Publications by authors named "Sara Ezzat"

3 Publications

  • Page 1 of 1

Musculoskeletal Symptoms in Hemodialysis Patients and their Effect on Health-Related Quality of Life.

Blood Purif 2020 10;49(3):289-294. Epub 2020 Jan 10.

Rheumatology and Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Mansoura, Egypt.

Background/aims: Hemodialysis (HD) represents one of the most commonly used modalities as a renal replacement therapy. Health-related quality of life (HRQoL) is much lower in HD patients than general population. Musculoskeletal (MSK) symptoms are one of the most important health problems that affect patients on maintenance HD. The main purpose of this study was to investigate the association between MSK symptoms and HRQoL among HD patients.

Methods: The study was carried out on 200 patients with chronic renal failure on chronic HD at different nephrology units in Egypt. They completed the Arabic version of the Kidney Disease and Quality of Life-Short Form 1.3 Questionnaire and answered the questions of MSK discomfort form based on the Nordic MSK Questionnaire.

Results: The mean age of the patients was 50.6 years, 61% were males. Of the 200 HD patients, 180 patients (90%) had MSK manifestations. The most commonly affected part was knee joint (51.5%). Regarding HRQoL, patients with MSK symptoms had significantly lower scores than did patients without on the physical role (p = 0.035), pain domain (p = 0.003), general health (p = 0.017), quality of social interaction (p = 0.046), and sleep domain (p = 0.022).

Conclusion: MSK manifestations have a negative impact on HRQoL in HD patients. So, early identification and treatment are highly recommended.
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April 2021

Transforming Growth Factor in Human Breast Milk and Its Correlation with Infants' Parameters.

Breastfeed Med 2019 Jul/Aug;14(6):404-407. Epub 2019 Apr 26.

3 Central Labs of Egypt, Cairo, Egypt.

Breastfeeding provides optimal nutrition and health protection for the infant; it contains many anti-inflammatory factors, including transforming growth factor beta-1 (TGF-β1). Our study aimed to measure the level of TGF-β1 in human milk and to find its correlation with some infant anthropometric characteristics. A milk sample was collected from 84 mothers and the level of TGF-β1 was measured using enzyme-linked immunosorbent assay. TGF-β1 was significantly higher in vegetarian mothers compared with nonvegetarian mothers ( = 0.044). Additionally, the mean value of breast milk TGF-β1 was significantly higher in mothers using contraceptive pills compared with those who do not ( = 0.021). Also, the mean value of TGF-β1 was significantly higher in infants 3-6 months than those <3 months ( = 0.010); also there was a significant difference regarding infants' weight and length with average weight and length ( = 0.042) and ( = 0.009), respectively. TGF-β1 in human milk may play a role in infants' growth and development; mothers' diet is known to influence TGF-β1 level and its relation to infants' age and weight. Contraceptive method could have an influence on TGF-β1 levels during breastfeeding.
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April 2020

Autophagy in osteoporosis: Relation to oxidative stress.

J Cell Biochem 2018 Sep 14. Epub 2018 Sep 14.

Orthopedic Surgery and Traumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Impaired autophagy and oxidative stress are implicated in the development of many diseases. This study aimed to investigate the involvement of autophagy represented by autophagy-related gene 7 (Atg7) and oxidative stress represented by superoxide dismutase 2 (SOD2) gene expression and enzyme activity in the pathogenesis of osteoporosis. Atg7 and SOD2 gene relative expression were evaluated by SYBR green quantitative real-time-polymerase chain reaction in the osteoporotic group (n = 26) versus the osteoporosis free group (n = 14). SOD2 enzyme activity was evaluated by colorimetric method in both study groups. Both Atg7 and SOD2 relative expression showed highly significant decrease (P < 0.01) between both groups. However, SOD2 enzyme activity showed no significant difference between the two groups. There was a significant direct correlation between Atg7 and SOD2 gene expression in both study groups. Atg7 relative expression showed significant ( P < 0.01) direct correlation with vitamin D serum levels and body mass index in osteoporotic group. In conclusion, both genes are involved in the pathogenesis of osteoporosis and this could be amenable to future therapeutic intervention.
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September 2018