Sarah Spiegel

Sarah Spiegel

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Sarah Spiegel

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The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation.

Am J Respir Crit Care Med 2019 Feb;199(4):478-488

1 National Heart and Lung Institute, Imperial College London, London, United Kingdom; and.

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https://www.atsjournals.org/doi/10.1164/rccm.201803-0438OC
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http://dx.doi.org/10.1164/rccm.201803-0438OCDOI Listing
February 2019

Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity.

Arch Pharm (Weinheim) 2019 Jan 16:e1800298. Epub 2019 Jan 16.

Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), San Luis, Argentina.

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http://doi.wiley.com/10.1002/ardp.201800298
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http://dx.doi.org/10.1002/ardp.201800298DOI Listing
January 2019

New insights into functions of the sphingosine-1-phosphate transporter SPNS2.

J Lipid Res 2019 Jan 17. Epub 2019 Jan 17.

VCU School of Medicine, United States.

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http://dx.doi.org/10.1194/jlr.S091959DOI Listing
January 2019

Niemann-Pick type C disease: The atypical sphingolipidosis.

Adv Biol Regul 2018 Dec 28;70:82-88. Epub 2018 Aug 28.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327306PMC
December 2018

Introduction to the special issue on sphingolipid signaling in chronic disease.

Adv Biol Regul 2018 Dec 14;70:1-2. Epub 2018 Nov 14.

Department of Biochemistry and Molecular Biology, Mann T. and Sara D. Lowry Chair of Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22124926183015
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http://dx.doi.org/10.1016/j.jbior.2018.11.005DOI Listing
December 2018

Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition.

Cancer Biol Ther 2018 Nov 2:1-11. Epub 2018 Nov 2.

a Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.

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http://dx.doi.org/10.1080/15384047.2018.1538616DOI Listing
November 2018

Non-alcoholic fatty liver disease: Insights from sphingolipidomics.

Biochem Biophys Res Commun 2018 Oct 21;504(3):608-616. Epub 2018 May 21.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Hunter Holmes McGuire Veteran's Affairs Medical Center, Richmond, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.05.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175671PMC
October 2018

Editorial for BBRC lipidomics special issue.

Biochem Biophys Res Commun 2018 Oct;504(3):iii

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183205
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http://dx.doi.org/10.1016/j.bbrc.2018.09.117DOI Listing
October 2018

Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era.

Adv Cancer Res 2018 19;140:327-366. Epub 2018 Jun 19.

Department of Pharmacology, University of Virginia, Charlottesville, VA, United States; University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, United States.

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http://dx.doi.org/10.1016/bs.acr.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320700PMC
June 2018

Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

Cancer Res 2018 Apr 19;78(7):1713-1725. Epub 2018 Jan 19.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1423DOI Listing
April 2018

Sphingosine kinase 1 in breast cancer.

Adv Biol Regul 2018 Jan 16;67:59-65. Epub 2017 Oct 16.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22124926173016
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http://dx.doi.org/10.1016/j.jbior.2017.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807162PMC
January 2018

Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology.

Crit Rev Biochem Mol Biol 2017 10 15;52(5):543-553. Epub 2017 Jun 15.

a Department of Biochemistry and Molecular Biology and the Massey Cancer Center , VCU School of Medicine , Richmond , VA , USA.

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http://dx.doi.org/10.1080/10409238.2017.1337706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944845PMC
October 2017

An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.

Eur J Med Chem 2017 Oct 10;139:461-481. Epub 2017 Aug 10.

Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), Chacabuco 915, 5700 San Luis, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284402PMC
October 2017

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation.

Pain 2017 Sep;158(9):1733-1742

aDepartment of Pharmacology, University of Arizona, Tucson, AZ, USA bDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, USA cDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580091PMC
September 2017

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.

J Biol Chem 2017 02 3;292(8):3074-3088. Epub 2017 Jan 3.

From the Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298

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http://dx.doi.org/10.1074/jbc.M116.762377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336145PMC
February 2017

Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods.

Heliyon 2016 Dec 22;2(12):e00219. Epub 2016 Dec 22.

Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA; Department of Surgery, University at Buffalo, The State University of New York, Jacobs School of Medicine and Biomedical Sciences, New York.

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http://dx.doi.org/10.1016/j.heliyon.2016.e00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198727PMC
December 2016

Murine model of long-term obstructive jaundice.

