Sarah G Hymowitz

Sarah G Hymowitz

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Sarah G Hymowitz

Sarah G Hymowitz

Publications by authors named "Sarah G Hymowitz"

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51Publications

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Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.

Nat Struct Mol Biol 2020 Feb 27;27(2):134-141. Epub 2020 Jan 27.

Department of Structural Biology, Genentech Inc., South San Francisco, USA.

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http://dx.doi.org/10.1038/s41594-019-0365-0DOI Listing
February 2020

Targeting the MAPK Pathway in RAS Mutant Cancers.

Cold Spring Harb Perspect Med 2018 11 1;8(11). Epub 2018 Nov 1.

Department of Discovery Oncology, Genentech Inc., South San Francisco, California 94080.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a031492DOI Listing
November 2018

Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.

Structure 2018 05 26;26(5):767-777.e5. Epub 2018 Apr 26.

Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126183012
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http://dx.doi.org/10.1016/j.str.2018.04.002DOI Listing
May 2018

Unveiling the Structural and Dynamic Nature of the Ubiquitin Code.

Structure 2016 Apr;24(4):498-499

Department of Protein Chemistry & Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.03.013DOI Listing
April 2016

Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.

Cancer Cell 2014 Sep 21;26(3):402-413. Epub 2014 Aug 21.

Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.07.007DOI Listing
September 2014

Shining LIGHT on functional promiscuity in the TNF and TNFR superfamilies.

Structure 2014 Sep;22(9):1221-1222

Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.08.003DOI Listing
September 2014

Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction.

Proc Natl Acad Sci U S A 2013 Dec 18;110(49):19896-901. Epub 2013 Nov 18.

Departments of Structural Biology and Immunology, Genentech, Inc., South San Francisco, CA 94080.

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http://dx.doi.org/10.1073/pnas.1310838110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856818PMC
December 2013

Engineering and structural characterization of a linear polyubiquitin-specific antibody.

J Mol Biol 2012 May 29;418(3-4):134-44. Epub 2011 Dec 29.

Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.12.053DOI Listing
May 2012

Phosphorylation-dependent activity of the deubiquitinase DUBA.

Nat Struct Mol Biol 2012 Jan 15;19(2):171-5. Epub 2012 Jan 15.

Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nsmb.2206DOI Listing
January 2012

Preparation of distinct ubiquitin chain reagents of high purity and yield.

Structure 2011 Aug;19(8):1053-63

Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.str.2011.06.010DOI Listing
August 2011

Regulation and functions of the IL-10 family of cytokines in inflammation and disease.

Annu Rev Immunol 2011 ;29:71-109

Department of Immunology, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1146/annurev-immunol-031210-101312DOI Listing
June 2011

Modulation of K11-linkage formation by variable loop residues within UbcH5A.

J Mol Biol 2011 May 10;408(3):420-31. Epub 2011 Mar 10.

Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.03.011DOI Listing
May 2011

Unleashing cell death: the Fas-FADD complex.

Nat Struct Mol Biol 2010 Nov;17(11):1289-90

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http://dx.doi.org/10.1038/nsmb1110-1289DOI Listing
November 2010

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.

Mol Cell 2010 Nov;40(4):548-57

Department of Structural Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.10.009DOI Listing
November 2010

Interactions between Hedgehog proteins and their binding partners come into view.

Genes Dev 2010 Sep;24(18):2001-12

Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1101/gad.1951710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939362PMC
September 2010

Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.

J Biol Chem 2010 Aug 26;285(34):26570-80. Epub 2010 May 26.

Department of Protein Engineering, Genentech, Inc., South San Francisco, California 94080, USA.

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http://www.jbc.org/content/285/34/26570.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M110.112284
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http://dx.doi.org/10.1074/jbc.M110.112284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924095PMC
August 2010

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.

Mol Cell 2010 Aug 22;39(3):477-84. Epub 2010 Jul 22.

Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.07.001DOI Listing
August 2010

A20: from ubiquitin editing to tumour suppression.

Nat Rev Cancer 2010 May 12;10(5):332-41. Epub 2010 Apr 12.

Department of Structural Biology, Genentech, Inc.1 DNA Way, M/S 40, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1038/nrc2775DOI Listing
May 2010

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Nat Struct Mol Biol 2009 Jul 28;16(7):691-7. Epub 2009 Jun 28.

Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nsmb.1632DOI Listing
July 2009

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.

J Biol Chem 2007 Nov 19;282(48):35018-23. Epub 2007 Sep 19.

Department of Protein Engineering, Genentech, Incorporated, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M706233200DOI Listing
November 2007

Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists.

J Mol Biol 2006 Aug 7;361(3):522-36. Epub 2006 Jul 7.

Department of Protein Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.06.042DOI Listing
August 2006

The crystal structure of the costimulatory OX40-OX40L complex.

Structure 2006 Aug;14(8):1321-30

Department of Protein Engineering, Genentech, Incorporated, 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1016/j.str.2006.06.015DOI Listing
August 2006

Toward small-molecule agonists of TNF receptors.

Nat Chem Biol 2005 Dec;1(7):353-4

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http://dx.doi.org/10.1038/nchembio1205-353DOI Listing
December 2005

Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex.

J Biol Chem 2005 Nov 16;280(47):39553-61. Epub 2005 Sep 16.

Department of Protein Engineering, Genentech, Inc., S. San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M507629200DOI Listing
November 2005

Molecular recognition by a binary code.

J Mol Biol 2005 May 1;348(5):1153-62. Epub 2005 Apr 1.

Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.03.041DOI Listing
May 2005

Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.

J Biol Chem 2005 Feb 12;280(8):7218-27. Epub 2004 Nov 12.

Department of Protein Engineering, Molecular Oncology, Medicinal Chemistry, and Immunology, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M411714200DOI Listing
February 2005

The crystal structure of a proliferation-inducing ligand, APRIL.

J Mol Biol 2004 Oct;343(2):283-90

Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.08.040DOI Listing
October 2004

The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.

Structure 2003 Dec;11(12):1513-20

Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.str.2003.11.009DOI Listing
December 2003

BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.

Biochemistry 2003 May;42(20):5977-83

Department of Protein Engineering, Genentech, Inc., One DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1021/bi034017gDOI Listing
May 2003