Publications by authors named "Savas Celebi"

24 Publications

  • Page 1 of 1

Appraisal of transthoracic echocardiography for opportunistic screening of abdominal aortic aneurysm.

Medicine (Baltimore) 2021 Jun;100(22):e26171

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

Abstract: Abdominal aortic aneurysm is a life threatening disease. Most of the patients diagnosed incidentally because of the asymptomatic nature of this disease. This study aimed to determine the frequency of abdominal aortic aneurysm and evaluate the value of opportunistic screening during transthoracic echocardiography.A total of 5138 patients referred for echocardiographic evaluation for any reason were screened for abdominal aortic aneurysm between November 2014 to July 2019. The aneurysm was defined as an abdominal aorta with a diameter greater than 30 mm, or segmental dilatation of more than 50% of its size in non-dilated parts.The overall frequency of abdominal aortic aneurysm was 2.2% (n = 109) in the study population. Male sex (P < .001), older age (P < .001), presence of diastolic dysfunction (P = .036), hypertension (P < .001), coronary artery disease (P < .001), and hyperlipidemia (P < .001) were associated with abdominal aortic aneurysm. Patients with aneurysm had significantly increased diameters of the aortic trunk (P < .001) and ascending aorta (P < .001), significantly thicker interventricular septum (P < .001) and posterior wall (P < .001), significantly increased end-diastolic diameter (P < .001) and enlarged left atrium (P < .001), and significantly decreased ejection fraction (P < .001). The mostly met criteria for screening abdominal aortic aneurysm in international guidelines was the age of the patients.Based on the results of this study, screening patients over 60 years of age who undergo a transthoracic echocardiography for any reason would be beneficial to detect an asymptomatic abdominal aortic aneurysm in Turkish population.
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http://dx.doi.org/10.1097/MD.0000000000026171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183806PMC
June 2021

An extremely rare coronary artery anomaly: Monster left anterior descending coronary artery.

Anatol J Cardiol 2021 Jan;25(1):E1-E2

Department of Cardiology, Faculty of Medicine, University of Health Sciences; Ankara-Turkey.

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http://dx.doi.org/10.14744/AnatolJCardiol.2020.68782DOI Listing
January 2021

The association between thrombotic and inflammatory biomarkers and lower-extremity peripheral artery disease.

Int Wound J 2020 Oct 22;17(5):1346-1355. Epub 2020 May 22.

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

Lower-extremity peripheral artery disease (LEAD) is associated with increased rates of mortality and morbidity. The aim of this study was to evaluate the associations among inflammatory and thrombotic markers and lower-extremity peripheral disease. A total of 280 patients were enrolled in this study. Of these patients, 152 patients had LEAD on peripheral angiography that was performed because of suspected lower-extremity peripheral disease based on history, physical examination, and non-invasive tests. The control group consisted of 128 patients without LEAD on peripheral angiography. Patients with LEAD were classified according to trans-atlantic inter-society consensus (TASC) II classification. Subsequently, patients in TASC A to B were defined as having mild to moderate peripheral artery disease, and those in TASC C to D were defined as having advanced peripheral artery disease. Thrombotic and inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), the high-sensitivity C (hs-C) reactive protein level, the monocyte-to-high-density lipoprotein-cholesterol ratio, the fibrinogen to albumin ratio (FAR), and whole-blood viscosity at high shear rate (HSR) and low shear rate (LSR), were evaluated in this population. The NLR, the monocyte-to-high-density lipoprotein-cholesterol ratio, the FAR, and whole-blood viscosity, both at a LSR and a HSR, were significantly higher in patients with lower-extremity peripheral disease compared with patients without lower-extremity peripheral disease. We determined that lower-extremity peripheral disease severity was correlated with the NLR, monocyte-to-high-density lipoprotein-cholesterol ratio, FAR, whole-blood viscosity at LSR, and whole-blood viscosity at HSR (r = 0.719, P = .004; r = 0.25, P = .008; r = 0.691, P = .002; r = 0.546, P < .001; and r = 0.448, P = .001, respectively). However hs-C reactive protein levels were similar between patients with or without LEAD (2.47 ± 1.32 1.61 ± 0.91 P = .685). In addition, there was no correlation between the severity of LEAD and hs-C reactive levels. In this study, we determined that the levels of inflammatory and thrombotic biomarkers are elevated in peripheral artery disease, and these levels predict disease severity.
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http://dx.doi.org/10.1111/iwj.13407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948564PMC
October 2020

The association between the fibrinogen-to-albumin ratio and coronary artery disease severity in patients with stable coronary artery disease.

