Sara Lustigman

Sara Lustigman

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Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans.

PLoS Negl Trop Dis 2019 Sep 16;13(9):e0007730. Epub 2019 Sep 16.

Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0007730DOI Listing
September 2019

Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel.

PLoS Pathog 2019 Sep 25;15(9):e1008041. Epub 2019 Sep 25.

Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1008041DOI Listing
September 2019

Pyruvate produced by Brugia spp. via glycolysis is essential for maintaining the mutualistic association between the parasite and its endosymbiont, Wolbachia.

PLoS Pathog 2019 Sep 30;15(9):e1008085. Epub 2019 Sep 30.

Molecular Parasitology, New York Blood Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1008085DOI Listing
September 2019

Integrating multiple biomarkers to increase sensitivity for the detection of Onchocerca volvulus infection.

J Infect Dis 2019 Jun 14. Epub 2019 Jun 14.

Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/infdis/jiz307DOI Listing
June 2019

Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms.

PLoS Negl Trop Dis 2019 01 17;13(1):e0007108. Epub 2019 Jan 17.

Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0007108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353222PMC
January 2019

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.

PLoS Negl Trop Dis 2018 12 12;12(12):e0006977. Epub 2018 Dec 12.

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia Pennsylvania, United States of America.

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http://dx.plos.org/10.1371/journal.pntd.0006977
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http://dx.doi.org/10.1371/journal.pntd.0006977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306240PMC
December 2018

Cysteine proteases during larval migration and development of helminths in their final host.

PLoS Negl Trop Dis 2018 08 23;12(8):e0005919. Epub 2018 Aug 23.

Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0005919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107106PMC
August 2018

Development of a toolkit for piggyBac-mediated integrative transfection of the human filarial parasite Brugia malayi.

PLoS Negl Trop Dis 2018 05 21;12(5):e0006509. Epub 2018 May 21.

Center for Global Health Infectious Disease Research, Department of Global Health, University of South Florida, Tampa, FL, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0006509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983866PMC
May 2018

Onchocerca volvulus: The Road from Basic Biology to a Vaccine.

Trends Parasitol 2018 01 22;34(1):64-79. Epub 2017 Sep 22.

Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, Section of Pediatric Tropical Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.pt.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748257PMC
January 2018

Lessons from the genomes and transcriptomes of filarial nematodes.

Mol Biochem Parasitol 2017 07 23;215:23-29. Epub 2017 Jan 23.

Center for Genomics and Systems Biology, Department of Biology, New York University, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474361PMC
July 2017

Metabolite profiling of infection-associated metabolic markers of onchocerciasis.

Mol Biochem Parasitol 2017 07 8;215:58-69. Epub 2017 Feb 8.

Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2017.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474354PMC
July 2017

Defining the target and the effect of imatinib on the filarial c-Abl homologue.

PLoS Negl Trop Dis 2017 Jul 20;11(7):e0005690. Epub 2017 Jul 20.

Laboratory of Parasitic Diseases, Helminth Immunology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0005690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538754PMC
July 2017

Response to the Letter to the Editor by Eberhard et al.

Parasit Vectors 2017 05 16;10(1):240. Epub 2017 May 16.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Norfolk Place, London, W2 1PG, UK.

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http://dx.doi.org/10.1186/s13071-017-2125-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434579PMC
May 2017

The role of 'omics' in the quest to eliminate human filariasis.

PLoS Negl Trop Dis 2017 04 20;11(4):e0005464. Epub 2017 Apr 20.

Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0005464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398502PMC
April 2017

Defining Brugia malayi and Wolbachia symbiosis by stage-specific dual RNA-seq.

PLoS Negl Trop Dis 2017 03 30;11(3):e0005357. Epub 2017 Mar 30.

Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0005357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373514PMC
March 2017

Glucose and Glycogen Metabolism in Brugia malayi Is Associated with Wolbachia Symbiont Fitness.

PLoS One 2016 14;11(4):e0153812. Epub 2016 Apr 14.

