Sara Wells

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.

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December 2020

Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata.

Authors:

Colline Poirier Suliann Ben Hamed Pamela Garcia-Saldivar Sze Chai Kwok Adrien Meguerditchian Hugo Merchant Jeffrey Rogers Sara Wells Andrew S Fox

Neuroimage 2021 03 6;228:117679. Epub 2021 Jan 6.

California National Primate Research Center, Department of Psychology, University of California, Davis, Davis, CA, 95616, USA.

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March 2021

Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model.

Authors:

Fadil M Hannan Caroline M Gorvin Valerie N Babinsky Mie K Olesen Michelle Stewart Sara Wells Roger D Cox Edward F Nemeth Rajesh V Thakker

JBMR Plus 2020 Oct 7;4(10):e10402. Epub 2020 Sep 7.

Academic Endocrine Unit, Radcliffe Department of Medicine Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford Oxford UK.

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October 2020

Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits.

Authors:

Gareth T Banks Mathilde C C Guillaumin Ines Heise Petrina Lau Minghui Yin Nora Bourbia Carlos Aguilar Michael R Bowl Chris Esapa Laurence A Brown Sibah Hasan Erica Tagliatti Elizabeth Nicholson Rasneer Sonia Bains Sara Wells Vladyslav V Vyazovskiy Kirill Volynski Stuart N Peirson Patrick M Nolan

Sci Adv 2020 Aug 12;6(33):eabb3567. Epub 2020 Aug 12.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science and Innovation Campus, Oxfordshire, UK.

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August 2020

Phenotyping in Mice Using Continuous Home Cage Monitoring and Ultrasonic Vocalization Recordings.

Authors:

Liane Hobson Rasneer S Bains Simon Greenaway Sara Wells Patrick M Nolan

Curr Protoc Mouse Biol 2020 Sep;10(3):e80

Medical Research Council Harwell Institute, Harwell, Oxfordshire, United Kingdom.

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September 2020

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells.

Authors:

Jing-Yi Jeng Stuart L Johnson Adam J Carlton Lara De Tomasi Richard J Goodyear Francesca De Faveri David N Furness Sara Wells Steve D M Brown Matthew C Holley Guy P Richardson Mirna Mustapha Michael R Bowl Walter Marcotti

J Physiol 2020 09 22;598(18):3891-3910. Epub 2020 Jul 22.

Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.

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September 2020

Universal Southern blot protocol with cold or radioactive probes for the validation of alleles obtained by homologous recombination.

Authors:

Gemma F Codner Valerie Erbs Jorik Loeffler Lauren Chessum Adam Caulder Nicolas Jullien Sara Wells Marie-Christine Birling Lydia Teboul

Methods 2020 Jun 26. Epub 2020 Jun 26.

The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon OX11 0RD, UK. Electronic address:

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June 2020

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.

Authors:

Eleanor Herbert Michelle Stewart Marie Hutchison Ann M Flenniken Dawei Qu Lauryl M J Nutter Colin McKerlie Liane Hobson Brenda Kick Bonnie Lyons Jean-Paul Wiegand Rosalinda Doty Juan Antonio Aguilar-Pimentel Martin Hrabe de Angelis Mary Dickinson John Seavitt Jacqueline K White Cheryl L Scudamore Sara Wells

PLoS One 2020 15;15(6):e0230162. Epub 2020 Jun 15.

Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, United Kingdom.

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August 2020

Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical Safety.

Authors:

Lydia Teboul Yann Herault Sara Wells Waseem Qasim Guillaume Pavlovic

Mol Ther 2020 06 20;28(6):1422-1431. Epub 2020 Mar 20.

Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-Institut Clinique de la Souris, Celphedia, Strasbourg 67404, France. Electronic address:

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June 2020

The Deep Genome Project.

Genome Biol 2020 02 3;21(1):18. Epub 2020 Feb 3.

Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.

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February 2020

Human and mouse essentiality screens as a resource for disease gene discovery.

Nat Commun 2020 01 31;11(1):655. Epub 2020 Jan 31.

Clinical Pharmacology, William Harvey Research Institute, School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.

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January 2020

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

Authors:

Amy S Findlay Lisa McKie Margaret Keighren Sharon Clementson-Mobbs Luis Sanchez-Pulido Sara Wells Sally H Cross Ian J Jackson

Sci Rep 2020 01 16;10(1):437. Epub 2020 Jan 16.

MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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January 2020

Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13.

