Satu Mustjoki

Satu Mustjoki

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Satu Mustjoki

Publications by authors named "Satu Mustjoki"

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Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients.

Cancer Immunol Immunother 2020 May 8;69(5):717-730. Epub 2020 Feb 8.

Hematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Haartmaninkatu 8, 00290, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00262-020-02497-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183505PMC
May 2020

Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma.

Cancers (Basel) 2020 Apr 4;12(4). Epub 2020 Apr 4.

Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.3390/cancers12040877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225916PMC
April 2020

Modelling of killer T-cell and cancer cell subpopulation dynamics under immuno- and chemotherapies.

J Theor Biol 2020 Mar 27;488:110136. Epub 2019 Dec 27.

Department of Mathematics and Statistics, University of Turku, Turku, Finland; Western Finland Cancer Centre (FICAN West), Turku University Hospital, Turku, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2019.110136DOI Listing
March 2020

Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy.

Leuk Res 2020 Mar 23;90:106310. Epub 2020 Jan 23.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Section of Hematology, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.leukres.2020.106310DOI Listing
March 2020

Mutation Is Associated with STAT3 Activation in CD30 ALK ALCL.

Cancers (Basel) 2020 Mar 16;12(3). Epub 2020 Mar 16.

Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, 00290 Helsinki, Finland.

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http://dx.doi.org/10.3390/cancers12030702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140109PMC
March 2020

Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML.

Cancer Res 2020 Feb 10. Epub 2020 Feb 10.

Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2175DOI Listing
February 2020

JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL.

Cancers (Basel) 2019 Nov 21;11(12). Epub 2019 Nov 21.

Department I of Internal Medicine, Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, University of Cologne (UoC), 50937 Cologne, Germany.

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http://dx.doi.org/10.3390/cancers11121833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966610PMC
November 2019

Therapy de-escalation before stopping in chronic myeloid leukaemia.

Authors:
Satu Mustjoki

Lancet Haematol 2019 07 11;6(7):e345-e346. Epub 2019 Jun 11.

Translational Immunology Research Program, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki 00290, Finland.

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http://dx.doi.org/10.1016/S2352-3026(19)30093-6DOI Listing
July 2019

Characterization of polydactyly chondrocytes and their use in cartilage engineering.

Sci Rep 2019 03 12;9(1):4275. Epub 2019 Mar 12.

Tissue Engineering + Biofabrication, Institute for Biomechanics, Swiss Federal Institute of Technology Zürich (ETH Zürich), Otto-Stern-Weg 7, CH-8093, Zürich, Switzerland.

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http://www.nature.com/articles/s41598-019-40575-w
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http://dx.doi.org/10.1038/s41598-019-40575-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414529PMC
March 2019

Immune cell phenotype and functional defects in Netherton syndrome.

Orphanet J Rare Dis 2018 11 26;13(1):213. Epub 2018 Nov 26.

Department of Dermatology and Allergology, Helsinki University Hospital and University of Helsinki, P.O.Box 160, FI-00029 HUS, Helsinki, Finland.

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0
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http://dx.doi.org/10.1186/s13023-018-0956-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258305PMC
November 2018

Non-Ph variants in CML: guilty drivers?

Authors:
Satu Mustjoki

Blood 2018 08;132(9):880-881

University of Helsinki; Helsinki University Hospital Comprehensive Cancer Center.

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http://dx.doi.org/10.1182/blood-2018-07-862698DOI Listing
August 2018

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML.

Leukemia 2018 07 20;32(7):1643-1656. Epub 2018 Jun 20.

Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41375-018-0175-0DOI Listing
July 2018

Clonal hematopoiesis in patients with rheumatoid arthritis.

Blood Cancer J 2018 07 26;8(8):69. Epub 2018 Jul 26.

Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41408-018-0107-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066480PMC
July 2018

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

Cancer Res 2018 05 26;78(9):2407-2418. Epub 2018 Feb 26.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3644DOI Listing
May 2018

ADA2 deficiency: Clonal lymphoproliferation in a subset of patients.

J Allergy Clin Immunol 2018 04 31;141(4):1534-1537.e8. Epub 2018 Jan 31.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.01.012DOI Listing
April 2018

Somatic mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia.

Haematologica 2018 02 7;103(2):304-312. Epub 2017 Dec 7.

Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Finland

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2017.175729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792275PMC
February 2018

Sex bias in MHC I-associated shaping of the adaptive immune system.

Proc Natl Acad Sci U S A 2018 02 12;115(9):2168-2173. Epub 2018 Feb 12.

