Scott A Armstrong

Scott A Armstrong

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Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia.

Cancer Discov 2019 Nov 26. Epub 2019 Nov 26.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0209DOI Listing
November 2019

Rationale for targeting BCL6 in -rearranged acute lymphoblastic leukemia.

Genes Dev 2019 09 8;33(17-18):1265-1279. Epub 2019 Aug 8.

Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.

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http://dx.doi.org/10.1101/gad.327593.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719625PMC
September 2019

Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.

Exp Hematol 2019 Jun 13;74:42-51.e3. Epub 2019 May 13.

Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.04.003DOI Listing
June 2019

Targeting chromatin complexes in fusion protein-driven malignancies.

Nat Rev Cancer 2019 05;19(5):255-269

Department of Pediatric Oncology, Dana Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41568-019-0132-xDOI Listing
May 2019

Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification.

Bioorg Med Chem Lett 2018 12 3;28(22):3514-3519. Epub 2018 Oct 3.

Middle Tennessee State University, Department of Chemistry, 1301 E. Main St., Murfreesboro, TN 37132, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183078
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http://dx.doi.org/10.1016/j.bmcl.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246776PMC
December 2018

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

Cancer Cell 2018 10 27;34(4):643-658.e5. Epub 2018 Sep 27.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179449PMC
October 2018

Location, Location, Location: Mutant NPM1c Cytoplasmic Localization Is Required to Maintain Stem Cell Genes in AML.

Cancer Cell 2018 09;34(3):355-357

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.013DOI Listing
September 2018

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

Cell 2018 02;172(5):1007-1021.e17

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02210, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052445PMC
February 2018

Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia.

Cold Spring Harb Perspect Med 2017 Nov 1;7(11). Epub 2017 Nov 1.

Department of Pediatric Oncology, Dana Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/cshperspect.a026658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666623PMC
November 2017

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.

Nature 2017 03 1;543(7644):265-269. Epub 2017 Mar 1.

Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature21687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372383PMC
March 2017

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

Cancer Cell 2016 Dec 23;30(6):863-878. Epub 2016 Nov 23.

Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501282PMC
December 2016

Discovery and Characterization of a Peptoid with Antifungal Activity against .

ACS Med Chem Lett 2016 Dec 3;7(12):1139-1144. Epub 2016 Oct 3.

Department of Chemistry and Department of Biology, Middle Tennessee State University , 1301 East Main Street, Murfreesboro, Tennessee 37132, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150681PMC
December 2016

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

Cancer Discov 2016 10 17;6(10):1166-1181. Epub 2016 Aug 17.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584808PMC
October 2016

Forward genetic screen of human transposase genomic rearrangements.

BMC Genomics 2016 Aug 4;17:548. Epub 2016 Aug 4.

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1186/s12864-016-2877-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973553PMC
August 2016

Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.

Cancer Cell 2016 Apr;29(4):464-476

The Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889129PMC
April 2016

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.

Cell Rep 2016 Mar 18;14(8):1953-65. Epub 2016 Feb 18.

Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, Aurora, CO 80045, USA; Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790111PMC
March 2016

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci Data 2014 30;1:140035. Epub 2014 Sep 30.

Broad Institute of Harvard and MIT, 7 Cambridge Center , Cambridge, Massachusetts 02142, USA ; Department of Medical, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Departments of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/sdata201435
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http://dx.doi.org/10.1038/sdata.2014.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432652PMC
February 2016

The role of DOT1L in the maintenance of leukemia gene expression.

Curr Opin Genet Dev 2016 02 3;36:68-72. Epub 2016 May 3.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2016.03.015DOI Listing
February 2016

Editorial overview: Differentiation and disease.

Curr Opin Cell Biol 2015 Dec 25;37:v-vi. Epub 2015 Nov 25.

University of California at Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, Berkeley, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.11.001DOI Listing
December 2015

Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.

Exp Hematol 2015 Nov 26;43(11):930-935.e6. Epub 2015 Jun 26.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, and Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.exphem.2015.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630114PMC
November 2015

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.

Cell Stem Cell 2015 Nov 24;17(5):611-23. Epub 2015 Sep 24.

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Cancer Science Institute, National University of Singapore, Singapore, 117599. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636971PMC
November 2015

Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.

Mol Cell 2015 Nov;60(4):561-70

Cancer Biology and Genetics Program, Departments of Medicine and Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(15)00833-3
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http://linkinghub.elsevier.com/retrieve/pii/S109727651500833
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http://dx.doi.org/10.1016/j.molcel.2015.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701197PMC
November 2015

JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.

Genes Dev 2015 Oct;29(20):2123-39

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA;

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http://dx.doi.org/10.1101/gad.267278.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617977PMC
October 2015

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.

Exp Hematol 2015 Aug 25;43(8):673-84. Epub 2015 Jun 25.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540610PMC
August 2015

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition.

Haematologica 2015 May 16;100(5):e190-3. Epub 2015 Jan 16.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2014.115337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420229PMC
May 2015

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.

