Publications by authors named "Sarah C R Lummis"

100Publications

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.

Pharmacol Rev 2021 Jan;73(1):310-520

Neuropharmacology Research Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom (N.M.B., A.R.); Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia (N.M.B., D.H.); Department of Pharmacology, Georgetown University Medical Center, Washington, DC (G.P.A.); Institut de Génomique Functionnelle, Université Montpellier, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Montpellier, France (C.B., J.B., S.C.-D., S.C., P.M.); Université de Montpellier, Montpellier, France (C.B., J.B., S.C.-D., S.C., P.M.); C.E.N.T.E.R. Division of Gastroenterology and Hepatology Mayo Clinic, Rochester, Minnesota (M.C.); Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (K.A.C., R.M.H.); School of Life Sciences, Medical School, Queen's Medical Centre, The University of Nottingham, Nottingham, United Kingdom (K.C.F.); Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York (M.G.); Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta (G.D.G.); Department of Physiology, Department of Obstetrics and Gynaecology, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (N.M.G., E.K.L.); Department of Psychiatry, University of California San Diego, La Jolla, California (A.L.H.); Theranyx, Marseille, France (G.H.); Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York (K.H.-D.); Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland (R.H., H.V.); Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy (E.L., M.L.); Department of Pharmacology, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway (F.O.L.); Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom (S.C.R.L.); INSERM UMR-S 1270, Paris, France (L.M., A.R.); Sorbonne Université, Paris, France (L.M., A.R.); Institut du Fer à Moulin, Paris, France (L.M., A.R.); Drug Development, Grunenthal GmbH, Aachen, Germany (A.C.M.); Tucson, Arizona (D.L.N.); Departments of Psychiatry and Behavioral Sciences and Pharmacology, University of Washington, Seattle, Washington (J.F.N.); Neurolixis Inc., Dana Point, California (A.N.-T.); Université Grenoble Alpes, Institut de Biologie Structurale, Grenoble, France (H.N.); CNRS, Institut de Biologie Structurale, Grenoble, France (H.N.); Commissariat à l'Energie Atomique et aux Energies Alternatives, DSV, Institut de Biologie Structurale, Grenoble, France (H.N.); Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina (B.L.R.); Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom (G.J.S.); Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York (M.T.); Department of Pharmacology, University of Oxford, Oxford, United Kingdom (T.S.); Cinvestav-Coapa, Pharmacobiology, Mexico City, Tlalpan, Mexico (C.M.V.); Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (S.W.W.); The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia (D.H.); and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California (D.H.).

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January 2021

M4, the Outermost Helix, is Extensively Involved in Opening of the α4β2 nACh Receptor.

ACS Chem Neurosci 2021 Jan 9;12(1):133-139. Epub 2020 Dec 9.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB 1QW, United Kingdom.

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January 2021

Proline Residues Contribute to Efficient GABA Receptor Function.

ACS Chem Neurosci 2020 12 17;11(24):4215-4222. Epub 2020 Nov 17.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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December 2020

Many Proline Residues in the Extracellular Domain Contribute to Glycine Receptor Function.

ACS Chem Neurosci 2020 09 10;11(17):2658-2665. Epub 2020 Aug 10.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, U.K.

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September 2020

The M4 Helix Is Involved in α7 nACh Receptor Function.

ACS Chem Neurosci 2020 05 4;11(10):1406-1412. Epub 2020 May 4.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB 1QW, United Kingdom.

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May 2020

Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT and nACh Receptors.

ACS Chem Neurosci 2019 07 5;10(7):3327-3333. Epub 2019 Jul 5.

Department of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1GA , United Kingdom.

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July 2019

Characterization of Residues in the 5-HT Receptor M4 Region That Contribute to Function.

ACS Chem Neurosci 2019 07 5;10(7):3167-3172. Epub 2019 Mar 5.

Department of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB 1QW , United Kingdom.

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July 2019

Modeling and Mutational Analysis of the Binding Mode for the Multimodal Antidepressant Drug Vortioxetine to the Human 5-HT Receptor.

Mol Pharmacol 2018 12 26;94(6):1421-1434. Epub 2018 Sep 26.

Interdisciplinary Nanoscience Center, Department of Chemistry, Aarhus University, Aarhus, Denmark (L.K.L., B.S.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (L.M., A.J.P., A.S.K.); Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom (S.C.R.L.); Lundbeck Research, H. Lundbeck A/S, Valby, Denmark (B.B.-A.); and Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia (T.B.)

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December 2018

The roles of aromatic residues in the glycine receptor transmembrane domain.

BMC Neurosci 2018 Sep 6;19(1):53. Epub 2018 Sep 6.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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September 2018

Identification of Novel Functionally Important Aromatic Residue Interactions in the Extracellular Domain of the Glycine Receptor.

Biochemistry 2018 07 27;57(27):4029-4035. Epub 2018 Jun 27.

Department of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1QH , U.K.

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July 2018

Multiple regions in the extracellular domain of the glycine receptor determine receptor activity.

J Biol Chem 2018 09 25;293(36):13889-13896. Epub 2018 Jun 25.

From the Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom

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September 2018

Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC.

Biochemistry 2018 07 21;57(27):4036-4043. Epub 2018 Jun 21.

Department of Biochemistry , University of Cambridge , Tennis Court Road , Cambridge CB2 1GA , U.K.

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July 2018

Characterization of a 5-HT-ELIC Chimera Revealing the Sites of Action of Modulators.

ACS Chem Neurosci 2018 06 6;9(6):1409-1415. Epub 2018 Mar 6.

Department of Biochemistry , University of Cambridge , Cambridge CB2 1QW , U.K.

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June 2018

Aromatic Residues in the Fourth Transmembrane-Spanning Helix M4 Are Important for GABAρ Receptor Function.

ACS Chem Neurosci 2018 02 9;9(2):284-290. Epub 2017 Nov 9.

Department of Biochemistry, University of Cambridge , Tennis Court Road, Cambridge CB 1QW, United Kingdom.

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February 2018

The Proton Responsiveness in the Extracellular Domain of GLIC Differs in the Presence of the ELIC Transmembrane Domain.

Biochemistry 2017 04 6;56(15):2134-2138. Epub 2017 Apr 6.

Department of Biochemistry, University of Cambridge , Cambridge CB2 1QW, U.K.

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April 2017

Subtle Differences among 5-HTAC, 5-HTAD, and 5-HTAE Receptors Are Revealed by Partial Agonists.

ACS Chem Neurosci 2017 05 3;8(5):1085-1091. Epub 2017 Apr 3.

Department of Biochemistry, University of Cambridge , Tennis Court Road, Cambridge CB 1QW, United Kingdom.

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May 2017

Crotonic Acid Blocks the Gloeobacter Ligand-Gated Ion Channel (GLIC) via the Extracellular Domain.

Biochemistry 2016 Oct 14;55(42):5947-5951. Epub 2016 Oct 14.

Department of Biochemistry, University of Cambridge , Cambridge CB2 1QW, U.K.

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October 2016

Palonosetron-5-HT Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.

ACS Chem Neurosci 2016 12 22;7(12):1641-1646. Epub 2016 Sep 22.

Department of Biochemistry, University of Cambridge , Tennis Court Road, Cambridge CB2 1QW, United Kingdom.

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December 2016

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors.

J Biol Chem 2016 Mar 14;291(12):6272-80. Epub 2015 Dec 14.

the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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March 2016