Sara Wells

Sara Wells

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Sara Wells

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Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13.

Authors:
Catherine Livermore Michelle Simon Richard Reeves Isabelle Stévant Serge Nef Madeleine Pope Ann-Marie Mallon Sara Wells Nick Warr Andy Greenfield

Genetics 2020 Feb 13;214(2):467-477. Epub 2019 Dec 13.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1534/genetics.119.302786DOI Listing
February 2020

The Deep Genome Project.

Authors:
K C Kent Lloyd David J Adams Gareth Baynam Arthur L Beaudet Fatima Bosch Kym M Boycott Robert E Braun Mark Caulfield Ronald Cohn Mary E Dickinson Michael S Dobbie Ann M Flenniken Paul Flicek Sanjeev Galande Xiang Gao Anne Grobler Jason D Heaney Yann Herault Martin Hrabě de Angelis James R Lupski Stanislas Lyonnet Ann-Marie Mallon Fabio Mammano Calum A MacRae Roderick McInnes Colin McKerlie Terrence F Meehan Stephen A Murray Lauryl M J Nutter Yuichi Obata Helen Parkinson Michael S Pepper Radislav Sedlacek Je Kyung Seong Toshihiko Shiroishi Damian Smedley Glauco Tocchini-Valentini David Valle Chi-Kuang Leo Wang Sara Wells Jacqueline White Wolfgang Wurst Ying Xu Steve D M Brown

Genome Biol 2020 02 3;21(1):18. Epub 2020 Feb 3.

Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1186/s13059-020-1931-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996159PMC
February 2020

Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa.

Authors:
Brian D Guth Anne F Grobler Kendall S Frazier Andrea Greiter-Wilke Danuta Herzyk Tertius A Hough Asrar Ali Khan Michael Markert James D Smith Karen L Svenson Sara Wells Michael K Pugsley

J Pharmacol Toxicol Methods 2019 Jul - Aug;98:106579. Epub 2019 May 11.

Safety Pharmacology Society, Fairfield, CT, USA.

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http://dx.doi.org/10.1016/j.vascn.2019.106579DOI Listing
January 2020

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

Authors:
Amy S Findlay Lisa McKie Margaret Keighren Sharon Clementson-Mobbs Luis Sanchez-Pulido Sara Wells Sally H Cross Ian J Jackson

Sci Rep 2020 Jan 16;10(1):437. Epub 2020 Jan 16.

MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/s41598-019-57398-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965129PMC
January 2020

Human and mouse essentiality screens as a resource for disease gene discovery.

Authors:
Pilar Cacheiro Violeta Muñoz-Fuentes Stephen A Murray Mary E Dickinson Maja Bucan Lauryl M J Nutter Kevin A Peterson Hamed Haselimashhadi Ann M Flenniken Hugh Morgan Henrik Westerberg Tomasz Konopka Chih-Wei Hsu Audrey Christiansen Denise G Lanza Arthur L Beaudet Jason D Heaney Helmut Fuchs Valerie Gailus-Durner Tania Sorg Jan Prochazka Vendula Novosadova Christopher J Lelliott Hannah Wardle-Jones Sara Wells Lydia Teboul Heather Cater Michelle Stewart Tertius Hough Wolfgang Wurst Radislav Sedlacek David J Adams John R Seavitt Glauco Tocchini-Valentini Fabio Mammano Robert E Braun Colin McKerlie Yann Herault Martin Hrabě de Angelis Ann-Marie Mallon K C Kent Lloyd Steve D M Brown Helen Parkinson Terrence F Meehan Damian Smedley

Nat Commun 2020 Jan 31;11(1):655. Epub 2020 Jan 31.

Clinical Pharmacology, William Harvey Research Institute, School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/s41467-020-14284-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994715PMC
January 2020

Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight.

Authors:
Catherine Livermore Nick Warr Nicolas Chalon Pam Siggers Joffrey Mianné Gemma Codner Lydia Teboul Sara Wells Andy Greenfield

Sci Rep 2019 Nov 20;9(1):17195. Epub 2019 Nov 20.

Mammalian Genetics Unit, Medical Research Council, Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1038/s41598-019-53900-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868159PMC
November 2019

When all is not lost: considering genetic compensation in laboratory animals.

Authors:
Rosie K A Bunton-Stasyshyn Sara Wells Lydia Teboul

Lab Anim (NY) 2019 10;48(10):282-284

The Mary Lyon Centre, Medical Research Council Harwell Institute, Oxon, United Kingdom.

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http://dx.doi.org/10.1038/s41684-019-0397-4DOI Listing
October 2019

Correction: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.

Authors:
Naila Haq Christoph Schmidt-Hieber Fernando J Sialana Lorenza Ciani Janosch P Heller Michelle Stewart Liz Bentley Sara Wells Richard J Rodenburg Patrick M Nolan Elizabeth Forsythe Michael C Wu Gert Lubec Patricia C Salinas Michael Häusser Philip L Beales Sofia Christou-Savina

PLoS Biol 2019 Oct 8;17(10):e3000520. Epub 2019 Oct 8.

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http://dx.doi.org/10.1371/journal.pbio.3000520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782084PMC
October 2019

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

Authors:
Lucy A Dunbar Pranav Patni Carlos Aguilar Philomena Mburu Laura Corns Helena Rr Wells Sedigheh Delmaghani Andrew Parker Stuart Johnson Debbie Williams Christopher T Esapa Michelle M Simon Lauren Chessum Sherylanne Newton Joanne Dorning Prashanthini Jeyarajan Susan Morse Andrea Lelli Gemma F Codner Thibault Peineau Suhasini R Gopal Kumar N Alagramam Ronna Hertzano Didier Dulon Sara Wells Frances M Williams Christine Petit Sally J Dawson Steve Dm Brown Walter Marcotti Aziz El-Amraoui Michael R Bowl

EMBO Mol Med 2019 09 26;11(9):e10288. Epub 2019 Aug 26.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell, UK.

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http://dx.doi.org/10.15252/emmm.201910288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728604PMC
September 2019

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.

Authors:
Naila Haq Christoph Schmidt-Hieber Fernando J Sialana Lorenza Ciani Janosch P Heller Michelle Stewart Liz Bentley Sara Wells Richard J Rodenburg Patrick M Nolan Elizabeth Forsythe Michael C Wu Gert Lubec P Salinas Michael Häusser Philip L Beales Sofia Christou-Savina

PLoS Biol 2019 09 3;17(9):e3000414. Epub 2019 Sep 3.

Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.3000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743795PMC
September 2019

Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis.

Authors:
Caroline M Gorvin Nellie Y Loh Michael J Stechman Sara Falcone Fadil M Hannan Bushra N Ahmad Sian E Piret Anita Ac Reed Jeshmi Jeyabalan Paul Leo Mhairi Marshall Siddharth Sethi Paul Bass Ian Roberts Jeremy Sanderson Sara Wells Tertius A Hough Liz Bentley Paul T Christie Michelle M Simon Ann-Marie Mallon Herbert Schulz Roger D Cox Matthew A Brown Norbert Huebner Steve D Brown Rajesh V Thakker

J Bone Miner Res 2019 Jul 4;34(7):1324-1335. Epub 2019 Mar 4.

Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/jbmr.3695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658219PMC
July 2019

A refinement to the formalin test in mice.

Authors:
Douglas M Lopes Heather L Cater Matthew Thakur Sara Wells Stephen B McMahon

F1000Res 2019 20;8:891. Epub 2019 Jun 20.

Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London SE1 1UL, London, UK.

