Publications by authors named "Sarah J Michelson"

4 Publications

  • Page 1 of 1

Cryotherapy for the management of refractory hypotony secondary to post-goniotomy cyclodialysis cleft.

Am J Ophthalmol Case Rep 2020 Dec 18;20:100876. Epub 2020 Aug 18.

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, 1000 Wall St, Ann Arbor, MI, 48105, USA.

Purpose: To report on the management of an unusual case of post-goniotomy hypotony.

Observation: A 41-year-old female with pigmentary glaucoma presented with a post-goniotomy cyclodialysis cleft and signs of hypotony maculopathy. Indirect cyclopexy closed the visible cleft but did not resolve her hypotony, despite neither ultrasonographic nor gonioscopic evidence of an open cleft or communication channel. Cryotherapy-induced cyclopexy and subsequent viscoelastic agent fill increased the intraocular pressure back to baseline.

Conclusions: This is the first reported case of cryotherapy correcting hypotony in a patient with no gonioscopic or ultrasonographic evidence of a cyclodialysis cleft. It demonstrates the utility of cryotherapy in the management of persistent ocular hypotony despite no detectable channel of aqueous outlet.
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December 2020

Socket Reconstruction With Bleomycin, Gentamicin, and Gelatin Sponges Following Eyelid-Sparing Orbital Exenteration for a Colobomatous Macrocyst in an Infant.

Ophthalmic Plast Reconstr Surg 2018 Nov/Dec;34(6):e201-e203

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, U.S.A.

Microphthalmia is defined by a globe axial length greater than or equal to 2 standard deviations below the age-adjusted mean and can occur as part of a broader syndrome. The presence of a colobomatous cyst with microphthalmia signifies failure of the embryonic neuroectodermal fissure to close appropriately during development of the globe, creating a protuberant globular appendage that inhibits normal growth and development of the eye itself. Cystic reaccumulation of fluid is common after aspiration or surgical removal. Here, the authors describe a case of a young boy with a colobomatous cyst who underwent eyelid-sparing orbital exenteration followed by reconstruction with absorbable gelatin sponge (Gelfoam, Pfizer, Inc.) and the chemotherapeutic agent bleomycin to promote scarring, achieving the equivalent of a biointegrated implant and facilitating satisfactory placement of an ocular prosthesis. A 2-year follow-up MRI revealed adequate volume in the posterior orbit.
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May 2019

Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster.

Exp Neurol 2014 Nov 27;261:772-81. Epub 2014 Aug 27.

Department of Biology, Drexel University, Philadelphia, PA, USA; Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address:

The biggest risk factor for developing Alzheimer's disease (AD) is age. Depending on the age of onset, AD is clinically categorized into either the early-onset form (before age 60years old), or the late-onset form (after age 65years old), with the vast majority of AD diagnosed as late onset (LOAD). LOAD is a progressive neurodegenerative disorder that involves the accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles in the brains of elderly patients. Affected individuals often experience symptoms including memory loss, confusion, and behavioral changes. Though many animal models of AD exist, very few are capable of analyzing the effect of older age on AD pathology. In an attempt to better model LOAD, we developed a novel "aged AD" model using Drosophila melanogaster. In our model, we express low levels of the human AD proteins APP (amyloid precursor protein) and BACE1 (β-site APP cleaving enzyme BACE) specifically in the fly's central nervous system. Advantages of our model include the onset of behavioral and neuropathological symptoms later in the fly's lifespan due to a gradual accrual of Aβ within the central nervous system (CNS), making age the key factor in the behavioral and neuroanatomical phenotypes that we observe in this model.
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November 2014

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.

PLoS One 2011 6;6(6):e20799. Epub 2011 Jun 6.

Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America.

Transgenic models of Alzheimer's disease (AD) have made significant contributions to our understanding of AD pathogenesis, and are useful tools in the development of potential therapeutics. The fruit fly, Drosophila melanogaster, provides a genetically tractable, powerful system to study the biochemical, genetic, environmental, and behavioral aspects of complex human diseases, including AD. In an effort to model AD, we over-expressed human APP and BACE genes in the Drosophila central nervous system. Biochemical, neuroanatomical, and behavioral analyses indicate that these flies exhibit aspects of clinical AD neuropathology and symptomology. These include the generation of Aβ(40) and Aβ(42), the presence of amyloid aggregates, dramatic neuroanatomical changes, defects in motor reflex behavior, and defects in memory. In addition, these flies exhibit external morphological abnormalities. Treatment with a γ-secretase inhibitor suppressed these phenotypes. Further, all of these phenotypes are present within the first few days of adult fly life. Taken together these data demonstrate that this transgenic AD model can serve as a powerful tool for the identification of AD therapeutic interventions.
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September 2011