Publications


Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity.
Nat Plants 2017 Oct 2;3(10):825-832. Epub 2017 Oct 2.
Department of Biological Sciences, Graduate School of Science, University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.



Differential binding of prohibitin-2 to estrogen receptor α and to drug-resistant ERα mutants.
Biochem Biophys Res Commun 2015 Aug 4;463(4):726-31. Epub 2015 Jun 4.
Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan; Department of Bioengineering, School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan. Electronic address:

Osteomodulin regulates diameter and alters shape of collagen fibrils.
Biochem Biophys Res Commun 2015 Jul 20;463(3):292-6. Epub 2015 May 20.
Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan; Department of Bioengineering, School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan; Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address:


The interaction of hyperthermophilic TATA-box binding protein with single-stranded DNA is entropically favorable and exhibits a large negative heat capacity change at high salt concentration.
Mol Biosyst 2009 Sep 13;5(9):957-61. Epub 2009 May 13.
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.

Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex.
PLoS One 2014 27;9(1):e87099. Epub 2014 Jan 27.
Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan ; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan ; Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan ; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Structural basis for amino acid export by DMT superfamily transporter YddG.
Nature 2016 06 30;534(7607):417-20. Epub 2016 May 30.
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes.
Biochem Biophys Res Commun 2017 11 14;493(2):1109-1114. Epub 2017 Sep 14.
Department of Bioengineering, School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan; Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. Electronic address:

Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery.
Biochem Biophys Res Commun 2018 02 9;496(2):614-620. Epub 2018 Jan 9.
Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan; Department of Advanced Medical Innovation, St. Marianna University School of Medicine, Kanagawa, Japan. Electronic address:

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