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http://dx.doi.org/10.12688/f1000research.18338.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707399.2PMC
June 2019

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice.

Authors:
Caroline M Gorvin Bushra N Ahmad Michael J Stechman Nellie Y Loh Tertius A Hough Paul Leo Mhairi Marshall Siddharth Sethi Liz Bentley Sian E Piret Anita Reed Jeshmi Jeyabalan Paul T Christie Sara Wells Michelle M Simon Ann-Marie Mallon Herbert Schulz Norbert Huebner Matthew A Brown Roger D Cox Steve D Brown Rajesh V Thakker

J Bone Miner Res 2019 Mar 14;34(3):497-507. Epub 2018 Dec 14.

Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1002/jbmr.3624
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http://dx.doi.org/10.1002/jbmr.3624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446808PMC
March 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:
Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Loss of disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.

Authors:
Michelle Stewart Petrina Lau Gareth Banks Rasneer Sonia Bains Enrico Castroflorio Peter L Oliver Christine L Dixon Michael C Kruer Dimitri M Kullmann Abraham Acevedo-Arozena Sara E Wells Silvia Corrochano Patrick M Nolan

Dis Model Mech 2019 02 22;12(2). Epub 2019 Feb 22.

MRC Harwell Institute, Harwell Campus, Oxfordshire OX11 0RD, UK

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http://dx.doi.org/10.1242/dmm.036806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398485PMC
February 2019

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Authors:
Bret A Moore Brian C Leonard Lionel Sebbag Sydney G Edwards Ann Cooper Denise M Imai Ewan Straiton Luis Santos Christopher Reilly Stephen M Griffey Lynette Bower David Clary Jeremy Mason Michel J Roux Hamid Meziane Yann Herault Colin McKerlie Ann M Flenniken Lauryl M J Nutter Zorana Berberovic Celeste Owen Susan Newbigging Hibret Adissu Mohammed Eskandarian Chih-Wei Hsu Sowmya Kalaga Uchechukwu Udensi Chinwe Asomugha Ritu Bohat Juan J Gallegos John R Seavitt Jason D Heaney Arthur L Beaudet Mary E Dickinson Monica J Justice Vivek Philip Vivek Kumar Karen L Svenson Robert E Braun Sara Wells Heather Cater Michelle Stewart Sharon Clementson-Mobbs Russell Joynson Xiang Gao Tomohiro Suzuki Shigeharu Wakana Damian Smedley J K Seong Glauco Tocchini-Valentini Mark Moore Colin Fletcher Natasha Karp Ramiro Ramirez-Solis Jacqueline K White Martin Hrabe de Angelis Wolfgang Wurst Sara M Thomasy Paul Flicek Helen Parkinson Steve D M Brown Terrence F Meehan Patsy M Nishina Stephen A Murray Mark P Krebs Ann-Marie Mallon K C Kent Lloyd Christopher J Murphy Ala Moshiri

Commun Biol 2018 21;1:236. Epub 2018 Dec 21.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1038/s42003-018-0226-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303268PMC
December 2018

Helios is a key transcriptional regulator of outer hair cell maturation.

Authors:
Lauren Chessum Maggie S Matern Michael C Kelly Stuart L Johnson Yoko Ogawa Beatrice Milon Mark McMurray Elizabeth C Driver Andrew Parker Yang Song Gemma Codner Christopher T Esapa Jack Prescott Graham Trent Sara Wells Abigail K Dragich Gregory I Frolenkov Matthew W Kelley Walter Marcotti Steve D M Brown Ran Elkon Michael R Bowl Ronna Hertzano

Nature 2018 11 21;563(7733):696-700. Epub 2018 Nov 21.

Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41586-018-0728-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542691PMC
November 2018

Characterisation and use of a functional Gadd45g bacterial artificial chromosome.

Authors:
Nick Warr Joel May Lydia Teboul Toru Suzuki Maki Asami Anthony C F Perry Sara Wells Andy Greenfield

Sci Rep 2018 11 23;8(1):17318. Epub 2018 Nov 23.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1038/s41598-018-35458-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251886PMC
November 2018

Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice.

Authors:
Michael Curley Laura Milne Sarah Smith Nina Atanassova Diane Rebourcet Annalucia Darbey Patrick W F Hadoke Sara Wells Lee B Smith

Sci Rep 2018 08 1;8(1):11532. Epub 2018 Aug 1.

MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-30011-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070476PMC
August 2018

High-throughput mouse phenomics for characterizing mammalian gene function.

Authors:
Steve D M Brown Chris C Holmes Ann-Marie Mallon Terrence F Meehan Damian Smedley Sara Wells

Nat Rev Genet 2018 06;19(6):357-370

MRC Harwell Institute, Harwell, UK.

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http://www.nature.com/articles/s41576-018-0005-2
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http://dx.doi.org/10.1038/s41576-018-0005-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582361PMC
June 2018

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants.

Authors:
Gemma F Codner Joffrey Mianné Adam Caulder Jorik Loeffler Rachel Fell Ruairidh King Alasdair J Allan Matthew Mackenzie Fran J Pike Christopher V McCabe Skevoulla Christou Sam Joynson Marie Hutchison Michelle E Stewart Saumya Kumar Michelle M Simon Loranne Agius Quentin M Anstee Kirill E Volynski Dimitri M Kullmann Sara Wells Lydia Teboul

BMC Biol 2018 06 21;16(1):70. Epub 2018 Jun 21.

The Mary Lyon Centre, MRC Harwell Institute, Didcot, Oxon, OX11 0RD, UK.

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http://dx.doi.org/10.1186/s12915-018-0530-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011369PMC
June 2018

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.

Authors:
Abigail Harris Pam Siggers Silvia Corrochano Nick Warr Danielle Sagar Daniel T Grimes Makoto Suzuki Rebecca D Burdine Feng Cong Bon-Kyoung Koo Hans Clevers Isabelle Stévant Serge Nef Sara Wells Raja Brauner Bochra Ben Rhouma Neïla Belguith Caroline Eozenou Joelle Bignon-Topalovic Anu Bashamboo Ken McElreavey Andy Greenfield

Proc Natl Acad Sci U S A 2018 05 7;115(21):5474-5479. Epub 2018 May 7.

Mammalian Genetics Unit, Medical Research Council, Harwell Institute, OX11 0RD Oxfordshire, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1801223115
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http://dx.doi.org/10.1073/pnas.1801223115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003506PMC
May 2018

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

Authors:
Sheona Watson-Scales Bernadett Kalmar Eva Lana-Elola Dorota Gibbins Federica La Russa Frances Wiseman Matthew Williamson Rachele Saccon Amy Slender Anna Olerinyova Radma Mahmood Emma Nye Heather Cater Sara Wells Y Eugene Yu David L H Bennett Linda Greensmith Elizabeth M C Fisher Victor L J Tybulewicz

PLoS Genet 2018 05 10;14(5):e1007383. Epub 2018 May 10.

The Francis Crick Institute, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963810PMC
May 2018

Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools.

Authors:
Rasneer S Bains Sara Wells Rowland R Sillito J Douglas Armstrong Heather L Cater Gareth Banks Patrick M Nolan

J Neurosci Methods 2018 04 26;300:37-47. Epub 2017 Apr 26.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science Campus, Oxfordshire, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909039PMC
April 2018

Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.

