Publications by authors named "Sara Hooshmand"

12 Publications

  • Page 1 of 1

Protective effects of a standardized extract of on pancreas and liver in streptozotocin-induced diabetic rats.

Res Pharm Sci 2021 Feb 30;16(1):71-78. Epub 2020 Dec 30.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.

Background And Purpose: Previous studies have shown the antioxidant, anti-inflammatory, immunomodulatory, and hypolipidemic activities of . The aim of the present study was to evaluate the protective effects of hydroalcoholic extract of rhizomes on streptozotocin-induced diabetic rats.

Experimental Approach: Twenty-four male Wistar rats were randomly assigned into four groups including a normal control group, diabetic control group, diabetic groups treated for 4 weeks with 100 and 200 mg/kg/day of the extract (IGE).

Findings/results: Induction of diabetes significantly decreased the body weight gain and considerably increased the serum levels of glucose, triglyceride, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Diabetes also diminished the antioxidant capacity of the liver (decrease of thiol groups) and significantly degenerated pancreatic islands. The IGE at both doses of 100 and 200 mg/kg significantly reduced the levels of glucose, triglyceride, AST, ALT, and ALP. Moreover, IGE increased the total antioxidant capacity of the liver and ameliorated pancreatic island morphology. The extract had no significant effect on body weight and BUN level.

Conclusion And Implication: These findings suggest that rhizomes inhibits the progression of hyperglycemia and hypertriglyceridemia and has protective effects against diabetes-induced injury of the liver and pancreas. Therefore, this plant has the potential to be used as a natural product for controlling diabetes.
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http://dx.doi.org/10.4103/1735-5362.305190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074805PMC
February 2021

Protective Effects of Morus nigra and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies.

Pharmacology 2021 Apr 13:1-11. Epub 2021 Apr 13.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Our liver has a variety of vital functions including removing poisons, storing energy, immunological roles, and secretory and excretory functions. It may face some kinds of diseases caused by viruses, hepatotoxic chemicals, drugs, alcohol, and inherited disorders. Oxidative stress and inflammation are in the core of mechanisms of liver damages induced by viruses or chemical agents.

Summary: Morus nigra (M. nigra), generally known as black mulberry, exhibited wide-spectrum pharmacological effects including antidiabetic, antinociceptive, anticancer, and hepatoprotective activities. Different parts of this plant particularly the fruit and leaf have shown beneficial effects on hepatocytes in cell culture and animal models of liver damages induced by chemicals (e.g., CCl4), drugs (e.g., paracetamol), diet (e.g., high fat), diabetes, etc. The beneficial effects of M. nigra on the liver are attributed to the presence of considerable amounts of phenolic compounds such as anthocyanins, flavonols, and phenolic acids. The present review is aimed to focus on the hepatoprotective activities of M. nigra and its phytochemicals and the mechanisms responsible for these activities. Key Messages: The evidence reviewed in this study can help design clinical trials on M. nigra in patients with liver disorders and develop a hepatoprotective herbal medicine.
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http://dx.doi.org/10.1159/000515032DOI Listing
April 2021

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma.

Phytother Res 2021 Feb 23. Epub 2021 Feb 23.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

Morus nigra is a rich source of anthocyanins, phytochemicals that have anticancer effects. This study aimed to investigate the effects of M. nigra extract (MNE) on diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC). Male Sprague-Dawley rats were assigned into four groups (n = 10): control, DEN, and DEN +100 or 400 mg/kg of MNE. After 4 months, the DEN group showed a significant mortality rate, hepatic lipid peroxidation, dysplastic nodules in the cirrhotic liver, and an increase of blood bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Also, the body weight gain, blood albumin and glucose, liver antioxidant capacity (thiol groups), and some hematological parameters (RBC, hematocrit, hemoglobin, and platelet) were significantly decreased in the DEN group. MNE significantly increased survival, reduced the size of HCC nodules, improved liver oxidant/antioxidant status, and prevented the above-mentioned changes in the blood (except ALP, glucose, and platelet). Quantitative real-time PCR showed that MNE decreased the expression of Wnt4 and β-catenin, while had no significant effect on PI3K, Akt, and PTEN expression. The MNE did not exhibit antiproliferative activity against HepG2 liver cancer cells. In conclusion, MNE exhibits a hepatoprotective effect through inhibiting oxidative stress and Wnt4/β-catenin pathway and therefore prolongs the survival of rats with HCC.
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http://dx.doi.org/10.1002/ptr.7056DOI Listing
February 2021

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering.

