Publications by authors named "Sascha Gutmann"

16Publications

Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.

ACS Med Chem Lett 2019 Oct 6;10(10):1467-1472. Epub 2019 Sep 6.

Global Discovery Chemistry, Autoimmunity, Transplantation & Inflammation, Chemical Biology & Therapeutics, and PK Sciences, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792172PMC
October 2019

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.

ACS Med Chem Lett 2017 Sep 25;8(9):975-980. Epub 2017 Aug 25.

Global Discovery Chemistry, PK Sciences, Chemical Biology and Therapeutics, and Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601375PMC
September 2017

Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.

ACS Med Chem Lett 2016 Aug 2;7(8):762-7. Epub 2016 Jun 2.

Global Discovery Chemistry, Center for Proteomic Chemistry, Metabolism and Pharmacokinetics, Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research , Novartis Campus, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983741PMC
August 2016

Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors.

J Med Chem 2016 08 17;59(16):7544-60. Epub 2016 Aug 17.

Global Discovery Chemistry, ‡Analytical Sciences, §Center for Proteomic Chemistry, ∥Preclinical Safety, and ⊥Autoimmunity Transplantation Inflammation, Novartis Institutes for BioMedical Research , CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00598DOI Listing
August 2016

BMX and its role in inflammation, cardiovascular disease, and cancer.

Int Rev Immunol 2012 Apr;31(2):166-73

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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http://www.tandfonline.com/doi/full/10.3109/08830185.2012.66
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http://dx.doi.org/10.3109/08830185.2012.663838DOI Listing
April 2012

Origin and temperature dependence of radiation damage in biological samples at cryogenic temperatures.

Proc Natl Acad Sci U S A 2010 Jan 28;107(3):1094-9. Epub 2009 Dec 28.

Paul Scherrer Institut, Swiss Light Source, CH-5232 Villigen, Switzerland.

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http://dx.doi.org/10.1073/pnas.0905481107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798883PMC
January 2010

A new aspect of specific radiation damage: hydrogen abstraction from organic molecules.

J Synchrotron Radiat 2009 Mar 25;16(Pt 2):183-90. Epub 2009 Feb 25.

HASYLAB-DESY, Notkestrasse 85, D-22607 Hamburg, Germany.

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http://journals.iucr.org/s/issues/2009/02/00/xh0004/xh0004.p
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http://scripts.iucr.org/cgi-bin/paper?S0909049509002192
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http://dx.doi.org/10.1107/S0909049509002192DOI Listing
March 2009

Structural basis of enzyme encapsulation into a bacterial nanocompartment.

Nat Struct Mol Biol 2008 Sep;15(9):939-47

ETH Zurich, Institute of Molecular Biology and Biophysics, Schafmattstrasse 20, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nsmb.1473DOI Listing
September 2008

The molecular organization of cypovirus polyhedra.

Nature 2007 Mar;446(7131):97-101

School of Biological Sciences, University of Auckland, 1010, New Zealand.

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http://dx.doi.org/10.1038/nature05628DOI Listing
March 2007

Dial tm for rescue: tmRNA engages ribosomes stalled on defective mRNAs.

Curr Opin Struct Biol 2004 Feb;14(1):58-65

Institute for Pharmaceutical Chemistry, Philipps University Marburg, Germany.

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http://dx.doi.org/10.1016/j.sbi.2004.01.010DOI Listing
February 2004

Crystal structure of the transfer-RNA domain of transfer-messenger RNA in complex with SmpB.

Nature 2003 Aug;424(6949):699-703

Institut für Molekularbiologie und Biophysik, Eidgenössische Technische Hochschule Hönggerberg (ETH Zürich), HPK Gebäude, CH-8093 Zürich, Switzerland.

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http://dx.doi.org/10.1038/nature01831DOI Listing
August 2003