Sara J Brown

Sara J Brown

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Sara J Brown

Sara J Brown

Publications by authors named "Sara J Brown"

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EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis.

J Allergy Clin Immunol 2019 Aug 31;144(2):470-481. Epub 2019 May 31.

Skin Research Group, Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital, Dundee, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193074
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http://dx.doi.org/10.1016/j.jaci.2019.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683598PMC
August 2019

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance.

Dermatology 2019 14;235(5):355-364. Epub 2019 Jun 14.

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1159/000500402DOI Listing
June 2019

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council.

J Allergy Clin Immunol 2019 Jan 7;143(1):36-45. Epub 2018 Nov 7.

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183157
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http://dx.doi.org/10.1016/j.jaci.2018.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626639PMC
January 2019

Research Techniques Are Not Simple.

Authors:
Sara J Brown

J Invest Dermatol 2018 10;138(10):2089-2090

Professor of Molecular and Genetic Dermatology, Wellcome Trust Senior Research Fellow in Clinical Science, Honorary Consultant Dermatologist, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.07.019DOI Listing
October 2018

Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts.

J Allergy Clin Immunol 2018 03 10;141(3):964-971. Epub 2017 Nov 10.

Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital, Dundee, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840507PMC
March 2018

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

J Am Acad Dermatol 2017 Oct 10;77(4):623-633. Epub 2017 Aug 10.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2017.06.042DOI Listing
October 2017

Genetic prediction of treatment response in psoriasis is still a work in progress.

Br J Dermatol 2017 08;177(2):344-345

Skin Research Group, School of Medicine, University of Dundee, Dundee, U.K.

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http://dx.doi.org/10.1111/bjd.15691DOI Listing
August 2017

Molecular mechanisms in atopic eczema: insights gained from genetic studies.

Authors:
Sara J Brown

J Pathol 2017 Jan 14;241(2):140-145. Epub 2016 Nov 14.

School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/path.4810DOI Listing
January 2017

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema.

J Allergy Clin Immunol 2016 Apr 29;137(4):1280-1282.e3. Epub 2016 Jan 29.

Dermatology and Genetic Medicine, Medical Research Institute, College of Medicine, Dentistry and Nursing, Ninewells Hospital and Medical School, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819769PMC
April 2016

Atopic eczema.

Authors:
Sara J Brown

Clin Med (Lond) 2016 Feb;16(1):66-9

Wellcome Trust senior research fellow in clinical science and honorary consultant dermatologist, Skin Research Group, Ninewells Hospital and Medical School, Dundee, UK

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http://dx.doi.org/10.7861/clinmedicine.16-1-66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954337PMC
February 2016

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.

Authors:
Lavinia Paternoster Marie Standl Johannes Waage Hansjörg Baurecht Melanie Hotze David P Strachan John A Curtin Klaus Bønnelykke Chao Tian Atsushi Takahashi Jorge Esparza-Gordillo Alexessander Couto Alves Jacob P Thyssen Herman T den Dekker Manuel A Ferreira Elisabeth Altmaier Patrick Ma Sleiman Feng Li Xiao Juan R Gonzalez Ingo Marenholz Birgit Kalb Maria Pino Yanes Cheng-Jian Xu Lisbeth Carstensen Maria M Groen-Blokhuis Cristina Venturini Craig E Pennell Sheila J Barton Albert M Levin Ivan Curjuric Mariona Bustamante Eskil Kreiner-Møller Gabrielle A Lockett Jonas Bacelis Supinda Bunyavanich Rachel A Myers Anja Matanovic Ashish Kumar Joyce Y Tung Tomomitsu Hirota Michiaki Kubo Wendy L McArdle A J Henderson John P Kemp Jie Zheng George Davey Smith Franz Rüschendorf Anja Bauerfeind Min Ae Lee-Kirsch Andreas Arnold Georg Homuth Carsten O Schmidt Elisabeth Mangold Sven Cichon Thomas Keil Elke Rodríguez Annette Peters Andre Franke Wolfgang Lieb Natalija Novak Regina Fölster-Holst Momoko Horikoshi Juha Pekkanen Sylvain Sebert Lise L Husemoen Niels Grarup Johan C de Jongste Fernando Rivadeneira Albert Hofman Vincent Wv Jaddoe Suzanne Gma Pasmans Niels J Elbert André G Uitterlinden Guy B Marks Philip J Thompson Melanie C Matheson Colin F Robertson Janina S Ried Jin Li Xian Bo Zuo Xiao Dong Zheng Xian Yong Yin Liang Dan Sun Maeve A McAleer Grainne M O'Regan Caoimhe Mr Fahy Linda E Campbell Milan Macek Michael Kurek Donglei Hu Celeste Eng Dirkje S Postma Bjarke Feenstra Frank Geller Jouke Jan Hottenga Christel M Middeldorp Pirro Hysi Veronique Bataille Tim Spector Carla Mt Tiesler Elisabeth Thiering Badri Pahukasahasram James J Yang Medea Imboden Scott Huntsman Natàlia Vilor-Tejedor Caroline L Relton Ronny Myhre Wenche Nystad Adnan Custovic Scott T Weiss Deborah A Meyers Cilla Söderhäll Erik Melén Carole Ober Benjamin A Raby Angela Simpson Bo Jacobsson John W Holloway Hans Bisgaard Jordi Sunyer Nicole M Probst Hensch L Keoki Williams Keith M Godfrey Carol A Wang Dorret I Boomsma Mads Melbye Gerard H Koppelman Deborah Jarvis Wh Irwin McLean Alan D Irvine Xue Jun Zhang Hakon Hakonarson Christian Gieger Esteban G Burchard Nicholas G Martin Liesbeth Duijts Allan Linneberg Marjo-Riitta Jarvelin Markus M Noethen Susanne Lau Norbert Hübner Young-Ae Lee Mayumi Tamari David A Hinds Daniel Glass Sara J Brown Joachim Heinrich David M Evans Stephan Weidinger

