Sarah A Tishkoff

Sarah A Tishkoff

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Sarah A Tishkoff

Sarah A Tishkoff

Publications by authors named "Sarah A Tishkoff"

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The Missing Diversity in Human Genetic Studies.

Cell 2019 Mar;177(1):26-31

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.02.048DOI Listing
March 2019

The Plight of Muntaser Ibrahim.

PLoS Genet 2019 03 25;15(3):e1008100. Epub 2019 Mar 25.

Department of Biology and the Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1008100
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http://dx.doi.org/10.1371/journal.pgen.1008100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433285PMC
March 2019

Investigating zoonotic infection barriers to ape Plasmodium parasites using faecal DNA analysis.

Int J Parasitol 2018 06 21;48(7):531-542. Epub 2018 Feb 21.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971147PMC
June 2018

Divergent Patterns of Mitochondrial and Nuclear Ancestry Are Associated with the Risk for Preterm Birth.

J Pediatr 2018 03 14;194:40-46.e4. Epub 2017 Dec 14.

Department of Genetics, The University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2017.10.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987530PMC
March 2018

Global variation in gene expression and the value of diverse sampling.

Curr Opin Syst Biol 2017 Feb 3;1:102-108. Epub 2017 Mar 3.

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.coisb.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458633PMC
February 2017

Inferences of African evolutionary history from genomic data.

Curr Opin Genet Dev 2016 Dec 1;41:159-166. Epub 2016 Nov 1.

Department of Genetics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161638PMC
December 2016

The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.

Nature 2016 Oct 21;538(7624):201-206. Epub 2016 Sep 21.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature18964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161557PMC
October 2016

Going global by adapting local: A review of recent human adaptation.

Science 2016 10;354(6308):54-59

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.aaf5098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154245PMC
October 2016

Telomere Length and the Cancer-Atherosclerosis Trade-Off.

PLoS Genet 2016 07 7;12(7):e1006144. Epub 2016 Jul 7.

The Center of Human Development and Aging, New Jersey Medical School, Rutgers, Newark, New Jersey, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936693PMC
July 2016

Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection.

Genome Res 2016 Mar 17;26(3):279-90. Epub 2016 Feb 17.

Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA; Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1101/gr.192971.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772011PMC
March 2016

Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies.

Genome Res 2016 Mar 17;26(3):291-300. Epub 2016 Feb 17.

Arizona Research Laboratories Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA;

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http://dx.doi.org/10.1101/gr.196634.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772012PMC
March 2016

Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles.

Am J Hum Genet 2014 Oct;95(4):408-20

Departments of Biology and Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185123PMC
October 2014

Ancient human genomes suggest three ancestral populations for present-day Europeans.

Authors:
Iosif Lazaridis Nick Patterson Alissa Mittnik Gabriel Renaud Swapan Mallick Karola Kirsanow Peter H Sudmant Joshua G Schraiber Sergi Castellano Mark Lipson Bonnie Berger Christos Economou Ruth Bollongino Qiaomei Fu Kirsten I Bos Susanne Nordenfelt Heng Li Cesare de Filippo Kay Prüfer Susanna Sawyer Cosimo Posth Wolfgang Haak Fredrik Hallgren Elin Fornander Nadin Rohland Dominique Delsate Michael Francken Jean-Michel Guinet Joachim Wahl George Ayodo Hamza A Babiker Graciela Bailliet Elena Balanovska Oleg Balanovsky Ramiro Barrantes Gabriel Bedoya Haim Ben-Ami Judit Bene Fouad Berrada Claudio M Bravi Francesca Brisighelli George B J Busby Francesco Cali Mikhail Churnosov David E C Cole Daniel Corach Larissa Damba George van Driem Stanislav Dryomov Jean-Michel Dugoujon Sardana A Fedorova Irene Gallego Romero Marina Gubina Michael Hammer Brenna M Henn Tor Hervig Ugur Hodoglugil Aashish R Jha Sena Karachanak-Yankova Rita Khusainova Elza Khusnutdinova Rick Kittles Toomas Kivisild William Klitz Vaidutis Kučinskas Alena Kushniarevich Leila Laredj Sergey Litvinov Theologos Loukidis Robert W Mahley Béla Melegh Ene Metspalu Julio Molina Joanna Mountain Klemetti Näkkäläjärvi Desislava Nesheva Thomas Nyambo Ludmila Osipova Jüri Parik Fedor Platonov Olga Posukh Valentino Romano Francisco Rothhammer Igor Rudan Ruslan Ruizbakiev Hovhannes Sahakyan Antti Sajantila Antonio Salas Elena B Starikovskaya Ayele Tarekegn Draga Toncheva Shahlo Turdikulova Ingrida Uktveryte Olga Utevska René Vasquez Mercedes Villena Mikhail Voevoda Cheryl A Winkler Levon Yepiskoposyan Pierre Zalloua Tatijana Zemunik Alan Cooper Cristian Capelli Mark G Thomas Andres Ruiz-Linares Sarah A Tishkoff Lalji Singh Kumarasamy Thangaraj Richard Villems David Comas Rem Sukernik Mait Metspalu Matthias Meyer Evan E Eichler Joachim Burger Montgomery Slatkin Svante Pääbo Janet Kelso David Reich Johannes Krause

