Satoshi Umemura

Satoshi Umemura

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Satoshi Umemura

Publications by authors named "Satoshi Umemura"

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Viewpoint on Guidelines for Treatment of Hypertension in Japan.

Circ Res 2019 Mar;124(7):981-983

Tohoku University Graduate School of Medicine, Sendai, Japan (S.I.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314991DOI Listing
March 2019

Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice.

Hypertens Res 2018 Sep 27;41(9):699-707. Epub 2018 Jun 27.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

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http://dx.doi.org/10.1038/s41440-018-0067-8DOI Listing
September 2018

Arterial wall hypertrophy is ameliorated by α2-adrenergic receptor antagonist or aliskiren in kidneys of angiotensinogen-knockout mice.

Clin Exp Nephrol 2018 Aug 11;22(4):773-781. Epub 2017 Dec 11.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

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http://dx.doi.org/10.1007/s10157-017-1520-8DOI Listing
August 2018

Within-visit blood pressure variability and cardiovascular risk factors in hypertensive patients with non-dialysis chronic kidney disease.

Clin Exp Hypertens 2017 21;39(7):665-671. Epub 2017 Jun 21.

a Department of Medical Science and Cardiorenal Medicine , Yokohama City University Graduate School of Medicine , Yokohama , Japan.

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http://dx.doi.org/10.1080/10641963.2017.1313850DOI Listing
April 2018

An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in a chronic kidney disease model.

Kidney Int 2017 05 10;91(5):1115-1125. Epub 2017 Jan 10.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.10.035DOI Listing
May 2017

Blood pressure differences between office and home settings among Japanese normotensive subjects and hypertensive patients.

Hypertens Res 2017 Mar 6;40(3):277-283. Epub 2016 Oct 6.

Yokohama Rousai Hospital, Japan Organization of Occupational Health and Safety, Yokohama, Japan.

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http://dx.doi.org/10.1038/hr.2016.125DOI Listing
March 2017

Impact of preoperative dual antiplatelet therapy on bleeding complications in patients with acute coronary syndromes who undergo urgent coronary artery bypass grafting.

J Cardiol 2017 01 15;69(1):156-161. Epub 2016 Mar 15.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.jjcc.2016.02.013DOI Listing
January 2017

Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism.

EBioMedicine 2016 Nov 20;13:237-247. Epub 2016 Oct 20.

Department of Medical Science and Cardio-Renal Medicine, Yokohama City University, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.

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http://dx.doi.org/10.1016/j.ebiom.2016.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264349PMC
November 2016

The results of a survey of physicians about the Japanese Society of Hypertension Guidelines for the Management of Hypertension 2014 and its clinical use.

Hypertens Res 2016 Sep 12;39(9):660-3. Epub 2016 May 12.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.

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http://dx.doi.org/10.1038/hr.2016.42DOI Listing
September 2016

Role of renin-angiotensin system inhibitors in retardation of progression of end-stage renal failure: a retrospective study.

Clin Exp Nephrol 2016 Aug 30;20(4):603-610. Epub 2015 Oct 30.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Yokohama, Japan.

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http://link.springer.com/10.1007/s10157-015-1191-2
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http://dx.doi.org/10.1007/s10157-015-1191-2DOI Listing
August 2016

Activation of Peroxisome Proliferator-activated Receptor γ Prevents Development of Heart Failure With Preserved Ejection Fraction; Inhibition of Wnt-β-catenin Signaling as a Possible Mechanism.

J Cardiovasc Pharmacol 2016 Aug;68(2):155-61

*Department of Medicine, Cardiology, University of Mississippi Medical Center, Jackson, MS; and †Department of Medical Science and Cardiorenal Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

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http://dx.doi.org/10.1097/FJC.0000000000000397DOI Listing
August 2016

Obituary: a tribute to Yoshihiro Kaneko, MD.

Authors:
Satoshi Umemura

Hypertens Res 2016 Aug;39(8):565-6

Yokohama City University, Department of Medical Science and Cardiorenal Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1038/hr.2016.59DOI Listing
August 2016

Circadian blood pressure rhythm as a possible key target of SGLT2 inhibitors used for the treatment of Type 2 diabetes.

Hypertens Res 2016 Jun 28;39(6):396-8. Epub 2016 Jan 28.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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http://www.nature.com/articles/hr20161
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http://dx.doi.org/10.1038/hr.2016.1DOI Listing
June 2016

An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice.

Sci Rep 2016 06 3;6:27137. Epub 2016 Jun 3.

Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardio-Renal Medicine.

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http://dx.doi.org/10.1038/srep27137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891730PMC
June 2016

From mercury sphygmomanometer to electric device on blood pressure measurement: correspondence of Minamata Convention on Mercury.

Hypertens Res 2016 Apr 28;39(4):179-82. Epub 2016 Jan 28.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1038/hr.2015.158DOI Listing
April 2016

Pulmonary Thromboembolism Caused by Prolonged Compression at the Femoral Access Site and a Venous Aneurysm of the Ipsilateral Popliteal Vein.

Ann Vasc Dis 2016 12;9(1):58-61. Epub 2016 Feb 12.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University, School of Medicine, Yokohama, Kanagawa, Japan.

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http://dx.doi.org/10.3400/avd.cr.15-00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807218PMC
April 2016

Development of Atrioventricular Block and Diagnostic Value of Stored Electrograms in Patients With Sick Sinus Syndrome and Implanted Pacemaker.

Circ J 2015 5;79(6):1263-8. Epub 2015 Mar 5.

Department of Cardiology, Yokohama City University Hospital, Yokohama; Department of Cardiovascular Center, Yokohama City University Medical Center, Yokohama, Japan; Department of Cardiology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

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https://www.jstage.jst.go.jp/article/circj/79/6/79_CJ-14-125
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http://dx.doi.org/10.1253/circj.CJ-14-1255DOI Listing
March 2016

Clinical utility and significance of intravascular ultrasound and optical coherence tomography in guiding percutaneous coronary interventions.

Circ J 2015 19;79(1):24-33. Epub 2014 Dec 19.

Division of Cardiology, Yokohama City University Medical Center.

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http://dx.doi.org/10.1253/circj.CJ-14-1044DOI Listing
February 2016

Effects of pitavastatin add-on therapy on chronic kidney disease with albuminuria and dyslipidemia.

Lipids Health Dis 2015 Dec 9;14:161. Epub 2015 Dec 9.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

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http://dx.doi.org/10.1186/s12944-015-0164-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673714PMC
December 2015

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

[Treatment of hypertension in Japan--the present condition and future prospects].

Authors:
Satoshi Umemura

Nihon Rinsho 2015 Nov;73(11):1815-24

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November 2015

Acceleration of iron utilization after intravenous iron administration during activated erythropoiesis in hemodialysis patients: a randomized study.

Ther Apher Dial 2015 Apr 26;19(2):131-7. Epub 2014 Sep 26.

Yokodai Central Clinic, Yokohama, Kanagawa, Japan; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Yokohama, Kanagawa, Japan.

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http://dx.doi.org/10.1111/1744-9987.12237DOI Listing
April 2015

Effect of impaired renal function on the maintenance dose of warfarin in Japanese patients.

J Cardiol 2015 Mar 30;65(3):178-84. Epub 2014 Oct 30.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.jjcc.2014.08.008DOI Listing
March 2015

Renal tubule angiotensin II type 1 receptor-associated protein promotes natriuresis and inhibits salt-sensitive blood pressure elevation.

J Am Heart Assoc 2015 Mar 19;4(3):e001594. Epub 2015 Mar 19.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan (H.W., K.U., K.T., M.O., K.A., R.K., K.O., T.D., T.K., Y.T.I., M.M., K.H., M.Y., T.F., S.U.).

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http://dx.doi.org/10.1161/JAHA.114.001594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392439PMC
March 2015

Differences in negative T waves between acute pulmonary embolism and acute coronary syndrome.

Circ J 2014 3;78(2):483-9. Epub 2013 Dec 3.

Division of Cardiology, Yokohama City University Medical Center.

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http://dx.doi.org/10.1253/circj.cj-13-1064DOI Listing
February 2015

Effects of Ang II receptor blocker irbesartan on adipose tissue function in mice with metabolic disorders.

Int J Med Sci 2014 27;11(6):646-51. Epub 2014 Apr 27.

1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.7150/ijms.8577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021097PMC
December 2014

Changes in hepcidin and reticulocyte hemoglobin equivalent levels in response to continuous erythropoietin receptor activator administration in hemodialysis patients: a randomized study.

Ther Apher Dial 2014 Oct 24;18(5):421-6. Epub 2014 Jan 24.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

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http://dx.doi.org/10.1111/1744-9987.12161DOI Listing
October 2014

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

Hum Mol Genet 2014 Oct 26;23(20):5492-504. Epub 2014 May 26.

Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.

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http://hmg.oxfordjournals.org/content/early/2014/06/20/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu248
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http://dx.doi.org/10.1093/hmg/ddu248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168820PMC
October 2014

Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial.

J Hypertens 2014 Oct;32(10):2054-63; discussiom 2063

aMorinomiya University of Medical Sciences, Osaka bKeio University, Tokyo cOsaka University Graduate School of Medicine, Osaka dSapporo Medical University, Hokkaido eDokkyo Medical University fShin-Oyama City Hospital, Tochigi gTohoku University Graduate School of Medicine, Miyagi hEhime University Graduate School of Medicine, Ehime iKurume University School of Medicine, Fukuoka jUniversity of the Ryukyus School of Medicine, Okinawa kSaitama Medical University, Saitama lAsahi Rousai Hospital, Aichi mYokohama City University Graduate School of Medicine, Kanagawa nSapporo Nishimaruyama Hospital, Hokkaido oTokyo Medical University, Tokyo pKawasaki Medical School, Okayama qKanazawa University Hospital, Ishikawa, Japan.

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http://dx.doi.org/10.1097/HJH.0000000000000281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166009PMC
October 2014

Fetal programming by high-sucrose diet during pregnancy affects the vascular angiotensin II receptor-PKC-L-type Ca(2+) channels (Cav1.2) axis to enhance pressor responses.

Hypertens Res 2014 Sep 19;37(9):796-8. Epub 2014 Jun 19.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1038/hr.2014.105DOI Listing
September 2014

Genetic variation in NEDD4L, salt sensitivity, and hypertension: human NEDD4L rs4149601 G allele generates evolutionary new isoform I with C2 domain.

J Hypertens 2014 Sep;32(9):1905

Department of Medical Science and Cardio-renal Medicine, Yokohama City University Graduate School of Medicine, Yokohama-city, Kanagawa, Japan.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HJH.0000000000000293DOI Listing
September 2014

Loss of amino acids into dialysate during hemodialysis using hydrophilic and nonhydrophilic polyester-polymer alloy and polyacrylonitrile membrane dialyzers.

Ther Apher Dial 2014 Aug 10;18(4):340-6. Epub 2013 Nov 10.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1111/1744-9987.12145DOI Listing
August 2014

Longitudinal stent deformation elongating to left main trunk.

Cardiovasc Interv Ther 2014 Jul 25;29(3):247-51. Epub 2013 Oct 25.

Division of Cardiology, Fujisawa City Hospital, 2-6-1 Fujisawa, Fujisawa, Kanagawa, 251-8511, Japan,

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http://dx.doi.org/10.1007/s12928-013-0220-xDOI Listing
July 2014

Identification of bona fide alternative renin transcripts expressed along cortical tubules and potential roles in promoting insulin resistance in vivo without significant plasma renin activity elevation.

Hypertension 2014 Jul 28;64(1):125-33. Epub 2014 Apr 28.

From the Department of Medical Science and Cardio-Renal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03394DOI Listing
July 2014

Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice.

J Hypertens 2014 Jul;32(7):1415-23; discussion 1423

aDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine bDepartment of Nephrology and Hypertension, Yokohama City University Medical Center cMolecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama dCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto eDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon fDepartment of Health Science, Shiga University of Medical Science, Otsu gCardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1097/HJH.0000000000000206DOI Listing
July 2014

Endovascular treatment of renal artery stenosis improves contralateral renal hypertrophy with nephrotic syndrome.

CEN Case Rep 2014 May 17;3(1):53-55. Epub 2013 Jun 17.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

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http://dx.doi.org/10.1007/s13730-013-0085-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413675PMC
May 2014

Small proximal aortic diameter is associated with higher central pulse pressure and poor outcome in patients with congestive heart failure.

Hypertens Res 2014 Jan 19;37(1):57-63. Epub 2013 Sep 19.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1038/hr.2013.111DOI Listing
January 2014

Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension.

Cardiovasc Res 2013 Dec 4;100(3):511-9. Epub 2013 Nov 4.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.1093/cvr/cvt225DOI Listing
December 2013

Relationship between coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance and serum eicosapentaenoic acid.

J Cardiovasc Magn Reson 2013 Dec 20;15:106. Epub 2013 Dec 20.

Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomiokahigashi, Kanazawa-ku, Yokohama, Kanagawa 236-0051, Japan.

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http://dx.doi.org/10.1186/1532-429X-15-106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878179PMC
December 2013