Satoshi Sakai

Satoshi Sakai

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Satoshi Sakai

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Long Noncoding RNA Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial-Mesenchymal Transition.

Cancer Res 2019 06 5;79(11):2821-2838. Epub 2019 Apr 5.

Department of Molecular Biology, Hamamatsu University School of Medicine, Shizuoka, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3210DOI Listing
June 2019

Endothelin and the heart in health and diseases.

Peptides 2019 01 21;111:77-88. Epub 2018 Oct 21.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183018
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http://dx.doi.org/10.1016/j.peptides.2018.10.002DOI Listing
January 2019

Experience of using water-dispersed paper bedding for equine scintigraphy.

J Equine Sci 2018 Dec 18;29(4):105-109. Epub 2018 Dec 18.

Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.

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http://dx.doi.org/10.1294/jes.29.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306292PMC
December 2018

MicroRNA-205-5p suppresses the invasiveness of oral squamous cell carcinoma by inhibiting TIMP‑2 expression.

Int J Oncol 2018 Mar 31;52(3):841-850. Epub 2018 Jan 31.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan.

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http://dx.doi.org/10.3892/ijo.2018.4260DOI Listing
March 2018

Exercise habituation is effective for improvement of periodontal disease status: a prospective intervention study.

Ther Clin Risk Manag 2018 20;14:565-574. Epub 2018 Mar 20.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.2147/TCRM.S153397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865566PMC
March 2018

Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis.

Int J Mol Sci 2018 Feb 6;19(2). Epub 2018 Feb 6.

Department of Molecular Biology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan.

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http://dx.doi.org/10.3390/ijms19020474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855696PMC
February 2018

Homeobox Transcription Factor NKX2-1 Promotes Transcription in Lung Adenocarcinomas.

Mol Cancer Res 2017 10 20;15(10):1388-1397. Epub 2017 Jun 20.

Department of Molecular Biology, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-17-0114DOI Listing
October 2017

Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair.

Nat Commun 2017 07 18;8:16102. Epub 2017 Jul 18.

Department of Molecular Biology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan.

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http://dx.doi.org/10.1038/ncomms16102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520108PMC
July 2017

Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development.

Curr Cancer Drug Targets 2016 ;16(2):147-56

Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuho-ku, Nagoya 467-8603, Japan.

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http://dx.doi.org/10.2174/1568009616666151112122645DOI Listing
October 2016

p62 modulates the intrinsic signaling of UVB-induced apoptosis.

J Dermatol Sci 2016 09 10;83(3):226-33. Epub 2016 May 10.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2016.05.005DOI Listing
September 2016

Antagonists to endothelin receptor type B promote apoptosis in human pulmonary arterial smooth muscle cells.

Life Sci 2016 Aug 26;159:116-120. Epub 2016 Mar 26.

Division of Cardiovascular Medicine, Department of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2016.03.044DOI Listing
August 2016

Bosentan reverses the hypoxia-induced downregulation of the bone morphogenetic protein signaling in pulmonary artery smooth muscle cells.

Life Sci 2016 Aug 14;159:111-115. Epub 2016 May 14.

Laboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.lfs.2016.05.018DOI Listing
August 2016

Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.

J Control Release 2016 05 12;230:109-15. Epub 2016 Apr 12.

Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-Naka, Kita-ku, Okayama-shi, Okayama 700-8530, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.04.007DOI Listing
May 2016

MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis.

J Oral Pathol Med 2016 Apr 26;45(4):248-55. Epub 2015 Aug 26.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1111/jop.12351DOI Listing
April 2016

Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein.

Anticancer Res 2016 Apr;36(4):1605-11

Department of Molecular Biology, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan.

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April 2016

Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.

Mol Cell Biol 2015 Nov 14;35(22):3909-20. Epub 2015 Sep 14.

WT and MRC Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom Institute of Molecular Health Sciences, ETH, Zurich, Switzerland

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http://dx.doi.org/10.1128/MCB.00561-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609750PMC
November 2015

Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension.

J Heart Lung Transplant 2015 Mar 28;34(3):468-78. Epub 2014 Sep 28.