Authors:
Gwenn-Aël Carré Pam Siggers Marilena Xipolita Paul Brindle Beat Lutz Sara Wells Andy Greenfield

Hum Mol Genet 2018 01;27(1):190-198

Mammalian Genetics Unit, Medical Research Council, Harwell Institute, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/hmg/ddx398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886154PMC
January 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Authors:
Jan Rozman Birgit Rathkolb Manuela A Oestereicher Christine Schütt Aakash Chavan Ravindranath Stefanie Leuchtenberger Sapna Sharma Martin Kistler Monja Willershäuser Robert Brommage Terrence F Meehan Jeremy Mason Hamed Haselimashhadi Tertius Hough Ann-Marie Mallon Sara Wells Luis Santos Christopher J Lelliott Jacqueline K White Tania Sorg Marie-France Champy Lynette R Bower Corey L Reynolds Ann M Flenniken Stephen A Murray Lauryl M J Nutter Karen L Svenson David West Glauco P Tocchini-Valentini Arthur L Beaudet Fatima Bosch Robert B Braun Michael S Dobbie Xiang Gao Yann Herault Ala Moshiri Bret A Moore K C Kent Lloyd Colin McKerlie Hiroshi Masuya Nobuhiko Tanaka Paul Flicek Helen E Parkinson Radislav Sedlacek Je Kyung Seong Chi-Kuang Leo Wang Mark Moore Steve D Brown Matthias H Tschöp Wolfgang Wurst Martin Klingenspor Eckhard Wolf Johannes Beckers Fausto Machicao Andreas Peter Harald Staiger Hans-Ulrich Häring Harald Grallert Monica Campillos Holger Maier Helmut Fuchs Valerie Gailus-Durner Thomas Werner Martin Hrabe de Angelis

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Authors:
Mary E Dickinson Ann M Flenniken Xiao Ji Lydia Teboul Michael D Wong Jacqueline K White Terrence F Meehan Wolfgang J Weninger Henrik Westerberg Hibret Adissu Candice N Baker Lynette Bower James M Brown L Brianna Caddle Francesco Chiani Dave Clary James Cleak Mark J Daly James M Denegre Brendan Doe Mary E Dolan Sarah M Edie Helmut Fuchs Valerie Gailus-Durner Antonella Galli Alessia Gambadoro Juan Gallegos Shiying Guo Neil R Horner Chih-Wei Hsu Sara J Johnson Sowmya Kalaga Lance C Keith Louise Lanoue Thomas N Lawson Monkol Lek Manuel Mark Susan Marschall Jeremy Mason Melissa L McElwee Susan Newbigging Lauryl M J Nutter Kevin A Peterson Ramiro Ramirez-Solis Douglas J Rowland Edward Ryder Kaitlin E Samocha John R Seavitt Mohammed Selloum Zsombor Szoke-Kovacs Masaru Tamura Amanda G Trainor Ilinca Tudose Shigeharu Wakana Jonathan Warren Olivia Wendling David B West Leeyean Wong Atsushi Yoshiki Wolfgang Wurst Daniel G MacArthur Glauco P Tocchini-Valentini Xiang Gao Paul Flicek Allan Bradley William C Skarnes Monica J Justice Helen E Parkinson Mark Moore Sara Wells Robert E Braun Karen L Svenson Martin Hrabe de Angelis Yann Herault Tim Mohun Ann-Marie Mallon R Mark Henkelman Steve D M Brown David J Adams K C Kent Lloyd Colin McKerlie Arthur L Beaudet Maja Bućan Stephen A Murray

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Authors:
Michael R Bowl Michelle M Simon Neil J Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R Bower Dave A Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey Glauco P Tocchini-Valentini Xiang Gao Allan Bradley William C Skarnes Mark Moore Arthur L Beaudet Monica J Justice John Seavitt Mary E Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M J Nutter Ann M Flenniken Colin McKerlie Stephen A Murray Karen L Svenson Robert E Braun David B West K C Kent Lloyd David J Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F Meehan Helen E Parkinson Lydia M Teboul Sara Wells Karen P Steel Ann-Marie Mallon Steve D M Brown

Nat Commun 2017 10 12;8(1):886. Epub 2017 Oct 12.

Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1038/s41467-017-00595-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638796PMC
October 2017

Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.

Authors:
Sarah A Howles Fadil M Hannan Caroline M Gorvin Sian E Piret Anju Paudyal Michelle Stewart Tertius A Hough M Andrew Nesbit Sara Wells Stephen Dm Brown Roger D Cox Rajesh V Thakker

JCI Insight 2017 10 19;2(20). Epub 2017 Oct 19.

Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.96540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846897PMC
October 2017

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.

Authors:
Valerie N Babinsky Fadil M Hannan Reshma D Ramracheya Quan Zhang M Andrew Nesbit Alison Hugill Liz Bentley Tertius A Hough Elizabeth Joynson Michelle Stewart Abhishek Aggarwal Maximilian Prinz-Wohlgenannt Caroline M Gorvin Enikö Kallay Sara Wells Roger D Cox Duncan Richards Patrik Rorsman Rajesh V Thakker

Endocrinology 2017 08;158(8):2486-2502

Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, United Kingdom.

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http://dx.doi.org/10.1210/en.2017-00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551547PMC
August 2017

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Authors:
Terrence F Meehan Nathalie Conte David B West Julius O Jacobsen Jeremy Mason Jonathan Warren Chao-Kung Chen Ilinca Tudose Mike Relac Peter Matthews Natasha Karp Luis Santos Tanja Fiegel Natalie Ring Henrik Westerberg Simon Greenaway Duncan Sneddon Hugh Morgan Gemma F Codner Michelle E Stewart James Brown Neil Horner Melissa Haendel Nicole Washington Christopher J Mungall Corey L Reynolds Juan Gallegos Valerie Gailus-Durner Tania Sorg Guillaume Pavlovic Lynette R Bower Mark Moore Iva Morse Xiang Gao Glauco P Tocchini-Valentini Yuichi Obata Soo Young Cho Je Kyung Seong John Seavitt Arthur L Beaudet Mary E Dickinson Yann Herault Wolfgang Wurst Martin Hrabe de Angelis K C Kent Lloyd Ann M Flenniken Lauryl M J Nutter Susan Newbigging Colin McKerlie Monica J Justice Stephen A Murray Karen L Svenson Robert E Braun Jacqueline K White Allan Bradley Paul Flicek Sara Wells William C Skarnes David J Adams Helen Parkinson Ann-Marie Mallon Steve D M Brown Damian Smedley

Nat Genet 2017 Aug 26;49(8):1231-1238. Epub 2017 Jun 26.

William Harvey Research Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/ng.3901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546242PMC
August 2017

The trouble with collective nouns for genome editing.

Authors:
Sara Wells Jean Stéphane Joly

Mamm Genome 2017 Aug 18;28(7-8):365-366. Epub 2017 Jul 18.

TEFOR Infrastructure, Neuro-PSI, CNRS, 1 Avenue de la Terrasse, 91198, Gif-sur-yvette, France.

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August 2017

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.

Authors:
Michael Crompton Tom Purnell Hayley E Tyrer Andrew Parker Greg Ball Rachel E Hardisty-Hughes Richard Gale Debbie Williams Charlotte H Dean Michelle M Simon Ann-Marie Mallon Sara Wells Mahmood F Bhutta Martin J Burton Hilda Tateossian Steve D M Brown

PLoS Genet 2017 Aug 14;13(8):e1006969. Epub 2017 Aug 14.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1006969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570507PMC
August 2017

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Authors:
Natasha A Karp Jeremy Mason Arthur L Beaudet Yoav Benjamini Lynette Bower Robert E Braun Steve D M Brown Elissa J Chesler Mary E Dickinson Ann M Flenniken Helmut Fuchs Martin Hrabe de Angelis Xiang Gao Shiying Guo Simon Greenaway Ruth Heller Yann Herault Monica J Justice Natalja Kurbatova Christopher J Lelliott K C Kent Lloyd Ann-Marie Mallon Judith E Mank Hiroshi Masuya Colin McKerlie Terrence F Meehan Richard F Mott Stephen A Murray Helen Parkinson Ramiro Ramirez-Solis Luis Santos John R Seavitt Damian Smedley Tania Sorg Anneliese O Speak Karen P Steel Karen L Svenson Shigeharu Wakana David West Sara Wells Henrik Westerberg Shay Yaacoby Jacqueline K White

Nat Commun 2017 06 26;8:15475. Epub 2017 Jun 26.