Nature 2014 Sep;513(7518):409-13

1] Institute for Archaeological Sciences, University of Tübingen, Tübingen 72074, Germany. [2] Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tübingen, 72070 Tübingen, Germany. [3] Max Planck Institut für Geschichte und Naturwissenschaften, Jena 07745, Germany.

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https://genetics.med.harvard.edu/reich/Reich_Lab/Welcome_fil
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http://biorxiv.org/content/biorxiv/early/2013/12/23/001552.f
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http://www.geo.uni-tuebingen.de/fileadmin/website/arbeitsber
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http://www.nature.com/doifinder/10.1038/nature13673
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http://dx.doi.org/10.1038/nature13673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170574PMC
September 2014

Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers.

BMC Med Genomics 2014 Aug 28;7:53. Epub 2014 Aug 28.

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/1755-8794-7-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159108PMC
August 2014

Genetic variation and adaptation in Africa: implications for human evolution and disease.

Cold Spring Harb Perspect Biol 2014 Jul 1;6(7):a008524. Epub 2014 Jul 1.

Department of Genetics and Biology, School of Medicine and School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/cshperspect.a008524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067985PMC
July 2014

Genetic origins of lactase persistence and the spread of pastoralism in Africa.

Am J Hum Genet 2014 Apr 13;94(4):496-510. Epub 2014 Mar 13.

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140006
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http://dx.doi.org/10.1016/j.ajhg.2014.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980415PMC
April 2014

Population Genomics of Human Adaptation.

Annu Rev Ecol Evol Syst 2013 Nov;44:123-143

Departments of Biology and Genetics, University of Pennsylvania, Philadelphia, PA 19104 USA.

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http://www.annualreviews.org/doi/10.1146/annurev-ecolsys-110
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http://dx.doi.org/10.1146/annurev-ecolsys-110512-135833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221232PMC
November 2013

Recent human adaptation: genomic approaches, interpretation and insights.

Nat Rev Genet 2013 Oct;14(10):692-702

1] Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [2] Coriell Institute for Medical Research, Camden, New Jersey 08103, USA.

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http://dx.doi.org/10.1038/nrg3604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882605PMC
October 2013

Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure.

Hum Genet 2013 Sep 23;132(9):987-99. Epub 2013 Apr 23.

Department of Genetics and Biology, School of Medicine and School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00439-013-1284-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916218PMC
September 2013

SNP ascertainment bias in population genetic analyses: why it is important, and how to correct it.

Bioessays 2013 Sep 9;35(9):780-6. Epub 2013 Jul 9.

Departments of Biology and Genetics, University of Pennsylvania, Philadelphia, PA, USA.

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http://ceet.upenn.edu/wp-content/uploads/2014/07/Lachance-J-
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http://doi.wiley.com/10.1002/bies.201300014
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http://dx.doi.org/10.1002/bies.201300014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849385PMC
September 2013

Great ape genetic diversity and population history.

Nature 2013 Jul 3;499(7459):471-5. Epub 2013 Jul 3.

Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, PRBB, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.

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http://dx.doi.org/10.1038/nature12228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822165PMC
July 2013

Human evolutionary genomics: ethical and interpretive issues.

Trends Genet 2012 Mar 20;28(3):137-45. Epub 2012 Jan 20.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.tig.2011.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210170PMC
March 2012

Genetic adaptation to high altitude in the Ethiopian highlands.

Genome Biol 2012 Jan 20;13(1):R1. Epub 2012 Jan 20.

Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/gb-2012-13-1-r1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334582PMC
January 2012

Haplotype variation and genotype imputation in African populations.

Genet Epidemiol 2011 Dec;35(8):766-80

Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1002/gepi.20626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568705PMC
December 2011

Exploring genomic studies in Africa.

Genome Med 2011 Jul 8;3(7):45. Epub 2011 Jul 8.

Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, 519 Light Hall, 2215 Garland avenue, Nashville, TN 37232-0700, USA.

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http://dx.doi.org/10.1186/gm261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221546PMC
July 2011

Evidence from Cameroon reveals differences in the genetic structure and histories of chimpanzee populations.

Proc Natl Acad Sci U S A 2011 Mar 28;108(12):4766-71. Epub 2011 Feb 28.

