Sara J Buhrlage

Sara J Buhrlage

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Sara J Buhrlage

Sara J Buhrlage

Publications by authors named "Sara J Buhrlage"

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31Publications

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Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors.

J Med Chem 2019 Nov 20. Epub 2019 Nov 20.

Department of Cancer Biology , Dana-Farber Cancer Institute , Boston , Massachusetts 02215 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01138DOI Listing
November 2019

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).

J Biol Chem 2019 03 24;294(12):4511-4519. Epub 2019 Jan 24.

From the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.005428
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http://dx.doi.org/10.1074/jbc.RA118.005428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433055PMC
March 2019

Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme.

Cell Chem Biol 2019 02;26(2):153-155

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.006DOI Listing
February 2019

Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

Cell Chem Biol 2017 12 19;24(12):1490-1500.e11. Epub 2017 Oct 19.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749250PMC
December 2017

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

Bioorg Med Chem 2017 12 20;25(24):6479-6485. Epub 2017 Oct 20.

Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173139
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http://dx.doi.org/10.1016/j.bmc.2017.10.025DOI Listing
December 2017

Crystal structure of human IRAK1.

Proc Natl Acad Sci U S A 2017 12 5;114(51):13507-13512. Epub 2017 Dec 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1714386114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754798PMC
December 2017

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib.

Blood 2016 06 3;127(25):3237-52. Epub 2016 May 3.

Department of Medical Oncology, Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA;

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http://dx.doi.org/10.1182/blood-2016-01-695098DOI Listing
June 2016

Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein.

J Biol Chem 2015 Apr 27;290(16):10504-17. Epub 2015 Feb 27.

From the Departments of Cancer Immunology and AIDS and Neurology (Microbiology), Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1074/jbc.M114.626903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400358PMC
April 2015

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.

Biochem J 2014 Jan;457(1):215-25

*MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BJ20131152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969223PMC
January 2014

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

Mol Cancer Ther 2013 Dec 15;12(12):2651-62. Epub 2013 Oct 15.

Corresponding Authors: Kalindi Parmar, Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0103-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089878PMC
December 2013

Developing irreversible inhibitors of the protein kinase cysteinome.

Chem Biol 2013 Feb;20(2):146-59

Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107455211200487
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http://dx.doi.org/10.1016/j.chembiol.2012.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583020PMC
February 2013

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011).

Expert Opin Ther Pat 2012 Dec 6;22(12):1415-26. Epub 2012 Nov 6.

Xiamen University, School of Life Sciences, State Key Laboratory of Cellular Stress Biology, Fujian 361005, China.

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http://dx.doi.org/10.1517/13543776.2012.729041DOI Listing
December 2012

Transcriptional up-regulation in cells mediated by a small molecule.

J Am Chem Soc 2007 Sep 11;129(35):10654-5. Epub 2007 Aug 11.

Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0736865
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http://dx.doi.org/10.1021/ja0736865DOI Listing
September 2007

Stereochemical promiscuity in artificial transcriptional activators.

J Am Chem Soc 2005 Sep;127(36):12456-7

Department of Chemistry and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja0536567DOI Listing
September 2005