Scot J Matkovich

Scot J Matkovich

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Scot J Matkovich

Scot J Matkovich

Publications by authors named "Scot J Matkovich"

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62Publications

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Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles.

Sci Rep 2018 Sep 17;8(1):13919. Epub 2018 Sep 17.

Department of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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September 2018

G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.

J Mol Cell Cardiol 2018 Aug 30;121:60-68. Epub 2018 Jun 30.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, United States. Electronic address:

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August 2018

Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.

FASEB J 2018 Jul 20:fj201800361R. Epub 2018 Jul 20.

Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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July 2018

Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury.

JCI Insight 2018 Jun 7;3(11). Epub 2018 Jun 7.

Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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June 2018

Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure.

Circ Heart Fail 2018 May;11(5):e004351

Center for Cardiovascular Research, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO.

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May 2018

Nuclear export factor 3 regulates localization of small nucleolar RNAs.

J Biol Chem 2017 12 11;292(49):20228-20239. Epub 2017 Oct 11.

From the Diabetes Research Center, Department of Medicine, and

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December 2017

Changes of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging.

PLoS One 2017 3;12(1):e0169213. Epub 2017 Jan 3.

College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States of America.

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August 2017

Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.

PLoS One 2016 19;11(5):e0156065. Epub 2016 May 19.

Hypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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July 2017

Chronic Contractile Dysfunction without Hypertrophy Does Not Provoke a Compensatory Transcriptional Response in Mouse Hearts.

PLoS One 2016 30;11(6):e0158317. Epub 2016 Jun 30.

Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

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July 2017

Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.

Crit Care Med 2017 Mar;45(3):407-414

1Center for Pharmacogenomics, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO. 2Center for Cardiovascular Research, Cardiovascular Division, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO. 3Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA. 4Department of Biomedical Engineering, George Washington University, Washington, DC. 5Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO.

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March 2017

Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.

Mol Cell Endocrinol 2017 01 20;439:328-336. Epub 2016 Sep 20.

College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA; Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznan, Poland. Electronic address:

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January 2017

Feed My Heart or Eat It: miR-22 Decides.

J Am Coll Cardiol 2016 10;68(14):1572-4

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

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October 2016

Of Caps and Gaps, Postnatal Hearts, Elusive Facts, and lncs.

Authors:
Scot J Matkovich

Circ Cardiovasc Genet 2016 10;9(5):389-391

From the Division of Cardiology, Department of Internal Medicine, Washington University, School of Medicine, St Louis, MO.

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October 2016

A balancing act in cardiac hypertrophy.

Authors:
Scot J Matkovich

Cardiovasc Res 2016 07 23;111(1):8-9. Epub 2016 May 23.

Department of Internal Medicine, Center for Pharmacogenomics,Washington University School of Medicine, 660 S Euclid Ave., Campus Box 8220, St. Louis, MO 63110, USA

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July 2016

Transcriptome analysis in heart failure.

Authors:
Scot J Matkovich

Curr Opin Cardiol 2016 May;31(3):242-8

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA.

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May 2016

Deep sequencing of cardiac microRNA-mRNA interactomes in clinical and experimental cardiomyopathy.

Methods Mol Biol 2015 ;1299:27-49

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA,

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December 2015

Cardiac Disease Status Dictates Functional mRNA Targeting Profiles of Individual MicroRNAs.

Circ Cardiovasc Genet 2015 Dec 9;8(6):774-84. Epub 2015 Nov 9.

From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO.

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December 2015

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice.

Science 2015 Dec 3;350(6265):aad2459. Epub 2015 Dec 3.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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December 2015

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.

Nat Commun 2015 Sep 2;6:8084. Epub 2015 Sep 2.

Department of Fundamental Neurosciences, University of Lausanne, Lausanne 1005, Switzerland.

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September 2015

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.

Circ Res 2015 Jul 2;117(4):346-51. Epub 2015 Jun 2.

From the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (M.S., G.G., S.J.M., G.W.D.); Department of Biomedical Sciences, University of Montreal, Quebec, Canada (Y.B.); Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA (A.B.G.); and Departments of Medicine (Cardiology) and Cell Biology, and Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY (R.N.K.).

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July 2015

Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase.

J Biol Chem 2015 May 19;290(18):11741-8. Epub 2015 Mar 19.

From the Diabetic Cardiovascular Disease Center and

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May 2015

Epitranscriptional regulation of cardiovascular development and disease.

J Physiol 2015 Apr 23;593(8):1799-808. Epub 2014 Dec 23.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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April 2015

Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.

Sci Signal 2015 Apr 21;8(373):ra39. Epub 2015 Apr 21.

Center for Pharmacogenomics and Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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April 2015

Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation.

Circ Res 2015 Feb 20;116(5):e28-39. Epub 2015 Jan 20.

From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO (S.J.M., G.W.D.); Department of Cardiology, University Medical Center Groningen, Unversity of Groningen, Groningen, The Netherlands (B.D.W.)

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February 2015

Mitochondrial genome linearization is a causative factor for cardiomyopathy in mice and Drosophila.

Antioxid Redox Signal 2014 Nov 22;21(14):1949-59. Epub 2013 Oct 22.

Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine , St. Louis, Missouri.

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November 2014

Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs.

