Publications by authors named "Scott A Armstrong"

99Publications

Targeting Chromatin Complexes in Myeloid Malignancies and Beyond: From Basic Mechanisms to Clinical Innovation.

Cells 2020 Dec 21;9(12). Epub 2020 Dec 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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December 2020

Chromatin Complexes Maintain Self-Renewal of Myeloid Progenitors in AML: Opportunities for Therapeutic Intervention.

Stem Cell Reports 2020 07 18;15(1):6-12. Epub 2020 Jun 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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July 2020

It's Not What You Say But How You Say It: Targeting RNA Methylation in AML.

Mol Cell 2020 06;78(6):996-998

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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June 2020

Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes.

Mol Cancer Res 2020 09 9;18(9):1302-1314. Epub 2020 Jun 9.

Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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September 2020

Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development.

iScience 2020 Mar 27;23(3):100941. Epub 2020 Feb 27.

Department of Pediatric Oncology, Dana Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, 450 Brookline Avenue, Boston, MA 02215-5450, USA. Electronic address:

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March 2020

Rationale for targeting BCL6 in -rearranged acute lymphoblastic leukemia.

Genes Dev 2019 09 8;33(17-18):1265-1279. Epub 2019 Aug 8.

Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.

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September 2019

Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.

Exp Hematol 2019 06 13;74:42-51.e3. Epub 2019 May 13.

Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA. Electronic address:

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June 2019

Targeting chromatin complexes in fusion protein-driven malignancies.

Nat Rev Cancer 2019 05;19(5):255-269

Department of Pediatric Oncology, Dana Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

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May 2019

Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification.

Bioorg Med Chem Lett 2018 12 3;28(22):3514-3519. Epub 2018 Oct 3.

Middle Tennessee State University, Department of Chemistry, 1301 E. Main St., Murfreesboro, TN 37132, United States. Electronic address:

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December 2018

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

Cancer Cell 2018 10 27;34(4):643-658.e5. Epub 2018 Sep 27.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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October 2018

Location, Location, Location: Mutant NPM1c Cytoplasmic Localization Is Required to Maintain Stem Cell Genes in AML.

Cancer Cell 2018 09;34(3):355-357

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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September 2018

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

Cell 2018 02;172(5):1007-1021.e17

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02210, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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February 2018

Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia.

Cold Spring Harb Perspect Med 2017 Nov 1;7(11). Epub 2017 Nov 1.

Department of Pediatric Oncology, Dana Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02215.

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November 2017

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.

Nature 2017 03 1;543(7644):265-269. Epub 2017 Mar 1.

Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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March 2017

Discovery and Characterization of a Peptoid with Antifungal Activity against .

ACS Med Chem Lett 2016 Dec 3;7(12):1139-1144. Epub 2016 Oct 3.

Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.

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December 2016

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

Cancer Cell 2016 Dec 23;30(6):863-878. Epub 2016 Nov 23.

Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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December 2016

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

Cancer Discov 2016 10 17;6(10):1166-1181. Epub 2016 Aug 17.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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October 2016

Forward genetic screen of human transposase genomic rearrangements.

BMC Genomics 2016 Aug 4;17:548. Epub 2016 Aug 4.

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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August 2016

The role of DOT1L in the maintenance of leukemia gene expression.

Curr Opin Genet Dev 2016 02 3;36:68-72. Epub 2016 May 3.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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February 2016

Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.

Cancer Cell 2016 Apr;29(4):464-476

The Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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April 2016

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.

Cell Rep 2016 Mar 18;14(8):1953-65. Epub 2016 Feb 18.

Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, Aurora, CO 80045, USA; Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address:

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March 2016

Editorial overview: Differentiation and disease.

Curr Opin Cell Biol 2015 Dec 25;37:v-vi. Epub 2015 Nov 25.

University of California at Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, Berkeley, CA, USA. Electronic address:

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December 2015

Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.

Mol Cell 2015 Nov;60(4):561-70

Cancer Biology and Genetics Program, Departments of Medicine and Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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November 2015

JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.