Coron Artery Dis 2020 09;31(6):512-517

Department of Cardiology, TOBB Economics and Technology University Medical School.

Objective: Fibrinogen-to-albumin ratio (FAR) is an inexpensive and easily measurable novel inflammatory index that has been found to be associated with atherosclerosis. In this study, we aimed to investigate the association between the FAR and coronary artery disease (CAD) severity in patients with stable CAD.

Methods: In total, 356 consecutive patients with CAD were classified into three groups, those with a low Synergy between percutaneous coronary intervention and the Taxus and Cardiac Surgery Study (SYNTAX) score (≤22), those with an intermediate SYNTAX score (23≥ SYNTAX score ≤32) and those with a high SYNTAX score (>32).

Results: We determined that there were significant differences in the mean age (P < 0.001), male gender (P = 0.008), serum fibrinogen (P = 0.03), low-density lipoprotein cholesterol (P < 0.001) and FAR (P < 0.001) among the SYNTAX score groups. A strong positive correlation was detected between FAR and SYNTAX score (r = 0.899; P < 0.001), and the cutoff level of FAR for high SYNTAX score was 82 (sensitivity of 82%, specificity of 88.3% and an area under the curve of 0.826).

Conclusion: The novel inflammatory index, FAR, is significantly associated with the severity of CAD in patients with stable CAD.
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http://dx.doi.org/10.1097/MCA.0000000000000868DOI Listing
September 2020

Screening of lower extremity artery disease.

Vascular 2020 06 3;28(3):329-330. Epub 2020 Feb 3.

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

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http://dx.doi.org/10.1177/1708538120902295DOI Listing
June 2020

Blood Group Types O and Non-O Are Associated With Coronary Collateral Circulation Development.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029619900544

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

Blood group types are associated with coronary artery disease. However, data are scarce about the impact of blood group types on coronary collateral circulation. In this study, we aimed to investigate the relationship between the blood group types and coronary collateral circulation. Two hundred and twelve patients who underwent coronary angiography in our department and had a stenosis of ≥ 90% in at least one major epicardial vessel were included in our study. Collateral degree was graded according to Rentrop-Cohen classification. After grading, patients were divided into poor coronary collateral circulation (Rentrop grade 0 and 1) and good coronary collateral circulation (Rentrop 2 and 3) groups. The ABO blood type of all participants was determined. The incidence rates of O blood group type were significantly higher in the good coronary collateral group compared to the poor collateral group (37.9% vs 17.1%, < .001). The O type blood group was an independent predictor of good coronary collateral circulation (odds ratio = 1.83, 95% confidence interval = 1.56-6.18, = .015). Coronary collateral circulation is associated with blood group types. The O blood group predicts good coronary collateral development among patients with coronary artery disease.
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http://dx.doi.org/10.1177/1076029619900544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098203PMC
July 2020

The Usefulness of Admission Plasma NT-pro BNP Level to Predict Left Ventricular Aneurysm Formation after Acute ST-Segment Elevation Myocardial Infarction.

Arq Bras Cardiol 2019 12;113(6):1129-1137

University of Health Science, Turkiye Yuksek Ihtisas Training and Research Hospital - Cardiology, Ankara - Turkey.

Background: Left ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. In this study, we investigated the role of N- Terminal pro B type natriuretic peptide level to predict the LVA development after acute ST-segment elevation myocardial infarction (STEMI).

Methods: We prospectively enrolled 1519 consecutive patients with STEMI. Patients were divided into two groups according to LVA development within the six months after index myocardial infarction. Patients with or without LVAs were examined to determine if a significant relationship existed between the baseline N- Terminal pro B type natriuretic peptide values and clinical characteristics. A p-value < 0.05 was considered statistically significant.

Results: LVA was detected in 157 patients (10.3%). The baseline N- Terminal pro- B type natriuretic peptide level was significantly higher in patients who developed LVA after acute MI (523.5 ± 231.1 pg/mL vs. 192.3 ± 176.6 pg/mL, respectively, p < 0.001). Independent predictors of LVA formation after acute myocardial infarction was age > 65 y, smoking, Killip class > 2, previous coronary artery bypass graft, post-myocardial infarction heart failure, left ventricular ejection fraction < 50%, failure of reperfusion, no-reflow phenomenon, peak troponin I and CK-MB and NT-pro BNP > 400 pg/mL at admission.

