Satish Srinivasan

Satish Srinivasan

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Satish Srinivasan

Satish Srinivasan

Publications by authors named "Satish Srinivasan"

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40Publications

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Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages.

FASEB J 2019 Aug 7;33(8):9167-9181. Epub 2019 May 7.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.201900010RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662975PMC
August 2019

Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype.

PLoS One 2018 21;13(12):e0209489. Epub 2018 Dec 21.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303035PMC
June 2019

Paediatric Peripheral Primitive Neuroectodermal Tumour - A Clinico-Pathological Study from Southern India.

J Clin Diagn Res 2017 Sep 1;11(9):EC09-EC12. Epub 2017 Sep 1.

Associate Professor, Department of Radiation Oncology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.7860/JCDR/2017/26486.10593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713736PMC
September 2017

Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.

Biochim Biophys Acta Bioenerg 2017 Aug 16;1858(8):602-614. Epub 2017 Jan 16.

The Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, #189E, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487289PMC
August 2017

Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.

Biochim Biophys Acta Bioenerg 2017 Jul 23;1858(7):519-528. Epub 2017 Apr 23.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507603PMC
July 2017

Desmoplastic Ameloblastoma Arising in a Dentigerous Cyst - A Case Report and Discussion.

J Clin Diagn Res 2016 Aug 1;10(8):ZD38-40. Epub 2016 Aug 1.

Dental Surgeon, Mar Timotheus Charitable Hospital , Thrissur, Kerala, India .

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http://dx.doi.org/10.7860/JCDR/2016/20013.8362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028469PMC
August 2016

ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.

Am J Cancer Res 2016 15;6(4):781-96. Epub 2016 Mar 15.

Gastroenterology Division, Department of Medicine, University of Pennsylvania Perelman School of MedicinePhiladelphia, PA, USA; University of Pennsylvania Abramson Cancer CenterPhiladelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859883PMC
May 2016

Mitochondrial respiratory defects promote the Warburg effect and cancer progression.

Mol Cell Oncol 2016 Mar 10;3(2):e1085120. Epub 2015 Dec 10.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/23723556.2015.1085120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905388PMC
March 2016

Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene.

Ann N Y Acad Sci 2016 Jan 18;1364:52-61. Epub 2015 Mar 18.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/nyas.12709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575226PMC
January 2016

Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis.

Genom Data 2015 Dec 14;6:99-107. Epub 2015 Aug 14.

The Department of Biomedical Sciences, School of Veterinary Medicines, University of Pennsylvania, PA, United States.

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http://dx.doi.org/10.1016/j.gdata.2015.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664720PMC
December 2015

LocSigDB: a database of protein localization signals.

Database (Oxford) 2015 27;2015. Epub 2015 Feb 27.

Department of Genetics, Cell Biology and Anatomy, Bioinformatics and Systems Biology Core, Department of Biochemistry and Molecular Biology, Fred and Pamela Buffet Cancer Center and Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA Department of Genetics, Cell Biology and Anatomy, Bioinformatics and Systems Biology Core, Department of Biochemistry and Molecular Biology, Fred and Pamela Buffet Cancer Center and Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA Department of Genetics, Cell Biology and Anatomy, Bioinformatics and Systems Biology Core, Department of Biochemistry and Molecular Biology, Fred and Pamela Buffet Cancer Center and Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA Department of Genetics, Cell Biology and Anatomy, Bioinformatics and Systems Biology Core, Department of Biochemistry and Molecular Biology, Fred and Pamela Buffet Cancer Center and Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA Department of Genetics, Cell Biology and Anatomy, Bioinformatics and Systems Biology Core, Department of Biochemistry and Molecular Biology, Fred and Pamela Buffet Cancer Center and Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA

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https://academic.oup.com/database/article-lookup/doi/10.1093
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http://dx.doi.org/10.1093/database/bav003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343182PMC
September 2015

Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.

J Biol Chem 2014 Oct 26;289(43):29614-30. Epub 2014 Aug 26.

From the Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and

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http://dx.doi.org/10.1074/jbc.M114.583062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207977PMC
October 2014

Oxidative stress induced mitochondrial protein kinase A mediates cytochrome c oxidase dysfunction.

PLoS One 2013 10;8(10):e77129. Epub 2013 Oct 10.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077129PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795003PMC
June 2014

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.

Proc Natl Acad Sci U S A 2013 Jul 17;110(27):11115-20. Epub 2013 Jun 17.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19147, USA.

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http://dx.doi.org/10.1073/pnas.1220919110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704019PMC
July 2013

Mining for class-specific motifs in protein sequence classification.

BMC Bioinformatics 2013 Mar 15;14:96. Epub 2013 Mar 15.

Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198-5145, USA.

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http://dx.doi.org/10.1186/1471-2105-14-96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610217PMC
March 2013

Cytochrome c oxidase dysfunction in oxidative stress.

Free Radic Biol Med 2012 Sep 25;53(6):1252-63. Epub 2012 Jul 25.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436951PMC
September 2012

Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.

J Biol Chem 2012 May 6;287(19):15284-97. Epub 2012 Mar 6.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M111.314062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346148PMC
May 2012

Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.

Cancer Res 2012 Feb 6;72(4):1001-12. Epub 2011 Dec 6.

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-11-0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867810PMC
February 2012

Role of mitochondrial reactive oxygen species in osteoclast differentiation.

Ann N Y Acad Sci 2010 Mar;1192:245-52

Department of Animal Biology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05377.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856121PMC
March 2010

Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease.

Mol Cell 2008 Oct;32(1):32-42

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743273PMC
October 2008

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers.

Free Radic Biol Med 2008 Mar 4;44(5):835-46. Epub 2007 Dec 4.

Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692199PMC
March 2008

Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.

Dev Dyn 2008 Jan;237(1):51-61

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/dvdy.21379DOI Listing
January 2008

Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling.

Proc Natl Acad Sci U S A 2008 Jan 2;105(1):186-91. Epub 2008 Jan 2.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0706183104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224183PMC
January 2008

Hypoxia-mediated mitochondrial stress in RAW264.7 cells induces osteoclast-like TRAP-positive cells.

Ann N Y Acad Sci 2007 Nov;1117:51-61

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1196/annals.1402.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446731PMC
November 2007

Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress.

J Biol Chem 2007 May 13;282(19):14536-46. Epub 2007 Mar 13.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M611693200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800738PMC
May 2007

Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.

J Biol Chem 2006 Jan 22;281(4):2061-70. Epub 2005 Nov 22.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M507741200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271455PMC
January 2006