Publications by authors named "Sarita Beri"

23 Publications

  • Page 1 of 1

Arteritic anterior ischaemic optic neuropathy: An update.

Eur J Ophthalmol 2021 Apr 23:11206721211009447. Epub 2021 Apr 23.

Department of Ophthalmology, Lady Hardinge Medical College and Associated Hospitals, University of Delhi, New Delhi, India.

Ischaemic optic neuropathy (ION) is a major cause of blindness. The clinical approach and management is a matter of debate for the treating neurologist and the ophthalmologist. Of the two broad varieties namely the posterior (PION) and anterior ischaemic optic neuropathy (AION), the arteritic variety of the AION (AAION) is usually due to giant cell arteritis. Giant cell arteritis may only present with visual loss in up to 25% of cases. AAION is a neuro-ophthalmic emergency. Early recognition and differentiation from AAION is imperative in order to prevent further devastating visual loss. A literature search was conducted on pubmed using key words as AAION, arteritic anterior ischaemic optic neuropathy, giant cell arteritis (GCA) and articles from the year 2000 till date were included. In any case very few reviews are available on AAION. The literature search on pubmed provided holistic overview about this clinical significant entity and the same is compiled in this review. Moreover the histopathologic features of a temporal artery biopsy have been described with its microscopic images. In any case reviews are mostly available on the Non arteritic variety of AION. This review recapitulates the diagnostic and management protocol of a patient presenting with AAION.
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http://dx.doi.org/10.1177/11206721211009447DOI Listing
April 2021

Sub-internal limiting membrane haemorrhage following pancytopenia in megaloblastic anemia.

Clin Exp Optom 2021 Jul 1;104(5):653-655. Epub 2021 Mar 1.

Department of Ophthalmology, Lady Hardinge Medical College and Associated SSKH and KSC Hospital, University of Delhi, New Delhi, India.

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http://dx.doi.org/10.1080/08164622.2021.1878842DOI Listing
July 2021

Conjunctivitis in Novel Coronavirus Disease (COVID-19).

Indian J Occup Environ Med 2020 May-Aug;24(2):129-130. Epub 2020 Aug 19.

Department of Ophthalmology, Lady Hardinge Medical College and Associated Hospitals, University of Delhi, New Delhi, India.

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http://dx.doi.org/10.4103/ijoem.IJOEM_85_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703821PMC
August 2020

Role of povidone iodine in ophthalmic clinical practice amidst COVID-19 pandemic.

Eur J Ophthalmol 2021 01 3;31(1):NP1-NP3. Epub 2020 Nov 3.

Department of Ophthalmology, Lady Hardinge Medical College, New Delhi, India.

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http://dx.doi.org/10.1177/1120672120969610DOI Listing
January 2021

Metastatic subretinal abscess in a patient with perinephric abscess.

Indian J Ophthalmol 2020 Nov;68(11):2580-2582

Department of Ophthalmology, Lady Hardinge Medical College and Associated Hospitals, University of Delhi, New Delhi, India.

An 80-year-old lady with uncontrolled type 2 diabetes developed fever and abdominal pain followed by a sudden diminution of vision in her left eye. Right infra-renal abscess accounted for abdominal pain. A metastatic left subretinal abscess was diagnosed subsequently. Medical management for her systemic condition initiated. Vitreous biopsy was performed along-with intravitreal antibiotic administration. Because of no clinical recovery, patient underwent pars plana vitrectomy. Prompt systemic stabilization and a timely surgical intervention in the left eye resulted in a satisfactory visual gain. Metastatic subretinal abscess following a perinephric abscess is rare phenomenon and only a few cases are reported to date.
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http://dx.doi.org/10.4103/ijo.IJO_1369_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774150PMC
November 2020

Effect of metformin and insulin combination on monocyte chemoattractant protein-1 and cathepsin-D in type 2 diabetes mellitus.

Diabetes Metab Syndr 2020 Nov-Dec;14(6):1703-1710. Epub 2020 Aug 25.