Conclusions: Our findings indicate that plasma N- Terminal pro B type natriuretic peptide level at admission among other variables provides valuable predictive information regarding the development of LVA after acute STEMI.
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http://dx.doi.org/10.5935/abc.20190226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021256PMC
December 2019

Invasive screening for lower extremity peripheral artery disease: Killing two birds with one stone?

Vascular 2020 04 11;28(2):196-202. Epub 2019 Oct 11.

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

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http://dx.doi.org/10.1177/1708538119881592DOI Listing
April 2020

Predictors of Early and Late New-Onset Atrial Fibrillation in the Course of Acute Myocardial Infarction.

Angiology 2020 02 12;71(2):193. Epub 2019 Sep 12.

Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319719874619DOI Listing
February 2020

Right ventricular pacing maneuvers for the differential diagnosis of supraventricular tachycardia.

Pacing Clin Electrophysiol 2019 10 18;42(10):1419-1420. Epub 2019 Sep 18.

Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13786DOI Listing
October 2019

A dangerous and risky relationship: Esophagus and left atrium.

Pacing Clin Electrophysiol 2019 05 21;42(5):568-569. Epub 2019 Feb 21.

Department of Cardiology, University of Health Sciences, Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13630DOI Listing
May 2019

Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease.

Rom J Intern Med 2019 Jun;57(2):159-165

TOBB Economy and Technology University Cardiology Department, Ankara, Turkey.

Background: Platelet to lymphocyte ratio (PLR) has been demonstrated as a risk and prognostic marker in many of cardiovascular diseases. A relationship between PLR and severity of carotid stenosis has been shown. The aim of our study was to investigate the relationship between PLR and all cause mortality in patients with carotid arterial disease.

Methods: This retrospective study included 146 patients who had been performed selective carotid angiography. Carotid stenosis were graded by the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria. Platelet to lymphocyte ratio was calculated as the ratio of platelets to lymphocytes. The end point of the study was all-cause mortality.

Results: During median follow-up of 16 months (0-65 months) 15 (10.3%) patients suffered all-cause mortality. 50 patients (34.2%) underwent carotid endarterectomy and 69 patients (47.3%) had non-carotid cardiac surgery. 38 patients (26.02%) had cerebrovascular events (stroke/transient ischemic attack) at admission. NASCET grades were not different between survivors and non-survivors. Non-survivors had significantly lower hemoglobin (Hb) levels (12.7 ± 1.6 g/dL vs. 13.7 ± 1.7 g/dL, p = 0.031) and they were older than survivors (74.2 ± 8.4 years vs. 68.6 ± 8.5 years, p = 0.029). Non-survivors had significantly higher PLR values compared with survivors (190.3 ± 85.6 and 126.8 ± 53.8, p = 0.017). In multivariate analysis, only PLR predicted all-cause mortality in patients with carotid artery stenosis.

Conclusion: In our study, higher PLR was associated with increased all-cause mortality.
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http://dx.doi.org/10.2478/rjim-2018-0040DOI Listing
June 2019

New horizon for ventricular pacing.

Pacing Clin Electrophysiol 2018 12 11;41(12):1691. Epub 2018 Nov 11.

Department of Cardiology, Yüksek Ihtisas Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

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http://dx.doi.org/10.1111/pace.13518DOI Listing
December 2018

Beyond Lipids: Antiarrhythmic Effects of Statins.

Angiology 2019 03 13;70(3):283. Epub 2018 Sep 13.

Department of Cardiology, University of Health Sciences, Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1177/0003319718799585DOI Listing
March 2019

An unusual cause of angina pectoris due to dynamic coronary artery compression and successful treatment with cardiac surgical reconstruction.

Interact Cardiovasc Thorac Surg 2019 02;28(2):318-320

Department of Cardiovascular Surgery, TOBB Economy and Tecnology University Hospital, Ankara, Turkey.

Extrinsic compression of coronary arteries causing angina pectoris is very unusual. No data regarding the optimal treatment for coronary artery compression due to dilated cardiac chambers have been reported. In this case report, we describe a man with severe mitral valve stenosis and the dilated left atrium, which resulted in coronary artery compression, and the successful management of his condition by surgical reconstruction.
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http://dx.doi.org/10.1093/icvts/ivy218DOI Listing
February 2019

Procalcitonin: a marker of heart failure.