Molecules 2020 Oct 6;25(19). Epub 2020 Oct 6.

Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.

Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.
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http://dx.doi.org/10.3390/molecules25194559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583868PMC
October 2020

Quantum Dots: A Review from Concept to Clinic.

Biotechnol J 2020 Dec 12;15(12):e2000117. Epub 2020 Oct 12.

Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Quantum dots (QDs) are semiconductor materials that have gained great interest due to their unique characteristics like optical properties. They are extensively being used in different areas, including solar cells, light-emitting diodes, laser technology, as well as biological and biomedical applications. In this review, comprehensive information about different aspects of QDs is provided, including their types and classifications, synthesis approaches, in vitro and in vivo toxicity, biological applications, and potentials in clinical applications. With a focus on the biological aspects, the respective in vitro and in vivo studies are collected and presented. Various surface modifications on QDs are discussed as directly influencing their properties like toxicity and optical abilities. Given the promising results, these materials are clinically used for targeted molecular therapy and imaging. However, there are a large number of questions that should be addressed before the wide application of QDs in a clinical setting. Regarding the existing barriers to QDs, suggestions are given and discussed to present an appropriate route for the clinical use of these materials.
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http://dx.doi.org/10.1002/biot.202000117DOI Listing
December 2020

Biomedical Waste Management by Using Nanophotocatalysts: The Need for New Options.

Materials (Basel) 2020 Aug 9;13(16). Epub 2020 Aug 9.

Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea.

Biomedical waste management is getting significant consideration among treatment technologies, since insufficient management can cause danger to medicinal service specialists, patients, and their environmental conditions. The improvement of waste administration protocols, plans, and policies are surveyed, despite setting up training programs on legitimate waste administration for all healthcare service staff. Most biomedical waste substances do not degrade in the environment, and may also not be thoroughly removed through treatment processes. Therefore, the long-lasting persistence of biomedical waste can effectively have adverse impact on wildlife and human beings, as well. Hence, photocatalysis is gaining increasing attention for eradication of pollutants and for improving the safety and clearness of the environment due to its great potential as a green and eco-friendly process. In this regard, nanostructured photocatalysts, in contrast to their regular counterparts, exhibit significant attributes such as non-toxicity, low cost and higher absorption efficiency in a wider range of the solar spectrum, making them the best candidate to employ for photodegradation. Due to these unique properties of nanophotocatalysts for biomedical waste management, we aim to critically evaluate various aspects of these materials in the present review and highlight their importance in healthcare service settings.
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http://dx.doi.org/10.3390/ma13163511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476041PMC
August 2020

Preparation and Applications of Superparamagnetic Iron Oxide Nanoparticles in Novel Drug Delivery Systems: An Overview.

Curr Med Chem 2021 ;28(4):777-799

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Nanocarriers, as drug delivery frameworks, have been intended to enhance the pharmacological and restorative properties of traditional medications. The consolidation of medical atoms as nanocarriers can function as the drug that is required against corruption, as well as offer the desired potential outcomes in regards to targeting and controlled discharge. In the present overview article, applications of magnetic nanoparticles (MNPs) in medication conveyance are outlined. The MNPs have increased the excitement due to their biocompatibility - low poisonous quality, and their capacity to be handled in a magnetic field, which enables their applications as drug-bearing vehicles. The simplicity of surface modification of these particles can provide opportunities for targeting the moieties that are linked to the particle surface. We trust that the intriguing particles will gain further attention alongside achievements in the current ones in the near future.
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http://dx.doi.org/10.2174/0929867327666200123152006DOI Listing
March 2021

Effects of stress on functional connectivity during verbal processing.

