Publications by authors named "Sarah K Bergren"

13Publications

CRISPR/Cas9-Mediated Point Mutation in Prolongs Protein Half-Life and Reverses Effects Allelic Loss.

Cancer Res 2020 Nov 17;80(21):4805-4814. Epub 2020 Sep 17.

Division of Hematology/Oncology, University of Arizona Medical Center, Tucson, Arizona.

View Article and Find Full Text PDF
November 2020

NestinNG2 Cells Form a Reserve Stem Cell Population in the Mouse Prostate.

Stem Cell Reports 2019 06 23;12(6):1201-1211. Epub 2019 May 23.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

View Article and Find Full Text PDF
June 2019

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.

Cell 2018 04;173(2):515-528.e17

Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA; Department of Urology, Columbia University Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

View Article and Find Full Text PDF
April 2018

A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue.

Nat Commun 2017 04 21;8:14662. Epub 2017 Apr 21.

Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA.

View Article and Find Full Text PDF
April 2017

Single luminal epithelial progenitors can generate prostate organoids in culture.

Nat Cell Biol 2014 Oct 21;16(10):951-61, 1-4. Epub 2014 Sep 21.

1] Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA [2] Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA [3] Department of Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA [4] Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

View Article and Find Full Text PDF
October 2014

Luminal cells are favored as the cell of origin for prostate cancer.

Cell Rep 2014 Sep 28;8(5):1339-46. Epub 2014 Aug 28.

Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address:

View Article and Find Full Text PDF
September 2014

Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity.

Nat Cell Biol 2013 Mar 24;15(3):274-83. Epub 2013 Feb 24.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

View Article and Find Full Text PDF
March 2013

Fine mapping of an epilepsy modifier gene on mouse Chromosome 19.

Mamm Genome 2009 Jun 10;20(6):359-66. Epub 2009 Jun 10.

Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
June 2009

Evidence for a direct role of the disease modifier SCNM1 in splicing.

Hum Mol Genet 2007 Oct 26;16(20):2506-16. Epub 2007 Jul 26.

Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109-0618, USA.

View Article and Find Full Text PDF
October 2007

Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2.

Hum Mol Genet 2006 Mar 7;15(6):1043-8. Epub 2006 Feb 7.

Department of Human Genetics, 4909 Buhl Building 0618, 1241 E. Catherine Street, Ann Arbor, MI 48109-0618, USA.

View Article and Find Full Text PDF
March 2006

Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a.

Mamm Genome 2005 Sep 19;16(9):683-90. Epub 2005 Oct 19.

Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article and Find Full Text PDF
September 2005