Scott B Ficarro

Scott B Ficarro

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Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.

Nature 2019 Oct 3. Epub 2019 Oct 3.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1660-yDOI Listing
October 2019

Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

Bioorg Med Chem Lett 2019 Aug 23;29(15):1985-1993. Epub 2019 May 23.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.05.024DOI Listing
August 2019

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.

Science 2019 08 27;365(6452). Epub 2019 Jun 27.

Department of Cell Biology, Harvard Medical School, and Howard Hughes Medical Institute, 240 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aax1033DOI Listing
August 2019

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

Cell Chem Biol 2019 Jun 21;26(6):792-803.e10. Epub 2019 Mar 21.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biology Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588464PMC
June 2019

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

Cell Chem Biol 2019 Jun 11;26(6):818-829.e9. Epub 2019 Apr 11.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193007
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http://dx.doi.org/10.1016/j.chembiol.2019.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634314PMC
June 2019

In vitro analysis of RNA polymerase II elongation complex dynamics.

Genes Dev 2019 05 7;33(9-10):578-589. Epub 2019 Mar 7.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.324202.119
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http://dx.doi.org/10.1101/gad.324202.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499329PMC
May 2019

In vitro assembly and proteomic analysis of RNA polymerase II complexes.

Methods 2019 Apr 4;159-160:96-104. Epub 2019 Mar 4.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589106PMC
April 2019

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.

Cell 2018 08 2;174(4):897-907.e14. Epub 2018 Aug 2.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139374PMC
August 2018

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform.

Cell Chem Biol 2018 04 22;25(4):460-470.e6. Epub 2018 Feb 22.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183003
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http://dx.doi.org/10.1016/j.chembiol.2018.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973797PMC
April 2018

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors.

Cell Chem Biol 2018 02 21;25(2):135-142.e5. Epub 2017 Dec 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389506PMC
February 2018

Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.

Cell Rep 2017 Dec;21(11):3317-3328

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734865PMC
December 2017

Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation.

Genes Dev 2017 11 4;31(21):2162-2174. Epub 2017 Dec 4.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.306324.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749164PMC
November 2017

multiplierz v2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry data.

Proteomics 2017 Aug;17(15-16)

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1002/pmic.201700091DOI Listing
August 2017

mzStudio: A Dynamic Digital Canvas for User-Driven Interrogation of Mass Spectrometry Data.

Proteomes 2017 Aug 1;5(3). Epub 2017 Aug 1.

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA.

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http://www.mdpi.com/2227-7382/5/3/20
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http://dx.doi.org/10.3390/proteomes5030020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620537PMC
August 2017

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

Cell Chem Biol 2017 Aug 3;24(8):1005-1016.e3. Epub 2017 Aug 3.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.06.017DOI Listing
August 2017

Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells.

Proc Natl Acad Sci U S A 2017 03 27;114(11):E2186-E2194. Epub 2017 Feb 27.

Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1615015114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358377PMC
March 2017

Structure-guided development of covalent TAK1 inhibitors.

Bioorg Med Chem 2017 02 9;25(3):838-846. Epub 2016 Dec 9.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484537PMC
February 2017

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

Structure 2017 02 12;25(2):287-294. Epub 2017 Jan 12.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299031PMC
February 2017

A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.

ACS Infect Dis 2017 02 6;3(2):112-118. Epub 2016 Dec 6.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 250 Longwood Avenue, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480311PMC
February 2017

Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.

J Biol Chem 2017 Jan 21;292(1):112-120. Epub 2016 Nov 21.

From the Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 and

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http://dx.doi.org/10.1074/jbc.M116.750299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217671PMC
January 2017

Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization.

Blood 2016 09 30;128(11):1465-74. Epub 2016 Jun 30.

Joslin Diabetes Center, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025898PMC
http://dx.doi.org/10.1182/blood-2016-05-711424DOI Listing
September 2016

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.

Cell Stem Cell 2016 07 16;19(1):66-80. Epub 2016 Jun 16.

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.05.009DOI Listing
July 2016

Development of small molecules targeting the pseudokinase Her3.

