Schahram Akbarian

Schahram Akbarian

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Schahram Akbarian

Publications by authors named "Schahram Akbarian"

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Spatial genome exploration in the context of cognitive and neurological disease.

Curr Opin Neurobiol 2019 12 27;59:112-119. Epub 2019 Jun 27.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2019.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889018PMC
December 2019

Special volume: The genomics and epigenomics of schizophrenia.

Schizophr Res 2019 Dec 5. Epub 2019 Dec 5.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.11.056DOI Listing
December 2019

Use of the epigenetic toolbox
to contextualize common variants associated with schizophrenia risk
.

Dialogues Clin Neurosci 2019 12;21(4):407-416

Department of Psychiatry; Friedman Brain Institute; Icahn School of Medicine at Mount Sinai, New York, NY, US.

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http://dx.doi.org/10.31887/DCNS.2019.21.4/sakbarianDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952750PMC
December 2019

CRISPR-based functional evaluation of schizophrenia risk variants.

Schizophr Res 2019 Jul 2. Epub 2019 Jul 2.

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939156PMC
July 2019

Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.

Prog Mol Biol Transl Sci 2018 30;157:21-40. Epub 2018 Mar 30.

Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S18771173173020
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http://dx.doi.org/10.1016/bs.pmbts.2017.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318347PMC
March 2019

Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1.

Cell Rep 2018 06;23(11):3209-3222

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-2324, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309677PMC
June 2018

Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells.

Front Pediatr 2018 3;6:82. Epub 2018 Apr 3.

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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http://dx.doi.org/10.3389/fped.2018.00082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891587PMC
April 2018

The epigenomics of schizophrenia, in the mouse.

Am J Med Genet B Neuropsychiatr Genet 2017 Sep 12;174(6):631-640. Epub 2017 Jul 12.

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1002/ajmg.b.32566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573750PMC
September 2017

Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes.

Stem Cell Reports 2017 08 27;9(2):615-628. Epub 2017 Jul 27.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550013PMC
August 2017

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

Nat Commun 2017 05 9;8:15142. Epub 2017 May 9.

Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncomms15142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436068PMC
May 2017

Understanding the genetic liability to schizophrenia through the neuroepigenome.

Schizophr Res 2016 11 27;177(1-3):115-124. Epub 2016 Jan 27.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mental Illness Research, Education, and Clinical Center (VISN 3), James J. Peters VA Medical Center, Bronx, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2016.01.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963306PMC
November 2016

Spatial genome organization and cognition.

Nat Rev Neurosci 2016 11 6;17(11):681-691. Epub 2016 Oct 6.

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, 10029 New York, USA.

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http://dx.doi.org/10.1038/nrn.2016.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503467PMC
November 2016

Epigenetic Basis of Mental Illness.

Neuroscientist 2016 10 8;22(5):447-63. Epub 2015 Oct 8.

Departments of Neuroscience and Psychiatry, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1177/1073858415608147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826318PMC
October 2016

Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex.

Nat Commun 2016 09 6;7:12743. Epub 2016 Sep 6.

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncomms12743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025847PMC
September 2016

Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds?

Biol Psychiatry 2016 08;80(4):260-262

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522745PMC
August 2016

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Biol Psychiatry 2016 07;80(2):84-86

Department of Psychiatry, University Neuropsychiatric Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150945PMC
July 2016

The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease.

PLoS One 2015 4;10(12):e0144398. Epub 2015 Dec 4.

Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144398PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670094PMC
June 2016

Cognition and mood-related behaviors in L3mbtl1 null mutant mice.

PLoS One 2015 7;10(4):e0121252. Epub 2015 Apr 7.

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121252PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388653PMC
March 2016

Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse.

Neuropsychopharmacology 2016 Mar 30;41(4):1014-23. Epub 2015 Jul 30.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/npp.2015.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748426PMC
March 2016

Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders.

Curr Opin Pharmacol 2016 Feb 26;26:61-6. Epub 2015 Oct 26.

Department of Psychiatry and Psychotherapy, University Clinic of Regensburg, Regensbrug, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716874PMC
February 2016

Back to the past in schizophrenia genomics.

Nat Neurosci 2016 Jan;19(1):1-2

Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nn.4203DOI Listing
January 2016

DNA methylation levels of α-synuclein intron 1 in the aging brain.

Neurobiol Aging 2015 Dec 8;36(12):3334.e7-3334.e11. Epub 2015 Sep 8.

Department of Neurology, University Clinic, University of Bonn, Bonn, Germany; Department of Neurology, German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.08.028DOI Listing
December 2015

The PsychENCODE project.