J Surg Res 2016 11 18;206(1):118-125. Epub 2016 Jul 18.

Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia; Division of Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2016.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142243PMC
November 2016

Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.

J Surg Res 2016 10 9;205(2):510-517. Epub 2016 Jul 9.

Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, Virginia; Breast Surgery, Roswell Park Cancer Institute, Buffalo, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2016.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656061PMC
October 2016

VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells.

Clin Cancer Res 2016 Aug 13;22(16):4249-58. Epub 2016 Apr 13.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987212PMC
August 2016

Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans.

FASEB J 2016 08 29;30(8):2945-58. Epub 2016 Apr 29.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine and the Massey Cancer Center, Richmond, Virginia, USA;

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http://dx.doi.org/10.1096/fj.201600394RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970610PMC
August 2016

ORMDL proteins regulate ceramide levels during sterile inflammation.

J Lipid Res 2016 08 16;57(8):1412-22. Epub 2016 Jun 16.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298

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http://dx.doi.org/10.1194/jlr.M065920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959857PMC
August 2016

In Memoriam: Roscoe Owen Brady (1923-2016).

J Lipid Res 2016 Aug 17. Epub 2016 Aug 17.

NIH/NIDDK, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036358PMC
http://dx.doi.org/10.1194/jlr.E071548DOI Listing
August 2016

Modified breast cancer model for preclinical immunotherapy studies.

J Surg Res 2016 08 8;204(2):467-474. Epub 2016 Jun 8.

Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and The Massey Cancer Center, Richmond, Virginia; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and The Massey Cancer Center, Richmond, Virginia; Breast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002312PMC
August 2016

Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.

J Mammary Gland Biol Neoplasia 2016 06 19;21(1-2):9-17. Epub 2016 May 19.

Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, and Massey Cancer Center, PO Box 980011, West Hospital 7-402, 1200 East Broad Street, Richmond, VA, 23298-0011, USA.

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http://dx.doi.org/10.1007/s10911-016-9354-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947521PMC
June 2016

Differential regulation of autophagy and cell viability by ceramide species.

Cancer Biol Ther 2015 ;16(5):733-42

a Department of Biochemistry and Molecular Biology; Virginia Commonwealth University ; Richmond , VA , USA.

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http://dx.doi.org/10.1080/15384047.2015.1026509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623104PMC
March 2016

Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling.

Mol Cell Biol 2016 01 9;36(2):320-9. Epub 2015 Nov 9.

Instituto Multidisciplinario de Investigaciones Biológicas San Luis (IMIBIO-SL) CONICET and Universidad Nacional de San Luis, San Luis, Argentina

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http://dx.doi.org/10.1128/MCB.00554-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719300PMC
January 2016

Sphingosine-1-phosphate and estrogen signaling in breast cancer.

Adv Biol Regul 2016 Jan 19;60:160-165. Epub 2015 Oct 19.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2015.09.006DOI Listing
January 2016

Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop.

FASEB J 2015 Dec 5;29(12):4853-65. Epub 2015 Aug 5.

*Department of Biochemistry and Molecular Biology, Department of Physiology and Biophysics, and Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

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http://www.fasebj.org/doi/10.1096/fj.15-275180
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http://dx.doi.org/10.1096/fj.15-275180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653053PMC
December 2015

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.

FASEB J 2015 Dec 31;29(12):5018-28. Epub 2015 Aug 31.

*Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, USA; and Department of Biochemistry and Molecular Biology, and Department of Surgery and Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

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http://www.fasebj.org/content/early/2015/08/31/fj.15-274936.
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http://www.fasebj.org/cgi/doi/10.1096/fj.15-274936
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http://dx.doi.org/10.1096/fj.15-274936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653056PMC
December 2015

Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

J Allergy Clin Immunol 2015 Oct 2;136(4):1035-46.e6. Epub 2015 Apr 2.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Va. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591101PMC
October 2015

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.

Exp Cell Res 2015 May 11;333(2):195-200. Epub 2015 Mar 11.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2015.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415605PMC
May 2015

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression.

Hepatology 2015 Apr 9;61(4):1216-26. Epub 2015 Mar 9.

Department of Surgery, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA; Department of Biochemistry and Molecular Biology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA; Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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http://dx.doi.org/10.1002/hep.27592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376566PMC
April 2015

Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.