Clin Cancer Res 2015 May 16;21(10):2348-58. Epub 2015 Feb 16.

Division of Hematology/Oncology, Department of Pediatric Oncology, Boston Children's Hospital, Dana-Farber-Cancer Institute, and Harvard Medical School, Boston, Massachusetts. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Harvard Stem Cell Institute, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/content/early/2015/02/
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http://clincancerres.aacrjournals.org/content/early/2015/04/
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-1290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433811PMC
May 2015

Designed to kill: novel menin-MLL inhibitors target MLL-rearranged leukemia.

Cancer Cell 2015 Apr;27(4):431-3

Cancer Biology and Genetics Program and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.012DOI Listing
April 2015

Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.

Clin Cancer Res 2015 Jan;21(2):240-8

Department of Hematology and Oncology, Center for Internal Medicine, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1436DOI Listing
January 2015

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

Cancer Cell 2014 Dec 20;26(6):896-908. Epub 2014 Nov 20.

Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA; Department of Pediatrics and the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291116PMC
December 2014

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.

Cell Stem Cell 2014 Dec;15(6):775-90

Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317339PMC
December 2014

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.

Stem Cell Reports 2014 Nov 25;3(5):832-40. Epub 2014 Sep 25.

Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235746PMC
November 2014

Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche.

Cell Stem Cell 2014 Sep 10;15(3):365-375. Epub 2014 Jul 10.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156919PMC
September 2014

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Genes Dev 2014 Aug;28(16):1800-14

Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA;

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http://dx.doi.org/10.1101/gad.244368.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197965PMC
August 2014

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.

Blood 2014 Jul 24;124(1):13-23. Epub 2014 Apr 24.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Consortium for Translational Cancer Research, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2014-02-558114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190617PMC
July 2014

Pathprinting: An integrative approach to understand the functional basis of disease.

Genome Med 2013 26;5(7):68. Epub 2013 Jul 26.

Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA ; Bioinformatics Core, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA ; Harvard Stem Cell Institute, 1350 Massachusetts Ave, Cambridge, MA 02138.

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http://dx.doi.org/10.1186/gm472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971351PMC
May 2014

Genomic dark matter sheds light on EVI1-driven leukemia.

Cancer Cell 2014 Apr;25(4):407-8

Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046890PMC
April 2014

Targeting epigenetic regulators for cancer therapy.

Ann N Y Acad Sci 2014 Feb;1309:30-6

Bristol Myers Squibb Company, Princeton, New Jersey.

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http://dx.doi.org/10.1111/nyas.12356DOI Listing
February 2014

Stem cells: Dual response to Ras mutation.

Nature 2013 Dec 27;504(7478):91-2. Epub 2013 Nov 27.

Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature12840DOI Listing
December 2013

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia.

Blood 2013 Jun 6;121(24):4847-53. Epub 2013 May 6.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, and Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1182/blood-2013-02-474833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682337PMC
June 2013

DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.

Mol Cell Biol 2013 May 19;33(9):1735-45. Epub 2013 Feb 19.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01463-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624170PMC
May 2013

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.

J Exp Med 2013 Jan 31;210(1):15-22. Epub 2012 Dec 31.

Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20120596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549713PMC
January 2013

Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.

Trends Immunol 2012 Nov 3;33(11):563-70. Epub 2012 Aug 3.

Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.it.2012.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034385PMC
November 2012

Cancer. Can one cell influence cancer heterogeneity?

Science 2012 Nov;338(6110):1035-6

Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1231594DOI Listing
November 2012

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

Cell Stem Cell 2012 Sep;11(3):429-39

Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Harvard Medical School and the Harvard Stem Cell Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.stem.2012.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743253PMC
September 2012

iCanPlot: visual exploration of high-throughput omics data using interactive Canvas plotting.

PLoS One 2012 29;7(2):e31690. Epub 2012 Feb 29.

Division of Hematology/Oncology, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031690PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290527PMC
July 2012

Targeting epigenetic programs in MLL-rearranged leukemias.

Hematology Am Soc Hematol Educ Program 2011 ;2011:354-60

Division of Hematology/Oncology, Children's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1182/asheducation-2011.1.354DOI Listing
April 2012

Chromatin-modifying enzymes as modulators of reprogramming.

Nature 2012 Mar 4;483(7391):598-602. Epub 2012 Mar 4.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature10953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501145PMC
March 2012

Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

Proc Natl Acad Sci U S A 2012 Mar 6;109(13):5028-33. Epub 2012 Mar 6.

Dana-Farber/Children's Hospital Cancer Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1202258109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324004PMC
March 2012

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.

Genes Dev 2012 Feb;26(4):344-9

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.184341.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289882PMC
February 2012

A role for DOT1L in MLL-rearranged leukemias.

Epigenomics 2011 Dec;3(6):667-70

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http://dx.doi.org/10.2217/epi.11.98DOI Listing
December 2011

eXframe: reusable framework for storage, analysis and visualization of genomics experiments.

BMC Bioinformatics 2011 Nov 21;12:452. Epub 2011 Nov 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-12-452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235155PMC
November 2011