The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/ncomms15475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490203PMC
June 2017

Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control.

Authors:
Joffrey Mianné Gemma F Codner Adam Caulder Rachel Fell Marie Hutchison Ruairidh King Michelle E Stewart Sara Wells Lydia Teboul

Methods 2017 05 28;121-122:68-76. Epub 2017 Mar 28.

The Mary Lyon Centre, MRC Harwell Institute, Didcot, Oxon OX11 0RD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.03.016DOI Listing
May 2017

N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 () Mutations Establish Loss-of-Function Mice.

Authors:
Caroline M Gorvin Angela Rogers Michelle Stewart Anju Paudyal Tertius A Hough Lydia Teboul Sara Wells Steve Dm Brown Roger D Cox Rajesh V Thakker

JBMR Plus 2017 May;1(1):3-15

Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, UK.

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http://doi.wiley.com/10.1002/jbm4.10001
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824975PMC
May 2017

Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features.

Authors:
Teresa Santiago-Sim Lindsay C Burrage Frédéric Ebstein Mari J Tokita Marcus Miller Weimin Bi Alicia A Braxton Jill A Rosenfeld Maher Shahrour Andrea Lehmann Benjamin Cogné Sébastien Küry Thomas Besnard Bertrand Isidor Stéphane Bézieau Isabelle Hazart Honey Nagakura LaDonna L Immken Rebecca O Littlejohn Elizabeth Roeder Bulent Kara Katia Hardies Sarah Weckhuysen Patrick May Johannes R Lemke Orly Elpeleg Bassam Abu-Libdeh Kiely N James Jennifer L Silhavy Mahmoud Y Issa Maha S Zaki Joseph G Gleeson John R Seavitt Mary E Dickinson M Cecilia Ljungberg Sara Wells Sara J Johnson Lydia Teboul Christine M Eng Yaping Yang Peter-Michael Kloetzel Jason D Heaney Magdalena A Walkiewicz

Am J Hum Genet 2017 Apr 23;100(4):676-688. Epub 2017 Mar 23.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Baylor Miraca Genetics Laboratories, Baylor College of Medicine, Houston, TX 77021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384096PMC
April 2017

A scoring system for the evaluation of the mutated -derived retinal lesions in C57BL/6N mice.

Authors:
Danilo Concas Heather Cater Sara Wells

F1000Res 2017 31;6:404. Epub 2017 Mar 31.

Mary Lyon Centre, Harwell Campus, MRC Harwell Institute, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.12688/f1000research.11252.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580417PMC
March 2017

G mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

Authors:
Caroline M Gorvin Fadil M Hannan Sarah A Howles Valerie N Babinsky Sian E Piret Angela Rogers Andrew J Freidin Michelle Stewart Anju Paudyal Tertius A Hough M Andrew Nesbit Sara Wells Tonia L Vincent Stephen Dm Brown Roger D Cox Rajesh V Thakker

JCI Insight 2017 02 9;2(3):e91103. Epub 2017 Feb 9.

Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.91103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291742PMC
February 2017

A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior.

Authors:
Ingrid Ehrmann Matthew R Gazzara Vittoria Pagliarini Caroline Dalgliesh Mahsa Kheirollahi-Chadegani Yaobo Xu Eleonora Cesari Marina Danilenko Marie Maclennan Kate Lowdon Tanja Vogel Piia Keskivali-Bond Sara Wells Heather Cater Philippe Fort Mauro Santibanez-Koref Silvia Middei Claudio Sette Gavin J Clowry Yoseph Barash Mark O Cunningham David J Elliott

Cell Rep 2016 12;17(12):3269-3280

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199341PMC
December 2016

High-throughput discovery of novel developmental phenotypes.

Authors:
Mary E Dickinson Ann M Flenniken Xiao Ji Lydia Teboul Michael D Wong Jacqueline K White Terrence F Meehan Wolfgang J Weninger Henrik Westerberg Hibret Adissu Candice N Baker Lynette Bower James M Brown L Brianna Caddle Francesco Chiani Dave Clary James Cleak Mark J Daly James M Denegre Brendan Doe Mary E Dolan Sarah M Edie Helmut Fuchs Valerie Gailus-Durner Antonella Galli Alessia Gambadoro Juan Gallegos Shiying Guo Neil R Horner Chih-Wei Hsu Sara J Johnson Sowmya Kalaga Lance C Keith Louise Lanoue Thomas N Lawson Monkol Lek Manuel Mark Susan Marschall Jeremy Mason Melissa L McElwee Susan Newbigging Lauryl M J Nutter Kevin A Peterson Ramiro Ramirez-Solis Douglas J Rowland Edward Ryder Kaitlin E Samocha John R Seavitt Mohammed Selloum Zsombor Szoke-Kovacs Masaru Tamura Amanda G Trainor Ilinca Tudose Shigeharu Wakana Jonathan Warren Olivia Wendling David B West Leeyean Wong Atsushi Yoshiki Daniel G MacArthur Glauco P Tocchini-Valentini Xiang Gao Paul Flicek Allan Bradley William C Skarnes Monica J Justice Helen E Parkinson Mark Moore Sara Wells Robert E Braun Karen L Svenson Martin Hrabe de Angelis Yann Herault Tim Mohun Ann-Marie Mallon R Mark Henkelman Steve D M Brown David J Adams K C Kent Lloyd Colin McKerlie Arthur L Beaudet Maja Bućan Stephen A Murray

Nature 2016 09 14;537(7621):508-514. Epub 2016 Sep 14.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/nature19356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295821PMC
September 2016

Building for the future: essential infrastructure for rodent ageing studies.

Authors:
Sara E Wells Ilaria Bellantuono

Mamm Genome 2016 08 24;27(7-8):440-4. Epub 2016 May 24.

Department of Oncology and Metabolism, The Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.

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http://dx.doi.org/10.1007/s00335-016-9646-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935732PMC
August 2016

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.