J Biol Chem 2015 Mar 27;290(12):7861-70. Epub 2015 Jan 27.

From the Department of Internal Medicine, Section on Molecular Medicine, and the Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157 and

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http://dx.doi.org/10.1074/jbc.M114.631101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367285PMC
March 2015

An improved syngeneic orthotopic murine model of human breast cancer progression.

Breast Cancer Res Treat 2014 Oct 9;147(3):501-12. Epub 2014 Sep 9.

Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, West Hospital 7-402, 1200 East Broad Street, PO Box 980011, Richmond, VA, 23298-0011, USA.

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http://dx.doi.org/10.1007/s10549-014-3118-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176514PMC
October 2014

Export of sphingosine-1-phosphate and cancer progression.

J Lipid Res 2014 Sep 28;55(9):1839-46. Epub 2014 Jan 28.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, VA 23298.

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http://dx.doi.org/10.1194/jlr.R046656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617347PMC
September 2014

Lysophospholipid receptor nomenclature review: IUPHAR Review 8.

Br J Pharmacol 2014 Aug 12;171(15):3575-94. Epub 2014 Jul 12.

Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/bph.12678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128058PMC
August 2014

A real-time high-throughput fluorescence assay for sphingosine kinases.

J Lipid Res 2014 07 2;55(7):1525-30. Epub 2014 May 2.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298.

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http://dx.doi.org/10.1194/jlr.D048132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076073PMC
July 2014

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Nat Neurosci 2014 Jul 25;17(7):971-80. Epub 2014 May 25.

1] Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. [2] Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

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http://dx.doi.org/10.1038/nn.3728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256678PMC
July 2014

Sphingolipid metabolites in inflammatory disease.

Nature 2014 Jun;510(7503):58-67

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1038/nature13475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320971PMC
June 2014

Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.

Adv Biol Regul 2014 Jan 16;54:112-20. Epub 2013 Oct 16.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2013.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946530PMC
January 2014

The potential of histone deacetylase inhibitors in Niemann - Pick type C disease.

FEBS J 2013 Dec 23;280(24):6367-72. Epub 2013 Sep 23.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

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http://dx.doi.org/10.1111/febs.12505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857996PMC
December 2013

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.

Nat Rev Drug Discov 2013 Sep 19;12(9):688-702. Epub 2013 Aug 19.

1] Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, 2-017 Sanger Hall, Richmond, Virginia 23298, USA. [2].

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http://dx.doi.org/10.1038/nrd4099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908769PMC
September 2013

Is tail vein injection a relevant breast cancer lung metastasis model?

J Thorac Dis 2013 Aug;5(4):385-92

Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, and the Massey Cancer Center Richmond, Virginia, USA.

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http://dx.doi.org/10.3978/j.issn.2072-1439.2013.06.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755653PMC
August 2013

Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate.

PLoS One 2013 11;8(1):e53927. Epub 2013 Jan 11.

Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543313PMC
July 2013

Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden.

Surgery 2013 Jun 13;153(6):771-8. Epub 2013 Mar 13.

Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298-0011, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S003960601300054
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http://dx.doi.org/10.1016/j.surg.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664113PMC
June 2013

Sphingosine kinase: a closer look at last.

Structure 2013 May;21(5):690-2

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.str.2013.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711075PMC
May 2013

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.

FASEB J 2013 Mar 24;27(3):1001-11. Epub 2012 Nov 24.

Department of Biochemistry and Molecular Biology, VCU School of Medicine, 1101 E. Marshall St., 2011 Sanger Hall, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1096/fj.12-219618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574288PMC
March 2013

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

J Allergy Clin Immunol 2013 Feb 30;131(2):501-11.e1. Epub 2012 Aug 30.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Va 23298-0614, USA.

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http://dx.doi.org/10.1016/j.jaci.2012.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563730PMC
February 2013

Structure of the first sphingosine 1-phosphate receptor.

Sci Signal 2012 May 22;5(225):pe23. Epub 2012 May 22.

Department of Chemistry, The University of Memphis, 213 Smith Chemistry Building, Memphis, TN 38152, USA.

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http://dx.doi.org/10.1126/scisignal.2003160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632326PMC
May 2012

Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

Cancer Res 2012 Feb;72(3):726-35

Division of Surgical Oncology, Department of Biochemistry and Molecular Biology, and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289261PMC
February 2012

Sphingosine-1-phosphate signaling and its role in disease.