Brain Imaging Behav 2020 Dec;14(6):2708-2723

Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO, USA.

Effects of stress on functional connectivity (FC) in specific language processing regions of the brain during verbal fluency tasks were explored. Roles of gender and serotonin transporter gene polymorphisms (5-HTTLPR), associated with stress susceptibility, were also examined to understand their effect. Forty-five healthy volunteers (Mean age: 19.6 ± 1.6 years; 28 females) participated. Functional magnetic resonance imaging was carried out while participants performed letter and category fluency tasks. These tasks were interposed with the Montreal Imaging Stress Test to induce stress or a no-stress control task. Buccal swabs collected were used to genotype for the presence of polymorphisms on the SLC6A4 gene known to contribute to atypical stress responses. Significant variations in strength of FC were noted between several ROIs, including left inferior frontal gyrus and left middle temporal gyrus. Overall, males showed regional increases in FC strength over long and short distances during task under stress. Additionally, variability in effects of stress on task performance was associated with effects of stress on FC. Results suggest that long distance FC may be strengthened to compensate for additional cognitive load of the stressor but that specific short distance functional connections may be strengthened in a gender specific manner. Additionally, FC may serve as a marker for effects of stress on performance. This is the first study exploring stress effects on language tasks with imaging markers. Future studies will need to explore stress susceptible populations and establish the role of FC as a marker, with implications for targeted therapeutic interventions.
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http://dx.doi.org/10.1007/s11682-019-00221-5DOI Listing
December 2020

Hydrophilic modified magnetic multi-walled carbon nanotube for dispersive solid/liquid phase microextraction of sunitinib in human samples.

Anal Biochem 2018 02 29;542:76-83. Epub 2017 Nov 29.

Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran. Electronic address:

In this paper, a novel approach for the efficient microextraction and determination of anticancer drug, sunitinib from human samples is described. We synthesized a new nanocomposite; honey coated magnetic multi-walled carbon nanotubes (Honey@magnetic-CNTs). This nanocomposite retains the magnetic properties of individual magnetic nanoparticles (MNPs) and can be effectively separated under an external magnetic field. The synthesized nanoparticles were characterized by FT-IR, VSM, EDAX and XRD and TEM studies. The spherical particles obtained before and after the functionalization had sizes of 14 nm and 16 nm, respectively. The method is based on Honey@magnetic-CNTs assisted dispersive solid-liquid phase microextraction for determination and analysis of the drug. The influences of experimental parameters were investigated. Under optimal conditions, the applied nanocomposite showed good performance, high sensitivity and fast extraction of the analyte from biological samples. In linearity test, the regression correlation coefficient was obtained more than 99% for analyte of interest and linear dynamic range for the proposed method was from 5 to 5000 ng mL. Method detection and quantification limits were 1.58 ng mL and 5.28 ng mL, respectively. Relative standard deviation was 3.15%.
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http://dx.doi.org/10.1016/j.ab.2017.11.019DOI Listing
February 2018

Simultaneous quantification of arginine, alanine, methionine and cysteine amino acids in supplements using a novel bioelectro-nanosensor based on CdSe quantum dot/modified carbon nanotube hollow fiber pencil graphite electrode via Taguchi method.

J Pharm Biomed Anal 2017 Nov 30;146:226-235. Epub 2017 Aug 30.

Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran. Electronic address:

A number of four amino acids have been simultaneously determined at CdSe quantum dot-modified/multi-walled carbon nanotube hollow fiber pencil graphite electrode in different bodybuilding supplements. CdSe quantum dots were synthesized and applied to construct a modified carbon nanotube hollow fiber pencil graphite electrode. FT-IR, TEM, XRD and EDAX methods were applied for characterization of the synthesized CdSe QDs. The electro-oxidation of arginine (Arg), alanine (Ala), methionine (Met) and cysteine (Cys) at the surface of the modified electrode was studied. Then the Taguchi's method was applied using MINITAB 17 software to find out the optimum conditions for the amino acids determination. Under the optimized conditions, the differential pulse (DP) voltammetric peak currents of Arg, Ala, Met and Cys increased linearly with their concentrations in the ranges of 0.287-33670μM and detection limits of 0.081, 0.158, 0.094 and 0.116μM were obtained for them, respectively. Satisfactory results were achieved for calibration and validation sets. The prepared modified electrode represents a very good resolution between the voltammetric peaks of the four amino acids which makes it suitable for the detection of each in presence of others in real samples.
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http://dx.doi.org/10.1016/j.jpba.2017.08.034DOI Listing
November 2017

Microfabricated disposable nanosensor based on CdSe quantum dot/ionic liquid-mediated hollow fiber-pencil graphite electrode for simultaneous electrochemical quantification of uric acid and creatinine in human samples.

Anal Chim Acta 2017 Jun 26;972:28-37. Epub 2017 Apr 26.

Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran. Electronic address:

In this research, a novel sensitive electrochemical nanosensor based on the cadmium selenide quantum dots (QDs)/ionic liquid mediated hollow fiber-pencil graphite electrode (HF-PGE) was prepared and applied for simultaneous determination of uric acid (UA) and creatinine (Crn) in urine and serum samples. The electrocatalytic oxidation of the analytes was investigated via differential pulse (DPV) and cyclic voltammetry (CV). The experiments were designed, in two different steps, according to Taguchi's method; OA9 L9 (3) and OA9 L9 (3) orthogonal array to optimize experimental runs. The results revealed that the electrode response was initially influenced by the types of sensor and types of ionic liquids and their ratios. The amount of QD, buffer pH, equilibration time and scan rate also influenced electrode response efficiency. According to the results of Taguchi analysis, the amount of tetra phenyl phosphonium chloride (TPPC) and QD were the most influencing parameters on the yield response of the modified electrodes. Linear ranges were obtained between 0.297-2.970 × 10 and 0.442-8.840 × 10 μM, with the detection limits of 0.083 and 0.229 μM and relative standard deviations (RSD) of 2.4% and 1.8%, for UA and Crn, respectively. Finally, the proposed method was successfully examined for simultaneous determination of UA and Crn in human urine and serum samples.
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http://dx.doi.org/10.1016/j.aca.2017.04.035DOI Listing
June 2017

Dispersive solid-liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline.

J Sep Sci 2015 May 26;38(9):1610-7. Epub 2015 Mar 26.

Department of Chemistry, Payame Noor University, Tehran, Iran.

In this study, a new, simple, rapid, and efficient method combined with ultraviolet visible spectrophotometry and high-performance liquid chromatography analysis was developed for the extraction and determination of nortriptyline. The tendency of the Preyssler tungsten heteropolyacid, H14 [NaP5 W30 O110 ], immobilized on the surface of mesoporous nanomagnetite to adsorb the drug from the solution has been investigated. This method involves the use of an appropriate mixture of nanosorbent that was homogenized in disperser solvent (1.0 mL, ethanol). At first, the mixture containing the nanomagnetic sorbent and disperser solvent was injected into the aqueous sample, and a cloudy solution was formed. Subsequently, separation of the two phases was carried out using a magnet. In the second stage, analyte was desorbed from the sorbent by methanol as the optimal desorption solvent using sonication method. The elution solvent containing enriched analyte was introduced to the instruments for further analysis. Optimization of experimental conditions with respect to the extraction efficiency was investigated. The method was linear in the range of 25-5000, while the detection limit (LOD = 3SB /m) was 7.9 ng/mL and the limit of quantification (LOQ = 10SB /m) was 26.4 ng/mL. The relative standard deviation was 4.66%. The method was successfully applied to human hair samples.
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http://dx.doi.org/10.1002/jssc.201401487DOI Listing
May 2015