Nat Neurosci 2015 Dec;18(12):1707-12

Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nn.4156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675669PMC
December 2015

Prefrontal Cortex and Social Cognition in Mouse and Man.

Front Psychol 2015 26;6:1805. Epub 2015 Nov 26.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York NY, USA ; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York NY, USA ; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York NY, USA ; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York NY, USA ; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York NY, USA.

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http://dx.doi.org/10.3389/fpsyg.2015.01805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659895PMC
December 2015

CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors!

Am J Psychiatry 2015 Nov;172(11):1054-6

From the Division of Psychiatric Epigenomics, Friedman Brain Institute and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, N.Y.

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http://dx.doi.org/10.1176/appi.ajp.2015.15081018DOI Listing
November 2015

Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia.

Neurobiol Learn Mem 2015 Oct 4;124:104-10. Epub 2015 Apr 4.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, United States; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568154PMC
October 2015

Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia.

Schizophr Res 2015 Sep 31;167(1-3):28-34. Epub 2014 Oct 31.

Departments of Psychiatry and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2014.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417100PMC
September 2015

The future of neuroepigenetics in the human brain.

Prog Mol Biol Transl Sci 2014 ;128:199-228

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1016/B978-0-12-800977-2.00008-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863594PMC
August 2015

Preface. Epigenetics and neuroplasticity--evidence and debate.

Prog Mol Biol Transl Sci 2014 ;128:xi-xiii

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http://dx.doi.org/10.1016/B978-0-12-800977-2.10000-2DOI Listing
August 2015

Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection.

Front Genet 2015 28;6:190. Epub 2015 May 28.

School of Life Sciences, École Polytechnique Fédérale de Lausanne Lausanne, Switzerland ; Swiss Institute of Bioinformatics Lausanne, Switzerland.

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http://dx.doi.org/10.3389/fgene.2015.00190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446996PMC
June 2015

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

J Neurosci 2015 Apr;35(13):5097-108

Department of Psychiatry and Friedman Brain Institute and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604,

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http://dx.doi.org/10.1523/JNEUROSCI.3004-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380991PMC
April 2015

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.

Am J Med Genet B Neuropsychiatr Genet 2015 Jan;168B(1):14-35

Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), Departments of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, SUNY Upstate Medical University, New York City, New York.

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http://dx.doi.org/10.1002/ajmg.b.32284DOI Listing
January 2015

Analytical tools and current challenges in the modern era of neuroepigenomics.

Nat Neurosci 2014 Nov 28;17(11):1476-90. Epub 2014 Oct 28.

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nn.3816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262187PMC
November 2014

A role for noncoding variation in schizophrenia.

Cell Rep 2014 Nov 6;9(4):1417-29. Epub 2014 Nov 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00869-9.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400869
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http://dx.doi.org/10.1016/j.celrep.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255904PMC
November 2014

Regulation of histone H3K4 methylation in brain development and disease.

Philos Trans R Soc Lond B Biol Sci 2014 Sep;369(1652)

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

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http://dx.doi.org/10.1098/rstb.2013.0514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142035PMC
September 2014

Epigenetic mechanisms in schizophrenia.

Dialogues Clin Neurosci 2014 Sep;16(3):405-17

Department of Psychiatry, Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214181PMC
September 2014

The genome in three dimensions: a new frontier in human brain research.

Biol Psychiatry 2014 Jun 16;75(12):961-9. Epub 2013 Aug 16.

Departments of Psychiatry and Neuroscience , Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Brudnick Neuropsychiatric Research Institute , University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925763PMC
June 2014

Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction.

Mol Genet Metab 2014 Feb 11;111(2):152-62. Epub 2013 Dec 11.

Center for Health Sciences, Biosciences Division, SRI International, Menlo Park, CA 94025, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2013.12.003DOI Listing
February 2014

MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.

PLoS Genet 2014 Feb 27;10(2):e1004188. Epub 2014 Feb 27.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America ; Genome Science Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937267PMC
February 2014

Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.

Biol Psychiatry 2013 Nov 7;74(9):696-705. Epub 2013 May 7.

Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester Massachusetts.

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http://dx.doi.org/10.1016/j.biopsych.2013.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797203PMC
November 2013

Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors.

Eur Arch Psychiatry Clin Neurosci 2013 Jun 5;263(4):273-84. Epub 2013 Feb 5.

Deparment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstr. 7, 80336 Munich, Germany.

