Publications by authors named "Scott E Plevy"

59Publications

Symbionts exploit complex signaling to educate the immune system.

Proc Natl Acad Sci U S A 2019 Dec 6. Epub 2019 Dec 6.

Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1915978116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936714PMC
December 2019

Whole-Virome Analysis Sheds Light on Viral Dark Matter in Inflammatory Bowel Disease.

Cell Host Microbe 2019 Dec 19;26(6):764-778.e5. Epub 2019 Nov 19.

APC Microbiome Ireland, School of Microbiology, University College Cork, Cork, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.10.009DOI Listing
December 2019

Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation.

Cells 2019 09 21;8(10). Epub 2019 Sep 21.

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.3390/cells8101121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829312PMC
September 2019

Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model.

Cell Mol Gastroenterol Hepatol 2019 9;8(2):193-195. Epub 2019 May 9.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661391PMC
July 2020

Publisher Correction: Get the IL-17F outta here!

Nat Immunol 2019 Mar;20(3):374

Janssen Immunology Research and Development, Spring House, PA, USA.

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http://dx.doi.org/10.1038/s41590-019-0332-2DOI Listing
March 2019

Get the IL-17F outta here!

Nat Immunol 2018 07;19(7):648-650

Janssen Immunology Research and Development, Spring House, PA, USA.

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http://dx.doi.org/10.1038/s41590-018-0141-zDOI Listing
July 2018

Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.

World J Gastrointest Pharmacol Ther 2015 Nov;6(4):213-22

Kunwar Shailubhai, Vaseem Palejwala, John A Foss, Stephen Comiskey, R and D Center, Synergy Pharmaceuticals Inc., Doylestown, PA 18902, United States.

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http://dx.doi.org/10.4292/wjgpt.v6.i4.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635161PMC
November 2015

Escherichia coli heme oxygenase modulates host innate immune responses.

Microbiol Immunol 2015 Aug;59(8):452-65

Department of Medicine and Center for GI Biology and Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599.

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http://dx.doi.org/10.1111/1348-0421.12282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582649PMC
August 2015

Infliximab Re-treatment in Inflammatory Bowel Disease: A Single-Center Routine Clinical Experience.

Clin Gastroenterol Hepatol 2015 Sep 14;13(9):1704-5. Epub 2014 May 14.

Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.cgh.2014.05.007DOI Listing
September 2015

Toward an understanding of the gene-specific and global logic of inducible gene transcription.

Cold Spring Harb Symp Quant Biol 2013 19;78:61-8. Epub 2014 Apr 19.

Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095.

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http://dx.doi.org/10.1101/sqb.2013.78.020313DOI Listing
March 2015

Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota.

Gut Microbes 2014 Mar-Apr;5(2):220-4. Epub 2013 Dec 20.

Departments of Medicine, Microbiology, and Immunology; University of North Carolina School Medicine; Chapel Hill, NC USA.

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http://dx.doi.org/10.4161/gmic.27290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063848PMC
February 2015

Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.

Sci Rep 2014 Jan 10;4:3631. Epub 2014 Jan 10.

1] Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219 [2] Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida 33458.

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http://dx.doi.org/10.1038/srep03631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887388PMC
January 2014

Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis.

Inflamm Bowel Dis 2013 Dec;19(13):2867-77

*Department of Clinical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina; †Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, New Mexico; and ‡Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, and §Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1097/MIB.0b013e3182a82ae9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880115PMC
December 2013

The role of macrophages and dendritic cells in the initiation of inflammation in IBD.

Inflamm Bowel Dis 2014 Jan;20(1):166-75

*Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; and †Center for Gastrointestinal Biology and Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1097/MIB.0b013e3182a69dcaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098861PMC
January 2014

In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery.

AAPS J 2013 Jan 30;15(1):288-98. Epub 2012 Nov 30.

Center for Nanotechnology in Drug Delivery, Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1208/s12248-012-9441-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535102PMC
January 2013

IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.

J Immunol 2012 Aug 11;189(4):1792-9. Epub 2012 Jul 11.

Department of Medicine, Center for Gastrointestinal Biology and Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.1200042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411910PMC
August 2012

Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.

J Immunol 2012 May 16;188(10):4897-905. Epub 2012 Apr 16.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.4049/jimmunol.1103558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373011PMC
May 2012

A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.

PLoS One 2012 27;7(3):e34172. Epub 2012 Mar 27.

Center for Gastrointestinal Biology and Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034172PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313977PMC
November 2012

A Crohn's disease patient who does not respond to infliximab: what is next?

Clin Gastroenterol Hepatol 2011 Dec 6;9(12):1033-8. Epub 2011 Jun 6.

Department of Medicine, Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/j.cgh.2011.05.027DOI Listing
December 2011

Future therapeutic approaches for inflammatory bowel diseases.

Gastroenterology 2011 May;140(6):1838-46

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076881PMC
http://dx.doi.org/10.1053/j.gastro.2011.02.014DOI Listing
May 2011

NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.