Authors:
Jérôme Nicod Robert W Davies Na Cai Carl Hassett Leo Goodstadt Cormac Cosgrove Benjamin K Yee Vikte Lionikaite Rebecca E McIntyre Carol Ann Remme Elisabeth M Lodder Jennifer S Gregory Tertius Hough Russell Joynson Hayley Phelps Barbara Nell Clare Rowe Joe Wood Alison Walling Nasrin Bopp Amarjit Bhomra Polinka Hernandez-Pliego Jacques Callebert Richard M Aspden Nick P Talbot Peter A Robbins Mark Harrison Martin Fray Jean-Marie Launay Yigal M Pinto David A Blizard Connie R Bezzina David J Adams Paul Franken Tom Weaver Sara Wells Steve D M Brown Paul K Potter Paul Klenerman Arimantas Lionikas Richard Mott Jonathan Flint

Nat Genet 2016 08 4;48(8):912-8. Epub 2016 Jul 4.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966644PMC
August 2016

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

Authors:
Paul K Potter Michael R Bowl Prashanthini Jeyarajan Laura Wisby Andrew Blease Michelle E Goldsworthy Michelle M Simon Simon Greenaway Vincent Michel Alun Barnard Carlos Aguilar Thomas Agnew Gareth Banks Andrew Blake Lauren Chessum Joanne Dorning Sara Falcone Laurence Goosey Shelley Harris Andy Haynes Ines Heise Rosie Hillier Tertius Hough Angela Hoslin Marie Hutchison Ruairidh King Saumya Kumar Heena V Lad Gemma Law Robert E MacLaren Susan Morse Thomas Nicol Andrew Parker Karen Pickford Siddharth Sethi Becky Starbuck Femke Stelma Michael Cheeseman Sally H Cross Russell G Foster Ian J Jackson Stuart N Peirson Rajesh V Thakker Tonia Vincent Cheryl Scudamore Sara Wells Aziz El-Amraoui Christine Petit Abraham Acevedo-Arozena Patrick M Nolan Roger Cox Anne-Marie Mallon Steve D M Brown

Nat Commun 2016 08 18;7:12444. Epub 2016 Aug 18.

MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1038/ncomms12444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992138PMC
August 2016

Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System.

Authors:
Rasneer S Bains Heather L Cater Rowland R Sillito Agisilaos Chartsias Duncan Sneddon Danilo Concas Piia Keskivali-Bond Timothy C Lukins Sara Wells Abraham Acevedo Arozena Patrick M Nolan J Douglas Armstrong

Front Behav Neurosci 2016 10;10:106. Epub 2016 Jun 10.

Actual Analytics LtdEdinburgh, UK; School of Informatics, University of EdinburghEdinburgh, UK.

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http://dx.doi.org/10.3389/fnbeh.2016.00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901040PMC
July 2016

Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy.

Authors:
Marianna Madeo Michelle Stewart Yuyang Sun Nadia Sahir Sarah Wiethoff Indra Chandrasekar Anna Yarrow Jill A Rosenfeld Yaping Yang Dawn Cordeiro Elizabeth M McCormick Colleen C Muraresku Tyler N Jepperson Lauren J McBeth Mohammed Zain Seidahmed Heba Y El Khashab Muddathir Hamad Hamid Azzedine Karl Clark Silvia Corrochano Sara Wells Mariet W Elting Marjan M Weiss Sabrina Burn Angela Myers Megan Landsverk Patricia L Crotwell Quinten Waisfisz Nicole I Wolf Patrick M Nolan Sergio Padilla-Lopez Henry Houlden Richard Lifton Shrikant Mane Brij B Singh Marni J Falk Saadet Mercimek-Mahmutoglu Kaya Bilguvar Mustafa A Salih Abraham Acevedo-Arozena Michael C Kruer

Am J Hum Genet 2016 06 26;98(6):1249-1255. Epub 2016 May 26.

Children's Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA; Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ 85004, USA; Neurogenetics Research Program, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ 85016, USA; Program in Neuroscience, Arizona State University, Tempe, AZ 85287, USA; Pediatric Movement Disorders Center, Barrow Neurological Institute, Phoenix Children's Hospital, Phoenix, AZ 85016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908178PMC
June 2016

Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.

Authors:
Nick Warr Pam Siggers Gwenn-Aël Carré Sara Wells Andy Greenfield

Biol Reprod 2016 05 23;94(5):103. Epub 2016 Mar 23.

Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire, United Kingdom

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http://dx.doi.org/10.1095/biolreprod.115.138057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842889PMC
May 2016

Pharmacological inhibition of FTO.

Authors:
Fiona McMurray Marina Demetriades WeiShen Aik Myrte Merkestein Holger Kramer Daniel S Andrew Cheryl L Scudamore Tertius A Hough Sara Wells Frances M Ashcroft Michael A McDonough Christopher J Schofield Roger D Cox

PLoS One 2015 1;10(4):e0121829. Epub 2015 Apr 1.

MRC Harwell, Harwell Oxford Campus, Oxfordshire, Oxford, OX11 0RD, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121829PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382163PMC
April 2016

Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.

Authors:
Helen Spiers Eilis Hannon Sara Wells Brenda Williams Cathy Fernandes Jonathan Mill

Mech Ageing Dev 2016 Mar 6;154:20-3. Epub 2016 Feb 6.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798846PMC
March 2016

Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair.

Authors:
Joffrey Mianné Lauren Chessum Saumya Kumar Carlos Aguilar Gemma Codner Marie Hutchison Andrew Parker Ann-Marie Mallon Sara Wells Michelle M Simon Lydia Teboul Steve D M Brown Michael R Bowl

Genome Med 2016 Feb 15;8(1):16. Epub 2016 Feb 15.

Mammalian Genetics Unit, MRC Harwell, Harwell, Oxford, OX11 0RD, UK.

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http://dx.doi.org/10.1186/s13073-016-0273-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753642PMC
February 2016

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse.

Authors:
Derek Hood Richard Moxon Tom Purnell Caroline Richter Debbie Williams Ali Azar Michael Crompton Sara Wells Martin Fray Steve D M Brown Michael T Cheeseman

Dis Model Mech 2016 Jan 26;9(1):69-79. Epub 2015 Nov 26.

MRC Mammalian Genetics Unit, MRC Harwell, Didcot, Oxford, OX11 0RD, UK Developmental Biology Division, The Roslin Institute and Royal (Dick) School of Veterinary Studies, Easter Bush Campus, University of Edinburgh, EH25 9RG, UK Mary Lyon Centre, MRC Harwell, Harwell, Didcot, Oxford, OX11 0RD, UK

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http://dmm.biologists.org/content/dmm/early/2015/11/19/dmm.0
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http://dmm.biologists.org/cgi/doi/10.1242/dmm.021659
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http://dx.doi.org/10.1242/dmm.021659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728332PMC
January 2016

Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss.

Authors:
Leanne Carrott Michael R Bowl Carlos Aguilar Stuart L Johnson Lauren Chessum Melissa West Susan Morse Joanne Dorning Elizabeth Smart Rachel Hardisty-Hughes Greg Ball Andrew Parker Alun R Barnard Robert E MacLaren Sara Wells Walter Marcotti Steve D M Brown

J Neurosci 2016 Jan;36(1):222-34

Mammalian Genetics Unit, Medical Research Council Harwell, Harwell Campus, Oxfordshire OX11 0RD, United Kingdom,

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http://dx.doi.org/10.1523/JNEUROSCI.1808-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701962PMC
January 2016

A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal.

Authors:
Pam Siggers Gwenn-Aël Carré Debora Bogani Nick Warr Sara Wells Helen Hilton Chris Esapa Mohammad K Hajihosseini Andy Greenfield

PLoS One 2014 23;9(6):e100447. Epub 2014 Jun 23.

Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100447PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067367PMC
November 2015

Talking welfare: the importance of a common language.

Authors:
James Bussell Sara E Wells

Mamm Genome 2015 Oct 19;26(9-10):482-5. Epub 2015 Aug 19.

Mary Lyon Centre, MRC Harwell, Nineteenth St, Didcot, OXON, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-015-9591-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602052PMC
October 2015

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.

Authors:
Alison J Hugill Michelle E Stewart Marianne A Yon Fay Probert I Jane Cox Tertius A Hough Cheryl L Scudamore Liz Bentley Gary Wall Sara E Wells Roger D Cox

Biol Open 2015 Oct 2;4(11):1367-75. Epub 2015 Oct 2.

Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, Oxfordshire OX11 0RD, UK

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http://bio.biologists.org/cgi/doi/10.1242/bio.013342
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http://dx.doi.org/10.1242/bio.013342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728350PMC
October 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Authors:
Michael J Parsons Marco Brancaccio Siddharth Sethi Elizabeth S Maywood Rahul Satija Jessica K Edwards Aarti Jagannath Yvonne Couch Mattéa J Finelli Nicola J Smyllie Christopher Esapa Rachel Butler Alun R Barnard Johanna E Chesham Shoko Saito Greg Joynson Sara Wells Russell G Foster Peter L Oliver Michelle M Simon Ann-Marie Mallon Michael H Hastings Patrick M Nolan

Cell 2015 Jul;162(3):607-21

MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.06.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537516PMC
July 2015

¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

Authors:
Fay Probert Paul Rice Cheryl L Scudamore Sara Wells Roger Williams Tertius A Hough I Jane Cox

J Proteome Res 2015 May 20;14(5):2036-45. Epub 2015 Apr 20.

‡Institute of Hepatology, Foundation for Liver Research, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom.

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http://dx.doi.org/10.1021/pr501039kDOI Listing
May 2015

Applying the ARRIVE Guidelines to an In Vivo Database.

Authors:
Natasha A Karp Terry F Meehan Hugh Morgan Jeremy C Mason Andrew Blake Natalja Kurbatova Damian Smedley Julius Jacobsen Richard F Mott Vivek Iyer Peter Matthews David G Melvin Sara Wells Ann M Flenniken Hiroshi Masuya Shigeharu Wakana Jacqueline K White K C Kent Lloyd Corey L Reynolds Richard Paylor David B West Karen L Svenson Elissa J Chesler Martin Hrabě de Angelis Glauco P Tocchini-Valentini Tania Sorg Yann Herault Helen Parkinson Ann-Marie Mallon Steve D M Brown

PLoS Biol 2015 May 20;13(5):e1002151. Epub 2015 May 20.

Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1002151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439173PMC
May 2015

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.

Authors:
Jennifer N Murdoch Christine Damrau Anju Paudyal Debora Bogani Sara Wells Nicholas D E Greene Philip Stanier Andrew J Copp

Dis Model Mech 2014 Oct 15;7(10):1153-63. Epub 2014 Aug 15.

Newlife Birth Defects Research Centre, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1242/dmm.016758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174526PMC
October 2014

Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.

Authors:
Nick Warr Pam Siggers Gwenn-Aël Carré Debora Bogani Rachel Brixey Mika Akiyoshi Makoto Tachibana Lydia Teboul Sara Wells Jeremy Sanderson Andy Greenfield

Hum Mol Genet 2014 Jun 22;23(11):3035-44. Epub 2014 Jan 22.

Mammalian Genetics Unit and.

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http://dx.doi.org/10.1093/hmg/ddu020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014197PMC
June 2014

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features.

Authors:
Valter Tucci Tjitske Kleefstra Andrea Hardy Ines Heise Silvia Maggi Marjolein H Willemsen Helen Hilton Chris Esapa Michelle Simon Maria-Teresa Buenavista Liam J McGuffin Lucie Vizor Luca Dodero Sotirios Tsaftaris Rosario Romero Willy N Nillesen Lisenka E L M Vissers Marlies J Kempers Anneke T Vulto-van Silfhout Zafar Iqbal Marta Orlando Alessandro Maccione Glenda Lassi Pasqualina Farisello Andrea Contestabile Federico Tinarelli Thierry Nieus Andrea Raimondi Barbara Greco Daniela Cantatore Laura Gasparini Luca Berdondini Angelo Bifone Alessandro Gozzi Sara Wells Patrick M Nolan

J Clin Invest 2014 Apr 10;124(4):1468-82. Epub 2014 Mar 10.

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http://dx.doi.org/10.1172/JCI70372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973091PMC
April 2014

Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation.

Authors:
Silvia Mandillo Ines Heise Luciana Garbugino Glauco P Tocchini-Valentini Alessandro Giuliani Sara Wells Patrick M Nolan

Dis Model Mech 2014 Mar 13;7(3):397-407. Epub 2014 Jan 13.

CNR - Institute of Cell Biology and Neurobiology - EMMA, 00015 Monterotondo Scalo, Italy.

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http://dx.doi.org/10.1242/dmm.013946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944499PMC
March 2014

Shared Ageing Research Models (ShARM): a new facility to support ageing research.

Authors:
Adele L Duran Paul Potter Sara Wells Tom Kirkwood Thomas von Zglinicki Anne McArdle Cheryl Scudamore Qing-Jun Meng Gerald de Haan Anne Corcoran Ilaria Bellantuono

Biogerontology 2013 Dec 2;14(6):789-94. Epub 2013 Oct 2.

Department of Human Metabolism, Medical School, Mellanby Centre for Bone Research, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK,

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http://dx.doi.org/10.1007/s10522-013-9457-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847282PMC
December 2013

Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease.

Authors:
Hilda Tateossian Susan Morse Andrew Parker Philomena Mburu Nick Warr Abraham Acevedo-Arozena Michael Cheeseman Sara Wells Steve D M Brown

Hum Mol Genet 2013 Jul 3;22(13):2553-65. Epub 2013 Mar 3.

MRC Mammalian Genetics Unit, Harwell, UK

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http://dx.doi.org/10.1093/hmg/ddt103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674796PMC
July 2013

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.

Authors:
Michelle M Simon Simon Greenaway Jacqueline K White Helmut Fuchs Valérie Gailus-Durner Sara Wells Tania Sorg Kim Wong Elodie Bedu Elizabeth J Cartwright Romain Dacquin Sophia Djebali Jeanne Estabel Jochen Graw Neil J Ingham Ian J Jackson Andreas Lengeling Silvia Mandillo Jacqueline Marvel Hamid Meziane Frédéric Preitner Oliver Puk Michel Roux David J Adams Sarah Atkins Abdel Ayadi Lore Becker Andrew Blake Debra Brooker Heather Cater Marie-France Champy Roy Combe Petr Danecek Armida di Fenza Hilary Gates Anna-Karin Gerdin Elisabetta Golini John M Hancock Wolfgang Hans Sabine M Hölter Tertius Hough Pierre Jurdic Thomas M Keane Hugh Morgan Werner Müller Frauke Neff George Nicholson Bastian Pasche Laura-Anne Roberson Jan Rozman Mark Sanderson Luis Santos Mohammed Selloum Carl Shannon Anne Southwell Glauco P Tocchini-Valentini Valerie E Vancollie Henrik Westerberg Wolfgang Wurst Min Zi Binnaz Yalcin Ramiro Ramirez-Solis Karen P Steel Ann-Marie Mallon Martin Hrabě de Angelis Yann Herault Steve D M Brown

Genome Biol 2013 Jul 31;14(7):R82. Epub 2013 Jul 31.

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http://dx.doi.org/10.1186/gb-2013-14-7-r82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053787PMC
July 2013

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

Authors:
Fiona McMurray Chris D Church Rachel Larder George Nicholson Sara Wells Lydia Teboul Y C Loraine Tung Debra Rimmington Fatima Bosch Veronica Jimenez Giles S H Yeo Stephen O'Rahilly Frances M Ashcroft Anthony P Coll Roger D Cox

PLoS Genet 2013 3;9(1):e1003166. Epub 2013 Jan 3.

MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1003166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536712PMC
May 2013

A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy.

