Sarah A Teichmann

Sarah A Teichmann

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Sarah A Teichmann

Publications by authors named "Sarah A Teichmann"

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Deciphering immunity at high plexity and resolution.

Nat Rev Immunol 2019 Dec 4. Epub 2019 Dec 4.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/s41577-019-0254-0DOI Listing
December 2019

Immunology Driven by Large-Scale Single-Cell Sequencing.

Trends Immunol 2019 Nov 20;40(11):1011-1021. Epub 2019 Oct 20.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1016/j.it.2019.09.004DOI Listing
November 2019

BBKNN: Fast Batch Alignment of Single Cell Transcriptomes.

Bioinformatics 2019 Aug 10. Epub 2019 Aug 10.

Cellular Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1093/bioinformatics/btz625DOI Listing
August 2019

In conversation with Sarah Teichmann.

FEBS J 2019 Apr;286(8):1445-1450

Wellcome Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1111/febs.14806DOI Listing
April 2019

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.

Cell 2019 02 10;176(4):882-896.e18. Epub 2019 Jan 10.

Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK; Theory of Condensed Matter, Cavendish Laboratory, 19 JJ Thomson Ave, Cambridge CB3 0HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.11.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370901PMC
February 2019

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.

Immunity 2019 02 5;50(2):493-504.e7. Epub 2019 Feb 5.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382439PMC
February 2019

A test metric for assessing single-cell RNA-seq batch correction.

Nat Methods 2019 01 20;16(1):43-49. Epub 2018 Dec 20.

Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany.

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http://www.nature.com/articles/s41592-018-0254-1
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http://dx.doi.org/10.1038/s41592-018-0254-1DOI Listing
January 2019

A rapid and robust method for single cell chromatin accessibility profiling.

Nat Commun 2018 12 17;9(1):5345. Epub 2018 Dec 17.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41467-018-07771-0
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http://dx.doi.org/10.1038/s41467-018-07771-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297232PMC
December 2018

Editorial overview: Sequences and topology: Dynamic sequences and topologies of proteins.

Curr Opin Struct Biol 2018 06;50:vii-viii

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2018.07.005DOI Listing
June 2018

SpatialDE: identification of spatially variable genes.

Nat Methods 2018 05 19;15(5):343-346. Epub 2018 Mar 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/nmeth.4636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350895PMC
May 2018

Exponential scaling of single-cell RNA-seq in the past decade.

Nat Protoc 2018 04 1;13(4):599-604. Epub 2018 Mar 1.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2017.149DOI Listing
April 2018

Mapping human development at single-cell resolution.

Development 2018 02 8;145(3). Epub 2018 Feb 8.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

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http://dx.doi.org/10.1242/dev.152561DOI Listing
February 2018

Circulating and Tissue-Resident CD4 T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.

Gastroenterology 2017 11 4;153(5):1320-1337.e16. Epub 2017 Aug 4.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.07.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687320PMC
November 2017

Single cell transcriptomics of pluripotent stem cells: reprogramming and differentiation.

Curr Opin Genet Dev 2017 Oct 1;46:66-76. Epub 2017 Jul 1.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge, UK; European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1016/j.gde.2017.06.003DOI Listing
October 2017

Single-cell transcriptomics to explore the immune system in health and disease.

Science 2017 10;358(6359):58-63

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/science.aan6828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654495PMC
October 2017

Computational approaches for interpreting scRNA-seq data.

FEBS Lett 2017 08 12;591(15):2213-2225. Epub 2017 Jun 12.

The European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.

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http://dx.doi.org/10.1002/1873-3468.12684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575496PMC
August 2017

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications.

Genome Med 2017 08 18;9(1):75. Epub 2017 Aug 18.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520, Turku, Finland.

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http://dx.doi.org/10.1186/s13073-017-0467-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561556PMC
August 2017

Wounding induces dedifferentiation of epidermal Gata6 cells and acquisition of stem cell properties.

Nat Cell Biol 2017 Jun 15;19(6):603-613. Epub 2017 May 15.

King's College London Centre for Stem Cells and Regenerative Medicine, 28th Floor, Tower Wing, Guy's Campus, Great Maze Pond, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/ncb3532DOI Listing
June 2017

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.

Nat Commun 2017 06 26;8(1):36. Epub 2017 Jun 26.

European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1038/s41467-017-00052-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484669PMC
June 2017

Power analysis of single-cell RNA-sequencing experiments.