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http://dx.doi.org/10.1007/s00406-013-0395-2DOI Listing
June 2013

Epigenetic determinants of healthy and diseased brain aging and cognition.

JAMA Neurol 2013 Jun;70(6):711-8

Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1001/jamaneurol.2013.1459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932340PMC
June 2013

Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.

Biol Psychiatry 2013 Nov 7;74(9):696-705. Epub 2013 May 7.

Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester Massachusetts.

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http://dx.doi.org/10.1016/j.biopsych.2013.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797203PMC
November 2013

Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood.

PLoS Genet 2013 Apr 11;9(4):e1003433. Epub 2013 Apr 11.

Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1003433
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http://dx.doi.org/10.1371/journal.pgen.1003433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623761PMC
April 2013

Exploring the epigenetics of cocaine resistance.

Nat Med 2013 Feb;19(2):136-7

Behavioral Neuroscience, research supported by Intramural Research Program of National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nm.3091DOI Listing
February 2013

Epigenetics in the human brain.

Neuropsychopharmacology 2013 Jan 30;38(1):183-97. Epub 2012 May 30.

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA.

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http://dx.doi.org/10.1038/npp.2012.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521991PMC
January 2013

Epigenetic mechanisms in psychiatry.

Neuropsychopharmacology 2013 Jan;38(1):1-2

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http://dx.doi.org/10.1038/npp.2012.185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521986PMC
January 2013

Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome.

Schizophr Res 2012 Sep 16;140(1-3):175-84. Epub 2012 Jul 16.

Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, MA 01604, USA.

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http://dx.doi.org/10.1016/j.schres.2012.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568668PMC
September 2012

Epigenetic mechanisms in neurological disease.

Nat Med 2012 Aug;18(8):1194-204

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://www.nature.com/articles/nm.2828
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http://dx.doi.org/10.1038/nm.2828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596876PMC
August 2012

The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD.

Neuropharmacology 2012 Jun 13;62(7):2409-12. Epub 2012 Feb 13.

Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2012.01.026DOI Listing
June 2012

Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia.

Schizophr Bull 2012 May 23;38(3):433-43. Epub 2010 Aug 23.

Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, MA, USA.

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http://dx.doi.org/10.1093/schbul/sbq091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329977PMC
May 2012

Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease.

Neurobiol Dis 2012 May 13;46(2):255-62. Epub 2011 Dec 13.

The Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.nbd.2011.12.008DOI Listing
May 2012

Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons.

Arch Gen Psychiatry 2012 Mar 7;69(3):314-24. Epub 2011 Nov 7.

Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1001/archgenpsychiatry.2011.151DOI Listing
March 2012

Balancing histone methylation activities in psychiatric disorders.

Trends Mol Med 2011 Jul 21;17(7):372-9. Epub 2011 Mar 21.

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14714914110003
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http://dx.doi.org/10.1016/j.molmed.2011.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134618PMC
July 2011

Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice.

Neuropharmacology 2011 Jun 30;60(7-8):1088-97. Epub 2010 Sep 30.

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2010.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025056PMC
June 2011

White matter neuron alterations in schizophrenia and related disorders.

Int J Dev Neurosci 2011 May 4;29(3):325-34. Epub 2010 Aug 4.

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA.

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http://dx.doi.org/10.1016/j.ijdevneu.2010.07.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992083PMC
May 2011

Epigenetics of schizophrenia.

Curr Top Behav Neurosci 2010 ;4:611-28

Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.

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http://dx.doi.org/10.1007/7854_2010_38DOI Listing
March 2011

The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.

PLoS One 2010 Dec 31;5(12):e15878. Epub 2010 Dec 31.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013128PMC
December 2010

Keep the 'phospho' on MAPK, be happy.

Nat Med 2010 Nov;16(11):1187-8

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http://dx.doi.org/10.1038/nm1110-1187DOI Listing
November 2010

Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.

J Biol Chem 2010 Sep 30;285(36):27767-75. Epub 2010 Jun 30.

Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.M110.115410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934644PMC
September 2010

RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.

Autism Res 2010 Aug;3(4):153-61

Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1002/aur.141DOI Listing
August 2010

A simple method for improving the specificity of anti-methyl histone antibodies.

Epigenetics 2010 Jul 1;5(5):392-5. Epub 2010 Jul 1.

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.4161/epi.5.5.11874DOI Listing
July 2010

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex.

Proc Natl Acad Sci U S A 2010 May 26;107(19):8824-9. Epub 2010 Apr 26.

Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.

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http://dx.doi.org/10.1073/pnas.1001702107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889328PMC
May 2010