Department of Pharmacology, Lady Hardinge Medical College & Smt. S.K. Hospital, New Delhi, 110 001, India. Electronic address:

Background And Aims: Monocyte chemoattractant protein-1 (MCP-1) and cathepsin-D are progressively raised in type 2 diabetes mellitus (T2DM) with both non proliferative and proliferative retinal disease. This study aimed to evaluate the effect of antidiabetic medications on MCP-1 and cathepsin-D.

Methods: 60 patients of T2DM without retinopathy and 60 of diabetic retinopathy were enrolled to receive metformin (500 mg-1000 mg) combined with either glimepiride (1 mg-2 mg) or insulin. The effect of antidiabetic medications on serum MCP-1 and cathepsin-D was assessed.

Results: Mean MCP-1 (pg/ml) and cathepsin-D (ng/ml) levels were significantly lower in patients of T2DM with and without retinopathy treated with metformin + insulin (468.52 ± 272.84 vs 234.30 ± 180.58; p < 0.01 and 460.15 ± 128.52 vs 517.33 ± 213.49; p = 0.214) as compared to patients treated with metformin + glimepiride (1434.02 ± 105.27 vs 1256.27 ± 76.76; p < 0.01 and 1689.36 ± 752.57 vs 919.69 ± 675.05; p = < 0.01). No significant correlation of MCP-1 and cathepsin-D with HbA1c, fasting and post prandial blood glucose were found.

Conclusion: Patients treated with metformin and insulin combination had lower serum MCP-1 and cathepsin-D levels which suggests that this combination may be more effective in reducing the progression of diabetic retinopathy. (CTRI/2018/05/013601).
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http://dx.doi.org/10.1016/j.dsx.2020.08.016DOI Listing
August 2020

Central corneal thickness and corneal diameter in preterm and term newborns and preterm neonates at term.

Indian J Ophthalmol 2019 10;67(10):1575-1578

Department of Ophthalmology, Lady Hardinge Medical College, New Delhi, India.

Purpose: To record central corneal thickness and corneal diameter in preterm and term newborns within first week of their birth and in preterm neonates at term age.

Methods: Babies born at ≤34 weeks of gestation period (n = 100), term babies who have a gestation period of >37 weeks (n = 100) and preterm neonates at term age (38-42 weeks) who were born at ≤34 weeks (n = 100) were included in this hospital based observational descriptive study. Corneal diameter was taken by Castroviejo Calipers. Central corneal thickness was measured using portable ultrasonic pachymeter (Pachette 3). Refractive status of the eyes was measured using streak Wellch Allyn retinoscope under cyclopentolate cycloplegia.

Results: Measure of central corneal thickness and corneal diameter in preterm newborns was found to be 633.5 ± 2.8 μm and 8.1 ± 0.6 mm, in full term newborns it was 555.1 ± 2.7 μm and 9.5 ± 0.6 mm, and in preterm neonates at term age, it was 563.5 ± 2.5 μm and 9.6 ± 0.5 mm, respectively. Mean central corneal thickness was found to be more in preterm newborns 633.5 um then term newborns 555.1 um and the difference was statistically significant (P =0.001). Mean corneal diameter was found to be maximum (9.6 mm) in preterm neonates at term age.

Conclusion: Preterm babies have thick corneas and small corneal diameters. This study is useful with respect to the analysis of glaucoma in children and using preterm corneas as donor corneas in penetrating keratoplasty.
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http://dx.doi.org/10.4103/ijo.IJO_1988_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786215PMC
October 2019

Cerebral Palsy in North Indian Children: Clinico-etiological Profile and Comorbidities.

J Pediatr Neurosci 2019 Jan-Mar;14(1):30-35

Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India.

Aims And Objectives: Cerebral palsy (CP) is a common motor disability in children. This study aimed at elaborating various comorbidities and etiologies and also at correlating motor disability with other disabilities.

Material And Methods: This hospital-based study was conducted in the outpatient department of a tertiary care hospital in Delhi on 160 children with CP in the age group 2-15 years. A detailed history taking and examination were conducted for each patient and appropriate investigations were performed.

