Sara Wells

Sara Wells

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Sara Wells

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Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13.

Genetics 2020 Feb 13;214(2):467-477. Epub 2019 Dec 13.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1534/genetics.119.302786DOI Listing
February 2020

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

Sci Rep 2020 Jan 16;10(1):437. Epub 2020 Jan 16.

MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41598-019-57398-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965129PMC
January 2020

Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight.

Sci Rep 2019 Nov 20;9(1):17195. Epub 2019 Nov 20.

Mammalian Genetics Unit, Medical Research Council, Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1038/s41598-019-53900-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868159PMC
November 2019

When all is not lost: considering genetic compensation in laboratory animals.

Lab Anim (NY) 2019 10;48(10):282-284

The Mary Lyon Centre, Medical Research Council Harwell Institute, Oxon, United Kingdom.

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http://dx.doi.org/10.1038/s41684-019-0397-4DOI Listing
October 2019

A refinement to the formalin test in mice.

F1000Res 2019 20;8:891. Epub 2019 Jun 20.

Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London SE1 1UL, London, UK.

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http://dx.doi.org/10.12688/f1000research.18338.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707399.2PMC
June 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Characterisation and use of a functional Gadd45g bacterial artificial chromosome.

Sci Rep 2018 11 23;8(1):17318. Epub 2018 Nov 23.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1038/s41598-018-35458-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251886PMC
November 2018

Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice.

Sci Rep 2018 08 1;8(1):11532. Epub 2018 Aug 1.

MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-30011-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070476PMC
August 2018

Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools.

J Neurosci Methods 2018 04 26;300:37-47. Epub 2017 Apr 26.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science Campus, Oxfordshire, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909039PMC
April 2018

Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.

Hum Mol Genet 2018 01;27(1):190-198

Mammalian Genetics Unit, Medical Research Council, Harwell Institute, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/hmg/ddx398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886154PMC
January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

The trouble with collective nouns for genome editing.

Mamm Genome 2017 Aug 18;28(7-8):365-366. Epub 2017 Jul 18.

TEFOR Infrastructure, Neuro-PSI, CNRS, 1 Avenue de la Terrasse, 91198, Gif-sur-yvette, France.

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http://dx.doi.org/10.1007/s00335-017-9707-6DOI Listing
August 2017

Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control.

Methods 2017 05 28;121-122:68-76. Epub 2017 Mar 28.

The Mary Lyon Centre, MRC Harwell Institute, Didcot, Oxon OX11 0RD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.03.016DOI Listing
May 2017

N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 () Mutations Establish Loss-of-Function Mice.

JBMR Plus 2017 May;1(1):3-15

Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, UK.

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http://doi.wiley.com/10.1002/jbm4.10001
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http://dx.doi.org/10.1002/jbm4.10001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824975PMC
May 2017

A scoring system for the evaluation of the mutated -derived retinal lesions in C57BL/6N mice.

F1000Res 2017 31;6:404. Epub 2017 Mar 31.

Mary Lyon Centre, Harwell Campus, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.12688/f1000research.11252.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580417PMC
March 2017

High-throughput discovery of novel developmental phenotypes.

Nature 2016 09 14;537(7621):508-514. Epub 2016 Sep 14.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/nature19356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295821PMC
September 2016

Building for the future: essential infrastructure for rodent ageing studies.

Mamm Genome 2016 08 24;27(7-8):440-4. Epub 2016 May 24.

Department of Oncology and Metabolism, The Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.

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http://dx.doi.org/10.1007/s00335-016-9646-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935732PMC
August 2016

Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy.

Am J Hum Genet 2016 06 26;98(6):1249-1255. Epub 2016 May 26.

Children's Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ 85004, USA; Neurogenetics Research Program, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ 85016, USA; Program in Neuroscience, Arizona State University, Tempe, AZ 85287, USA; Pediatric Movement Disorders Center, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ 85016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908178PMC
June 2016

Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.

Biol Reprod 2016 05 23;94(5):103. Epub 2016 Mar 23.

Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire, United Kingdom

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http://dx.doi.org/10.1095/biolreprod.115.138057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842889PMC
May 2016

Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.

Mech Ageing Dev 2016 Mar 6;154:20-3. Epub 2016 Feb 6.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798846PMC
March 2016

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse.

Dis Model Mech 2016 Jan 26;9(1):69-79. Epub 2015 Nov 26.

MRC Mammalian Genetics Unit, MRC Harwell, Didcot, Oxford, OX11 0RD, UK Developmental Biology Division, The Roslin Institute and Royal (Dick) School of Veterinary Studies, Easter Bush Campus, University of Edinburgh, EH25 9RG, UK Mary Lyon Centre, MRC Harwell, Harwell, Didcot, Oxford, OX11 0RD, UK

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http://dmm.biologists.org/content/dmm/early/2015/11/19/dmm.0
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http://dmm.biologists.org/cgi/doi/10.1242/dmm.021659
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http://dx.doi.org/10.1242/dmm.021659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728332PMC
January 2016

Talking welfare: the importance of a common language.

Mamm Genome 2015 Oct 19;26(9-10):482-5. Epub 2015 Aug 19.

Mary Lyon Centre, MRC Harwell, Nineteenth St, Didcot, OXON, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-015-9591-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602052PMC
October 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

J Proteome Res 2015 May 20;14(5):2036-45. Epub 2015 Apr 20.

‡Institute of Hepatology, Foundation for Liver Research, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom.

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http://dx.doi.org/10.1021/pr501039kDOI Listing
May 2015

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.