Bioorg Med Chem Lett 2015 Aug 11;25(16):3382-9. Epub 2015 May 11.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.04.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633287PMC
August 2015

PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.

Cancer Discov 2014 Dec 24;4(12):1430-47. Epub 2014 Sep 24.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Genetics, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258125PMC
December 2014

Pharmacological targeting of the pseudokinase Her3.

Nat Chem Biol 2014 Dec 19;10(12):1006-12. Epub 2014 Oct 19.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Biological Chemistry &Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232461PMC
December 2014

Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics.

Mol Cancer Ther 2014 Nov 4;13(11):2751-62. Epub 2014 Sep 4.

Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria. Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221415PMC
November 2014

Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells.

Cell Stem Cell 2014 Jul 8;15(1):92-101. Epub 2014 May 8.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082735PMC
July 2014

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Nature 2014 Jul 22;511(7511):616-20. Epub 2014 Jun 22.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244910PMC
July 2014

Genome-scale proteome quantification by DEEP SEQ mass spectrometry.

Nat Commun 2013 ;4:2171

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215-5450, USA.

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http://dx.doi.org/10.1038/ncomms3171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770533PMC
January 2014

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.

Angew Chem Int Ed Engl 2014 Jan 20;53(1):199-204. Epub 2013 Nov 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215 (USA); Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115 (USA); Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138 (USA).

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http://ccc.chem.pitt.edu/wipf/Current%20Literature/Evan_3.pd
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http://doi.wiley.com/10.1002/anie.201307387
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http://dx.doi.org/10.1002/anie.201307387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914205PMC
January 2014

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.

Nat Struct Mol Biol 2013 Oct 8;20(10):1221-3. Epub 2013 Sep 8.

1] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.2673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863620PMC
October 2013

Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

J Biol Chem 2013 Aug 9;288(35):25477-89. Epub 2013 Jul 9.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M113.454850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757209PMC
August 2013

Library dependent LC-MS/MS acquisition via mzAPI/Live.

Proteomics 2013 May;13(9):1412-6

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA.

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http://dx.doi.org/10.1002/pmic.201200583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779148PMC
May 2013

Mass spectrometry-based proteomics: qualitative identification to activity-based protein profiling.

Wiley Interdiscip Rev Syst Biol Med 2012 Mar-Apr;4(2):141-62. Epub 2012 Jan 9.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1002/wsbm.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288153PMC
January 2013

Proteomic analysis demonstrates activator- and chromatin-specific recruitment to promoters.

J Biol Chem 2012 Oct 17;287(42):35397-408. Epub 2012 Aug 17.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M112.391581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471693PMC
October 2012

Nanoflow low pressure high peak capacity single dimension LC-MS/MS platform for high-throughput, in-depth analysis of mammalian proteomes.

Anal Chem 2012 Jun 10;84(11):5133-9. Epub 2012 May 10.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215-5450, United States.

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http://dx.doi.org/10.1021/ac2031404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416051PMC
June 2012

Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis.

Mol Cell Proteomics 2011 Nov 25;10(11):O111.011064. Epub 2011 Jul 25.

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1074/mcp.O111.011064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226414PMC
November 2011

Sub1 and RPA associate with RNA polymerase II at different stages of transcription.

Mol Cell 2011 Nov;44(3):397-409

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227220PMC
November 2011

Crystal structure of a coiled-coil domain from human ROCK I.

PLoS One 2011 Mar 21;6(3):e18080. Epub 2011 Mar 21.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018080PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061879PMC
March 2011

Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage.

J Proteome Res 2010 Dec 27;9(12):6242-55. Epub 2010 Oct 27.

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusettes, United States.

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http://dx.doi.org/10.1021/pr1004696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997187PMC
December 2010

multiplierz: an extensible API based desktop environment for proteomics data analysis.

BMC Bioinformatics 2009 Oct 29;10:364. Epub 2009 Oct 29.

Bioinformatics Program, Boston University, 24 Cummington Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/1471-2105-10-364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774704PMC
October 2009

Optimized Orbitrap HCD for quantitative analysis of phosphopeptides.

J Am Soc Mass Spectrom 2009 Aug 28;20(8):1425-34. Epub 2009 Mar 28.

