Saptarsi M Haldar

Saptarsi M Haldar

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Saptarsi M Haldar

Saptarsi M Haldar

Publications by authors named "Saptarsi M Haldar"

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Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.

J Clin Invest 2020 Feb 27. Epub 2020 Feb 27.

Cardiovascular Research Institute, Gladstone Institutes, San Francisco, United States of America.

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http://dx.doi.org/10.1172/JCI133753DOI Listing
February 2020

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Circ Res 2019 Sep 14;125(7):662-677. Epub 2019 Aug 14.

From the Department of Medicine, Division of Cardiology (M.S.S., R.A.B., M.B.F., A.S.R., B.Y.E., K.A.K., M.A.C., K.S., M.P.Y.L., T.A.M.), University of Colorado Anschutz Medical Campus, Aurora.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315125DOI Listing
September 2019

Epigenetic therapies in heart failure.

J Mol Cell Cardiol 2019 05 13;130:197-204. Epub 2019 Apr 13.

Gladstone Institutes, San Francisco, CA, United States of America; Division of Cardiology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, United States of America; Cardiometabolic Disorders, Amgen, South San Francisco, CA, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828193006
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http://dx.doi.org/10.1016/j.yjmcc.2019.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850768PMC
May 2019

Drugging transcription in heart failure.

J Physiol 2019 Mar 30. Epub 2019 Mar 30.

Division of Cardiology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA.

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http://dx.doi.org/10.1113/JP276745DOI Listing
March 2019

The Cardiac Myofibroblast.

Circ Res 2018 12;123(12):1258-1260

From the Gladstone Institutes, San Francisco, CA (M.A., S.M.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453134PMC
December 2018

Unusual transcription factor protects against heart failure.

Science 2018 12;362(6421):1359-1360

Gladstone Institutes, San Francisco, CA, USA.

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http://dx.doi.org/10.1126/science.aav8956DOI Listing
December 2018

Probing the Pathogenesis of Duchenne Muscular Dystrophy Using Mouse Models.

Methods Mol Biol 2018 ;1687:107-119

Gladstone Institutes, 1650 Owens Street, San Francisco, CA, 94158, USA.

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http://link.springer.com/10.1007/978-1-4939-7374-3_8
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http://dx.doi.org/10.1007/978-1-4939-7374-3_8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805135PMC
June 2018

Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform.

Circ Heart Fail 2018 02;11(2):e004793

From the Division of Cardiology, Department of Medicine, University of California San Francisco School of Medicine; and Gladstone Institute of Cardiovascular Disease, San Francisco, CA.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813833PMC
February 2018

BET bromodomain proteins regulate enhancer function during adipogenesis.

Proc Natl Acad Sci U S A 2018 02 14;115(9):2144-2149. Epub 2018 Feb 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1711155115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834672PMC
February 2018

BRD4 inhibition for the treatment of pathological organ fibrosis.

F1000Res 2017 28;6. Epub 2017 Jun 28.

Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.

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https://f1000research.com/articles/6-1015/v1
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http://dx.doi.org/10.12688/f1000research.11339.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497817PMC
June 2017

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA.

Cell Rep 2016 08 14;16(5):1366-1378. Epub 2016 Jul 14.

Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA; Medical Scientist Training Program, University of Colorado Denver, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972677PMC
August 2016

Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse.

Ultrastruct Pathol 2015 25;39(5):336-9. Epub 2015 Jun 25.

e Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University , Cleveland , OH , USA , and.

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http://dx.doi.org/10.3109/01913123.2015.1042610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827860PMC
July 2016

Sarcomeres and Cardiac Growth: Tension in the Relationship.

Trends Mol Med 2016 07 26;22(7):530-533. Epub 2016 May 26.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Pediatrics, Division of Cardiology, UCSF School of Medicine, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.05.001DOI Listing
July 2016

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.

Proc Natl Acad Sci U S A 2015 Dec 23;112(49):E6780-9. Epub 2015 Nov 23.

Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106; Gladstone Institutes, San Francisco, CA 94158; Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106; Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, CA 94158

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http://dx.doi.org/10.1073/pnas.1512968112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679037PMC
December 2015

Differential role of an NF-κB transcriptional response element in endothelial versus intimal cell VCAM-1 expression.

Circ Res 2015 Jul 1;117(2):166-77. Epub 2015 Jun 1.

