Publications by authors named "Sarah H Van Tassel"

17 Publications

  • Page 1 of 1

Adverse Events Associated with Femtosecond Laser-Assisted Cataract Surgery Reported to the FDA MAUDE Database.

J Cataract Refract Surg 2021 Jul 12. Epub 2021 Jul 12.

Weill Cornell Medicine, Department of Ophthalmology, 1305 York Avenue, New York, NY 10021, USA.

Purpose: To report real-world complications associated with femtosecond laser-assisted cataract surgery (FLACS).

Setting: De-identified database.

Design: Retrospective review of adverse events associated with FLACS reported to the Food and Drug Administration's (FDA) Manufacturer and User Facility Device Experience (MAUDE) database.

Methods: The MAUDE database was culled for adverse events involving ophthalmic femtosecond laser during cataract surgery from January 2010 to January 2020. Reports in which the narrative description was inadequate to determine the nature of the complication were excluded. Each report was reviewed for complications, which were subsequently assigned to a complication category as determined by these authors. The number of events per year was determined and compared.

Results: Between January 2010 and January 2020, the MAUDE database search yielded 2,927 reports involving femtosecond laser, of which 1,927 met inclusion criteria and were included for analysis. These reports revealed 2,704 complications: 1,115 capsule tears (41.2%), 329 of which required vitrectomy, 372 instances of suction loss, 321 other capsulotomy-related complications, and 432 corneal or incisional complications. Rare complications included 54 reports of miosis, 16 reports of endophthalmitis, and 4 reports of toxic anterior segment syndrome. The number of events in the MAUDE database increased year over year between 2011 and 2017, peaking in 2017 at 303 events.

Conclusions: By drawing on real-world data in the MAUDE database, this study identifies the complications of greatest importance in clinical practice. Surgeons should be aware of the spectrum of possible complications in order to best prepare for all potential outcomes and to effectively counsel patients.
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http://dx.doi.org/10.1097/j.jcrs.0000000000000739DOI Listing
July 2021

Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Weill Cornell Medical College, New York, United States.

Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography (OCT) imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein).

Methods: Case report and review of the relevant literature.

Patients: Single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services.

Results: A patient with a novel homozygous mutation in the MFRP gene (c.472C>T) presented with nanophthalmos, optic disc drusen, foveal hypoplasia, and extensive peripheral retinoschisis, which was revealed to be multilevel retinoschisis on ultra-wide field OCT. Unlike other reported cases, the findings associated with this novel mutation did not include foveoschisis nor clinically obvious retinitis pigmentosa. The patient underwent prophylactic peripheral laser iridotomy in both eyes.

Conclusion: Here we present a patient with nanophthalmos, optic disc drusen, and foveal hypoplasia associated with extensive peripheral retinoschisis imaged by ultra-widefield OCT, but not foveal retinoschisis or prominent retinitis pigmentosa. The findings may expand the clinical spectrum of MFRP-associated nanophthalmos.
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http://dx.doi.org/10.1097/ICB.0000000000001179DOI Listing
July 2021

Adverse Events Associated with Microinvasive Glaucoma Surgery Reported to the Food and Drug Administration.

Ophthalmol Glaucoma 2021 Jul-Aug;4(4):433-435. Epub 2021 Jan 7.

Weill Cornell Medicine, Department of Ophthalmology, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ogla.2020.12.012DOI Listing
January 2021

Overnight Safety Evaluation of a Multi-Pressure Dial in Eyes with Glaucoma: Prospective, Open-Label, Randomized Study.

Clin Ophthalmol 2020 21;14:2739-2746. Epub 2020 Sep 21.

Vance Thompson Vision, Sioux Falls, SD, USA.

Purpose: To investigate the safety and tolerability of the multi-pressure dial (MPD) worn overnight for seven consecutive days.

Design: Prospective, open-label, randomized, single-site study.

Subjects: Twenty eyes of 10 subjects with open-angle glaucoma were fitted with an MPD and randomized to negative pressure application of -10 mmHg in one eye (study eye) worn overnight for 7 consecutive days.

