Scott B Snapper

Scott B Snapper

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Scott B Snapper

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Humanized Mouse Models of Genetic Immune Disorders and Hematological Malignancies.

Biochem Pharmacol 2019 Oct 18:113671. Epub 2019 Oct 18.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113671DOI Listing
October 2019

Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model.

Cell Mol Gastroenterol Hepatol 2019 9;8(2):193-195. Epub 2019 May 9.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661391PMC
May 2019

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Dev Cell 2019 04 28;49(1):10-29. Epub 2019 Mar 28.

Department of Biomedical Informatics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.devcel.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346PMC
April 2019

STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.

Nat Commun 2019 02 22;10(1):912. Epub 2019 Feb 22.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-019-08743-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385318PMC
February 2019

The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies.

J Clin Immunol 2018 07 29;38(5):579-588. Epub 2018 Jun 29.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10875-018-0524-9DOI Listing
July 2018

An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning.

J Allergy Clin Immunol 2018 04 19;141(4):1354-1364.e9. Epub 2017 Dec 19.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425755PMC
April 2018

Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier.

Cell Mol Gastroenterol Hepatol 2018 Mar 15;5(3):273-288. Epub 2017 Dec 15.

Division of Gastroenterology/Nutrition and Center for Inflammatory Bowel Disease Treatment and Research, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jcmgh.2017.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904039PMC
March 2018

Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.

Inflamm Bowel Dis 2017 11;23(11):1950-1961

1Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; 4VEO-IBD Consortium; 5Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts; 6Harvard Medical School, Boston, Massachusetts; 7Great Ormond Street Hospital London, London, England; 8Translational Gastroenterology Unit, University of Oxford, Oxford, England; 9Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida; 10Division of Gastroenterology and Nutrition, The Children's Hospital at Montefiore, Bronx, New York; 11Pediatric Gastroenterology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 12Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan; 13Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; 14Department of Gastroenterology, Children's National Medical Center, Washington, DC; 15Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan; 16Hospital das Clınicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 17Division of Gastroenterology, McMaster Children's Hospital, West Hamilton, Ontario, Canada; 18Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany; 19Division of Pathology, Boston Children's Hospital, Boston, Massachusetts; 20Department of Pediatrics, University of Oxford, Oxford, England; 21Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; 22Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; 23Department of Biochemistry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; and 24Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000001270DOI Listing
November 2017

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis.

N Engl J Med 2017 07 28;377(1):52-61. Epub 2017 Jun 28.

From the Section of Molecular Development of the Immune System, Laboratory of Immunology (A.O., W.A.C., A.R.M., H.F.M., M.J.L.), the Clinical Genomics Program (A.O., W.A.C., A.R.M., Y.Z., H.F.M., H.C.S., M.J.L.), and the Human Immunological Diseases Section, Laboratory of Host Defenses (Y.Z., H.C.S.), National Institute of Allergy and Infectious Diseases, the Laboratory of Pathology, National Cancer Institute (S.P.), and Radiology and Imaging Sciences, Clinical Center (L.R.F.), National Institutes of Health, Bethesda, MD; the Department of Pediatrics, Division of Allergy and Immunology (A.O., E.K.-A., S.B., A. Kiykim, I.O.), and the Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition (E.T., D.E.), Marmara University, Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases (A.O., E.K.-A., S.B., A. Kiykim, I.O.), and the Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, İstanbul University Cerrahpaşa Faculty of Medicine (Ö.F.B., T.E.), Istanbul, and the Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Gazi University (B.D., S.S.), the Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, Başkent University (F.O., Z.B., M.G.), and the Pediatric Gastroenterology Clinic, Dr. Sami Ulus Children's Hospital (A.U.A.), Ankara - all in Turkey; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases and the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (R.C.A., C.D.C., N.K.S., A. Krolo, K.B.), Clinical Institute of Pathology (R.K.), the Department of Pediatrics and Adolescent Medicine (K.B.), and St. Anna Kinderspital and Children's Cancer Research Institute, Department of Pediatrics (K.B.), Medical University of Vienna, Vienna; Merck Research Laboratories (J.J.M.), and the Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Harvard Medical School (S.B.S.), Boston; and the Department of Pediatric Gastroenterology, University Medical Center-Wilhelmina Children's Hospital (R.H.J.H.), and the Department of Rheumatology and Clinical Immunology, University Medical Center (H.L.L.), Utrecht, the Netherlands.

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http://dx.doi.org/10.1056/NEJMoa1615887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690356PMC
July 2017

Haematopoietic stem and progenitor cells from human pluripotent stem cells.

Nature 2017 05 17;545(7655):432-438. Epub 2017 May 17.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature22370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872146PMC
May 2017

Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice.

