Sarah Withey

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia.

Authors:

Abrey J Yeo Kok L Chong Magtouf Gatei Dongxiu Zou Romal Stewart Sarah Withey Ernst Wolvetang Robert G Parton Adam D Brown Michael B Kastan David Coman Martin F Lavin

iScience 2021 Jan 23;24(1):101972. Epub 2020 Dec 23.

University of Queensland Centre for Clinical Research, The University of Queensland, Herston, Brisbane, Australia.

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January 2021

Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders.

Authors:

Dave T Gerrard Andrew A Berry Rachel E Jennings Matthew J Birket Peyman Zarrineh Myles G Garstang Sarah L Withey Patrick Short Sandra Jiménez-Gancedo Panos N Firbas Ian Donaldson Andrew D Sharrocks Karen Piper Hanley Matthew E Hurles José Luis Gomez-Skarmeta Nicoletta Bobola Neil A Hanley

Nat Commun 2020 08 6;11(1):3920. Epub 2020 Aug 6.

Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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August 2020

The Intriguing Effects of Substituents in the -Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments.

Molecules 2020 Jun 6;25(11). Epub 2020 Jun 6.

Department of Health and Human Services, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3373, USA.

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June 2020

Developing Improved Translational Models of Pain: A Role for the Behavioral Scientist.

Authors:

Sarah L Withey David R Maguire Brian D Kangas

Perspect Behav Sci 2020 Mar 3;43(1):39-55. Epub 2020 Jan 3.

1Harvard Medical School, McLean Hospital, Belmont, MA USA.

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March 2020

Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses.

Authors:

Dmitry A Ovchinnikov Sarah L Withey Hannah C Leeson U Wang Lei Ashmitha Sundarrajan Keerat Junday Michelle Pewarchuk Abrey J Yeo Amanda W Kijas Martin F Lavin Ernst J Wolvetang

Hum Mol Genet 2020 04;29(6):990-1001

Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.

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April 2020

Δ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons.

Authors:

Ahmed Hasbi Bertha K Madras Jack Bergman Stephen Kohut Zhicheng Lin Sarah L Withey Susan R George

iScience 2020 Jan 24;23(1):100794. Epub 2019 Dec 24.

Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

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January 2020

Discrimination learning in oxycodone-treated nonhuman primates.

Authors:

Sarah L Withey Rachel J Doyle Erica N Porter Jack Bergman Brian D Kangas

Drug Alcohol Depend 2020 02 27;207:107778. Epub 2019 Nov 27.

Behavioral Biology Program, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address:

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February 2020

Enhancement of Opioid Antinociception by Nicotine.

Authors:

Fernando Barreto de Moura Sarah Louise Withey Jack Bergman

J Pharmacol Exp Ther 2019 12 16;371(3):624-632. Epub 2019 Sep 16.

Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (F.B.d.M., S.L.W., J.B.) and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (F.B.d.M., S.L.W., J.B.)

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December 2019

Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment.

Authors:

Sarah L Withey Roger D Spealman Jack Bergman Carol A Paronis

J Pharmacol Exp Ther 2019 11 14;371(2):544-554. Epub 2019 Aug 14.

Behavioral Biology Program, McLean Hospital/Harvard Medical School, Belmont, Massachusetts

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November 2019

Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state.

Authors:

Connor Rogerson Edward Britton Sarah Withey Neil Hanley Yeng S Ang Andrew D Sharrocks

Genome Res 2019 05 8;29(5):723-736. Epub 2019 Apr 8.

School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom.

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May 2019

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis.

Authors:

Priscila Ramos-Ibeas Fei Sang Qifan Zhu Walfred W C Tang Sarah Withey Doris Klisch Liam Wood Matt Loose M Azim Surani Ramiro Alberio

Nat Commun 2019 01 30;10(1):500. Epub 2019 Jan 30.

School of Biosciences, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, UK.

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January 2019

Involvement of Nicotinic Receptor Subtypes in the Behavioral Effects of Nicotinic Drugs in Squirrel Monkeys.