Department of Biological Sciences, University at Albany-State University of New York, Albany, NY 12222, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1015422108
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http://dx.doi.org/10.1073/pnas.1015422108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064329PMC
March 2011

Living the high life: high-altitude adaptation.

Genome Biol 2010 10;11(9):133. Epub 2010 Sep 10.

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/gb-2010-11-9-133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965377PMC
February 2011

Colloquium paper: working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history.

Proc Natl Acad Sci U S A 2010 May 5;107 Suppl 2:8931-8. Epub 2010 May 5.

Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.1002563107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024023PMC
May 2010

The evolution of human genetic and phenotypic variation in Africa.

Curr Biol 2010 Feb;20(4):R166-73

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cub.2009.11.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945812PMC
February 2010

Genome-wide patterns of population structure and admixture in West Africans and African Americans.

Proc Natl Acad Sci U S A 2010 Jan 22;107(2):786-91. Epub 2009 Dec 22.

Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1073/pnas.0909559107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818934PMC
January 2010

African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping.

Annu Rev Genomics Hum Genet 2008 ;9:403-33

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1146/annurev.genom.9.081307.164258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953791PMC
December 2008

Divergent haplotypes and human history as revealed in a worldwide survey of X-linked DNA sequence variation.

Mol Biol Evol 2007 Mar 14;24(3):687-98. Epub 2006 Dec 14.

Department of Genetics, Rutgers University, NJ, USA.

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http://dx.doi.org/10.1093/molbev/msl196DOI Listing
March 2007

Whole-mtDNA genome sequence analysis of ancient African lineages.

Mol Biol Evol 2007 Mar 28;24(3):757-68. Epub 2006 Dec 28.

Department of Biology, University of Maryland, MD, USA.

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https://academic.oup.com/mbe/article-lookup/doi/10.1093/molb
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http://dx.doi.org/10.1093/molbev/msl209DOI Listing
March 2007

African human diversity, origins and migrations.

Curr Opin Genet Dev 2006 Dec 23;16(6):597-605. Epub 2006 Oct 23.

Department of Biology, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1016/j.gde.2006.10.008DOI Listing
December 2006

Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzees.

Mol Biol Evol 2006 Aug 2;23(8):1592-601. Epub 2006 Jun 2.

Center for Evolutionary Functional Genomics, The Biodesign Institute, Tempe, Arizona, USA.

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http://dx.doi.org/10.1093/molbev/msl024DOI Listing
August 2006

Positive selection can create false hotspots of recombination.

Genetics 2006 Mar 30;172(3):2011-4. Epub 2005 Dec 30.

Department of Biology, University of Maryland, College Park, Maryland 20742, USA.

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http://dx.doi.org/10.1534/genetics.105.052183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456281PMC
March 2006

Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphisms.

Gene 2006 Jan 10;365:11-20. Epub 2006 Jan 10.

Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1016/j.gene.2005.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847407PMC
January 2006

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.

Science 2005 Sep;309(5741):1717-20

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/science.1113722DOI Listing
September 2005

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.

Science 2005 Sep;309(5741):1720-2

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/science.1116815DOI Listing
September 2005

Molecular characterization of G6PD deficiency in Cyprus.

Blood Cells Mol Dis 2004 Jul-Aug;33(1):25-30

Department of Biochemical Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

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http://dx.doi.org/10.1016/j.bcmd.2004.03.004DOI Listing
January 2005

Implications of biogeography of human populations for 'race' and medicine.

Nat Genet 2004 Nov;36(11 Suppl):S21-7

Department of Biology, Building #144, University of Maryland, College Park, Maryland 20742, USA.

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http://dx.doi.org/10.1038/ng1438DOI Listing
November 2004

Signatures of selection and gene conversion associated with human color vision variation.

Am J Hum Genet 2004 Sep 13;75(3):363-75. Epub 2004 Jul 13.

Department of Biology, University of Maryland, College Park 20742, USA.

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http://dx.doi.org/10.1086/423287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182016PMC
September 2004

Patterns of human genetic diversity: implications for human evolutionary history and disease.

Annu Rev Genomics Hum Genet 2003 ;4:293-340

Department of Biology, University of Maryland, College Park, Maryland 20742, USA.

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http://dx.doi.org/10.1146/annurev.genom.4.070802.110226DOI Listing
December 2003

Role of evolutionary history on haplotype block structure in the human genome: implications for disease mapping.

Curr Opin Genet Dev 2003 Dec;13(6):569-75

Department of Biology, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1016/j.gde.2003.10.010DOI Listing
December 2003

Genetic analysis of African populations: human evolution and complex disease.

Nat Rev Genet 2002 Aug;3(8):611-21

Department of Biology, University of Maryland, College Park, Maryland 20742, USA.

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http://dx.doi.org/10.1038/nrg865DOI Listing
August 2002