Gastroenterology 2017 04 11;152(5):1151-1160. Epub 2017 Jan 11.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368009PMC
April 2017

Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakin Treatment Suggests Further Mechanism for Mucosal Healing.

J Clin Immunol 2017 02 7;37(2):104-107. Epub 2017 Jan 7.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100214, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s10875-016-0365-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325838PMC
February 2017

Erratum to: Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing.

J Clin Immunol 2017 02;37(2):108

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 SWArcher Rd, PO Box 100214, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s10875-017-0368-8DOI Listing
February 2017

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.

Cell Rep 2016 10;17(5):1318-1329

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106873PMC
October 2016

IL-10 induces a STAT3-dependent autoregulatory loop in T2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.

Sci Immunol 2016 Oct 11;1(5). Epub 2016 Nov 11.

Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509416PMC
October 2016

Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion.

Mol Hum Reprod 2016 09 11;22(9):613-21. Epub 2016 Jul 11.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China University of Chinese Academy of Sciences, Beijing 100101, P.R. China

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http://dx.doi.org/10.1093/molehr/gaw046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459223PMC
September 2016

Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor Deficiency and History of Infantile Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2016 07;63(1):e15-7

*Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital †Department of Pediatrics ‡Department of Medicine, Harvard Medical School, Boston, MA §Division of Pediatric Hematology and Oncology ||Division of Pathology, University of Michigan, Ann Arbor, MI ¶SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute #Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada **Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany ††Division of Gastroenterology, Brigham and Women's Hospital ‡‡interNational Early Onset Paediatric IBD Cohort Study (NEOPICS), Boston, MA.

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http://dx.doi.org/10.1097/MPG.0000000000000532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605893PMC
July 2016

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Gastroenterology 2016 05 4;150(5):1196-1207. Epub 2016 Feb 4.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085160012
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http://dx.doi.org/10.1053/j.gastro.2016.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842103PMC
May 2016

MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.

Science 2015 Aug 13;349(6251):993-7. Epub 2015 Aug 13.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston 02115, MA, USA. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaa9420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700932PMC
August 2015

Very-Early-Onset Inflammatory Bowel Disease.

Authors:
Scott B Snapper

Gastroenterol Hepatol (N Y) 2015 Aug;11(8):554-6

Wolpow Family Chair in IBD Treatment and Research Director, Inflammatory Bowel Disease Center and Basic & Translational Research (Gastroenterology, Children's Hospital) Director, Inflammatory Bowel Disease Research (Gastroenterology, Brigham and Women's Hospital) Associate Professor of Medicine, Harvard Medical School Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843045PMC
August 2015

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

Very early-onset inflammatory bowel disease: gaining insight through focused discovery.

Inflamm Bowel Dis 2015 May;21(5):1166-75

*Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts; †Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; ‡Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany; §Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada; ‖SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; ¶Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts; **Division of Gastroenterology and Hepatology, Brigham & Women's Hospital, Boston, Massachusetts; and ††Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165626PMC
May 2015

The diagnostic approach to monogenic very early onset inflammatory bowel disease.

Gastroenterology 2014 Nov 21;147(5):990-1007.e3. Epub 2014 Jul 21.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140091
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http://dx.doi.org/10.1053/j.gastro.2014.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376484PMC
November 2014

Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease.

Gastroenterology 2014 Oct 18;147(4):803-813.e7; quiz e14-5. Epub 2014 Jun 18.

Department of Paediatrics, University of Toronto, Toronto, Canada; SickKids Inflammatory Bowel Disease Center, Division of Gastroenterology Hepatology and Nutrition, Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2014.06.023DOI Listing
October 2014

The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment.

Cell Microbiol 2014 Sep 2;16(9):1405-24. Epub 2014 Jun 2.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA.

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http://dx.doi.org/10.1111/cmi.12302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146666PMC
September 2014

Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease.

Gastroenterology 2014 Sep 12;147(3):680-689.e2. Epub 2014 Jun 12.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.06.005DOI Listing
September 2014

CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis.

Inflamm Bowel Dis 2014 Jul;20(7):1165-76

Divisions of *Gastroenterology/Nutrition and †Immunology, Boston Children's Hospital; ‡Department of Pediatrics, Harvard Medical School; and §Department of Pathology, Brigham and Women's Hospital & Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249688PMC
July 2014

N-wasp is required for structural integrity of the blood-testis barrier.

PLoS Genet 2014 Jun 26;10(6):e1004447. Epub 2014 Jun 26.

The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072540PMC
June 2014

Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.

Adv Immunol 2014 ;122:177-210

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Gastroenterology, Brigham & Women's Hospital, Boston, Massachusetts, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97801280026740
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http://dx.doi.org/10.1016/B978-0-12-800267-4.00005-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741283PMC
May 2014

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

Immunity 2014 May 1;40(5):706-19. Epub 2014 May 1.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS). Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513358PMC
May 2014

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

Gastroenterology 2014 Apr 11;146(4):1028-39. Epub 2014 Jan 11.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002656PMC
April 2014

Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease.