Authors:

Sarah L Withey Michelle R Doyle Jack Bergman Rajeev I Desai

J Pharmacol Exp Ther 2018 08 21;366(2):397-409. Epub 2018 May 21.

Preclinical Pharmacology Laboratory, McLean Hospital/Harvard Medical School, Belmont, Massachusetts

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August 2018

Concurrent Assessment of the Antinociceptive and Behaviorally Disruptive Effects of Opioids in Squirrel Monkeys.

Authors:

Sarah L Withey Carol A Paronis Jack Bergman

J Pain 2018 07 2;19(7):728-740. Epub 2018 Mar 2.

Preclinical Pharmacology Laboratory, McLean Hospital/Harvard Medical School, Belmont, Massachusetts.

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July 2018

Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos.

Authors:

Rachel E Jennings Andrew A Berry David T Gerrard Stephen J Wearne James Strutt Sarah Withey Mariya Chhatriwala Karen Piper Hanley Ludovic Vallier Nicoletta Bobola Neil A Hanley

Stem Cell Reports 2017 11 19;9(5):1387-1394. Epub 2017 Oct 19.

Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine & Health, AV Hill Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK; Endocrinology Department, Manchester University NHS Foundation Trust, Grafton Street, Manchester M13 9WU, UK. Electronic address:

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November 2017

Principles of early human development and germ cell program from conserved model systems.

Authors:

Toshihiro Kobayashi Haixin Zhang Walfred W C Tang Naoko Irie Sarah Withey Doris Klisch Anastasiya Sybirna Sabine Dietmann David A Contreras Robert Webb Cinzia Allegrucci Ramiro Alberio M Azim Surani

Nature 2017 06 7;546(7658):416-420. Epub 2017 Jun 7.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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June 2017

Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice.

Authors:

Sarah L Withey Rob Hill Abigail Lyndon William L Dewey Eamonn Kelly Graeme Henderson

J Pharmacol Exp Ther 2017 04 27;361(1):51-59. Epub 2017 Jan 27.

School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, United Kingdom (S.L.W., R.H., A.L., E.K., G.H.); and Virginia Commonwealth University, Richmond, Virginia (W.L.D.)

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April 2017

Nicotinic effects of tobacco smoke constituents in nonhuman primates.

Authors:

Rajeev I Desai Michelle R Doyle Sarah L Withey Jack Bergman

Psychopharmacology (Berl) 2016 05 19;233(10):1779-89. Epub 2016 Feb 19.

Preclinical Pharmacology Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA, 02478, USA.

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May 2016

Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine.

Authors:

Rob Hill Abi Lyndon Sarah Withey Joanne Roberts Yvonne Kershaw John MacLachlan Anne Lingford-Hughes Eamonn Kelly Chris Bailey Matthew Hickman Graeme Henderson

Neuropsychopharmacology 2016 Feb 14;41(3):762-73. Epub 2015 Jul 14.

School of Physiology and Pharmacology, University of Bristol, Bristol, UK.

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February 2016

Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization.

Authors:

Janet D Lowe Helen S Sanderson Alexandra E Cooke Mehrnoosh Ostovar Elena Tsisanova Sarah L Withey Charles Chavkin Stephen M Husbands Eamonn Kelly Graeme Henderson Chris P Bailey

Mol Pharmacol 2015 Aug 26;88(2):347-56. Epub 2015 May 26.

School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (J.D.L., H.S.S., A.E.C., E.T., S.L.W., E.K., G.H.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (C.C.); and Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (M.O., S.M.H., C.P.B.)

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August 2015

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.

J Hepatol 2015 Mar 18;62(3):581-9. Epub 2014 Oct 18.

Centre for Endocrinology & Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, University of Manchester, Manchester Academic Health Science Centre, AV Hill Building, Oxford Road, Manchester, UK; Endocrinology Department, Central Manchester University Hospitals NHS Foundation Trust, Grafton St, Manchester, UK. Electronic address:

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March 2015

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