Laboratory of Physiology and Physiopathology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2014.09.011DOI Listing
March 2015

Association between skeletal muscle mass and insulin secretion in patients with type 2 diabetes mellitus.

Endocr J 2014 10;61(3):281-7. Epub 2014 Jan 10.

Department of Internal Medicine (I), Osaka Medical College, Takatsuki 569-8686, Japan.

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http://dx.doi.org/10.1507/endocrj.ej13-0375DOI Listing
November 2014

Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice.

Life Sci 2014 Nov 18;118(2):288-96. Epub 2014 Jan 18.

Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.01.007DOI Listing
November 2014

Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1: intravital microscopic observation and (31)P-MR spectroscopic studies.

Life Sci 2014 Nov 5;118(2):248-54. Epub 2014 Mar 5.

Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Life Science Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.02.024DOI Listing
November 2014

Fish oil constituent eicosapentaenoic acid inhibits endothelin-induced cardiomyocyte hypertrophy via PPAR-α.

Life Sci 2014 Nov 2;118(2):173-8. Epub 2014 May 2.

Department of Cardiovascular Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba; Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2014.04.025DOI Listing
November 2014

Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation.

J Am Heart Assoc 2014 Nov 5;3(6):e001052. Epub 2014 Nov 5.

Mie University Research Center for Matrix Biology and Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Japan (T.Y., K.I.Y.).

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http://dx.doi.org/10.1161/JAHA.114.001052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338691PMC
November 2014

Mechanisms explaining the late "catch-up" phenomenon after sirolimus-eluting stent implantation.

Int J Cardiol 2014 Nov 30;177(1):44-5. Epub 2014 Sep 30.

Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S01675273140183
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http://dx.doi.org/10.1016/j.ijcard.2014.09.116DOI Listing
November 2014

Effects of selective endothelin (ET)-A receptor antagonist versus dual ET-A/B receptor antagonist on hearts of streptozotocin-treated diabetic rats.

Life Sci 2014 Aug 20;111(1-2):6-11. Epub 2014 Jun 20.

Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2014.06.008DOI Listing
August 2014

Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy.

Life Sci 2014 May 21;102(2):98-104. Epub 2014 Mar 21.

Division of Cardiovascular Medicine, Department of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Division of Life Science Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.03.018DOI Listing
May 2014

Clinical value of plasma pentraxin 3 levels for predicting cardiac troponin elevation after percutaneous coronary intervention.

Life Sci 2014 Jan 12;95(1):40-4. Epub 2013 Dec 12.

Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.lfs.2013.11.021DOI Listing
January 2014

Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice.

Cardiovasc Drugs Ther 2013 Oct;27(5):413-24

Cardiovascular Division, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan,

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http://dx.doi.org/10.1007/s10557-013-6464-yDOI Listing
October 2013

Serum zinc levels and their relationship with diseases in racehorses.

J Vet Med Sci 2013 Jan 28;75(1):37-41. Epub 2012 Aug 28.

Equine Science Division, Hidaka Training and Research Center, Japan Racing Association, 535-13 Nishicha, Hokkaido 057-0171, Japan.

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http://dx.doi.org/10.1292/jvms.12-0122DOI Listing
January 2013

Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymerase II.

Life Sci 2012 Oct 30;91(13-14):572-7. Epub 2012 Apr 30.

Department of Cardiovascular Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1016/j.lfs.2012.04.034DOI Listing
October 2012

Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease.

Life Sci 2012 Oct 21;91(13-14):729-32. Epub 2012 Aug 21.

Life Science Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan.

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http://dx.doi.org/10.1016/j.lfs.2012.08.008DOI Listing
October 2012

Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis.

J Immunol 2012 Aug 13;189(4):2043-53. Epub 2012 Jul 13.

Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Tsukuba, Ibaraki 305-0843, Japan.

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http://dx.doi.org/10.4049/jimmunol.1103610DOI Listing
August 2012

Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids.

Chem Asian J 2012 May 29;7(5):911-4. Epub 2012 Feb 29.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

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http://dx.doi.org/10.1002/asia.201101043DOI Listing
May 2012

γ-Oryzanol reduces adhesion molecule expression in vascular endothelial cells via suppression of nuclear factor-κB activation.