Dis Model Mech 2014 Oct 15;7(10):1153-63. Epub 2014 Aug 15.

Newlife Birth Defects Research Centre, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1242/dmm.016758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174526PMC
October 2014

Shared Ageing Research Models (ShARM): a new facility to support ageing research.

Biogerontology 2013 Dec 2;14(6):789-94. Epub 2013 Oct 2.

Department of Human Metabolism, Medical School, Mellanby Centre for Bone Research, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK,

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http://dx.doi.org/10.1007/s10522-013-9457-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847282PMC
December 2013

A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy.

Invest Ophthalmol Vis Sci 2013 May 1;54(5):3569-78. Epub 2013 May 1.

MRC Human Genetics Unit, MRC Institute of Genetics & & Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1167/iovs.12-11125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025949PMC
May 2013

Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome.

Cardiovasc Res 2011 Apr 10;90(1):182-90. Epub 2010 Nov 10.

MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, UK.

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http://dx.doi.org/10.1093/cvr/cvq356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058731PMC
April 2011

Overexpression of Fto leads to increased food intake and results in obesity.

Nat Genet 2010 Dec 14;42(12):1086-92. Epub 2010 Nov 14.

MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, UK.

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http://dx.doi.org/10.1038/ng.713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018646PMC
December 2010

Establishing normal plasma and 24-hour urinary biochemistry ranges in C3H, BALB/c and C57BL/6J mice following acclimatization in metabolic cages.

Lab Anim 2010 Jul 10;44(3):218-25. Epub 2010 May 10.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1258/la.2010.009128DOI Listing
July 2010

EuroPhenome: a repository for high-throughput mouse phenotyping data.

Nucleic Acids Res 2010 Jan 23;38(Database issue):D577-85. Epub 2009 Nov 23.

MRC Harwell, Mammalian Genetics Unit, MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/nar/gkp1007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808931PMC
January 2010

Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy.

Mol Cell Neurosci 2009 Dec 14;42(4):296-307. Epub 2009 Aug 14.

Euan MacDonald Centre for MND Research, The University of Edinburgh, George Square, Edinburgh EH89JZ, UK.

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http://dx.doi.org/10.1016/j.mcn.2009.08.002DOI Listing
December 2009

Dedicated mouse production and husbandry.

Methods Mol Biol 2009 ;561:285-99

Medical Research Council, Harwell, UK.

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http://link.springer.com/10.1007/978-1-60327-019-9_19
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http://dx.doi.org/10.1007/978-1-60327-019-9_19DOI Listing
September 2009

Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data.

BMC Bioinformatics 2009 May 6;10 Suppl 5:S2. Epub 2009 May 6.

MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1186/1471-2105-10-S5-S2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679402PMC
May 2009

Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract.

Mamm Genome 2009 Mar 24;20(3):140-51. Epub 2009 Jan 24.

Mammalian Genetics Unit, MRC Harwell, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-008-9169-yDOI Listing
March 2009

Sfrp1 and Sfrp2 are required for normal male sexual development in mice.

Dev Biol 2009 Feb 7;326(2):273-84. Epub 2008 Dec 7.

Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, UK.

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http://dx.doi.org/10.1016/j.ydbio.2008.11.023DOI Listing
February 2009

Venous access in oncology and haematology patients: Part two.

Authors:
Sara Wells

Nurs Stand 2008 Sep 10-16;23(1):35-42

Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham.

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http://dx.doi.org/10.7748/ns2008.09.23.1.35.c6652DOI Listing
December 2008

ENU mutagenesis, a way forward to understand gene function.

Annu Rev Genomics Hum Genet 2008 ;9:49-69

MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom.

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http://dx.doi.org/10.1146/annurev.genom.9.081307.164224DOI Listing
December 2008

Venous access in oncology and haematology patients: part one.

Authors:
Sara Wells

Nurs Stand 2008 Sep 3-9;22(52):39-46

Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham.

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http://rcnpublishing.com/doi/abs/10.7748/ns2008.09.22.52.39.
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http://dx.doi.org/10.7748/ns2008.09.22.52.39.c6649DOI Listing
October 2008

A new coat color mouse line for testing germline transmission of embryonic stem cells while retaining an inbred genetic background.

J Am Assoc Lab Anim Sci 2007 May;46(3):37-40

Mammalian Genetics Disease Unit, School of Medicine and Biomedical Sciences, University of Shiffield, UK.

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May 2007

Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse.

Environ Mol Mutagen 2007 Mar;48(2):124-42

Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.1002/em.20286DOI Listing
March 2007

Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1.

J Biol Chem 2006 May 20;281(19):13733-42. Epub 2006 Mar 20.

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M602052200DOI Listing
May 2006

Visceral obesity without insulin resistance in late-onset obesity rats.

Endocrinology 2004 Jun 19;145(6):2666-79. Epub 2004 Mar 19.

Division of Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1210/en.2003-1608DOI Listing
June 2004

Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones.

J Physiol 2003 Aug 17;551(Pt 1):323-36. Epub 2003 Jun 17.

Division of Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://www.jphysiol.org/cgi/doi/10.1113/jphysiol.2002.037655
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http://dx.doi.org/10.1113/jphysiol.2002.037655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343152PMC
August 2003

Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus.

Front Neuroendocrinol 2003 Jan;24(1):11-26

Molecular Neuroendocrinology Research Group, University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, UK.

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http://dx.doi.org/10.1016/s0091-3022(02)00103-6DOI Listing
January 2003