Molecular Parasitology, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831766PMC
September 2016

The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice.

PLoS Negl Trop Dis 2016 07 7;10(7):e0004797. Epub 2016 Jul 7.

Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0004797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936747PMC
July 2016

Human anthelminthic vaccines: Rationale and challenges.

Vaccine 2016 06 9;34(30):3549-55. Epub 2016 May 9.

Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA; Department of Biology, Baylor University, Waco, TX, USA.

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http://dx.doi.org/10.1016/j.vaccine.2016.03.112DOI Listing
June 2016

Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings.

Parasit Vectors 2016 06 14;9(1):343. Epub 2016 Jun 14.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Norfolk Place, London, W2 1PG, UK.

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http://dx.doi.org/10.1186/s13071-016-1605-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908809PMC
June 2016

The case for vaccine development in the strategy to eradicate river blindness (onchocerciasis) from Africa.

Expert Rev Vaccines 2015 19;14(9):1163-5. Epub 2015 Jun 19.

Institute of Infection & Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, UK.

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http://dx.doi.org/10.1586/14760584.2015.1059281DOI Listing
May 2016

Human Onchocerciasis: Modelling the Potential Long-term Consequences of a Vaccination Programme.

PLoS Negl Trop Dis 2015 17;9(7):e0003938. Epub 2015 Jul 17.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St. Mary's Campus), Imperial College London, London, United Kingdom; Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St. Mary's Campus), Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0003938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506122PMC
April 2016

Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection.

PLoS Negl Trop Dis 2016 Apr 5;10(4):e0004586. Epub 2016 Apr 5.

Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0004586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821550PMC
April 2016

Enhanced humoral response to influenza vaccine in aged mice with a novel adjuvant, rOv-ASP-1.

Vaccine 2016 Feb 13;34(7):887-92. Epub 2016 Jan 13.

Department of Biology, Drexel University, 3245 Chestnut Street, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731280PMC
February 2016

Functional analysis of microRNA activity in Brugia malayi.

Int J Parasitol 2015 Aug 22;45(9-10):579-83. Epub 2015 May 22.

Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Blvd, Suite 304, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490087PMC
August 2015

Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping.

ACS Infect Dis 2015 May 18;1(5):198-202. Epub 2015 Mar 18.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acsinfecdis.5b00017DOI Listing
May 2015

A truncated fragment of Ov-ASP-1 consisting of the core pathogenesis-related-1 (PR-1) domain maintains adjuvanticity as the full-length protein.

Vaccine 2015 Apr 28;33(16):1974-80. Epub 2015 Feb 28.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.02.053DOI Listing
April 2015

Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate.

Hum Vaccin Immunother 2014 30;10(3):648-58. Epub 2013 Dec 30.

Lindsley F Kimball Research Institute; New York Blood Center; New York, NY USA; Key Laboratory of Medical Molecular Virology of MOE/MOH; Shanghai Medical College and Institute of Medical Microbiology; Fudan University; Shanghai, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130269PMC
http://dx.doi.org/10.4161/hv.27464DOI Listing
March 2015

Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.

ACS Med Chem Lett 2015 Mar 20;6(3):339-43. Epub 2015 Jan 20.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/ml500516rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360149PMC
March 2015

The Onchocerciasis Vaccine for Africa--TOVA--Initiative.

PLoS Negl Trop Dis 2015 Jan 29;9(1):e0003422. Epub 2015 Jan 29.

Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310604PMC
January 2015

Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia.

Int J Parasitol Drugs Drug Resist 2014 Dec 26;4(3):267-77. Epub 2014 Aug 26.

Department of Computational & Systems Biology, University of Pittsburgh School of Medicine, 3501 5th Avenue, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.ijpddr.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266806PMC
December 2014

Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae.

Int J Parasitol 2014 Sep 12;44(10):675-9. Epub 2014 Jun 12.

Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Drive, Baton Rouge, LA 70803, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2014.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335902PMC
September 2014

Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model.

Int J Parasitol 2014 Aug 5;44(9):637-46. Epub 2014 Jun 5.

Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, 233 S. 10th Street, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118642PMC
August 2014

Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.

J Med Chem 2014 Jul 20;57(13):5792-9. Epub 2014 Jun 20.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://pubs.acs.org/doi/10.1021/jm5006435
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http://dx.doi.org/10.1021/jm5006435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216208PMC
July 2014

Calling for rapid development of a safe and effective MERS vaccine.

Microbes Infect 2014 Jul 12;16(7):529-31. Epub 2014 Jun 12.

Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY, USA; Key Laboratory of Medical Molecular Virology of MOE/MOH, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.micinf.2014.05.002DOI Listing
July 2014

Antigen sparing and enhanced protection using a novel rOv-ASP-1 adjuvant in aqueous formulation with influenza vaccines.

Vaccine 2014 May 26;32(23):2696-702. Epub 2014 Mar 26.

Department of Microbiology, University of Pennsylvania Perelman School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080630PMC
May 2014

Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae.

Parasit Vectors 2014 Jan 22;7:43. Epub 2014 Jan 22.

Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Drive, Baton Rouge, LA 70803, USA.

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http://dx.doi.org/10.1186/1756-3305-7-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910689PMC
January 2014

A potential role for the interaction of Wolbachia surface proteins with the Brugia malayi glycolytic enzymes and cytoskeleton in maintenance of endosymbiosis.

PLoS Negl Trop Dis 2013 4;7(4):e2151. Epub 2013 Apr 4.

Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pntd.0002151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617236PMC
November 2013

Anti-Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, Peru.

Malar J 2012 Oct 30;11:361. Epub 2012 Oct 30.

Malaria Laboratory, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.

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http://dx.doi.org/10.1186/1475-2875-11-361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544580PMC
October 2012

Oligonucleotide based magnetic bead capture of Onchocerca volvulus DNA for PCR pool screening of vector black flies.

PLoS Negl Trop Dis 2012 19;6(6):e1712. Epub 2012 Jun 19.

Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México.

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http://dx.doi.org/10.1371/journal.pntd.0001712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378604PMC
September 2012

A research agenda for helminth diseases of humans: basic research and enabling technologies to support control and elimination of helminthiases.

PLoS Negl Trop Dis 2012 24;6(4):e1445. Epub 2012 Apr 24.

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.

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http://dx.plos.org/10.1371/journal.pntd.0001445
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http://dx.doi.org/10.1371/journal.pntd.0001445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335859PMC
August 2012

A research agenda for helminth diseases of humans: towards control and elimination.

PLoS Negl Trop Dis 2012 24;6(4):e1547. Epub 2012 Apr 24.

Lymphatic Filariasis Support Centre, Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.

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http://dx.doi.org/10.1371/journal.pntd.0001547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335858PMC
August 2012

A research agenda for helminth diseases of humans: the problem of helminthiases.

PLoS Negl Trop Dis 2012 24;6(4):e1582. Epub 2012 Apr 24.

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pntd.0001582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335854PMC
August 2012

A research agenda for helminth diseases of humans: health research and capacity building in disease-endemic countries for helminthiases control.

PLoS Negl Trop Dis 2012 24;6(4):e1602. Epub 2012 Apr 24.

Council for Scientific and Industrial Research, Water Research Institute, Department of Environmental Biology and Health, Accra, Ghana.

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http://dx.doi.org/10.1371/journal.pntd.0001602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335878PMC
August 2012

Analysis of transcriptional regulation of tetracycline responsive genes in Brugia malayi.

Mol Biochem Parasitol 2011 Dec 16;180(2):106-11. Epub 2011 Sep 16.

Global Health Infectious Disease Research Program, Department of Global Health, University of South Florida, Tampa, FL 33620, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2011.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205945PMC
December 2011

Immunization with the recombinant antigen Ss-IR induces protective immunity to infection with Strongyloides stercoralis in mice.

Vaccine 2011 Oct 19;29(45):8134-40. Epub 2011 Aug 19.

Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0264410X1101261
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http://dx.doi.org/10.1016/j.vaccine.2011.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191285PMC
October 2011

Interaction of a Wolbachia WSP-like protein with a nuclear-encoded protein of Brugia malayi.

Int J Parasitol 2011 Aug 6;41(10):1053-61. Epub 2011 Jul 6.

Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ijpara.2011.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160744PMC
August 2011

Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.

J Med Chem 2011 Jun 12;54(11):3963-72. Epub 2011 May 12.

Department of Chemistry, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm200364n
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http://dx.doi.org/10.1021/jm200364nDOI Listing
June 2011

Control of important helminthic infections vaccine development as part of the solution.

Adv Parasitol 2010 ;73:297-326

Ingerod, Brastad, Sweden.

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http://dx.doi.org/10.1016/S0065-308X(10)73010-4DOI Listing
October 2010

Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant.

Vaccine 2010 Oct 21;28(44):7233-40. Epub 2010 Aug 21.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

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http://dx.doi.org/10.1016/j.vaccine.2010.08.049DOI Listing
October 2010

The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age.

PLoS Negl Trop Dis 2010 Aug 24;4(8):e800. Epub 2010 Aug 24.

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

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https://dx.plos.org/10.1371/journal.pntd.0000800
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http://dx.doi.org/10.1371/journal.pntd.0000800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927424PMC
August 2010

Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interference.

PLoS Negl Trop Dis 2009 3;3(2):e377. Epub 2009 Feb 3.

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0000377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634747PMC
March 2010

Repositioning of an existing drug for the neglected tropical disease Onchocerciasis.

Proc Natl Acad Sci U S A 2010 Feb 8;107(8):3424-9. Epub 2010 Feb 8.

Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0915125107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840490PMC
February 2010

Helminth genomics: The implications for human health.

PLoS Negl Trop Dis 2009 Oct 26;3(10):e538. Epub 2009 Oct 26.

Department of Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, D. C., USA.

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http://dx.doi.org/10.1371/journal.pntd.0000538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757907PMC
October 2009

Characterisation of novel protein families secreted by muscle stage larvae of Trichinella spiralis.

Int J Parasitol 2009 Apr 21;39(5):515-24. Epub 2008 Oct 21.

Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, London SW7 2AY, UK.

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http://dx.doi.org/10.1016/j.ijpara.2008.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680962PMC
April 2009

PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor.

PLoS One 2008 Oct 1;3(10):e3300. Epub 2008 Oct 1.

Laboratory of Blood-Borne Parasites, Lindsley Kimball Research Institute, The New York Blood Center, New York, New York, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003300PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553180PMC
October 2008

Tracking the odysseys of juvenile schistosomes to understand host interactions.

PLoS Negl Trop Dis 2008 Jul 16;2(7):e257. Epub 2008 Jul 16.

Division of Infectious Diseases, Queensland Institute of Medical Research, Herston, Queensland, Australia.

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http://dx.doi.org/10.1371/journal.pntd.0000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442878PMC
July 2008

Differential antibody responses to Plasmodium falciparum invasion ligand proteins in individuals living in malaria-endemic areas in Brazil and Cameroon.

Am J Trop Med Hyg 2007 Nov;77(5):977-83

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, USA.

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November 2007

Genomics and emerging drug discovery technologies.

Expert Opin Drug Discov 2007 Oct;2(s1):S83-9

Wellcome Trust Sanger Institute, Pathogen Sequencing Unit, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK.

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http://dx.doi.org/10.1517/17460441.2.S1.S83DOI Listing
October 2007

Draft genome of the filarial nematode parasite Brugia malayi.

Science 2007 Sep;317(5845):1756-60

Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1145406
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http://dx.doi.org/10.1126/science.1145406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613796PMC
September 2007

Ivermectin resistance in Onchocerca volvulus: toward a genetic basis.

PLoS Negl Trop Dis 2007 Aug 30;1(1):e76. Epub 2007 Aug 30.

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2041823PMC
August 2007

Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.