Methods: Safety measures included best-corrected visual acuity (BCVA), intraocular pressure (IOP) changes from baseline during and after negative pressure application, slit lamp and dilated fundus exam findings, and rate of adverse events. Subjective assessments were completed daily by the subjects during the 7-day study period and immediately following the study period.

Results: Prior to the 7-day testing period, application of 10 mmHg negative pressure reduced mean IOP from 18.2 ± 3.8 mmHg to 14.0 ± 2.1 mmHg (p<0.01), a 22% reduction. After 7 days of consecutive nightly wear, repeat IOP measurements with the application of negative pressure showed a decrease in mean IOP from 16.9 ± 4.3 mmHg to 13.5 ± 3.7 mmHg. The observed IOP reduction was in addition to the subjects' current treatment regimen. There were no statistically significant changes in IOP, BCVA from baseline following the 7-day period of nightly wear with the application of negative pressure. The patient-reported outcomes were favorable.

Conclusion: The MPD can safely and comfortably be worn overnight. The decrease in IOP of >20% in addition to current therapy is both clinically and statistically significant. The MPD shows promise as a potential new treatment option for nocturnal IOP control.
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http://dx.doi.org/10.2147/OPTH.S256891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518782PMC
September 2020

Hypopyon following selective laser trabeculoplasty.

Am J Ophthalmol Case Rep 2020 Jun 20;18:100675. Epub 2020 Mar 20.

Weill Cornell Medical College, Department of Ophthalmology, New York, NY, United States.

Purpose: To report a hypopyon following selective laser trabeculoplasty (SLT).

Observations: An 85-year-old woman with primary open-angle glaucoma underwent routine SLT. In the early post-procedural period, she presented with pain and decreased vision, and she was found to have hypopyon, trabeculitis, and corneal edema. The patient was treated with prednisolone acetate and empirically with valacyclovir due to the possibility of herpetic keratouveitis. Work-up for potential etiologies was unrevealing. Her symptoms resolved with treatment, and at eight months follow-up her visual acuity and intraocular pressure had stabilized to her baseline.

Conclusions: Though safe, SLT may be associated with rare adverse events requiring intervention. Hypopyon following SLT is extremely rare, and investigation for causes unrelated to the history of SLT should be undertaken as appropriate.

Importance: To the best of our knowledge, this is the first report of a hypopyon following SLT in a patient with no history of inflammatory intra-ocular disease.
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http://dx.doi.org/10.1016/j.ajoc.2020.100675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163075PMC
June 2020

Trends in Authorship of Original Scientific Articles in Journal of Glaucoma: An Analysis of 25 Years Since the Initiation of the Journal.

J Glaucoma 2020 07;29(7):561-566

The George Washington University School of Medicine and Health Sciences, Washington, DC.

PRéCIS:: Publications in glaucoma have seen an increase in the number of authors and disclosures per article, authors with dual degrees, and international authors, but contributions of women to articles published remains low.

Purpose: Authorship trends have been studied across many medical specialties and in ophthalmology as a whole, but not specifically in glaucoma. The authors explored the authorship trends of original scientific articles in the Journal of Glaucoma.

Materials And Methods: The authors recorded the number of authors and disclosures per article, degree type of first and last authors, geographical origin of the corresponding author, and sex of first and last authors of original content from the Journal of Glaucoma published in 1992, 1997, 2002, 2007, 2012, and 2017.

Results: A total of 642 articles were analyzed. From 1992 to 2017, annual published articles increased from 38 to 242 (P=0.02), the mean number of authors per article increased from 3.2 to 5.2 (P<0.01), the mean number of disclosures per article increased from 0.3 to 1.0 (P=0.04), the proportion of first and last authors with dual degrees (medical plus advanced degrees) also increased (both P<0.03), whereas the proportion with a sole medical degree decreased (both P<0.05). There was a proportional decrease in articles from North America (P=0.03), and proportional increase from the "Far East" (P=0.04) and "Other" regions (P=0.04). No significant changes in proportions of female first and last authors were found (both P>0.28).