Clin Transl Gastroenterol 2014 Jan 16;5:e46. Epub 2014 Jan 16.

1] SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada [2] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada [3] Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ctg.2013.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912315PMC
January 2014

N-wasp is essential for the negative regulation of B cell receptor signaling.

PLoS Biol 2013 Nov 5;11(11):e1001704. Epub 2013 Nov 5.

Department of Cell Biology & Molecular Genetics, University of Maryland, College Park, Maryland, United States of America.

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https://dx.plos.org/10.1371/journal.pbio.1001704
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http://dx.doi.org/10.1371/journal.pbio.1001704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818172PMC
November 2013

Colitis and colon cancer in WASP-deficient mice require helicobacter species.

Inflamm Bowel Dis 2013 Sep;19(10):2041-50

Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02139, USA.

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http://dx.doi.org/10.1097/MIB.0b013e318295fd8fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082694PMC
September 2013

Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

Infect Immun 2012 Dec 10;80(12):4071-7. Epub 2012 Sep 10.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/IAI.06148-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497443PMC
December 2012

Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.

Gastroenterology 2012 Sep 15;143(3):719-729.e2. Epub 2012 Jun 15.

Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Department of Gastroenterology/Nutrition, Children's Hospital, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760724PMC
September 2012

The age of gene discovery in very early onset inflammatory bowel disease.

Gastroenterology 2012 Aug 21;143(2):285-8. Epub 2012 Jun 21.

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http://dx.doi.org/10.1053/j.gastro.2012.06.025DOI Listing
August 2012

The actin regulator N-WASp is required for muscle-cell fusion in mice.

Proc Natl Acad Sci U S A 2012 Jul 26;109(28):11211-6. Epub 2012 Jun 26.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1073/pnas.1116065109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396508PMC
July 2012

Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance.

J Gastroenterol 2012 Jan 5;47(1):1-8. Epub 2012 Jan 5.

Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s00535-011-0521-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592148PMC
January 2012

The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release.

Development 2011 Jul;138(13):2729-39

Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1242/dev.059865DOI Listing
July 2011

N-WASP is required for membrane wrapping and myelination by Schwann cells.

J Cell Biol 2011 Jan;192(2):243-50

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1083/jcb.201010013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172181PMC
January 2011

Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.

PLoS Pathog 2010 Aug 19;6(8):e1001056. Epub 2010 Aug 19.

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1371/journal.ppat.1001056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924363PMC
August 2010

Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.

J Clin Invest 2010 Feb 11;120(2):446-56. Epub 2010 Jan 11.

Gastrointestinal Unit and Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1172/JCI36478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810069PMC
February 2010

Phosphorylation of WASp is a key regulator of activity and stability in vivo.

Proc Natl Acad Sci U S A 2009 Sep 1;106(37):15738-43. Epub 2009 Sep 1.

Molecular Immunology Unit, Wolfson Centre for Gene Therapy of Childhood Disease and Centre for Immunodeficiency, UCL Institute of Child Health, London, WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0904346106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736139PMC
September 2009

Activating mutations of N-WASP alter Shigella pathogenesis.

Biochem Biophys Res Commun 2009 Jul 18;384(3):284-9. Epub 2009 Apr 18.

Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.04.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697925PMC
July 2009

Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men.

Curr Opin Immunol 2008 Dec 12;20(6):646-54. Epub 2008 Nov 12.

Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.coi.2008.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605935PMC
December 2008

Regulatory T cells in inflammatory bowel disease.

Curr Opin Gastroenterol 2008 Nov;24(6):733-41

Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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November 2008

Challenges in IBD research: Assessing progress and rethinking the research agenda.

Inflamm Bowel Dis 2008 May;14(5):687-708

Washington University, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/ibd.20371DOI Listing
May 2008

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Proc Natl Acad Sci U S A 2007 Sep 18;104(39):15424-9. Epub 2007 Sep 18.

Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.0706881104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000553PMC
September 2007

Teaching tolerance with a probiotic antigen delivery system.

Gastroenterology 2007 Aug;133(2):706-9

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http://dx.doi.org/10.1053/j.gastro.2007.06.055DOI Listing
August 2007

A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis.

Eur J Immunol 2005 Oct;35(10):3064-73

Immunology, Department of Biology, Faculty of Sciences, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1002/eji.200526167DOI Listing
October 2005

Role of the WASP family proteins for Mycobacterium marinum actin tail formation.

Proc Natl Acad Sci U S A 2005 Oct 30;102(41):14837-42. Epub 2005 Sep 30.

Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0504663102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1239894PMC
October 2005