J Immunol 2011 Apr 7;186(8):4649-55. Epub 2011 Mar 7.

Center for Gastrointestinal Biology and Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.1003888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172700PMC
April 2011

Characterization of an interferon-stimulated response element (ISRE) in the Il23a promoter.

J Biol Chem 2011 Jan 21;286(2):1174-80. Epub 2010 Nov 21.

Department of Medicine and Microbiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M110.147884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020724PMC
January 2011

Dosage adjustment during long-term adalimumab treatment for Crohn's disease: clinical efficacy and pharmacoeconomics.

Inflamm Bowel Dis 2011 Jan;17(1):141-51

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1002/ibd.21328DOI Listing
January 2011

The role of the macrophage in sentinel responses in intestinal immunity.

Curr Opin Gastroenterol 2010 Nov;26(6):578-82

Department of Medicine, Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1097/MOG.0b013e32833d4b71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214652PMC
November 2010

Cutting edge: IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis.

J Immunol 2010 Apr 12;184(8):4069-73. Epub 2010 Mar 12.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.0903600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956738PMC
April 2010

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.

J Leukoc Biol 2009 Sep 19;86(3):633-43. Epub 2009 May 19.

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1189/jlb.1008662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735284PMC
September 2009

Poorly responsive ulcerative colitis in the hospital.

Clin Gastroenterol Hepatol 2009 Jun 21;7(6):635-40. Epub 2009 Mar 21.

Department of Medicine, Division of Gastroenterology and Hepatology, Multidisciplinary Inflammatory Bowel Disease Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1016/j.cgh.2009.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865179PMC
June 2009

Infliximab prevents Crohn's disease recurrence after ileal resection.

Gastroenterology 2009 Feb 31;136(2):441-50.e1; quiz 716. Epub 2008 Oct 31.

Inflammatory Bowel Disease Center and Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.10.051DOI Listing
February 2009

Farm animals and inflammatory bowel disease: old MacDonald had poor hygiene.

Gastroenterology 2008 Mar;134(3):886-7; discussion 887-8

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http://dx.doi.org/10.1053/j.gastro.2008.01.047DOI Listing
March 2008

Optimizing the use of biologic therapies in the treatment of inflammatory bowel disease.

Authors:
Scott E Plevy

Gastroenterol Hepatol (N Y) 2007 Aug;3(8):592-4

Associate Professor Department of Medicine Department of Microbiology and Immunology University of North Carolina at Chapel Hill.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099294PMC
August 2007

Cutting edge: transgenic expression of human MUC1 in IL-10-/- mice accelerates inflammatory bowel disease and progression to colon cancer.

J Immunol 2007 Jul;179(2):735-9

Department of Immunology, University of Pittsburgh School of Medicine, PA 15261, USA.

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http://dx.doi.org/10.4049/jimmunol.179.2.735DOI Listing
July 2007

Enteroendocrine cells express functional Toll-like receptors.

Am J Physiol Gastrointest Liver Physiol 2007 Jun 29;292(6):G1770-83. Epub 2007 Mar 29.

Div. of Gastroenterology and Hepatology, Univ. of North Carolina School of Medicine, 103 Mason Farm Rd., Campus Box 7032, 7341C MBRB, Chapel Hill, NC 27599-7032, USA.

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http://dx.doi.org/10.1152/ajpgi.00249.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203538PMC
June 2007

Innate immune receptor genetic polymorphisms in pouchitis: is CARD15 a susceptibility factor?

Inflamm Bowel Dis 2005 Nov;11(11):965-71

Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1097/01.mib.0000186407.25694.cfDOI Listing
November 2005

The benefit/risk profile of TNF-blocking agents: findings of a consensus panel.

Semin Arthritis Rheum 2005 Jun;34(6):819-36

Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore 21201, USA.

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http://dx.doi.org/10.1016/j.semarthrit.2004.11.006DOI Listing
June 2005

Inflammatory pseudotumor of the liver associated with Crohn's disease.

J Clin Gastroenterol 2004 Oct;38(9):818-22

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1097/00004836-200410000-00020DOI Listing
October 2004

Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation.

J Immunol 2004 Feb;172(4):2559-68

Immunobiology Center and Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.4049/jimmunol.172.4.2559DOI Listing
February 2004

Inhibition of interleukin-12 p40 transcription and NF-kappaB activation by nitric oxide in murine macrophages and dendritic cells.

J Biol Chem 2004 Mar 16;279(11):10776-83. Epub 2003 Dec 16.

Immunobiology Center, The Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313416200
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http://dx.doi.org/10.1074/jbc.M313416200DOI Listing
March 2004

Corticosteroid-sparing treatments in patients with Crohn's disease.

Authors:
Scott E Plevy

Am J Gastroenterol 2002 Jul;97(7):1607-17

Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1111/j.1572-0241.2002.05818.xDOI Listing
July 2002