From the Vascular Research Division, Department of Pathology, Center for Excellence in Vascular Biology (D.S.M., P.O.D., V.M.D., T.C.) and Cardiovascular Division (J.P., J.D.B.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Advanced Diagnostics Division, Toronto General Research Institute, University Health Network Toronto, Ontario, Canada (M.I., M.C., A.S., A.C.L., S.-N.Z., M.F.B., J.J.-B., M.I.C.); Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada (M.I., M.C., A.S., A.C.L., S.-N.Z., M.F.B., J.J.-B., M.I.C.); Department of Geriatric Medicine, Kyoto University Hospital, Kyoto, Japan (M.I.); Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH (S.M.H.); and Department of Pathology, Children's Hospital and Harvard Medical School, Boston, MA (T.C.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.30666
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http://dx.doi.org/10.1161/CIRCRESAHA.117.306666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758452PMC
July 2015

Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning.

J Mol Cell Cardiol 2015 Mar 7;80:114-25. Epub 2015 Jan 7.

Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, OH, USA; Marshall Institute for Interdisciplinary Research, Huntington, WV, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827870PMC
March 2015

Neuroprotection in ischemic stroke: AhR we making progress?

Circulation 2014 Dec 30;130(23):2002-4. Epub 2014 Oct 30.

From the Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (A.P.); Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH (S.M.H.); and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH (S.M.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013533DOI Listing
December 2014

BET-ting on chromatin-based therapeutics for heart failure.

J Mol Cell Cardiol 2014 Sep 14;74:98-102. Epub 2014 May 14.

Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115033PMC
September 2014

Epigenetic mechanisms in heart failure pathogenesis.

Circ Heart Fail 2014 Sep;7(5):850-863

Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland OH.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169025PMC
September 2014

BET bromodomains mediate transcriptional pause release in heart failure.

Cell 2013 Aug;154(3):569-82

Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://www.cell.com/cms/attachment/2021781429/2041682307/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741300884
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http://dx.doi.org/10.1016/j.cell.2013.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090947PMC
August 2013

String mitochondria in mouse soleus muscle.

Microsc Res Tech 2013 Mar 23;76(3):237-41. Epub 2012 Nov 23.

Electron Microscopy Facility, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1002/jemt.22158DOI Listing
March 2013

S-nitrosylation: integrator of cardiovascular performance and oxygen delivery.

J Clin Invest 2013 Jan 2;123(1):101-10. Epub 2013 Jan 2.

Department of Medicine and Cardiovascular Division, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1172/JCI62854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533273PMC
January 2013

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.

Proc Natl Acad Sci U S A 2012 Apr 9;109(17):6739-44. Epub 2012 Apr 9.

Harrington Heart and Vascular Institute and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1073/pnas.1121060109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340075PMC
April 2012

Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness.

Am J Respir Cell Mol Biol 2011 Sep 21;45(3):642-9. Epub 2011 Jan 21.

Department of Molecular and Cellular Pharmacology, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0369OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175579PMC
September 2011

S-Nitrosylation at the interface of autophagy and disease.

Mol Cell 2011 Jul;43(1):1-3

Institute for Transformative Molecular Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.06.014DOI Listing
July 2011

The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.

Immunity 2011 May 12;34(5):715-28. Epub 2011 May 12.

Case Cardiovascular Research Institute, Department of Medicine, Harrington-McLaughlin Heart and Vascular Institute, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.immuni.2011.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103656PMC
May 2011

Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy.

J Mol Cell Cardiol 2010 Aug 28;49(2):334-8. Epub 2010 Apr 28.

Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885477PMC
August 2010

Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.

Sci Transl Med 2010 Apr;2(26):26ra26

Case Cardiovascular Research Institute, Department of Medicine, Harrington-McLaughlin Heart and Vascular Institute, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1126/scitranslmed.3000502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003709PMC
April 2010

Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium.

J Biol Chem 2009 Jul 1;284(31):20522-30. Epub 2009 Jun 1.

University Hospitals Harrington-McLaughlin Heart & Vascular Institute and Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.M109.025346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742816PMC
July 2009

The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.

J Mol Cell Cardiol 2008 Aug 20;45(2):193-7. Epub 2008 May 20.

Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine/University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2008.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566509PMC
August 2008

Kruppel-like Factors (KLFs) in muscle biology.

J Mol Cell Cardiol 2007 Jul 19;43(1):1-10. Epub 2007 Apr 19.

Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine and University Hospitals of Cleveland / Case Medical Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2007.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743293PMC
July 2007

Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.

Proc Natl Acad Sci U S A 2007 Apr 16;104(17):7074-9. Epub 2007 Apr 16.

Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, 2103 Cornell Road, Room 4-503, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1073/pnas.0701981104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855421PMC
April 2007

Infective endocarditis: diagnosis and management.

Nat Clin Pract Cardiovasc Med 2006 Jun;3(6):310-7

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncpcardio0535DOI Listing
June 2006