Conclusions: Consistent with authorship trends across various other medical specialties, glaucoma has seen an increase in the number of authors and disclosures per article, authors with dual degrees, and authors from the "Far East" and "Other" regions. However, contributions of women to articles published in Journal of Glaucoma remain low.
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http://dx.doi.org/10.1097/IJG.0000000000001503DOI Listing
July 2020

Retinal nerve fiber layer changes based on historic CD4 nadir among HIV positive patients undergoing glaucoma evaluation.

Int J Ophthalmol 2019 18;12(5):789-794. Epub 2019 May 18.

Department of Ophthalmology, Weill Cornell Medicine, New York 10021, United States.

Aim: To determine relationships between retinal nerve fiber layer (RNFL) thickness and nadir CD4 cell count in human immunodeficiency virus (HIV) positive patients evaluated for glaucoma suspicion.

Methods: Data were reviewed for 329 HIV positive patients evaluated for glaucoma suspicion. High-definition optical coherence tomography (OCT) RNFL measurements were obtained at least 6mo apart. Analyses were performed to identify relationships between nadir CD4 count and RNFL thickness.

Results: Totally 110 eyes of 55 patients met inclusion criteria, of which 46 eyes were from subjects with nadir CD4<200 cells/mm and 64 had nadir CD4≥200 cells/mm. Patients with nadir CD4<200 cells/mm had significantly thicker superior (119.7±18.6 µm) and temporal (63.8±11.7 µm) quadrants at time of initial OCT compared to the superior (112.8±16.8 µm, =0.048) and temporal (57.1±11.9 µm, =0.004) quadrants of patients with higher nadir CD4. This trend toward thicker RNFL among subjects with lower nadir CD4 cell counts persisted at the time of follow up OCT where participants with nadir CD4<200 cells/mm showed average RNFL thickness in the superior and temporal quadrants of 117.9±18.3 µm and 63.8±12.8 µm, respectively, compared to a superior thickness of 110.5±16.9 µm (=0.034) and temporal thickness of 57.3±11.6 µm (=0.007) among those with higher nadir CD4.

Conclusion: Patients with lower nadir CD4 cell counts have thicker RNFL in the superior and temporal quadrants compared to those with higher nadir CD4 counts. RNFL thickness in HIV positive patients may be affected by historic HIV disease control and should be considered when evaluating HIV positive patients for glaucoma.
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http://dx.doi.org/10.18240/ijo.2019.05.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520263PMC
May 2019

Metal Intraocular Particles Following Microinvasive Glaucoma Surgery with Stents.

Ophthalmol Glaucoma 2019 Sep - Oct;2(5):363

Department of Ophthalmology, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1016/j.ogla.2019.07.002DOI Listing
August 2021

Possible Undiagnosed Glaucoma Detected by MultiColor Imaging of Retinal Diseases.

Ophthalmol Glaucoma 2019 Jan - Feb;2(1):22-27. Epub 2018 Nov 15.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. Electronic address:

Purpose: To evaluate for the presence of visible retinal nerve fiber layer (RNFL) defects consistent with undiagnosed glaucoma in MultiColor images (Heidelberg Engineering, Heidelberg, Germany) obtained at clinicians' discretion for the diagnosis and management of retinal diseases.

Design: Retrospective chart review of MultiColor images obtained as part of routine clinical care between December 25, 2013 and June 24, 2014. Images were reviewed by 2 fellowship-trained glaucoma specialists (S.H.V.T., S.G.A.) for the presence of RNFL defects in the superotemporal or inferotemporal quadrants. No attention was given to the optic nerve head when identifying candidate images. Retinal nerve fiber layer defects were not considered glaucomatous if they traced to regions of retinal atrophy.

Participants: A total of 157 retina clinic patients aged 18 years or older who carried at least 1 retinal diagnosis; patients were subsequently excluded if medical records review revealed a history of glaucoma or glaucoma suspect diagnoses at the time of imaging.

Methods: MultiColor confocal scanning laser ophthalmoscopy images were obtained using the Heidelberg Spectralis HRA+OCT (Heidelberg Engineering, Heidelberg, Germany).