Clin Vaccine Immunol 2007 Mar 31;14(3):281-7. Epub 2007 Jan 31.

Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Ross Hall Room 727, 2300 Eye St. NW, Washington, DC 20037, USA.

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http://dx.doi.org/10.1128/CVI.00404-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828853PMC
March 2007

Associations between defined polymorphic variants in the PfRH ligand family and the invasion pathways used by P. falciparum field isolates from Brazil.

Mol Biochem Parasitol 2006 Oct 23;149(2):246-51. Epub 2006 Jun 23.

Molecular Parasitology, LFKRI, New York Blood Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2006.05.011DOI Listing
October 2006

The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization.

J Biol Chem 2006 Sep 20;281(38):28415-29. Epub 2006 Jul 20.

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10021, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M600254200
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http://dx.doi.org/10.1074/jbc.M600254200DOI Listing
September 2006

Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein.

J Immunol 2006 May;176(10):6085-92

Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.176.10.6085DOI Listing
May 2006

rOv-ASP-1, a recombinant secreted protein of the helminth Onchocercavolvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens.

Vaccine 2005 May;23(26):3446-52

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, The New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.vaccine.2005.01.098DOI Listing
May 2005

RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting.

Mol Biochem Parasitol 2004 Dec;138(2):165-70

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2004.08.003DOI Listing
December 2004

Invasion profiles of Brazilian field isolates of Plasmodium falciparum: phenotypic and genotypic analyses.

Infect Immun 2004 Oct;72(10):5886-91

Molecular Parasitology, Lindsley Kimball Research Institute, New York Blood Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1128/IAI.72.10.5886-5891.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517604PMC
October 2004

A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling.

Mol Biochem Parasitol 2004 Aug;136(2):227-42

Department of Biological Sciences, Imperial College of Science and Technology, London SW7 2AY, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2004.03.015DOI Listing
August 2004

Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice.

J Infect Dis 2004 Apr 12;189(7):1282-90. Epub 2004 Mar 12.

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1086/382484DOI Listing
April 2004

The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development.

J Biol Chem 2004 Feb 20;279(7):6035-45. Epub 2003 Nov 20.

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York 10021, USA.

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http://dx.doi.org/10.1074/jbc.M312346200DOI Listing
February 2004

Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae.

Infect Immun 2004 Feb;72(2):810-7

Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321619PMC
http://dx.doi.org/10.1128/iai.72.2.810-817.2004DOI Listing
February 2004

Specificity and mechanism of immunoglobulin M (IgM)- and IgG-dependent protective immunity to larval Strongyloides stercoralis in mice.

Infect Immun 2003 Dec;71(12):6835-43

Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC308934PMC
http://dx.doi.org/10.1128/iai.71.12.6835-6843.2003DOI Listing
December 2003

CD4+-dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions.

Int J Parasitol 2003 Sep;33(11):1161-71

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0020-7519(03)00170-xDOI Listing
September 2003

Glycophorin C is the receptor for the Plasmodium falciparum erythrocyte binding ligand PfEBP-2 (baebl).

Blood 2003 Jun 6;101(11):4628-31. Epub 2003 Feb 6.

Department of Molecular Parasitology, The Lindsley Kimball Research Institute, New York Blood Center, NY, NY 10021.

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http://dx.doi.org/10.1182/blood-2002-10-3076DOI Listing
June 2003

Characterization of PfRhop148, a novel rhoptry protein of Plasmodium falciparum.

Mol Biochem Parasitol 2003 Apr;128(1):59-65

Department of Molecular Parasitology, The Lindsley Kimball Research Institute, New York Blood Center, 310 E 67th St, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0166-6851(03)00050-1DOI Listing
April 2003

Towards a recombinant antigen vaccine against Onchocerca volvulus.

Trends Parasitol 2002 Mar;18(3):135-41

Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA.

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March 2002

Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice.

Exp Parasitol 2002 Feb;100(2):112-20

Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/S0014-4894(02)00008-5DOI Listing
February 2002