Department of Neurology, University of Muenster, 48149 Muenster, Germany;

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http://dx.doi.org/10.1073/pnas.1716146115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834686PMC
February 2018

T cells and cancer - why do the killers become exhausted?

Duodecim 2016;132(21):1984-92

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January 2018

Immune control in chronic myeloid leukemia.

Oncotarget 2017 Nov 3;8(61):102763-102764. Epub 2017 Nov 3.

Satu Mustjoki: Hematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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http://dx.doi.org/10.18632/oncotarget.22279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732686PMC
November 2017

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.

J Allergy Clin Immunol 2017 Sep 21;140(3):782-796. Epub 2017 Jan 21.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jaci.2016.10.054DOI Listing
September 2017

Early BCR-ABL1 Transcript Decline after 1 Month of Tyrosine Kinase Inhibitor Therapy as an Indicator for Treatment Response in Chronic Myeloid Leukemia.

PLoS One 2017 30;12(1):e0171041. Epub 2017 Jan 30.

Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Comprehensive Cancer Center, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171041PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279791PMC
August 2017

Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia.

J Cancer Res Clin Oncol 2017 Aug 23;143(8):1543-1554. Epub 2017 Mar 23.

Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Haartmaninkatu 8, 00290, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00432-017-2378-6DOI Listing
August 2017

Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34CD38 stem and progenitor cells in chronic myeloid leukemia.

Biochem Biophys Res Commun 2017 08 13;490(2):378-384. Epub 2017 Jun 13.

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.06.051DOI Listing
August 2017

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

J Allergy Clin Immunol 2017 04 29;139(4):1391-1393.e11. Epub 2016 Nov 29.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland; Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.jaci.2016.09.050DOI Listing
April 2017

A novel class of somatic mutations in blood detected preferentially in CD8+ cells.

Clin Immunol 2017 02 5;175:75-81. Epub 2016 Dec 5.

Molecular Neurology, Research Programs Unit, University of Helsinki, Department of Neurology, Helsinki University Hospital, Haartmaninkatu 8, FIN-00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341785PMC
February 2017

Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models.

Cancer Immunol Res 2017 02 10;5(2):157-169. Epub 2017 Jan 10.

Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-16-0061-TDOI Listing
February 2017

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia.

J Clin Oncol 2017 Jan 7;35(2):175-184. Epub 2016 Nov 7.

Sieghart Sopper, Günther Gastl, Matthias Baldauf, Zlatko Trajanoski, and Dominik Wolf, Medical University Innsbruck; Sieghart Sopper and Dominik Wolf, Tyrolean Cancer Research Institute; Matthias Baldauf, Oncotyrol, Innsbruck; Peter Valent, Medical University of Vienna, Vienna, Austria; Satu Mustjoki and Kimmo Porkka, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Deborah White and Timothy Hughes, South Australian Health and Medical Research Institute and University of Adelaide School of Medicine, Adelaide, South Australia, Australia; Andreas Burchert, Universitätsklinikum Gießen und Marburg and Philipps Universität Marburg, Marburg; Andreas Hochhaus, Thomas Ernst, and Thomas Schenk, Universitätsklinikum Jena, Jena; Dominik Wolf, University Hospital of Bonn, Bonn, Germany; Bjørn T. Gjertsen, University of Bergen, Bergen, Norway; Frank Giles, Northwestern University, Chicago, IL; and Jeroen J.W.M. Janssen and Gert J. Ossenkoppele, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2016.67.0893DOI Listing
January 2017

Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy.

Clin Cancer Res 2016 Aug 22;22(16):4030-8. Epub 2016 Mar 22.

Hematology Research Unit Helsinki, University of Helsinki and Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland. Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2791DOI Listing
August 2016

Assessment of bone marrow lymphocytic status during tyrosine kinase inhibitor therapy and its relation to therapy response in chronic myeloid leukaemia.

J Cancer Res Clin Oncol 2016 May 8;142(5):1041-50. Epub 2016 Jan 8.

Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Comprehensive Cancer Center, Haartmaninkatu 8, P.O. Box 700, 00290, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00432-015-2101-4DOI Listing
May 2016

The tyrosine kinase inhibitors imatinib and dasatinib reduce myeloid suppressor cells and release effector lymphocyte responses.

Mol Cancer Ther 2015 May 11;14(5):1181-91. Epub 2015 Mar 11.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Section of Hematology, Uppsala University Hospital, Uppsala, Sweden.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0849DOI Listing
May 2015

Imatinib and pegylated IFN-α2b discontinuation in first-line chronic myeloid leukemia patients following a major molecular response.