Nat Genet 2015 Dec 19;47(12):1449-1456. Epub 2015 Oct 19.

Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.3424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753676PMC
December 2015

Loss-of-Function Mutations in the Gene Encoding Filaggrin Are Not Strongly Associated with Chronic Actinic Dermatitis.

J Invest Dermatol 2015 Jul 3;135(7):1919-1921. Epub 2015 Mar 3.

Photobiology Unit, Department of Dermatology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.64DOI Listing
July 2015

Insight from the air-skin interface.

J Invest Dermatol 2015 Feb;135(2):331-333

Centre for Dermatology and Genetic Medicine, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.457DOI Listing
February 2015

Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-Seq and ESTs.

PLoS One 2014 10;9(4):e94270. Epub 2014 Apr 10.

Division of Computational Biology, University of Dundee, Dundee, United Kingdom; Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom; Centre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094270PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983147PMC
January 2015

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy.

J Allergy Clin Immunol 2015 Jan 18;135(1):164-70. Epub 2014 Nov 18.

Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282723PMC
January 2015

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis.

J Allergy Clin Immunol 2014 Jul 28;134(1):82-91. Epub 2014 May 28.

Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, United Kingdom; National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090750PMC
July 2014

Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling.

J Invest Dermatol 2013 Dec 6;133(12):2805-2808. Epub 2013 Jun 6.

Dermatology and Genetic Medicine, College of Life Sciences and College of Medicine, Dentistry and Nursing, University of Dundee, Dundee, UK; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826975PMC
December 2013

One remarkable molecule: filaggrin.

J Invest Dermatol 2012 Mar 8;132(3 Pt 2):751-62. Epub 2011 Dec 8.

Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/jid.2011.393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378480PMC
March 2012

Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations.

J Allergy Clin Immunol 2010 Jan;125(1):170-4.e1-2

Department of Paediatric Dermatology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jaci.2009.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038266PMC
January 2010

Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease.

J Allergy Clin Immunol 2009 Jun;123(6):1361-70.e7

Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Munich and ZAUM-Center for Allergy and Environment, Technische Universität München, Munich, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S009167490900524
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http://dx.doi.org/10.1016/j.jaci.2009.03.036DOI Listing
June 2009

Eczema genetics: current state of knowledge and future goals.

J Invest Dermatol 2009 Mar;129(3):543-52

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1534248
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http://dx.doi.org/10.1038/jid.2008.413DOI Listing
March 2009

Atopic eczema and the filaggrin story.

Semin Cutan Med Surg 2008 Jun;27(2):128-37

Royal Victoria Infirmary, Newcastle upon Tyne, UK.

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http://scmsjournal.com/article/buy_now/?id=163
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http://dx.doi.org/10.1016/j.sder.2008.04.001DOI Listing
June 2008

Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.

J Allergy Clin Immunol 2008 Apr 4;121(4):940-46.e3. Epub 2008 Mar 4.

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2008.01.013DOI Listing
April 2008