Publications by authors named "Sarah R Walker"

34Publications

CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.

Neoplasia 2020 01 22;22(1):47-59. Epub 2019 Nov 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881650PMC
January 2020

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

Nature 2019 09 28;573(7772):139-143. Epub 2019 Aug 28.

Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1511-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728214PMC
September 2019

The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.

Neoplasia 2018 05 2;20(5):489-498. Epub 2018 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916089PMC
May 2018

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Cell Discov 2016 20;2:16030. Epub 2016 Sep 20.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/celldisc.2016.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029543PMC
September 2016

Targeting BCL6 and STAT3 in triple negative breast cancer: the one-two punch?

Oncoscience 2015 21;2(11):912. Epub 2015 Nov 21.

Department of Medical Oncology, Dana-Farber Cancer Institute and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675785PMC
http://dx.doi.org/10.18632/oncoscience.270DOI Listing
December 2015

Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.

Genes Cancer 2015 Mar;6(3-4):153-68

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA ; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://www.impactjournals.com/genesandcancer/index.php?abs=5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426952PMC
http://dx.doi.org/10.18632/genesandcancer.58DOI Listing
March 2015

Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation.

J Immunol 2015 Apr 27;194(7):3180-90. Epub 2015 Feb 27.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1401635
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http://dx.doi.org/10.4049/jimmunol.1401635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369449PMC
April 2015

STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.

Cancers (Basel) 2014 Apr 23;6(2):958-68. Epub 2014 Apr 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/cancers6020958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074811PMC
April 2014

Fold change of nuclear NF-κB determines TNF-induced transcription in single cells.

Mol Cell 2014 Mar 13;53(6):867-79. Epub 2014 Feb 13.

Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977799PMC
March 2014

Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2.

Mol Cancer Ther 2014 May 16;13(5):1194-205. Epub 2014 Jan 16.

Authors' Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and Department of Immunology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013223PMC
May 2014

Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets.

JAKSTAT 2012 Oct;1(4):292-9

Department of Medical Oncology; Dana-Farber Cancer Institute; and Department of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/jkst.22662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670287PMC
October 2012

STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.

Mol Cell Biol 2013 Aug 28;33(15):2879-90. Epub 2013 May 28.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1128/MCB.01620-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719667PMC
August 2013

Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer.

Mol Cell Endocrinol 2014 Jan 24;382(1):616-621. Epub 2013 Mar 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732813PMC
January 2014

STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents.

Mol Cell Pharmacol 2011 Jan;3(1):13-19

Department of Medical Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177107PMC
January 2011

Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.

Mol Pharmacol 2010 Nov 6;78(5):903-8. Epub 2010 Aug 6.

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1124/mol.110.066316DOI Listing
November 2010

Reciprocal effects of STAT5 and STAT3 in breast cancer.

Mol Cancer Res 2009 Jun 2;7(6):966-76. Epub 2009 Jun 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://mcr.aacrjournals.org/content/early/2009/05/31/1541-77
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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-08
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http://dx.doi.org/10.1158/1541-7786.MCR-08-0238DOI Listing
June 2009

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

J Biol Chem 2006 Sep 13;281(36):26216-24. Epub 2006 Jul 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M605001200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427032PMC
September 2006

Neural substrates for motor imagery in severe hemiparesis.

Neurorehabil Neural Repair 2006 Jun;20(2):268-77

Program in Physical Therapy, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1177/1545968306286958DOI Listing
June 2006

Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.

J Biol Chem 2004 Dec 20;279(52):54724-30. Epub 2004 Oct 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M408464200DOI Listing
December 2004

Electrical wound-healing assay for cells in vitro.

Proc Natl Acad Sci U S A 2004 Feb 27;101(6):1554-9. Epub 2004 Jan 27.

School of Science, Rensselaer Polytechnic Institute, 8th Street, Troy, NY 12180, USA.

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http://dx.doi.org/10.1073/pnas.0307588100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC341773PMC
February 2004