Authors:

Catherine Livermore Michelle Simon Richard Reeves Isabelle Stévant Serge Nef Madeleine Pope Ann-Marie Mallon Sara Wells Nick Warr Andy Greenfield

Genetics 2020 02 13;214(2):467-477. Epub 2019 Dec 13.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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February 2020

Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight.

Authors:

Catherine Livermore Nick Warr Nicolas Chalon Pam Siggers Joffrey Mianné Gemma Codner Lydia Teboul Sara Wells Andy Greenfield

Sci Rep 2019 11 20;9(1):17195. Epub 2019 Nov 20.

Mammalian Genetics Unit, Medical Research Council, Harwell Institute, Oxfordshire, OX11 0RD, UK.

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November 2019

Correction: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.

Authors:

Naila Haq Christoph Schmidt-Hieber Fernando J Sialana Lorenza Ciani Janosch P Heller Michelle Stewart Liz Bentley Sara Wells Richard J Rodenburg Patrick M Nolan Elizabeth Forsythe Michael C Wu Gert Lubec Patricia C Salinas Michael Häusser Philip L Beales Sofia Christou-Savina

PLoS Biol 2019 Oct 8;17(10):e3000520. Epub 2019 Oct 8.

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October 2019

A refinement to the formalin test in mice.

Authors:

Douglas M Lopes Heather L Cater Matthew Thakur Sara Wells Stephen B McMahon

F1000Res 2019 20;8:891. Epub 2019 Jun 20.

Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London SE1 1UL, London, UK.

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June 2020

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.

Authors:

Naila Haq Christoph Schmidt-Hieber Fernando J Sialana Lorenza Ciani Janosch P Heller Michelle Stewart Liz Bentley Sara Wells Richard J Rodenburg Patrick M Nolan Elizabeth Forsythe Michael C Wu Gert Lubec P Salinas Michael Häusser Philip L Beales Sofia Christou-Savina

PLoS Biol 2019 09 3;17(9):e3000414. Epub 2019 Sep 3.

Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

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September 2019

When all is not lost: considering genetic compensation in laboratory animals.

Authors:

Rosie K A Bunton-Stasyshyn Sara Wells Lydia Teboul

Lab Anim (NY) 2019 10;48(10):282-284

The Mary Lyon Centre, Medical Research Council Harwell Institute, Oxon, United Kingdom.

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October 2019

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

EMBO Mol Med 2019 09 26;11(9):e10288. Epub 2019 Aug 26.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell, UK.

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September 2019

Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa.

Authors:

Brian D Guth Anne F Grobler Kendall S Frazier Andrea Greiter-Wilke Danuta Herzyk Tertius A Hough Asrar Ali Khan Michael Markert James D Smith Karen L Svenson Sara Wells Michael K Pugsley

J Pharmacol Toxicol Methods 2019 Jul - Aug;98:106579. Epub 2019 May 11.

Safety Pharmacology Society, Fairfield, CT, USA.

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January 2020

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:

Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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March 2019

Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis.

J Bone Miner Res 2019 07 4;34(7):1324-1335. Epub 2019 Mar 4.

Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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July 2019

Loss of disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.

Authors:

Michelle Stewart Petrina Lau Gareth Banks Rasneer Sonia Bains Enrico Castroflorio Peter L Oliver Christine L Dixon Michael C Kruer Dimitri M Kullmann Abraham Acevedo-Arozena Sara E Wells Silvia Corrochano Patrick M Nolan

Dis Model Mech 2019 02 22;12(2). Epub 2019 Feb 22.

MRC Harwell Institute, Harwell Campus, Oxfordshire OX11 0RD, UK

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February 2019

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:

Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2018 21;1:236. Epub 2018 Dec 21.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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December 2018

Characterisation and use of a functional Gadd45g bacterial artificial chromosome.

Authors:

Nick Warr Joel May Lydia Teboul Toru Suzuki Maki Asami Anthony C F Perry Sara Wells Andy Greenfield

Sci Rep 2018 11 23;8(1):17318. Epub 2018 Nov 23.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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November 2018

Helios is a key transcriptional regulator of outer hair cell maturation.

Nature 2018 11 21;563(7733):696-700. Epub 2018 Nov 21.

Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

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November 2018

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice.

J Bone Miner Res 2019 03 14;34(3):497-507. Epub 2018 Dec 14.

Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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March 2019

Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice.

Authors:

Michael Curley Laura Milne Sarah Smith Nina Atanassova Diane Rebourcet Annalucia Darbey Patrick W F Hadoke Sara Wells Lee B Smith

Sci Rep 2018 08 1;8(1):11532. Epub 2018 Aug 1.

MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.

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August 2018

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