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115-6084, USA.

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http://dx.doi.org/10.1016/j.jasms.2009.03.019DOI Listing
August 2009

Identification of the plasticity-relevant fucose-alpha(1-2)-galactose proteome from the mouse olfactory bulb.

Biochemistry 2009 Aug;48(30):7261-70

Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1021/bi900640xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717711PMC
August 2009

Phosphoproteomic analysis of human embryonic stem cells.

Cell Stem Cell 2009 Aug;5(2):204-13

Genomics Institute of the Novartis Research Foundation, San Diego, CA 92109, USA.

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http://dx.doi.org/10.1016/j.stem.2009.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726933PMC
August 2009

Magnetic bead processor for rapid evaluation and optimization of parameters for phosphopeptide enrichment.

Anal Chem 2009 Jun;81(11):4566-75

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute.

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http://dx.doi.org/10.1021/ac9004452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692042PMC
June 2009

Niobium(V) oxide (Nb2O5): application to phosphoproteomics.

Anal Chem 2008 Jun 21;80(12):4606-13. Epub 2008 May 21.

Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, Massachusetts 02115-6084, USA.

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http://dx.doi.org/10.1021/ac800564hDOI Listing
June 2008

Autophosphorylation properties of inactive and active JNK2.

Cell Cycle 2007 Jul 10;6(14):1762-71. Epub 2007 May 10.

Inflammation and Infectious Diseases Center, Burnham Institute for Medical Research, La Jolla, California 92037 USA.

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http://dx.doi.org/10.4161/cc.6.14.4434DOI Listing
July 2007

Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.

Nat Chem Biol 2007 Jun 13;3(6):339-48. Epub 2007 May 13.

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/nchembio881DOI Listing
June 2007

Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor.

Am J Physiol Cell Physiol 2007 May 20;292(5):C1617-24. Epub 2006 Dec 20.

Department of Molecular Physiology and Biological Physics, University of Virginia, Box 800736, 1300 Jefferson Park Ave., Charlottesville, VA 22908, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00176.2006
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http://dx.doi.org/10.1152/ajpcell.00176.2006DOI Listing
May 2007

A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways.

Biochemistry 2006 Dec 19;45(51):15529-40. Epub 2006 Dec 19.

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/bi060971cDOI Listing
December 2006

Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

Mol Biol Cell 2006 Oct 9;17(10):4459-72. Epub 2006 Aug 9.

*The Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1091/mbc.e06-03-0241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635350PMC
October 2006

Enrichment and analysis of peptide subsets using fluorous affinity tags and mass spectrometry.

Nat Biotechnol 2005 Apr 13;23(4):463-8. Epub 2005 Mar 13.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1038/nbt1076DOI Listing
April 2005

Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.

Rapid Commun Mass Spectrom 2005 ;19(1):57-71

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1002/rcm.1746DOI Listing
March 2005

Parallel identification of O-GlcNAc-modified proteins from cell lysates.

J Am Chem Soc 2004 Sep;126(34):10500-1

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1021/ja047872bDOI Listing
September 2004

Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain.

Proc Natl Acad Sci U S A 2004 Sep 30;101(36):13132-7. Epub 2004 Aug 30.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1073/pnas.0403471101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516536PMC
September 2004

Exploring the phosphoproteome with mass spectrometry.

Mini Rev Med Chem 2004 Mar;4(3):313-24

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.2174/1389557043487330DOI Listing
March 2004

An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry.

Anal Chem 2003 May;75(10):2309-15

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.

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http://dx.doi.org/10.1021/ac026409jDOI Listing
May 2003

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

Proc Natl Acad Sci U S A 2003 Jan 9;100(2):443-8. Epub 2003 Jan 9.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1073/pnas.2436191100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141014PMC
January 2003

Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.

J Biol Chem 2002 Aug 15;277(32):29304-14. Epub 2002 May 15.

Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M204131200
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http://dx.doi.org/10.1074/jbc.M204131200DOI Listing
August 2002

Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.

Nat Biotechnol 2002 Mar;20(3):301-5

Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.

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http://dx.doi.org/10.1038/nbt0302-301DOI Listing
March 2002