Acta Cardiol 2015 Aug;70(4):473-8

Objective: Serum procalcitonin levels are associated with congestive heart failure, but are not established biomarkers of the disease. We evaluated the predictive value of serum procalcitonin levels for diagnosing heart failure and assessing its severity.

Methods And Results: This retrospective, case-control study involved 59 subjects (mean age 59.7-10.1 years; 38 males), including 21 outpa- tients and 19 inpatients with heart failure and left ventricular ejection fractions <45%, and 19 healthy controls. Serum procalcitonin levels were measured and compared among the 3 groups. Procalcitonin levels were significantly higher among inpatients (median [interquartile range], 1.45 [0.25-5.801 ng/mL) than among the outpatients (0.35 [0.001.-1.70] ng/mL; P< 0.001) or controls (0.05 [0.02-0.08] ng/mL; P< 0.0011. Using a procalcitonin cut-off level of 0.09 ng/mL, 35 (87.5%) of the 40 inpatients and outpatients were procalcitonin-positive; all control individuals were procalcitonin-negative. Serum procalcitonin levels differentiated between heart failure patients and healthy controls (sensitivity, 88.9% [95% confidence interval, 75.9-96.2%]; specificity, 100% [82.2-100.0%]; positive predictive value, 100% [91.1-100.0%]; negative predictive value, 79.2% [57.8-92.8%]). Pro calcitonin levels were >0.53 ng/mL in 4/21 (19%) outpatients and in 16/19 (84.2%) inpatients. The sensitivity and specificity of serum procalcitonin levels for differentiating between inpatients and outpatients were 84.2% and 81.0%, respectively (positive predictive value 80% [95% confidence interval, 67.6-92.4%] and 85.0% [73.9-96.1%], respectively).

Conclusion: Serum procalcitonin levels, showing high sensitivity and specificity for diagnosing and assessing the severity of heart failure in this small study, might be considered ootential heart failure biomarkers.
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http://dx.doi.org/10.1080/ac.70.4.3096896DOI Listing
August 2015

A rare presentation of cystic echinococcosis: aortic involvement.

Interact Cardiovasc Thorac Surg 2015 Oct 14;21(4):548-9. Epub 2015 Jul 14.

Department of Cardiovascular Surgery, TOBB ETU Hospital, Ankara, Turkey.

Cystic echinococcosis is an endemic parasitic infestation caused by the larval stage of Echinococcus granulosus. Although infestation of any part of human body can occur, isolated cardiac involvement is uncommon. We present a case of isolated hydatidosis involving the ascending aorta.
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http://dx.doi.org/10.1093/icvts/ivv153DOI Listing
October 2015

The effect of sinus rhythm restoration on high-sensitivity C-reactive protein levels and their association with long-term atrial fibrillation recurrence after electrical cardioversion.

Cardiology 2011 3;118(3):168-74. Epub 2011 Jun 3.

Department of Cardiology, Tokat State Hospital, Turkey. drozlemoz79 @ yahoo.com

Objective: Recent studies have shown that high-sensitivity C-reactive protein (hs-CRP) measured before cardioversion (CV) plays a significant role in predicting atrial fibrillation (AF) relapse. The time course of changes in hs-CRP after successful electrical CV remains controversial. The aim of the present study was to assess the prognostic value of pre- and post-CV hs-CRP levels in predicting the long-term risk of AF. Additionally, we evaluated changes in hs-CRP levels over time following a successful CV.

Methods: This prospective study comprised 216 patients with persistent AF who underwent CV (mean age 51.94 ± 8.07 years; 55.6% men). hs-CRP levels were examined in all patients, and blood samples were taken prior to and 1, 2, 7 and 30 days after CV. AF relapse was determined by 24-hour ambulatory electrocardiogram (ECG) monitoring and 12-lead standard ECG during 12 months of follow-up. We further divided the study population into two groups according to their rhythm at the end of the follow-up period (group A: patients with AF at the end of follow-up; group B: patients with sinus rhythm at the end of the follow-up period).