Nat Methods 2017 Apr 6;14(4):381-387. Epub 2017 Mar 6.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.4220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376499PMC
April 2017

Are cells from a snowman realistic? Cryopreserved tissues as a source for single-cell RNA-sequencing experiments.

Genome Biol 2017 03 24;18(1):54. Epub 2017 Mar 24.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://dx.doi.org/10.1186/s13059-017-1192-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364640PMC
March 2017

Regulation, evolution and consequences of cotranslational protein complex assembly.

Curr Opin Struct Biol 2017 02 12;42:90-97. Epub 2016 Dec 12.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.11.023DOI Listing
February 2017

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE.

J Exp Med 2017 01 19;214(1):183-196. Epub 2016 Dec 19.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, England, UK

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http://dx.doi.org/10.1084/jem.20161056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206502PMC
January 2017

Single-cell analysis at the threshold.

Nat Biotechnol 2016 11;34(11):1111-1118

Wellcome Trust Sanger Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/nbt.3721DOI Listing
November 2016

Genetics and immunity in the era of single-cell genomics.

Hum Mol Genet 2016 Oct 12;25(R2):R141-R148. Epub 2016 Jul 12.

Wellcome Trust Sanger Institute

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http://dx.doi.org/10.1093/hmg/ddw192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036872PMC
October 2016

Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.

Data Brief 2016 Sep 9;8:948-57. Epub 2016 Jul 9.

The Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1016/j.dib.2016.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961497PMC
September 2016

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.

Cell Rep 2016 09;17(1):179-192

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055476PMC
http://dx.doi.org/10.1016/j.celrep.2016.08.087DOI Listing
September 2016

Single-cell genomics: coming of age.

Genome Biol 2016 May 10;17:97. Epub 2016 May 10.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13059-016-0960-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862185PMC
May 2016

T cell fate and clonality inference from single-cell transcriptomes.

Nat Methods 2016 Apr 7;13(4):329-332. Epub 2016 Mar 7.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.3800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835021PMC
April 2016

AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription Regulators.

J Mol Biol 2016 Feb 25;428(4):671-678. Epub 2015 Sep 25.

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783282PMC
February 2016

Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells.

Cell Rep 2016 Feb 21;14(4):966-977. Epub 2016 Jan 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742565PMC
February 2016

Classification of low quality cells from single-cell RNA-seq data.

Genome Biol 2016 Feb 17;17:29. Epub 2016 Feb 17.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13059-016-0888-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758103PMC
February 2016

Structure, dynamics, assembly, and evolution of protein complexes.

Annu Rev Biochem 2015 8;84:551-75. Epub 2014 Dec 8.

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-biochem-060614-034142DOI Listing
December 2015

Principles of assembly reveal a periodic table of protein complexes.

Science 2015 Dec;350(6266):aaa2245

Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK. European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/science.aaa2245DOI Listing
December 2015

Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation.

Cell Stem Cell 2015 Oct;17(4):471-85

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595712PMC
October 2015

Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression.

Nat Commun 2015 Oct 22;6:8687. Epub 2015 Oct 22.

European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.

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http://dx.doi.org/10.1038/ncomms9687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627577PMC
October 2015

Computational assignment of cell-cycle stage from single-cell transcriptome data.

Methods 2015 Sep 2;85:54-61. Epub 2015 Jul 2.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Institute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10462023153000
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http://dx.doi.org/10.1016/j.ymeth.2015.06.021DOI Listing
September 2015

The technology and biology of single-cell RNA sequencing.

Mol Cell 2015 May;58(4):610-20

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(15)00261-0
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http://dx.doi.org/10.1016/j.molcel.2015.04.005DOI Listing
May 2015

An atlas of mouse CD4(+) T cell transcriptomes.

Biol Direct 2015 Apr 3;10:14. Epub 2015 Apr 3.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13062-015-0045-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384382PMC
April 2015

Computational and analytical challenges in single-cell transcriptomics.

Nat Rev Genet 2015 Mar 28;16(3):133-45. Epub 2015 Jan 28.

1] European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. [2] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://sv.epfl.ch/files/content/sites/svnew2/files/shared/LS
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http://www.nature.com/doifinder/10.1038/nrg3833
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http://dx.doi.org/10.1038/nrg3833DOI Listing
March 2015

Structural and evolutionary versatility in protein complexes with uneven stoichiometry.

Nat Commun 2015 Mar 16;6:6394. Epub 2015 Mar 16.

1] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK [2] Theory of Condensed Matter, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK [3] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/ncomms7394DOI Listing
March 2015

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells.