Results: Most patients, that is 64.4%, were younger than 5 years of age and 72.5% were males. Most common etiology was birth asphyxia (41.9%). Maximum patients were of bilateral spastic (spastic quadriplegic) CP accounting 43.1%. Intellectual disability was the most common comorbidity across all subtypes of CP followed by epilepsy. Comorbidities such as epilepsy and all visual problems except optic atrophy were more common in spastic quadriplegic CP. Hearing, speech impairment, and optic atrophy were more common in dyskinetic CP. Chewing, swallowing, and drooling problems were more common in spastic quadriplegic CP.

Conclusion: Most common risk factor of CP is birth asphyxia; thus, by improving health care facilities, its incidence can be reduced. CP affects not only motor functions but also other important functions of body as well, and the more severe the motor disabilities, the more are other comorbidities and their intensity also increases with that of the intensity of brain insult.
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http://dx.doi.org/10.4103/jpn.JPN_46_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601115PMC
July 2019

Sonographic Assessment of Optic Disc Cupping and its Diagnostic Performance in Glaucoma.

J Glaucoma 2019 02;28(2):131-138

All India Institute of Medical Sciences, Bhopal.

Purpose: The purpose of this study was to assess the optic cup diameter sonographically in glaucoma patients and in the normal population and correlate it with their photographic parameters to propose a cut-off value as a predictive index of glaucoma.

Methods: A total of 95/50 primary open-angle glaucoma and 87/44 control patients with clear media underwent visual field assessment, fundus photography, and B-scan ultrasound. Photographic vertical cup diameter (PVCD) of cases and controls were recorded after magnification correction using the Bengtsson formula. Sonographic vertical cup diameter (SVCD) was measured in the vertical transverse position.

Results: The mean SVCD was 1.13±0.23 mm in glaucoma and 0.72±0.25 mm in controls (P=0.001). The mean PVCD was 1.024±0.199 mm in glaucoma and 0.636±0.217 mm in controls (P=0.001). A strong correlation between PVCD and SVCD in both groups was found (correlation coefficient r=0.857; P=0.001; glaucoma and r=0.795; P=0.001; control). SVCD had a positive correlation with vertical cup disc ratio (r=0.675; P=0.001 in glaucoma patients) and (r=0.797; P=0.001 in controls) cup area (r=0.798; P=0.001; glaucoma) and (r=0.727, P=0.001; control) a negative correlation with vertical neuroretinal rim diameter (r=-0.5187; P=0.000; glaucoma patients) and (r=-0.699; P=0.001; controls). No correlation of SVCD was found with severity of field grade changes. The receiving operative curve analysis was performed, and Youden's optimal cut-off method was used to find a cut-off value for SVCD, which came out to be 1.06, with 65.3% (95% confidence interval, 54.8-74.7) sensitivity and 94.3% (95% confidence interval, 87.1-97.1) specificity.

Conclusions: The sonographic evaluation of the optic cup is a reliable noninvasive procedure and a potentially useful tool in the assessment of nonviewable suspected glaucomatous cups.
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http://dx.doi.org/10.1097/IJG.0000000000001123DOI Listing
February 2019

: An emerging entity for cluster endophthalmitis.

Indian J Ophthalmol 2017 Nov;65(11):1166-1171

Department of Ophthalmology, Lady Hardinge Medical College, New Delhi, India.

Purpose: This was a study of acute cluster endophthalmitis along with clinical features, culture results, and visual outcomes of 10 eyes of 10 patients after intravitreal injection of Avastin (bevacizumab) in one sitting from a single vial.

Methods: Retrospective review of intravitreal injection of 1.25 mg/0.05 ml bevacizumab that was given to 10 eyes of 10 patients on the same day from a freshly opened vial. All patients manifested with endophthalmitis the next day. Vitreous tap for direct smear and culture was done. Intravitreal antibiotics and steroids were injected and appropriate treatment begun. The injection vial of the same batch was sent for VITEKTM identification and antimicrobial susceptibility of isolates.