Proc Natl Acad Sci U S A 2014 Aug 28;111(33):12264-9. Epub 2014 Jul 28.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110

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August 2014

MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise.

Authors:
Scot J Matkovich

Cells 2014 Aug 5;3(3):778-801. Epub 2014 Aug 5.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63130, USA.

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August 2014

Menage a Trois: intimate relationship among a microRNA, long noncoding RNA, and mRNA.

Circ Res 2014 Apr;114(9):1362-5

From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO.

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April 2014

Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes.

J Cell Mol Med 2014 Mar 16;18(3):415-21. Epub 2014 Jan 16.

Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

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March 2014

A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.

PLoS One 2013 12;8(6):e66131. Epub 2013 Jun 12.

Department of Pathology and Immunology Washington University in St. Louis, St. Louis, Missouri, United States of America.

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January 2014

MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.

J Immunol 2013 Dec 13;191(12):5904-13. Epub 2013 Nov 13.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;

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December 2013

Regulation of cardiac microRNAs by cardiac microRNAs.

Circ Res 2013 Jun 26;113(1):62-71. Epub 2013 Apr 26.

Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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June 2013

A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription.

J Biol Chem 2013 May 19;288(22):15455-65. Epub 2013 Apr 19.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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May 2013

Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs.

Proc Natl Acad Sci U S A 2012 Nov 12;109(48):19864-9. Epub 2012 Nov 12.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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November 2012

Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy.

Circ Res 2012 Aug 29;111(5):521-31. Epub 2012 Jun 29.

Department of Internal Medicine, Center for Pharmacogenomics, 660 S Euclid Ave, Campus Box 8220, St Louis, MO 63110, USA.

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August 2012

A human 3' miR-499 mutation alters cardiac mRNA targeting and function.

Circ Res 2012 Mar 28;110(7):958-67. Epub 2012 Feb 28.

Center for Pharmacogenomics, Department of Internal Medicine and Center for Pharmacogenomics, 660 S. Euclid Ave., Campus Box 8220, St. Louis, MO 63110, USA.

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March 2012

Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure.

Circ Heart Fail 2011 Sep 18;4(5):659-68. Epub 2011 Jul 18.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

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September 2011

MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes.

Circ Res 2011 Sep 21;109(6):670-9. Epub 2011 Jul 21.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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September 2011

Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription.

J Biol Chem 2011 Jul 3;286(30):26943-51. Epub 2011 Jun 3.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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July 2011

RISC RNA sequencing for context-specific identification of in vivo microRNA targets.

Circ Res 2011 Jan 28;108(1):18-26. Epub 2010 Oct 28.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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January 2011

MARF and Opa1 control mitochondrial and cardiac function in Drosophila.

Circ Res 2011 Jan 9;108(1):12-7. Epub 2010 Dec 9.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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January 2011

Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains.

Circ Res 2010 Oct 5;107(7):903-12. Epub 2010 Aug 5.

Washington University Center for Pharmacogenomics, St Louis, MO 63110, USA.

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October 2010

Association of an intronic, but not any exonic, FRMD4B sequence variant and heart failure.

Clin Transl Sci 2010 Aug;3(4):134-9

The Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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August 2010

Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq.

Circ Res 2010 May 1;106(9):1459-67. Epub 2010 Apr 1.

Department of Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St Louis, Mo 63110, USA.

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May 2010

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy.

Proc Natl Acad Sci U S A 2010 May 23;107(20):9035-42. Epub 2010 Apr 23.

Department of Medicine, Center for Pharmacogenomics, and Departments of Medicine and Pathology and Immunology, Division of Molecular Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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May 2010

MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.

Circ Res 2010 Jan 5;106(1):166-75. Epub 2009 Nov 5.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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January 2010

Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.

J Clin Invest 2010 Jan 14;120(1):280-9. Epub 2009 Dec 14.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, 660 S. Eucliud Avenue, St. Louis, Missouri 63110, USA.

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January 2010

Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death.

J Clin Invest 2009 Jan 8;119(1):203-12. Epub 2008 Dec 8.

Center for Pharmacogenomics, Washington University in St. Louis, St. Louis, MO 63110, USA.

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January 2009

Put your chips on transcriptomics.

Circulation 2008 Jul;118(3):216-8

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July 2008

Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation.

Circulation 2008 Jan 4;117(3):396-404. Epub 2008 Jan 4.

Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH 45267-0839, USA.

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January 2008

Cardiomyocytes structure, function and associated pathologies.

Int J Biochem Cell Biol 2005 Sep;37(9):1746-51

Cellular Biochemistry Laboratory, Baker Heart Research Institute, Melbourne, Vic., Australia.

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September 2005

Ins(1,4,5)P3 receptors and inositol phosphates in the heart-evolutionary artefacts or active signal transducers?

Pharmacol Ther 2005 Aug;107(2):240-51

Cellular Biochemistry Laboratory, Baker Heart Research Institute, Commercial Road, Melbourne, Australia.

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August 2005

Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353.

J Biol Chem 2004 Apr 3;279(16):16311-6. Epub 2004 Feb 3.

Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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April 2004

Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.

J Biol Chem 2002 Jun 3;277(25):22734-42. Epub 2002 Apr 3.

Cellular Biochemistry Laboratory, Baker Medical Research Institute, PO Box 6492, St. Kilda Road Central, Melbourne, 8008, Victoria, Australia.

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June 2002