Publications

Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.
Crit Care Med 2017 Mar;45(3):407-414
1Center for Pharmacogenomics, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO. 2Center for Cardiovascular Research, Cardiovascular Division, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO. 3Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA. 4Department of Biomedical Engineering, George Washington University, Washington, DC. 5Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO.

Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.
Mol Cell Endocrinol 2017 Jan 20;439:328-336. Epub 2016 Sep 20.
College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA; Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznan, Poland. Electronic address:

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.
Circ Res 2015 Jul 2;117(4):346-51. Epub 2015 Jun 2.
From the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (M.S., G.G., S.J.M., G.W.D.); Department of Biomedical Sciences, University of Montreal, Quebec, Canada (Y.B.); Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA (A.B.G.); and Departments of Medicine (Cardiology) and Cell Biology, and Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY (R.N.K.).

Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation.
Circ Res 2015 Feb 20;116(5):e28-39. Epub 2015 Jan 20.
From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO (S.J.M., G.W.D.); Department of Cardiology, University Medical Center Groningen, Unversity of Groningen, Groningen, The Netherlands (B.D.W.)

MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.
J Immunol 2013 Dec 13;191(12):5904-13. Epub 2013 Nov 13.
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;


Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy.
Proc Natl Acad Sci U S A 2010 May 23;107(20):9035-42. Epub 2010 Apr 23.
Department of Medicine, Center for Pharmacogenomics, and Departments of Medicine and Pathology and Immunology, Division of Molecular Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Common variants in HSPB7 and FRMD4B associated with advanced heart failure.
Circ Cardiovasc Genet 2010 Apr 2;3(2):147-54. Epub 2010 Feb 2.
Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA.

MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.
Circ Res 2010 Jan 5;106(1):166-75. Epub 2009 Nov 5.
Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.
J Clin Invest 2010 Jan 14;120(1):280-9. Epub 2009 Dec 14.
Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, 660 S. Eucliud Avenue, St. Louis, Missouri 63110, USA.




Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.
PLoS One 2016 19;11(5):e0156065. Epub 2016 May 19.
Hypertrophic Cardiomyopathy Center of Excellence, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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