Authors:
Shalini Jadeja Richard L Mort Margaret Keighren Alan W Hart Russell Joynson Sara Wells Paul K Potter Ian J Jackson

Invest Ophthalmol Vis Sci 2013 May 1;54(5):3569-78. Epub 2013 May 1.

MRC Human Genetics Unit, MRC Institute of Genetics & & Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1167/iovs.12-11125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025949PMC
May 2013

Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.

Authors:
Nick Warr Gwenn-Aël Carre Pam Siggers Jessica Vitos Faleato Rachel Brixey Madeleine Pope Debora Bogani Melissa Childers Sara Wells Cheryl L Scudamore Marianna Tedesco Ivan del Barco Barrantes Angel R Nebreda Paul A Trainor Andy Greenfield

Dev Cell 2012 Nov 25;23(5):1020-31. Epub 2012 Oct 25.

Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1016/j.devcel.2012.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526779PMC
November 2012

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

Authors:
Abdel Ayadi Marie-Christine Birling Joanna Bottomley James Bussell Helmut Fuchs Martin Fray Valérie Gailus-Durner Simon Greenaway Richard Houghton Natasha Karp Sophie Leblanc Christoph Lengger Holger Maier Ann-Marie Mallon Susan Marschall David Melvin Hugh Morgan Guillaume Pavlovic Ed Ryder William C Skarnes Mohammed Selloum Ramiro Ramirez-Solis Tania Sorg Lydia Teboul Laurent Vasseur Alison Walling Tom Weaver Sara Wells Jacqui K White Allan Bradley David J Adams Karen P Steel Martin Hrabě de Angelis Steve D Brown Yann Herault

Mamm Genome 2012 Oct 9;23(9-10):600-10. Epub 2012 Sep 9.

Institut Clinique de la Souris, PHENOMIN, IGBMC/ICS-MCI, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1007/s00335-012-9418-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463797PMC
October 2012

KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.

Authors:
Lee B Smith Laura Milne Nancy Nelson Sharon Eddie Pamela Brown Nina Atanassova Moira K O'Bryan Liza O'Donnell Danielle Rhodes Sara Wells Diane Napper Patrick Nolan Zuzanna Lalanne Michael Cheeseman Josephine Peters

PLoS Genet 2012 24;8(5):e1002697. Epub 2012 May 24.

MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359976PMC
September 2012

HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.

Authors:
Michael T Cheeseman Hayley E Tyrer Debbie Williams Tertius A Hough Paras Pathak Maria R Romero Helen Hilton Sulzhan Bali Andrew Parker Lucie Vizor Tom Purnell Kate Vowell Sara Wells Mahmood F Bhutta Paul K Potter Steve D M Brown

PLoS Genet 2011 Oct 20;7(10):e1002336. Epub 2011 Oct 20.

MRC Mammalian Genetics Unit, MRC Harwell, Harwell, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197687PMC
October 2011

Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.

Authors:
Nick Warr Debora Bogani Pam Siggers Rachel Brixey Hilda Tateossian Asha Dopplapudi Sara Wells Michael Cheeseman Ying Xia Harry Ostrer Andy Greenfield

PLoS One 2011 May 3;6(5):e19572. Epub 2011 May 3.

Mammalian Genetics Unit, Medical Research Council, Harwell, Oxfordshire, UK.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019572PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086927PMC
May 2011

Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome.

Authors:
Lee B Smith Patrick W F Hadoke Emma Dyer Martin A Denvir David Brownstein Eileen Miller Nancy Nelson Sara Wells Michael Cheeseman Andy Greenfield

Cardiovasc Res 2011 Apr 10;90(1):182-90. Epub 2010 Nov 10.

MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, UK.

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http://dx.doi.org/10.1093/cvr/cvq356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058731PMC
April 2011

Overexpression of Fto leads to increased food intake and results in obesity.

Authors:
Chris Church Lee Moir Fiona McMurray Christophe Girard Gareth T Banks Lydia Teboul Sara Wells Jens C Brüning Patrick M Nolan Frances M Ashcroft Roger D Cox

Nat Genet 2010 Dec 14;42(12):1086-92. Epub 2010 Nov 14.

MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, UK.

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http://dx.doi.org/10.1038/ng.713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018646PMC
December 2010

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.

Authors:
Anju Paudyal Christine Damrau Victoria L Patterson Alexander Ermakov Caroline Formstone Zuzanna Lalanne Sara Wells Xiaowei Lu Dominic P Norris Charlotte H Dean Deborah J Henderson Jennifer N Murdoch

BMC Dev Biol 2010 Aug 12;10:87. Epub 2010 Aug 12.

MRC Harwell, Mammalian Genetics Unit, Harwell, Oxon OX11 0RD, UK.

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http://dx.doi.org/10.1186/1471-213X-10-87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930600PMC
August 2010

Establishing normal plasma and 24-hour urinary biochemistry ranges in C3H, BALB/c and C57BL/6J mice following acclimatization in metabolic cages.

Authors:
Michael J Stechman Bushra N Ahmad Nellie Y Loh Anita A C Reed Michelle Stewart Sara Wells Tertius Hough Liz Bentley Roger D Cox Steve D M Brown Rajesh V Thakker

Lab Anim 2010 Jul 10;44(3):218-25. Epub 2010 May 10.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1258/la.2010.009128DOI Listing
July 2010

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

Authors:
Houman Ashrafian Louise Docherty Vincenzo Leo Christopher Towlson Monica Neilan Violetta Steeples Craig A Lygate Tertius Hough Stuart Townsend Debbie Williams Sara Wells Dominic Norris Sarah Glyn-Jones John Land Ivana Barbaric Zuzanne Lalanne Paul Denny Dorota Szumska Shoumo Bhattacharya Julian L Griffin Iain Hargreaves Narcis Fernandez-Fuentes Michael Cheeseman Hugh Watkins T Neil Dear

PLoS Genet 2010 Jun 24;6(6):e1001000. Epub 2010 Jun 24.

Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1001000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891719PMC
June 2010

ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.

Authors:
Gaynor Miller Monica Neilan Ruth Chia Nabeia Gheryani Natalie Holt Annabelle Charbit Sara Wells Valter Tucci Zuzanne Lalanne Paul Denny Elizabeth M C Fisher Michael Cheeseman Graham N Askew T Neil Dear

PLoS One 2010 Feb 9;5(2):e9137. Epub 2010 Feb 9.

Mammalian Genetics of Disease Unit, School of Medicine, University of Sheffield, Sheffield, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009137PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817753PMC
February 2010

EuroPhenome: a repository for high-throughput mouse phenotyping data.

Authors:
Hugh Morgan Tim Beck Andrew Blake Hilary Gates Niels Adams Guillaume Debouzy Sophie Leblanc Christoph Lengger Holger Maier David Melvin Hamid Meziane Dave Richardson Sara Wells Jacqui White Joe Wood Martin Hrabé de Angelis Steve D M Brown John M Hancock Ann-Marie Mallon

Nucleic Acids Res 2010 Jan 23;38(Database issue):D577-85. Epub 2009 Nov 23.

MRC Harwell, Mammalian Genetics Unit, MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/nar/gkp1007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808931PMC
January 2010

Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy.

Authors:
Frances Wong Li Fan Sara Wells Robert Hartley Francesca E Mackenzie Oyinlola Oyebode Rosalind Brown Derek Thomson Michael P Coleman Gonzalo Blanco Richard R Ribchester

Mol Cell Neurosci 2009 Dec 14;42(4):296-307. Epub 2009 Aug 14.

Euan MacDonald Centre for MND Research, The University of Edinburgh, George Square, Edinburgh EH89JZ, UK.