Genes Dev 2015 Oct;29(20):2123-39

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA;

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October 2015

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

Cell Stem Cell 2015 Nov 24;17(5):611-23. Epub 2015 Sep 24.

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Cancer Science Institute, National University of Singapore, Singapore, 117599. Electronic address:

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November 2015

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.

Exp Hematol 2015 Aug 25;43(8):673-84. Epub 2015 Jun 25.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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August 2015

Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.

Exp Hematol 2015 Nov 26;43(11):930-935.e6. Epub 2015 Jun 26.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, and Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA.

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November 2015

Designed to kill: novel menin-MLL inhibitors target MLL-rearranged leukemia.

Cancer Cell 2015 Apr;27(4):431-3

Cancer Biology and Genetics Program and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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April 2015

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.

Clin Cancer Res 2015 May 16;21(10):2348-58. Epub 2015 Feb 16.

Division of Hematology/Oncology, Department of Pediatric Oncology, Boston Children's Hospital, Dana-Farber-Cancer Institute, and Harvard Medical School, Boston, Massachusetts. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Harvard Stem Cell Institute, Boston, Massachusetts.

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May 2015

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition.

Haematologica 2015 May 16;100(5):e190-3. Epub 2015 Jan 16.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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May 2015

Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.

Clin Cancer Res 2015 Jan;21(2):240-8

Department of Hematology and Oncology, Center for Internal Medicine, Otto-von-Guericke University, Magdeburg, Germany.

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January 2015

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.

Cell Stem Cell 2014 Dec;15(6):775-90

Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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December 2014

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

Cancer Cell 2014 Dec 20;26(6):896-908. Epub 2014 Nov 20.

Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA; Department of Pediatrics and the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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December 2014

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.

Stem Cell Reports 2014 Nov 25;3(5):832-40. Epub 2014 Sep 25.

Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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November 2014

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Genes Dev 2014 Aug;28(16):1800-14

Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA;

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August 2014

Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche.

Cell Stem Cell 2014 Sep 10;15(3):365-375. Epub 2014 Jul 10.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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September 2014

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.

Blood 2014 Jul 24;124(1):13-23. Epub 2014 Apr 24.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Consortium for Translational Cancer Research, Heidelberg, Germany;

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July 2014

Genomic dark matter sheds light on EVI1-driven leukemia.

Cancer Cell 2014 Apr;25(4):407-8

Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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April 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci Data 2014 30;1:140035. Epub 2014 Sep 30.

Broad Institute of Harvard and MIT, 7 Cambridge Center , Cambridge, Massachusetts 02142, USA ; Department of Medical, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Departments of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, USA.

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February 2016

Stem cells: Dual response to Ras mutation.

Nature 2013 Dec 27;504(7478):91-2. Epub 2013 Nov 27.

Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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December 2013

Pathprinting: An integrative approach to understand the functional basis of disease.

Genome Med 2013 26;5(7):68. Epub 2013 Jul 26.

Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA ; Bioinformatics Core, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA ; Harvard Stem Cell Institute, 1350 Massachusetts Ave, Cambridge, MA 02138.

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May 2014

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia.

Blood 2013 Jun 6;121(24):4847-53. Epub 2013 May 6.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, and Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA.

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June 2013

DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.

Mol Cell Biol 2013 May 19;33(9):1735-45. Epub 2013 Feb 19.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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May 2013

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.

J Exp Med 2013 Jan 31;210(1):15-22. Epub 2012 Dec 31.

Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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January 2013

Cancer. Can one cell influence cancer heterogeneity?

Science 2012 Nov;338(6110):1035-6

Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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November 2012

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

Cell Stem Cell 2012 Sep;11(3):429-39

Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Harvard Medical School and the Harvard Stem Cell Institute, Boston, MA 02115, USA.

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September 2012

Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.

Trends Immunol 2012 Nov 3;33(11):563-70. Epub 2012 Aug 3.

Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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November 2012