Nat Biotechnol 2015 Feb 19;33(2):155-60. Epub 2015 Jan 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nbt.3102DOI Listing
February 2015

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.

Cell Rep 2014 May 10;7(4):1130-42. Epub 2014 May 10.

EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039991PMC
May 2014

Protein flexibility facilitates quaternary structure assembly and evolution.

PLoS Biol 2014 May 27;12(5):e1001870. Epub 2014 May 27.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1001870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035275PMC
May 2014

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.

Bioessays 2014 Feb 25;36(2):209-18. Epub 2013 Nov 25.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1002/bies.201300134DOI Listing
February 2014

Evolution of protein structures and interactions from the perspective of residue contact networks.

Curr Opin Struct Biol 2013 Dec 25;23(6):954-63. Epub 2013 Jul 25.

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2013.07.004DOI Listing
December 2013

Immunology meets genomics.

Brief Funct Genomics 2013 Nov;12(6):469-70

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http://dx.doi.org/10.1093/bfgp/elt037DOI Listing
November 2013

Regulation of protein-protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes.

Mol Biosyst 2013 Jul 30;9(7):1620-6. Epub 2013 Jan 30.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1039/c3mb25514jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665713PMC
July 2013

Protein complexes are under evolutionary selection to assemble via ordered pathways.

Cell 2013 Apr;153(2):461-70

EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

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http://dx.doi.org/10.1016/j.cell.2013.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009401PMC
April 2013

Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.

Proc Natl Acad Sci U S A 2012 Dec 26;109(50):20461-6. Epub 2012 Nov 26.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1209312109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528536PMC
December 2012

Probing the diverse landscape of protein flexibility and binding.

Curr Opin Struct Biol 2012 Oct 20;22(5):643-50. Epub 2012 Sep 20.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1016/j.sbi.2012.08.008DOI Listing
October 2012

Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells.

Curr Opin Cell Biol 2012 Jun 11;24(3):350-8. Epub 2012 Apr 11.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.ceb.2012.03.007DOI Listing
June 2012

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture.

Biochem Soc Trans 2012 Jun;40(3):475-91

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, U.K.

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http://dx.doi.org/10.1042/BST20120056DOI Listing
June 2012

Evolution of oligomeric state through geometric coupling of protein interfaces.

Proc Natl Acad Sci U S A 2012 May 7;109(21):8127-32. Epub 2012 May 7.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1120028109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361393PMC
May 2012

Analysis and simulation of gene expression profiles in pure and mixed cell populations.

Phys Biol 2011 Jun 13;8(3):035013. Epub 2011 May 13.

MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1088/1478-3975/8/3/035013DOI Listing
June 2011

Relative solvent accessible surface area predicts protein conformational changes upon binding.

Structure 2011 Jun;19(6):859-67

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK.

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http://dx.doi.org/10.1016/j.str.2011.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145976PMC
June 2011

RNA sequencing reveals two major classes of gene expression levels in metazoan cells.

Mol Syst Biol 2011 Jun 7;7:497. Epub 2011 Jun 7.

Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/msb.2011.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159973PMC
June 2011

EpiChIP: gene-by-gene quantification of epigenetic modification levels.

Nucleic Acids Res 2011 Mar 3;39(5):e27. Epub 2010 Dec 3.

MRC Laboratory of Molecular Biology, Hills Rd, CB2 0QH Cambridge, UK.

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http://dx.doi.org/10.1093/nar/gkq1226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061070PMC
March 2011

The impact of gene expression regulation on evolution of extracellular signaling pathways.

Mol Cell Proteomics 2010 Dec 8;9(12):2666-77. Epub 2010 Oct 8.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB20QH, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M110.003020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101855PMC
December 2010

Assessing computational methods of cis-regulatory module prediction.

PLoS Comput Biol 2010 Dec 2;6(12):e1001020. Epub 2010 Dec 2.

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1001020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996316PMC
December 2010

Genomic repertoires of DNA-binding transcription factors across the tree of life.

Nucleic Acids Res 2010 Nov 30;38(21):7364-77. Epub 2010 Jul 30.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/nar/gkq617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995046PMC
November 2010

Lineage-specific expansion of DNA-binding transcription factor families.

Trends Genet 2010 Sep 31;26(9):388-93. Epub 2010 Jul 31.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01689525100012
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http://dx.doi.org/10.1016/j.tig.2010.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937223PMC
September 2010