Results: Endophthalmitis presented within 24 h of intravitreal injection. There was a remarkable absence of posterior pupillary synechia. Two cases were culture-positive (20%), showing pseudomonoid growth. The vial of the same batch revealed a pseudomonoid bacilli Stenotrophomonas maltophilia using VITEKTM, which was resistant to multiple drugs. Hence, the contaminated vial was identified as the source of infection in our case. Among 10 patients, two underwent pars plana vitrectomy. Visual acuity returned to preendophthalmitis levels in 9/10 eyes after 1 month. One patient was lost to follow-up. Late complications included retinal detachment in one case and neovascular glaucoma in another.

Conclusion: Early recognition and treatment are key factors in improving outcomes. Causative etiology could be microbial contamination of the drug vial. S. maltophilia should be considered a pathogenic organism of postintravitreal endophthalmitis.
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http://dx.doi.org/10.4103/ijo.IJO_314_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700586PMC
November 2017

Bitot spot: early marker for avoidable blindness.

CMAJ 2017 10;189(40):E1264

Department of Ophthalmology, Lady Hardinge Medical College and Associated Smt. Sucheta Kriplani Hospital & Kalawati Saran Children's Hospital, University of Delhi, New Delhi, India.

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http://dx.doi.org/10.1503/cmaj.170792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636630PMC
October 2017

Role of Serum Levels of Vascular Endothelial Growth Factor and Its Receptor in Retinopathy of Prematurity.

Iran J Pediatr 2015 Aug 24;25(4):e2373. Epub 2015 Aug 24.

Department of Biochemistry, Lady Hardinge Medical College & Associated SSK Hospital, New Delhi, India.

Background: Retinopathy of prematurity (ROP) is a disorder of developing retina of low birth weight preterm infants which can lead to blindness. One theory attributes the fibrosis seen in ROP to deregulation of vascularization in the retina. Vascular endothelial growth factor (VEGF) is one of the important mediators involved in vascularization.

Objectives: This study was carried out to assess the role of VEGF and its receptor in retinopathy of prematurity.

Patients And Methods: Around 200 preterm infants born in SSK hospital were screened at 33 - 34 weeks. These babies were followed up according to the international classification of retinopathy of prematurity (ICROP) criteria. Those infants who developed ROP at 38 - 40 weeks were enrolled in group A while an equal number of infants who did not develop ROP were included in group B. Each group comprised of 30 subjects each. Venous sampling was carried out twice, once at 33 - 34 weeks and then again at 38 - 40 weeks. VEGF and VEGF-R2 were estimated by commercially available ELISA kits.

Results: There was no statistically significant difference between the levels of VEGF and VEGF-R2 in both groups at first visit as well as the follow up visit. However, the intra-group difference was significant between the first and the final visit in VEGF and VEGF-R2 levels in the cases with ROP. In the control population, the VEGF levels were significantly lower in the follow up visit as compared to the initial visit.

Conclusions: Our study demonstrates that a significant difference is seen in the serum VEGF and VRGF-R2 in the second visit of the infants with ROP demonstrating that VEGF might be responsible for the initiation and aggravation of ROP.
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http://dx.doi.org/10.5812/ijp.2373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575799PMC
August 2015

An unusual case of posterior cerebral artery infarct in otherwise healthy man.

Oman J Ophthalmol 2014 May;7(2):106-7

Department of Ophthalmology, Lady Hardinge Medical College, New Delhi, India.

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http://dx.doi.org/10.4103/0974-620X.137180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134544PMC
May 2014

Free radical status in retinopathy of prematurity.

Indian J Clin Biochem 2012 Apr 25;27(2):196-9. Epub 2011 Dec 25.

Department of Ophthalmology, Lady Hardinge Medical College, New Delhi, India.

