Dr. Sarfaraz Alam, PhD Biological Science - CSIR-Central Institute of Medicinal and Aromatic Plants

Dr. Sarfaraz Alam

PhD Biological Science

CSIR-Central Institute of Medicinal and Aromatic Plants

Lucknow, UP | India

Main Specialties: Biology, Biotechnology, Chemistry

Additional Specialties: Computational Chemical Biology

ORCID logohttps://orcid.org/0000-0002-7246-8687


Top Author

Dr. Sarfaraz Alam, PhD Biological Science - CSIR-Central Institute of Medicinal and Aromatic Plants

Dr. Sarfaraz Alam

PhD Biological Science

Introduction

I am working in the area of Biomedical Research, to full fill my vision to contribute to providing affordable healthcare to all. I want to prepare myself for further challenging studies and research in the fields of drug discovery, by applying my skills in biomedical science, chemistry, and computer modeling.
I have an experience of working with Cheminformatics and Computer-Aided Drug Design studies, i.e., structure/ligand-based drug design, QSAR, Molecular Docking, ADME, pharmacophore modeling, Molecular Dynamics, virtual screening, PK/PD data analysis and modeling, Computational Toxicology, system pharmacology studies, Cell culture & Anti-cancer Drug evaluation.

Primary Affiliation: CSIR-Central Institute of Medicinal and Aromatic Plants - Lucknow, UP , India

Specialties:

Additional Specialties:

Research Interests:


View Dr. Sarfaraz Alam’s Resume / CV

Education

Dec 2018
AcSIR (Academy of Scientific and Innovative Research)
PhD

Experience

Central Institute of Medicinal and Aromatic Plants CSIR
Young Scientist Fellow
Metabolic and Structural Biology

Publications

17Publications

453Reads

325Profile Views

51PubMed Central Citations

In vitro antiproliferative activity of glabridin derivatives and their in silico target identification.

Nat Prod Res 2018 Dec 22:1-8. Epub 2018 Dec 22.

a Medicinal Chemistry Department , CSIR-Central Institute of Medicinal and Aromatic Plants , Lucknow , India.

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http://dx.doi.org/10.1080/14786419.2018.1530228DOI Listing
December 2018
5 Reads
0.919 Impact Factor

QSAR, docking, ADMET, and system pharmacology studies on tormentic acid derivatives for anticancer activity.

J Biomol Struct Dyn 2018 Jul 2;36(9):2373-2390. Epub 2017 Aug 2.

a Metabolic & Structural Biology Department , CSIR-Central Institute of Medicinal & Aromatic Plants , Lucknow , India.

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http://dx.doi.org/10.1080/07391102.2017.1355846DOI Listing
July 2018
208 Reads
1 Citation
2.983 Impact Factor

Virtual screening, Docking, ADMET and System Pharmacology studies on Garcinia caged Xanthone derivatives for Anticancer activity.

Sci Rep 2018 Apr 3;8(1):5524. Epub 2018 Apr 3.

Metabolic & Structural Biology Department, CSIR-Central Institute of Medicinal & Aromatic Plants, P.O.-CIMAP, Lucknow, 226015, Uttar Pradesh, India.

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http://dx.doi.org/10.1038/s41598-018-23768-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883056PMC
April 2018
51 Reads
5.080 Impact Factor

3D-QSAR studies on Maslinic acid analogs for Anticancer activity against Breast Cancer cell line MCF-7.

Sci Rep 2017 07 20;7(1):6019. Epub 2017 Jul 20.

Metabolic & Structural Biology Dept., CSIR-Central Institute of Medicinal & Aromatic Plants, P.O.-CIMAP, Lucknow, 226015, (U.P.), India.

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http://dx.doi.org/10.1038/s41598-017-06131-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519539PMC
July 2017
13 Reads
5.078 Impact Factor

Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels.

Eur J Pharmacol 2017 Mar 31;799:84-93. Epub 2017 Jan 31.

Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.01.044DOI Listing
March 2017
8 Reads
2.532 Impact Factor

Synthesis of 3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)benzopyran-4-one derivatives as anticancer agents.

Bioorg Med Chem Lett 2016 11 15;26(21):5322-5327. Epub 2016 Sep 15.

Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Kukrail Road, Lucknow 226015, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.09.036DOI Listing
November 2016
20 Reads
3 Citations
2.420 Impact Factor

Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer.

Chem Biol Drug Des 2016 11 6;88(5):625-634. Epub 2016 Aug 6.

CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1111/cbdd.12805DOI Listing
November 2016
15 Reads
3 Citations
2.485 Impact Factor

Recent Advances in chemistry and pharmacology of 2-methoxyestradiol: An anticancer investigational drug.