Main Outcome Measure: The primary end point was the presence of at least 1 RNFL defect tracking toward the optic nerve.

Results: Among 157 reviewed charts, 134 eyes of 80 patients met inclusion criteria, of whom 13 eyes of 10 patients had visible RNFL defects consistent with possible undiagnosed glaucoma. The average age of patients with presumed glaucomatous eyes was 67 years (range, 35-88 years; standard deviation, 15.7 years). The retinal diagnoses in the glaucomatous eyes included branch retinal vein occlusion (3 eyes and 1 fellow eye), neovascular age-related macular degeneration (2 eyes), non-neovascular age-related macular degeneration (both eyes of 1 patient), proliferative diabetic retinopathy (2 eyes), nonproliferative diabetic retinopathy (both eyes of 1 patient), and epiretinal membrane (1 eye).

Conclusions: Retinal nerve fiber layer defects consistent with glaucoma may be visible on MultiColor images obtained for the diagnosis and management of retinal diseases and may represent an underused opportunity to prevent additional visual dysfunction in patients already undergoing retinal disease management.
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http://dx.doi.org/10.1016/j.ogla.2018.11.003DOI Listing
August 2021

Response to: Comment on: Eponymous women in ophthalmology: syndromes with prominent eye manifestations named after female physicians.

Eye (Lond) 2019 05 18;33(5):851-852. Epub 2018 Dec 18.

Department of Ophthalmology, Weill Cornell Medicine, 1305 York Avenue, 11th floor, New York, NY, 10021, USA.

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http://dx.doi.org/10.1038/s41433-018-0314-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707324PMC
May 2019

Eponymous women in ophthalmology: syndromes with prominent eye manifestations named after female physicians.

Eye (Lond) 2018 08 14;32(8):1293-1295. Epub 2018 May 14.

Department of Ophthalmology, Weill Cornell Medicine, 1305 York Avenue, 11th Floor, New York, NY, 10021, USA.

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http://dx.doi.org/10.1038/s41433-018-0102-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085335PMC
August 2018

Endoscopic dacryocystorhinostomy following radioactive iodine thyroid ablation.

Orbit 2017 Apr 28;36(2):59-63. Epub 2017 Feb 28.

a Department of Ophthalmology , New York Presbyterian Hospital - Weill Cornell Medical College , New York , New York , USA.

This article evaluates the efficacy of endoscopic dacryocystorhinostomy (eDCR) for nasolacrimal duct obstruction (NLDO) in patients exposed to radioactive iodine (RAI) for treatment of thyroid carcinoma. Retrospective chart review of 7 eDCR procedures was performed on 6 patients, aged 18 or older, with prior RAI treatment, who underwent eDCR between January 1, 2008 and December 31, 2013 for treatment of epiphora due to NLDO. Average time to tube removal was 159 days, and average follow-up was 341 days. One patient noted complete epiphora relief at the time of their final visit. Partial symptom relief was noted by 3 patients, and recurrent epiphora was noted by 2 patients. In complex patients with RAI-associated NLDO, eDCR may be a reasonable option for relief of epiphora. Appropriate counseling, including the risks of incomplete symptom relief and need for additional surgery, should be discussed pre-operatively with these patients.
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http://dx.doi.org/10.1080/01676830.2017.1279653DOI Listing
April 2017

Juvenile X-Linked Retinoschisis: A Comparison of Imaging Modalities and Review of Angiographic Findings.

Retina 2016 Dec;36(12):e117-e119

*Department of Ophthalmology, Weill Cornell Medical College, New York, New York; and †Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1097/IAE.0000000000001046DOI Listing
December 2016

Comparison of the extrusion rate of Crawford tubes.

Int J Ophthalmol 2015 18;8(4):791-3. Epub 2015 Aug 18.

Department of Ophthalmology, Weill Cornell Medical College, New York 10021, USA.

Aim: To compare the outcomes of dacryocystorhinostomy (DCR) using traditional Crawford tubes (TCT) and Crawford tubes with suture (CTS) in the lumen.