Retinopathy of prematurity (ROP) is a major cause of blindness in children. Free radicals are implicated in the development of this retinopathy. We studied the role of free radicals in ROP and enrolled 60 preterm neonates at 30-32 weeks age. Thirty neonates predisposed to development of ROP, were placed in study group and 30 normal neonates in control group. Malondialdehyde and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) were measured in blood spectrophotometrically. Both the groups were followed-up to 40-42 weeks age. Serum MDA levels, erythrocyte SOD and plasma GPX were significantly high in study group at 30-32 weeks as compared to control group. At follow up visit significant increase in MDA level and decrease in SOD and GPX level among the study group was seen. This disturbance in equilibrium of oxidant and antioxidant status initiates an inflammatory process in retinal tissue leading to development of ROP.
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http://dx.doi.org/10.1007/s12291-011-0180-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358377PMC
April 2012

Henoch-Schönlein purpura with uveitis: an unusual case and review of literature.

Rheumatol Int 2012 Dec 15;32(12):4057-9. Epub 2011 Sep 15.

Department of Pediatrics, Kalawati Saran Children Hospital, Lady Hardinge Medical College, New Delhi, India.

Henoch-Schönlein purpura (HSP) is a small vessel vasculitis with IgA dominant immune complex deposition. It is characterized by a triad of palpable purpura (without thrombocytopenia), abdominal pain and arthritis. Uveitis is rarely associated with HSP with only 3 cases reported in literature. All these cases were in adult population and were associated with nephritis. However, this association is not reported in paediatric age group. We are reporting a case of an 11-year-old child of recurrent HSP with uveitis.
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http://dx.doi.org/10.1007/s00296-011-2087-4DOI Listing
December 2012

Clinical spectrum of pediatric blepharokeratoconjunctivitis.

J AAPOS 2010 Dec 19;14(6):527-9. Epub 2010 Nov 19.

Department of Ophthalmology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.

Purpose: To evaluate the incidence, symptoms, clinical signs, and therapy instituted in children with blepharokeratoconjunctivitis (BKC).

Methods: In this observational, retrospective case series, we reviewed all medical records of pediatric patients presenting to the ophthalmology clinic at the Kalawati Saran Children's Hospital, New Delhi, India from 2003 to 2006. History, clinical characteristics, and treatment protocol were noted, as well as reason for presentation/referral and subsequent diagnosis.

Results: Of 5,012 pediatric patients, 615 (12%) demonstrated features of BKC. Boys were more commonly affected (62%) than girls. The mean age at presentation was 6.7 years (range, 7 months to 16 years). Lid involvement and conjunctival congestion were consistent features. Anterior (seborrheic variety) blepharitis was seen in nearly half the children (302), followed by chalazion (18%), external hordeolum (17%), ulcerative anterior blepharitis (6%), phlyctenular keratoconjunctivitis (6%), and marginal ulcerative keratitis (2%). Refractive error was evident in 521 of 615 children (85%) with BKC. All patients were treated with daily eyelid hygiene, warm compresses, and topical antibiotics. Corticosteroid drops were prescribed in 14% and oral erythromycin in 23%.

Conclusions: BKC was the commonest diagnosis at consultation among all pediatric referrals. Anterior blepharitis was more common than posterior blepharitis. Severe cases with corneal involvement accounted for only 5% of the disease spectrum.
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http://dx.doi.org/10.1016/j.jaapos.2010.09.013DOI Listing
December 2010

Bilateral optic neuritis in pediatric systemic lupus erythematosus with antiphospholipid antibody syndrome.

Indian J Pediatr 2011 Feb 30;78(2):234-6. Epub 2010 Sep 30.

Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi, 110001, India.