J Agric Food Chem 2012 Apr 26;60(13):3367-72. Epub 2012 Mar 26.

Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

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http://pubs.acs.org/doi/10.1021/jf2043407
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http://dx.doi.org/10.1021/jf2043407DOI Listing
April 2012

Prediction of chronic renal insufficiency after coronary angiography by an early increase in oxidative stress and decrease in glomerular filtration rate.

Circ J 2011 16;75(2):437-42. Epub 2010 Nov 16.

Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1253/circj.cj-10-0622DOI Listing
May 2011

Dual mode of regulation of cell division cycle 25 A protein by TRB3.

Biol Pharm Bull 2010 ;33(7):1112-6

Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.

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http://dx.doi.org/10.1248/bpb.33.1112DOI Listing
November 2010

Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.

Biochem Biophys Res Commun 2010 Feb 11;392(3):289-94. Epub 2010 Jan 11.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.175DOI Listing
February 2010

Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid.

Chem Commun (Camb) 2008 Nov 2(44):5767-9. Epub 2008 Oct 2.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

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http://dx.doi.org/10.1039/b811726hDOI Listing
November 2008

The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations.

Am J Physiol Heart Circ Physiol 2008 Jul 2;295(1):H136-44. Epub 2008 May 2.

Institute of Clinical Medicine, Univ. of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1152/ajpheart.01417.2006DOI Listing
July 2008

Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia.

Eur J Clin Pharmacol 2007 Oct 31;63(10):951-7. Epub 2007 Jul 31.

Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ten-nodai 1-1-1, Tsukuba, Ibaraki, 305-8575, Japan.

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http://link.springer.com/10.1007/s00228-007-0348-7
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http://dx.doi.org/10.1007/s00228-007-0348-7DOI Listing
October 2007

[Effects of local administration of cyclophosphamide on mandibular condyle growth in growing rats].

Authors:
Satoshi Sakai

Kokubyo Gakkai Zasshi 2005 Jun;72(2):147-58

Section of Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial/Neck Reconstruction, Graduate School, Tokyo Medical and Dental University.

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http://dx.doi.org/10.5357/koubyou.72.147DOI Listing
June 2005

VUV single-photon ionization ion trap time-of-flight mass spectrometer for on-line, real-time monitoring of chlorinated organic compounds in waste incineration flue gas.

Anal Chem 2005 Feb;77(4):1007-12

Advanced Technology Research Center, Yokohama Research & Development Center, Mitsubishi Heavy Industries, Ltd, 1-8-1 Sachiura, Kanazawa-ku, Yokohama, Japan.

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http://dx.doi.org/10.1021/ac048761yDOI Listing
February 2005

Activation of peroxisome proliferator-activated receptor-alpha decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S358-61

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166303.33313.01DOI Listing
November 2004

Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure.

J Cardiovasc Pharmacol 2004 Nov;44 Suppl 1:S64-7

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1097/01.fjc.0000166212.04674.8bDOI Listing
November 2004

Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism.

Hypertens Res 2003 Oct;26(10):829-37

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.

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http://www.uftm.edu.br/patolo/cpgp/imagem/01.pdf
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http://dx.doi.org/10.1291/hypres.26.829DOI Listing
October 2003

[Combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats].

J Cardiol 2003 Jan;41(1):45-6

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575.

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January 2003

Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training.

Am J Physiol Heart Circ Physiol 2002 Nov;283(5):H1750-60

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan.

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http://dx.doi.org/10.1152/ajpheart.01051.2001DOI Listing
November 2002

Peroxisome proliferator-activated receptor-gamma activators inhibit endothelin-1-related cardiac hypertrophy in rats.

Clin Sci (Lond) 2002 Aug;103 Suppl 48:16S-20S

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

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http://dx.doi.org/10.1042/CS103S016SDOI Listing
August 2002

Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts.

Clin Sci (Lond) 2002 Aug;103 Suppl 48:284S-288S

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.

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http://dx.doi.org/10.1042/CS103S284SDOI Listing
August 2002

A combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats.

J Am Coll Cardiol 2002 Jul;40(1):175-81

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/s0735-1097(02)01911-3DOI Listing
July 2002