Methods: Retrospective case series consisting of patients who underwent DCR between 2008 and 2013.

Results: A total of 61 DCRs were performed on 50 patients. Patients who underwent DCR using CTS had higher rates of prolapse compared to the TCT group (50% vs 9.4%; P=0.003). Stent removal occurred earlier in patients who received CTS (3.3mo vs 5.1mo; P=0.004). Success rates were equivalent between the two groups (75% vs 81.1%; P=0.684).

Conclusion: CTS in the lumen increases the risk of prolapse, prompting earlier tube removal in patients following DCR for nasolacrimal duct obstruction (NLDO). Earlier removal of tubes does not appear to significantly decrease success rates.
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http://dx.doi.org/10.3980/j.issn.2222-3959.2015.04.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539631PMC
August 2015

One Year of Glaucoma Research in Review-2013 to 2014.

Asia Pac J Ophthalmol (Phila) 2015 Jul-Aug;4(4):228-35

From the *Department of Ophthalmology, Weill Cornell Medical College; and †Department of Ophthalmology, NYU School of Medicine, New York, NY.

Purpose: The purpose of this study was to provide the practicing clinical ophthalmologist with an update on relevant glaucoma literature published from 2013 to 2014.

Design: This study is a literature review.

Methods: The authors conducted a 1-year (October 1, 2013, to September 30, 2014) English-language glaucoma literature search on PubMed of articles containing "glaucoma" or "glaucomatous" with title/abstract as a filter. Medical subject headings filtered searching was not performed because of the newness of the reviewed material.

Results: Literature search yielded 2314 articles, after which we excluded reviews and letters to the editor. We highlighted articles featuring new or updated approaches to the pathophysiology, diagnosis, or treatment of glaucoma and gave preference to human research.

Conclusions: This review features literature that is of interest to ophthalmologists in practice and also highlights studies that may provide insight on future developments applicable to clinical ophthalmology.
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http://dx.doi.org/10.1097/APO.0000000000000133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520779PMC
April 2016

Association of blood and ocular perfusion pressure with structural glaucomatous progression by flicker chronoscopy.

Br J Ophthalmol 2013 Dec 24;97(12):1569-73. Epub 2013 Sep 24.

Department of Ophthalmology, Weill Cornell Medical College, , New York, NY, USA.

Background: Vascular risk factors have been associated with glaucomatous visual field progression.

Aim: We determined the relationship between vascular risk factors and structural glaucomatous progression using serial flicker chronoscopy images.

Methods: Two glaucoma fellowship-trained ophthalmologists, masked to temporal sequence, independently graded serial flicker chronoscopy images from one eye of a cohort of glaucoma patients for features of structural progression in this retrospective cohort study. After adjudication, simple and multiple logistic models were constructed to determine variables associated with increased odds of progression, including systolic blood pressure (BP), diastolic BP and mean ocular perfusion pressure.

Results: Seventy-two eyes of 72 patients were analysed. Patients with any form of structural progression (n=40) were older (67.0 vs 58.8 years; p=0.005) and had lower diastolic BP (71.8 vs 76.5 mm Hg; p=0.02) than patients without progression (n=32). In the univariable model, diastolic BP was associated with progressive retinal nerve fibre layer (RNFL) loss (OR=0.2 per 10 mm Hg, 95% CI 0.1 to 0.6, p<0.006) and neuroretinal rim loss (OR=0.4 per 10 mm Hg, 95% CI 0.2 to 0.8, p<0.01). Diastolic BP was also significant in the multivariable model for RNFL loss (p=0.009) and neuroretinal rim loss (p=0.003).

Conclusions: This study is the first to use structural progression and flicker chronoscopy to identify vascular glaucoma risk factors. Older age and lower diastolic BP were associated with progression. By multivariable analysis diastolic BP was associated with RNFL and neuroretinal rim loss. These findings suggest that diastolic BP is associated with structural glaucomatous progression which may have implications for management.
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http://dx.doi.org/10.1136/bjophthalmol-2013-303655DOI Listing
December 2013
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