Trends Cell Biol 2012 Jan 14;22(1):50-60. Epub 2011 Oct 14.

Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.tcb.2011.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253987PMC
January 2012

Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.

Pharmacol Ther 2011 Dec 27;132(3):352-60. Epub 2011 Aug 27.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2011.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205210PMC
December 2011

Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.

J Biol Chem 2011 Dec 3;286(52):44380-90. Epub 2011 Nov 3.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1074/jbc.M111.257519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247960PMC
December 2011

Targeting sphingosine-1-phosphate in hematologic malignancies.

Anticancer Agents Med Chem 2011 Nov;11(9):794-8

Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, 23298-0614, USA.

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November 2011

A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.

Basic Res Cardiol 2011 Nov 15;106(6):1341-53. Epub 2011 Oct 15.

Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1007/s00395-011-0223-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368250PMC
November 2011

The outs and the ins of sphingosine-1-phosphate in immunity.

Nat Rev Immunol 2011 Jun 6;11(6):403-15. Epub 2011 May 6.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1038/nri2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368251PMC
June 2011

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.

Pharmacol Rev 2010 Dec;62(4):579-87

Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://pharmrev.aspetjournals.org/cgi/doi/10.1124/pr.110.003
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http://dx.doi.org/10.1124/pr.110.003111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993255PMC
December 2010

Extracellular and intracellular actions of sphingosine-1-phosphate.

Adv Exp Med Biol 2010 ;688:141-55

Department of Biochemistry and Molecular Biology, VCU School of Medicine, 1101 E. Marshall Street, 2-011 Sanger Hall, Richmond, Virginia 23298, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951632PMC
November 2010

Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.

FEBS Lett 2010 Sep 7;584(18):4077-82. Epub 2010 Sep 7.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1016/j.febslet.2010.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947956PMC
September 2010

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Nature 2010 Jun;465(7301):1084-8

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1038/nature09128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946785PMC
June 2010

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

J Biol Chem 2010 Apr 28;285(14):10477-86. Epub 2010 Jan 28.

From the Division of Surgical Oncology, Massey Cancer Center, Virginia Commonwealth University School ofMedicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1074/jbc.M109.064162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856255PMC
April 2010

Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.

J Cell Physiol 2010 Mar;222(3):546-55

Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.

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http://dx.doi.org/10.1002/jcp.21969DOI Listing
March 2010

Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema.

J Exp Med 2010 Mar 1;207(3):465-74. Epub 2010 Mar 1.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1084/jem.20091513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839150PMC
March 2010

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.

Cancer Res 2010 Feb 26;70(3):1120-9. Epub 2010 Jan 26.

Department of Biochemistry and Molecular Biology, VCU Institute of Molecular Medicine, Neurosurgery, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298-0035, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890071PMC
February 2010

Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma.

Immunol Cell Biol 2009 Nov-Dec;87(8):601-5. Epub 2009 Jun 23.

Department of Biochemistry and Molecular Biology, Victorial Johnson Center for Obstructive Pulmonary Disease Research, Virginia Commonwealth University, Richmond, 23298, USA.

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http://doi.wiley.com/10.1038/icb.2009.45
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850593PMC
January 2010

Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.

FASEB J 2009 Oct 17;23(10):3506-15. Epub 2009 Jun 17.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, 1101 E. Marshall St., Richmond, VA 23298, USA.

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http://dx.doi.org/10.1096/fj.08-128900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236593PMC
October 2009

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

Science 2009 Sep;325(5945):1254-7

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1176709
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850596PMC
September 2009

Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.

J Neurochem 2009 Aug 31;110(4):1191-202. Epub 2009 May 31.

Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06202.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754148PMC
August 2009

Export and functions of sphingosine-1-phosphate.

Biochim Biophys Acta 2009 Jul 4;1791(7):692-6. Epub 2009 Mar 4.

Division of Surgical Oncology, Department of Surgery and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1016/j.bbalip.2009.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763566PMC
July 2009

Sphingosine-1-phosphate synthesis and functions in mast cells.

Future Lipidol 2008 Dec;3(6):665-674

Department of Biochemistry & Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA, Tel.: +1 804 828 9332.

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http://dx.doi.org/10.2217/17460875.3.6.665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749270PMC
December 2008