Bilateral optic neuritis is an extremely uncommon complication of pediatric systemic lupus erythematosus and sporadic cases are reported in the literature. The authors describe an 11-yr-old girl who presented with fever and progressively increasing pallor for 4 months, headache for 7 days, severe anemia and hepatosplenomegaly. Soon after admission, she developed rapid deterioration of vision, worsening to no perception of light with afferent pupillary defect. Fundoscopy showed bilateral optic neuritis. Investigations revealed autoimmune hemolytic anemia and thrombocytopenia. Anti-dsDNA and anti-phospholipid antibodies were positive. Magnetic resonance venography showed multiple thrombi in the cerebral venous sinuses, for which anticoagulant therapy was initiated. She was managed with intravenous methylprednisolone followed by cyclophosphamide pulse therapy for 6 months along with oral prednisolone. Though she went into remission, visual outcome has been dismal, with development of bilateral optic atrophy, and absence of perception of light.
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http://dx.doi.org/10.1007/s12098-010-0228-5DOI Listing
February 2011

Cholesterolosis Bulbi of the Anterior Chamber in Coats Disease.

J Pediatr Ophthalmol Strabismus 2009 Jun 25. Epub 2009 Jun 25.

Coats disease is characterized by the presence of cholesterol crystals and lipid-laden macrophages in the subretinal space. These cholesterol crystals may rarely be found in the anterior chamber in Coats disease, a phenomenon known as cholesterolosis bulbi. This report describes a patient with advanced Coats disease who presented with anterior chamber cholesterolosis.
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http://dx.doi.org/10.3928/01913913-20090616-04DOI Listing
June 2009

A neuroectodermal hypothesis of the cause and relationship of myopia in retinopathy of prematurity.

J Pediatr Ophthalmol Strabismus 2009 May-Jun;46(3):146-50

Lady Hardinge Medical College, D-38, Malka Ganj, New Delhi, India 110007.

Purpose: To analyze the oculometric parameters in preterm infants with and without retinopathy of prematurity (ROP) and to observe the effect of presence of ROP on development of myopia.

Methods: A prospective study of preterm infants screened for ROP. Examination included fundus examination, cycloplegic refraction, and biometric measurements at three visits.

Results: A total of 42 preterm infants were divided into two groups: preterm infants with ROP and preterm infants without ROP. Preterm infants with ROP who had myopia showed increased lens thickness with similar anterior segment lengths compared to preterm infants without ROP and preterm infants with ROP who did not have myopia.

Conclusion: Increased lens thickness in the absence of anterior segment arrest seems to be the major contributing factor for myopia in ROP.This change may be associated with altered neuroectodermal development in ROP.
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http://dx.doi.org/10.3928/01913913-20090505-05DOI Listing
June 2009

Acquired capillary hemangioma of the eyelid in a child.

J Pediatr Ophthalmol Strabismus 2009 Mar-Apr;46(2):118-9

Department of Ophthalmology, Lady Hardinge Medical College, Opp. Shivaji Stadium, Connaught Place, New Delhi 110001, India.

Acquired capillary hemangioma of the eyelid in adults is uncommon. The authors report an unusual case of acquired capillary hemangioma in a 12-year-old pubertal girl. The importance of development of such vascular lesions at puberty, due to hormonal changes and increased estrogen levels, is highlighted.
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http://dx.doi.org/10.3928/01913913-20090301-11DOI Listing
May 2009

Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial.

Indian J Physiol Pharmacol 2003 Jan;47(1):67-74

Division of Ocular Pharmacology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi-110 029.

A randomized double-masked single drop instillation clinical trial was conducted on 60 healthy volunteers divided into 3 equal groups to compare the efficacies of centbucridine and lignocaine. One eye of each volunteer was instilled with a single drop of either 0.5% centbucridine hydrochloride, 1% centbucridine hydrochloride or 4% lignocaine hydrochloride, with the other eye as an unanaesthetized control-side effects, if any, were also recorded. The onset of anaesthesia assessed both objectively and subjectively, was quickest with lignocaine 4% (P < 0.001) followed by centbucridine 0.5% and 1%. However, the period of peak activity as well as the total duration of surface anaesthesia, and also the depth of analgesia, were significantly highest with 1% centbucridine, followed by 0.5% centbucridine and 4% lignocaine respectively. Minor side effects like burning sensations were longest with 1% centbucridine--no significant adverse effects, local or systemic, were observed. Prolonged surface anaesthetic and analgesic actions of centbucridine 1% may be advantages for longer duration ophthalmic microsurgeries.
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