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http://dx.doi.org/10.1016/j.mcn.2009.08.002DOI Listing
December 2009

Dedicated mouse production and husbandry.

Authors:
Lucie Vizor Sara Wells

Methods Mol Biol 2009 ;561:285-99

Medical Research Council, Harwell, UK.

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http://link.springer.com/10.1007/978-1-60327-019-9_19
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http://dx.doi.org/10.1007/978-1-60327-019-9_19DOI Listing
September 2009

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.

Authors:
Debora Bogani Pam Siggers Rachel Brixey Nick Warr Sarah Beddow Jessica Edwards Debbie Williams Dagmar Wilhelm Peter Koopman Richard A Flavell Hongbo Chi Harry Ostrer Sara Wells Michael Cheeseman Andy Greenfield

PLoS Biol 2009 Sep 15;7(9):e1000196. Epub 2009 Sep 15.

Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1000196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733150PMC
September 2009

Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data.

Authors:
Tim Beck Hugh Morgan Andrew Blake Sara Wells John M Hancock Ann-Marie Mallon

BMC Bioinformatics 2009 May 6;10 Suppl 5:S2. Epub 2009 May 6.

MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1186/1471-2105-10-S5-S2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679402PMC
May 2009

Urethral obstruction by seminal coagulum is associated with medetomidine-ketamine anesthesia in male mice on C57BL/6J and mixed genetic backgrounds.

Authors:
Sara Wells Chris Trower Tertius A Hough Michelle Stewart Michael T Cheeseman

J Am Assoc Lab Anim Sci 2009 May;48(3):296-9

Mary Lyon Centre, MRC Harwell, Oxfordshire, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696834PMC
May 2009

Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract.

Authors:
Laura M Pastorelli Sara Wells Martin Fray Adrian Smith Tertius Hough Brian D Harfe Michael T McManus Lee Smith Adrian S Woolf Michael Cheeseman Andy Greenfield

Mamm Genome 2009 Mar 24;20(3):140-51. Epub 2009 Jan 24.

Mammalian Genetics Unit, MRC Harwell, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-008-9169-yDOI Listing
March 2009

Sfrp1 and Sfrp2 are required for normal male sexual development in mice.

Authors:
Nick Warr Pam Siggers Debora Bogani Rachel Brixey Laura Pastorelli Laura Yates Charlotte H Dean Sara Wells Wataru Satoh Akihiko Shimono Andy Greenfield

Dev Biol 2009 Feb 7;326(2):273-84. Epub 2008 Dec 7.

Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, UK.

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http://dx.doi.org/10.1016/j.ydbio.2008.11.023DOI Listing
February 2009

Venous access in oncology and haematology patients: Part two.

Authors:
Sara Wells

Nurs Stand 2008 Sep 10-16;23(1):35-42

Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham.

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http://dx.doi.org/10.7748/ns2008.09.23.1.35.c6652DOI Listing
December 2008

ENU mutagenesis, a way forward to understand gene function.

Authors:
Abraham Acevedo-Arozena Sara Wells Paul Potter Michelle Kelly Roger D Cox Steve D M Brown

Annu Rev Genomics Hum Genet 2008 ;9:49-69

MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom.

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http://dx.doi.org/10.1146/annurev.genom.9.081307.164224DOI Listing
December 2008

Venous access in oncology and haematology patients: part one.

Authors:
Sara Wells

Nurs Stand 2008 Sep 3-9;22(52):39-46

Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham.

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http://rcnpublishing.com/doi/abs/10.7748/ns2008.09.22.52.39.
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October 2008

An ENU-induced mutation in the Ankrd11 gene results in an osteopenia-like phenotype in the mouse mutant Yoda.

Authors:
Ivana Barbaric Mark J Perry T Neil Dear Alexandra Rodrigues Da Costa Daniela Salopek Ana Marusic Tertius Hough Sara Wells A Jackie Hunter Michael Cheeseman Steve D M Brown

Physiol Genomics 2008 Feb 6;32(3):311-21. Epub 2007 Nov 6.

MRC Mammalian Genetics Unit, Harwell.

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http://dx.doi.org/10.1152/physiolgenomics.00116.2007DOI Listing
February 2008

A new coat color mouse line for testing germline transmission of embryonic stem cells while retaining an inbred genetic background.

Authors:
Ivana Barbaric Michelle Stewart Sara Wells T Neil Dear

J Am Assoc Lab Anim Sci 2007 May;46(3):37-40

Mammalian Genetics Disease Unit, School of Medicine and Biomedical Sciences, University of Shiffield, UK.

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May 2007

Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse.

Authors:
Ivana Barbaric Sara Wells Andreas Russ T Neil Dear

Environ Mol Mutagen 2007 Mar;48(2):124-42

Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.1002/em.20286DOI Listing
March 2007

A panel of optimized primers and positive-control DNAs for PCR detection of common biological contaminants in mouse cell lines and tissue samples.

Authors:
Anne-Marie Ayral Sarah Clarkson Michael Cheeseman Sara Wells T Neil Dear

Lab Anim (NY) 2006 Sep;35(8):31-6

Medical Research Council, Harwell, Didcot OX11 0RD UK.

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http://dx.doi.org/10.1038/laban0906-31DOI Listing
September 2006

Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1.

Authors:
Boris Guyot Kasumi Murai Yuko Fujiwara Veronica Valverde-Garduno Michele Hammett Sara Wells Neil Dear Stuart H Orkin Catherine Porcher Paresh Vyas

J Biol Chem 2006 May 20;281(19):13733-42. Epub 2006 Mar 20.

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M602052200DOI Listing
May 2006

A gene-driven ENU-based approach to generating an allelic series in any gene.

Authors:
Mohamed Mohideen Quwailid Alison Hugill Neil Dear Lucie Vizor Sara Wells Emma Horner Shelly Fuller Jessica Weedon Hamish McMath Paul Woodman David Edwards David Campbell Susan Rodger Joanne Carey Ann Roberts Pete Glenister Zuzanna Lalanne Nick Parkinson Emma L Coghill Richard McKeone Sam Cox John Willan Andy Greenfield David Keays Saffron Brady Nigel Spurr Ian Gray Jackie Hunter Steve D M Brown Roger D Cox

Mamm Genome 2004 Aug;15(8):585-91

MRC Mammalian Genetics Unit, Medical Research Council, OX11 0RD, Harwell, Oxfordshire, UK.

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http://dx.doi.org/10.1007/s00335-004-2379-zDOI Listing
August 2004

Visceral obesity without insulin resistance in late-onset obesity rats.

Authors:
Randip K Bains Sara E Wells Dave M Flavell Keith M Fairhall Molly Strom Paul Le Tissier Iain C A F Robinson

Endocrinology 2004 Jun 19;145(6):2666-79. Epub 2004 Mar 19.

Division of Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1210/en.2003-1608DOI Listing
June 2004

Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones.

Authors:
Sara E Wells David M Flavell Gordon W Bisset Pamela A Houston Helen Christian Keith M Fairhall Iain C A F Robinson

J Physiol 2003 Aug 17;551(Pt 1):323-36. Epub 2003 Jun 17.

Division of Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://www.jphysiol.org/cgi/doi/10.1113/jphysiol.2002.037655
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http://dx.doi.org/10.1113/jphysiol.2002.037655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343152PMC
August 2003

Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus.

Authors:
Sara Wells David Murphy

Front Neuroendocrinol 2003 Jan;24(1):11-26

Molecular Neuroendocrinology Research Group, University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, UK.

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http://dx.doi.org/10.1016/s0091-3022(02)00103-6DOI Listing
January 2003