Sara L Sawyer

Sara L Sawyer

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Sara L Sawyer

Publications by authors named "Sara L Sawyer"

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A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species.

Proc Natl Acad Sci U S A 2019 Jun 21;116(23):11351-11360. Epub 2019 May 21.

BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303;

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http://dx.doi.org/10.1073/pnas.1814995116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561249PMC
June 2019

A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV).

Proc Natl Acad Sci U S A 2019 Jun 21;116(23):11460-11469. Epub 2019 May 21.

Department of Molecular, Cellular and Developmental Biology, BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303;

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http://dx.doi.org/10.1073/pnas.1813909116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561292PMC
June 2019

Selective use of primate CD4 receptors by HIV-1.

PLoS Biol 2019 Jun 10;17(6):e3000304. Epub 2019 Jun 10.

BioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586362PMC
June 2019

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.

Cell Rep 2019 Jun;27(11):3269-3283.e6

Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.040DOI Listing
June 2019

How host genetics dictates successful viral zoonosis.

PLoS Biol 2019 Apr 19;17(4):e3000217. Epub 2019 Apr 19.

BioFrontiers Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, United States of America.

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http://dx.plos.org/10.1371/journal.pbio.3000217
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http://dx.doi.org/10.1371/journal.pbio.3000217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474636PMC
April 2019

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.

Cell Host Microbe 2018 08;24(2):234-248.e5

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094942PMC
August 2018

Control of yeast retrotransposons mediated through nucleoporin evolution.

PLoS Genet 2018 04 25;14(4):e1007325. Epub 2018 Apr 25.

BioFrontiers Institute, Department of Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918913PMC
April 2018

Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes.

PLoS Pathog 2018 03 8;14(3):e1006906. Epub 2018 Mar 8.

BioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843284PMC
March 2018

Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir.

Elife 2018 03 20;7. Epub 2018 Mar 20.

Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, United States.

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http://dx.doi.org/10.7554/eLife.31919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860865PMC
March 2018

Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry.

Virology 2017 12;512:180-186

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Pathobiology, University of Washington, Seattle, WA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00426822173032
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http://dx.doi.org/10.1016/j.virol.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191650PMC
December 2017

Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.

Cell Host Microbe 2017 Nov 5;22(5):627-638.e7. Epub 2017 Nov 5.

BioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80303, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128173043
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http://dx.doi.org/10.1016/j.chom.2017.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309188PMC
November 2017

Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism.

Virol Rep 2016 Dec;6:53-60

Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, NY 10461.

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http://dx.doi.org/10.1016/j.virep.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959807PMC
December 2016

Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins.

PLoS Pathog 2016 Dec 27;12(12):e1006066. Epub 2016 Dec 27.

BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1006066
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http://dx.doi.org/10.1371/journal.ppat.1006066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189954PMC
December 2016

XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts.

PLoS Pathog 2016 Oct 6;12(10):e1005890. Epub 2016 Oct 6.

BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053509PMC
October 2016

An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.

Cell Host Microbe 2016 Aug;20(2):178-88

Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA; BioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982468PMC
August 2016

At the mercy of viruses.

Elife 2016 05 17;5. Epub 2016 May 17.

Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, United States.

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http://dx.doi.org/10.7554/eLife.16758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869909PMC
May 2016

A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction.

Heliyon 2016 Jan 21;2(1):e00056. Epub 2016 Jan 21.

Laboratory of Retrovirology, Department of Medical Biology and BioMed Research Group, Université du Québec à Trois-Rivières. 3351 Boulevard des Forges, CP500, Trois-Rivières, QC, G9A 5H7, Canada.

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http://dx.doi.org/10.1016/j.heliyon.2015.e00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945854PMC
January 2016

Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses.

J Virol 2015 Nov 9;89(22):11643-53. Epub 2015 Sep 9.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA Department of Molecular, Cellular, and Developmental Biology and the BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01408-15
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http://dx.doi.org/10.1128/JVI.01408-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645654PMC
November 2015

Identification of Owl Monkey CD4 Receptors Broadly Compatible with Early-Stage HIV-1 Isolates.

J Virol 2015 Aug 10;89(16):8611-22. Epub 2015 Jun 10.

Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA

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http://dx.doi.org/10.1128/JVI.00890-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524261PMC
August 2015

The effect of species representation on the detection of positive selection in primate gene data sets.

Mol Biol Evol 2015 Apr 2;32(4):1091-6. Epub 2015 Jan 2.

Department of Molecular Biosciences, University of Texas at Austin, Austin, TX

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http://dx.doi.org/10.1093/molbev/msu399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379402PMC
April 2015

Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.

Virology 2014 Jul 29;460-461:34-44. Epub 2014 May 29.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, 1301 Morris Park - Price Center 501, New York, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101048PMC
July 2014

Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.

PLoS Pathog 2014 Jul 10;10(7):e1004177. Epub 2014 Jul 10.

Department of Microbiology and Immunobiology, Harvard Medical School and Division of Neuroscience, New England Primate Research Center, Southborough, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092145PMC
July 2014

Rapid evolution of BRCA1 and BRCA2 in humans and other primates.

BMC Evol Biol 2014 Jul 11;14:155. Epub 2014 Jul 11.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.

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http://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2148-14-155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106182PMC
July 2014

Positive selection of primate genes that promote HIV-1 replication.