Steroids 2016 06 26;110:9-34. Epub 2016 Mar 26.

CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2016.03.017DOI Listing
June 2016
21 Reads
7 Citations
2.640 Impact Factor

Anti-tubercular agents from Glycyrrhiza glabra.

Curr Top Med Chem 2015 ;15(11):1043-9

Medicinal Chemistry Department, CSIR-CIMAP, Lucknow-226015, India.

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May 2016
19 Reads
3 Citations
3.402 Impact Factor

Synthesis, docking and ADMET studies of novel chalcone triazoles for anti-cancer and anti-diabetic activity.

Eur J Med Chem 2015 Mar 20;93:564-73. Epub 2015 Feb 20.

Toxicology Unit, Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.

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http://dx.doi.org/10.1016/j.ejmech.2015.02.027DOI Listing
March 2015
26 Reads
6 Citations
3.450 Impact Factor

Natural antitubulin agents: importance of 3,4,5-trimethoxyphenyl fragment.

Bioorg Med Chem 2015 Feb 20;23(3):373-89. Epub 2014 Dec 20.

CSIR-Central Drug Research Institute (CSIR-CDRI), B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.

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http://dx.doi.org/10.1016/j.bmc.2014.12.027DOI Listing
February 2015
10 Reads
5 Citations
2.793 Impact Factor

QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα.

Drug Des Devel Ther 2014 31;8:183-95. Epub 2014 Jan 31.

Metabolic and Structural Biology Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.2147/DDDT.S51577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916431PMC
November 2014
4 Reads
11 Citations
3.030 Impact Factor

Synthesis of cyclic 1,9-acetal derivatives of forskolin and their bioactivity evaluation.

Eur J Med Chem 2014 Nov 7;87:735-44. Epub 2014 Oct 7.

Metabolic & Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Kukrail Picnic Spot Road, Lucknow 226015, UP, India.

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http://dx.doi.org/10.1016/j.ejmech.2014.10.013DOI Listing
November 2014
8 Reads
2 Citations
3.450 Impact Factor

Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring.

Eur J Med Chem 2013 10;70:308-14. Epub 2013 Oct 10.

Natural Product Chemistry, CSIR-Central Institute of Medicinal and Aromatic Plants-Research Centre, Boduppal, Hyderabad 500092, A.P., India.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234130064
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http://dx.doi.org/10.1016/j.ejmech.2013.10.005DOI Listing
September 2014
16 Reads
3 Citations
3.450 Impact Factor

In silico and in vivo anti-malarial studies of 18β glycyrrhetinic acid from Glycyrrhiza glabra.

PLoS One 2013 24;8(9):e74761. Epub 2013 Sep 24.

Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074761PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782471PMC
August 2014
7 Reads
4 Citations
3.234 Impact Factor

Open access Mycobacterium tuberculosis clone repository: a community resource by OSDD members

Current Science

Current Science

Mycobacterium tuberculosis (Mtb),  the causative organism of tuberculosis (TB), is often described as one of the most successful pathogens.  With the release of the complete genome sequence of Mtb, a complete and comprehensive understanding of the pathogen is eagerly anticipated, so that novel strategies for tackling the disease could be evolved.  The  Open Source  Drug  Discovery  (OSDD) initiative of the Council of Scientific and Industrial  Research  (CSIR) has conceptualized and implemented integrated platforms where innovation  in drug discovery can be taken forward through a process-oriented activity for discovering novel therapeutic strategies against TB.

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January 2013

1 Citation

Impact Factor 0.850

4 Reads

Top co-authors

Feroz Khan
Feroz Khan

CSIR-Central Institute of Medicinal and Aromatic Plants

16
Suaib Luqman
Suaib Luqman

CSIR-Central Institute of Medicinal and Aromatic Plants

4
Arvind S Negi
Arvind S Negi

CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP)

4
Jayanta Sarkar
Jayanta Sarkar

CSIR-Central Drug Research Institute

3
Debabrata Chanda
Debabrata Chanda

CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP)

3
Mohammad Hasanain
Mohammad Hasanain

CSIR-Central Drug Research Institute

2
Dushyant Singh Raghuvanshi
Dushyant Singh Raghuvanshi

CSIR-Central Institute of Medicinal and Aromatic Plants

2
Niranjan Kumar Arigari
Niranjan Kumar Arigari

CSIR-Central Institute of Medicinal and Aromatic Plants- Research Centre

2
Vijaya Dubey
Vijaya Dubey

Central Drug Research Institute

2
Santosh Kumar Srivastava
Santosh Kumar Srivastava

Central Institute of Medicinal and Aromatic Plants

2