Results: The AF recurrence rate was 42.2% throughout the 12-month follow-up period. The basal hs-CRP levels were higher in patients with an AF relapse than in those without (1.68 ± 0.57 vs. 1.12 ± 0.53 mg/dl; p < 0.01). The hs-CRP levels were significantly decreased at 30 days in group B, whereas there was no significant decrease in group A (from 1.12 ± 0.53 to 0.69 ± 0.33 mg/dl, p < 0.01, and from 1.68 ± 0.57 to 1.69 ± 0.76 mg/dl, p > 0.05, respectively). By multivariate Cox analysis, the independent predictors of AF relapse time points were the basal and day-2 hs-CRP levels. Receiver operating characteristic curve analysis showed that the cutoff value of hs-CRP on the 2nd day for predicting AF relapse was 1.85 mg/dl, with a sensitivity of 62%, a specificity of 82%, a positive predictive value of 85.7% and a negative predictive value of 81.6%.

Conclusion: The hs-CRP levels both prior to and after CV predict the long-term risk of AF relapse. In the present study, hs-CRP levels were significantly decreased in patients who remained in sinus rhythm at the end of the study. In contrast, hs-CRP levels remained high throughout the follow-up in patients with an AF relapse.
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http://dx.doi.org/10.1159/000327998DOI Listing
December 2011

[Case images: a rare coronary artery anomaly: right coronary artery arising from the left anterior descending artery].

Turk Kardiyol Dern Ars 2011 Mar;39(2):180

Department of Cardiology, Tokat State Hospital, Tokat, Turkey.

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http://dx.doi.org/10.5543/tkda.2011.01222DOI Listing
March 2011

Inappropriate sinus tachycardia - successful treatment with ivabradine.

Kardiol Pol 2010 Aug;68(8):935-7

Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Inappropriate sinus tachycardia (IST) is characterised by an exaggerated increase of heart rate in response to normal physiologic demands. Therapeutic options including medical and radiofrequency ablation interventions are still under debate. Ivabradine inhibits spontaneous pacemaker activity of the sinus node by selectively blocking If channels of pacemaker cells. Here we present a case of a patient with IST, who was successfully treated with ivabradine after various ineffective therapeutic approaches.
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August 2010

[The effect of admission mean platelet volume on TIMI frame count measured after fibrinolytic therapy in patients with acute ST-segment elevation myocardial infarction].

Turk Kardiyol Dern Ars 2009 Jul;37(5):307-11

Ankara Numune Eğitim ve Araştirma Hastanesi Kardiyoloji Kliniği, Ankara, Turkey.

Objectives: Mean platelet volume has been reported as a predictor of unfavorable prognosis in patients with ST-segment elevation myocardial infarction (MI). We evaluated the relationship between admission mean platelet volume and the response to fibrinolytic therapy using the TIMI frame count in patients with acute ST-segment elevation MI.

Study Design: The study included 87 patients (58 males, 29 females; mean age 55+/-11 years) who received fibrinolytic therapy within the first 12 hours of symptom onset for acute ST-segment elevation MI. Venous blood samples were obtained to determine admission mean platelet volume and fibrinolytic therapy was administered. Coronary angiography was performed within the first 72 hours and the TIMI frame count was measured for infarct-related artery. TIMI frame counts of <40 and >or=40 were defined as complete and incomplete reperfusion, respectively.

Results: Reperfusion was complete in 35 patients (40.2%) and incomplete in 52 patients (59.8%). The mean TIMI frame counts were 31.8+/-5.9 and 61.2+/-15.3 in patients with complete and incomplete reperfusion, respectively (p<0.01). Patients with complete reperfusion had a significantly lower mean platelet volume (9.4+/-0.4 fl vs. 9.7+/-0.3 fl; p=0.016). There was a highly significant correlation between mean platelet volume and incomplete reperfusion (r=0.742, p<0.0001).

Conclusion: High levels of admission mean platelet volume might be associated with insufficient reperfusion response to fibrinolytic therapy in patients with acute ST-segment elevation MI.
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July 2009

An anomalous left coronary artery detected by multislice computed tomography.

Anadolu Kardiyol Derg 2007 Dec 8;7(4):E7. Epub 2007 Dec 8.

Department of Cardiology, Ankara Numune Research and Education Hospital, Ankara, Turkey.

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December 2007

[Spontaneous coronary artery dissection].

Anadolu Kardiyol Derg 2007 Sep;7(3):320-2

Ankara Numune Eğitim ve Araştirma Hastanesi, Kardiyoloji Kliniği, Ankara, Turkey.

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September 2007
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