Virology 2014 Apr 21;454-455:291-8. Epub 2014 Mar 21.

Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712-1191, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028154PMC
April 2014

Analyzing machupo virus-receptor binding by molecular dynamics simulations.

PeerJ 2014 27;2:e266. Epub 2014 Feb 27.

Department of Integrative Biology, Institute for Cellular and Molecular Biology, and Center for Computational Biology and Bioinformatics, The University of Texas at Austin , Austin, TX , USA.

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http://dx.doi.org/10.7717/peerj.266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940602PMC
March 2014

Dual host-virus arms races shape an essential housekeeping protein.

PLoS Biol 2013 28;11(5):e1001571. Epub 2013 May 28.

Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, USA.

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http://dx.doi.org/10.1371/journal.pbio.1001571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665890PMC
January 2014

High-throughput DNA sequencing errors are reduced by orders of magnitude using circle sequencing.

Proc Natl Acad Sci U S A 2013 Dec 15;110(49):19872-7. Epub 2013 Nov 15.

Department of Molecular Biosciences, Institute for Computational Engineering and Sciences, and Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712.

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http://dx.doi.org/10.1073/pnas.1319590110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856802PMC
December 2013

Recent host-shifts in ranaviruses: signatures of positive selection in the viral genome.

J Gen Virol 2013 Sep 19;94(Pt 9):2082-93. Epub 2013 Jun 19.

Section of Integrative Biology, University of Texas, Austin, TX 78712, USA.

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http://dx.doi.org/10.1099/vir.0.052837-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749056PMC
September 2013

D316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B.

Virology 2013 Jun 29;441(1):31-9. Epub 2013 Mar 29.

Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.virol.2013.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752335PMC
June 2013

Generation of an HIV resistant T-cell line by targeted "stacking" of restriction factors.

Mol Ther 2013 Apr 29;21(4):786-95. Epub 2013 Jan 29.

Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1038/mt.2012.284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616536PMC
April 2013

Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs.

PLoS Pathog 2012 3;8(5):e1002666. Epub 2012 May 3.

Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342950PMC
November 2012

A cross-species view on viruses.

Curr Opin Virol 2012 Oct 24;2(5):561-8. Epub 2012 Jul 24.

Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.

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http://dx.doi.org/10.1016/j.coviro.2012.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470745PMC
October 2012

Evidence for ACE2-utilizing coronaviruses (CoVs) related to severe acute respiratory syndrome CoV in bats.

J Virol 2012 Jun 21;86(11):6350-3. Epub 2012 Mar 21.

Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, USA.

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http://dx.doi.org/10.1128/JVI.00311-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372174PMC
June 2012

HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6.

J Virol 2012 Apr 1;86(7):3851-60. Epub 2012 Feb 1.

HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.06607-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302544PMC
April 2012

Species-specific features of DARC, the primate receptor for Plasmodium vivax and Plasmodium knowlesi.

Mol Biol Evol 2012 Feb 30;29(2):445-9. Epub 2011 Aug 30.

Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, The University of Texas at Austin.

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http://dx.doi.org/10.1093/molbev/msr204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258036PMC
February 2012

Identification of a genomic reservoir for new TRIM genes in primate genomes.

PLoS Genet 2011 Dec 1;7(12):e1002388. Epub 2011 Dec 1.

Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228819PMC
December 2011

Two-stepping through time: mammals and viruses.

Trends Microbiol 2011 Jun 30;19(6):286-94. Epub 2011 Apr 30.

Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.

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http://dx.doi.org/10.1016/j.tim.2011.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567447PMC
June 2011

Ancient and recent adaptive evolution of primate non-homologous end joining genes.

PLoS Genet 2010 Oct 21;6(10):e1001169. Epub 2010 Oct 21.

Section of Molecular Genetics and Microbiology, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA.

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http://dx.doi.org/10.1371/journal.pgen.1001169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958818PMC
October 2010

An expanded clade of rodent Trim5 genes.

Virology 2009 Mar 15;385(2):473-83. Epub 2009 Jan 15.

Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.virol.2008.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692226PMC
March 2009

Molecular evolution of the antiretroviral TRIM5 gene.

Immunogenetics 2009 Mar 24;61(3):163-76. Epub 2009 Feb 24.

Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA.

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http://dx.doi.org/10.1007/s00251-009-0358-yDOI Listing
March 2009

Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals.

PLoS Pathog 2007 Dec;3(12):e197

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.0030197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151084PMC
December 2007

Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis.

Proc Natl Acad Sci U S A 2006 Nov 13;103(47):17614-9. Epub 2006 Nov 13.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0605468103
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http://dx.doi.org/10.1073/pnas.0605468103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693795PMC
November 2006

High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.

Curr Biol 2006 Jan;16(1):95-100

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1016/j.cub.2005.11.045DOI Listing
January 2006

Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain.

Proc Natl Acad Sci U S A 2005 Feb 2;102(8):2832-7. Epub 2005 Feb 2.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0409853102
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http://dx.doi.org/10.1073/pnas.0409853102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549489PMC
February 2005

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.

PLoS Biol 2004 Sep 20;2(9):E275. Epub 2004 Jul 20.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1371/journal.pbio.0020275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC479043PMC
September 2004

Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae.

J Mol Biol 2004 Jul;340(2):195-202

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360400529
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http://dx.doi.org/10.1016/j.jmb.2004.04.066DOI Listing
July 2004