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https://link.aps.org/doi/10.1103/PhysRevLett.94.221101
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http://dx.doi.org/10.1103/PhysRevLett.94.221101DOI Listing
June 2005

Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha.

J Virol 2004 Dec;78(23):13104-12

Department of Pathobiological Sciences, School of Veterinary Medicine, Skip Bertman Dr., Louisiana State University, Baton Rouge, LA 70803, USA.

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http://dx.doi.org/10.1128/JVI.78.23.13104-13112.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525006PMC
December 2004

Polymorphisms in the Chlamydia trachomatis cytotoxin locus associated with ocular and genital isolates.

Infect Immun 2004 Dec;72(12):7063-72

College of Medicine, Department of Molecular Science, University of Tennessee, Memphis Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1128/IAI.72.12.7063-7072.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529170PMC
December 2004

Transgenic mouse model for echovirus myocarditis and paralysis.

Proc Natl Acad Sci U S A 2003 Dec 12;100(26):15906-11. Epub 2003 Dec 12.

Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.2535934100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307666PMC
December 2003

Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase.

J Biol Chem 2002 Jul 13;277(30):26893-903. Epub 2002 May 13.

Department of Medical Microbiology, University of Manitoba and National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba R3E 0W3, Canada.

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http://dx.doi.org/10.1074/jbc.M203937200DOI Listing
July 2002