Sarah Nutland

Sarah Nutland

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Sarah Nutland

Sarah Nutland

Publications by authors named "Sarah Nutland"

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Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).

Trials 2015 Mar 11;16:86. Epub 2015 Mar 11.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1186/s13063-015-0583-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369347PMC
March 2015

Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.

J Immunol 2014 Jul 13;193(2):889-900. Epub 2014 Jun 13.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1303389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082723PMC
July 2014

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

Diabetologia 2014 Feb 22;57(2):366-72. Epub 2013 Nov 22.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0XY, UK.

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http://link.springer.com/10.1007/s00125-013-3113-8
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http://dx.doi.org/10.1007/s00125-013-3113-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890035PMC
February 2014

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

J Immunol 2013 Mar 15;190(6):2554-66. Epub 2013 Feb 15.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1202914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614027PMC
March 2013

Evidence of association with type 1 diabetes in the SLC11A1 gene region.

BMC Med Genet 2011 Apr 27;12:59. Epub 2011 Apr 27.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1186/1471-2350-12-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114708PMC
April 2011

Reduced expression of IFIH1 is protective for type 1 diabetes.

PLoS One 2010 Sep 9;5(9). Epub 2010 Sep 9.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936573PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012646PLOS
September 2010

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

Nat Genet 2009 Sep 23;41(9):1011-5. Epub 2009 Aug 23.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, UK.

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http://www.nature.com/articles/ng.434
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http://dx.doi.org/10.1038/ng.434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749506PMC
September 2009

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:
Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng.2007.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680141PMC
November 2007

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.

J Leukoc Biol 2007 Mar 5;81(3):581-3. Epub 2007 Jan 5.

Juvenile Diabetes Research Foundation/Wellcome Trust, Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1189/jlb.0906577DOI Listing
March 2007

No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility.

Diabetes Metab Res Rev 2006 Sep-Oct;22(5):356-60

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY UK.

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http://dx.doi.org/10.1002/dmrr.628DOI Listing
November 2006

Strong association of insulin gene INS-VNTR polymorphisms with type 1 diabetes in the Romanian population.

Rom J Intern Med 2004 ;42(2):313-23

Clinic of Diabetes, Institute of Diabetes, Nutrition and Metabolic Diseases N. Paulescu, Bucharest, Romania.

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June 2006

No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.

Diabetes 2006 May;55(5):1525-8

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, U.K.

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http://dx.doi.org/10.2337/db05-1452DOI Listing
May 2006

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.

BMC Genet 2006 Apr 20;7:22. Epub 2006 Apr 20.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1471-2156-7-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479364PMC
April 2006

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

BMC Med Genet 2006 Mar 6;7:20. Epub 2006 Mar 6.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 2XY, UK.

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http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2350-7-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420277PMC
March 2006

Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.

Diabetes 2006 Feb;55(2):559-62

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK.

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http://dx.doi.org/10.2337/diabetes.55.02.06.db05-0826DOI Listing
February 2006

Population structure, differential bias and genomic control in a large-scale, case-control association study.

Nat Genet 2005 Nov 9;37(11):1243-6. Epub 2005 Oct 9.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, CB2 2XY, UK.

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http://www.nature.com/articles/ng1653
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http://dx.doi.org/10.1038/ng1653DOI Listing
November 2005

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes.

Biochem Biophys Res Commun 2005 Jun;331(2):435-41

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.203DOI Listing
June 2005

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.

Am J Hum Genet 2005 May 17;76(5):773-9. Epub 2005 Mar 17.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1086/429843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199367PMC
May 2005

Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.

Diabetes 2004 Oct;53(10):2709-12

Juvenile Diabetes Research Foundation/Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT/MRC building, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.2337/diabetes.53.10.2709DOI Listing
October 2004

Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.

Hum Mol Genet 2004 Aug 2;13(15):1633-9. Epub 2004 Jun 2.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/ddh169DOI Listing
August 2004

Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.

BMC Biotechnol 2004 Jul 27;4:15. Epub 2004 Jul 27.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes, Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.1186/1472-6750-4-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514612PMC
July 2004

Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes.

Diabetes 2004 Apr;53(4):1158-61

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.2337/diabetes.53.4.1158DOI Listing
April 2004

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

Diabetes 2004 Feb;53(2):505-9

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.

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http://dx.doi.org/10.2337/diabetes.53.2.505DOI Listing
February 2004

Association of intercellular adhesion molecule-1 gene with type 1 diabetes.

Lancet 2003 Nov;362(9397):1723-4

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, CB2 2XY, Cambridge, UK.

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http://dx.doi.org/10.1016/S0140-6736(03)14847-7DOI Listing
November 2003

Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes.

Hum Genet 2003 Jul 17;113(2):99-105. Epub 2003 Apr 17.

Department of Medical Genetics, JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1007/s00439-003-0940-6DOI Listing
July 2003

A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes.

Diabetes 2002 Sep;51(9):2866-70

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.

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http://dx.doi.org/10.2337/diabetes.51.9.2866DOI Listing
September 2002

Parameters for reliable results in genetic association studies in common disease.

Nat Genet 2002 Feb 22;30(2):149-50. Epub 2002 Jan 22.

JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/ng825DOI Listing
February 2002