Eur J Haematol 2014 28;92(5):413-20. Epub 2014 Jan 28.

Hematology Research Unit Helsinki, Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.

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http://doi.wiley.com/10.1111/ejh.12258
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http://dx.doi.org/10.1111/ejh.12258DOI Listing
December 2014

Enlarged memory T-cell pool and enhanced Th1-type responses in chronic myeloid leukemia patients who have successfully discontinued IFN-α monotherapy.

PLoS One 2014 31;9(1):e87794. Epub 2014 Jan 31.

Hematology Research Unit Helsinki, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087794PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909235PMC
October 2014

Spermidine/spermine N(1)-acetyltransferase activity associates with white blood cell count in myeloid leukemias.

Exp Hematol 2014 Jul 4;42(7):574-80. Epub 2014 Mar 4.

Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.02.008DOI Listing
July 2014

Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.

Ann Med 2014 May 11;46(3):114-22. Epub 2014 Feb 11.

Hematology Research Unit, Department of Medicine, University of Helsinki and Helsinki University Central Hospital , Helsinki , Finland.

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http://dx.doi.org/10.3109/07853890.2014.882105DOI Listing
May 2014

Novel TBL1XR1, EPHA7 and SLFN12 mutations in a Sezary syndrome patient discovered by whole exome sequencing.

Exp Dermatol 2014 May;23(5):366-8

Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Cancer Center, Helsinki, Finland.

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http://doi.wiley.com/10.1111/exd.12405
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http://dx.doi.org/10.1111/exd.12405DOI Listing
May 2014

Dasatinib promotes Th1-type responses in granzyme B expressing T-cells.

Oncoimmunology 2014 29;3:e28925. Epub 2014 May 29.

Hematology Research Unit Helsinki; University of Helsinki; Helsinki, Finland ; Department of Hematology; Helsinki University Central Hospital Cancer Center; Helsinki, Finland.

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http://dx.doi.org/10.4161/onci.28925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106168PMC
May 2014

Induction of sustained deep molecular response in a patient with chronic-phase T315I-mutated chronic myeloid leukemia with interferon-α monotherapy.

Leuk Lymphoma 2014 Apr 25;55(4):934-7. Epub 2013 Jul 25.

Hematology Research Unit Helsinki, Department of Medicine, University of Helsinki and Helsinki University Central Hospital , Helsinki , Finland.

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http://dx.doi.org/10.3109/10428194.2013.812788DOI Listing
April 2014

IFNα induces prolonged remissions modeling curative immunologic responses in chronic myeloid leukemia.

Oncoimmunology 2014 29;3:e28781. Epub 2014 Apr 29.

Hematology Research Unit; Department of Hematology; University of Helsinki and Helsinki University Central Hospital Cancer Center; Helsinki, Finland.

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http://dx.doi.org/10.4161/onci.28781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063137PMC
April 2014

Immunology and immunotherapy of chronic myeloid leukemia.

Curr Hematol Malig Rep 2014 Mar;9(1):17-23

Hematology Research Unit Helsinki, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland,

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http://dx.doi.org/10.1007/s11899-013-0190-1DOI Listing
March 2014

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Cancer Discov 2013 Dec 20;3(12):1416-29. Epub 2013 Sep 20.

1Institute for Molecular Medicine Finland, FIMM; 2Hematology Research Unit Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki; 3Department of Clinical Chemistry and TYKSLAB, Turku University Central Hospital, University of Turku, Turku; 4Department of Internal Medicine, Tampere University Hospital, Tampere, Finland; 5Department of Clinical Science, Hematology Section, University of Bergen; and 6Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0350DOI Listing
December 2013

Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia.

Mol Cytogenet 2013 Jul 16;6(1):27. Epub 2013 Jul 16.

Department of Pathology, Haartman Institute, and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1186/1755-8166-6-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751646PMC
July 2013

Phosphoprotein profiling predicts response to tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients.

Exp Hematol 2012 Sep 1;40(9):705-714.e3. Epub 2012 Jun 1.

Hematology Research Unit Helsinki, Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.exphem.2012.05.010DOI Listing
September 2012

Morphology antibody chromosome technique for determining phenotype and genetic status of the same cell.

Curr Protoc Hum Genet 2012 Jul;Chapter 4:Unit4.7

University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/0471142905.hg0407s74DOI Listing
July 2012