Sapna Gupta

Sapna Gupta

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Sapna Gupta

Sapna Gupta

Publications by authors named "Sapna Gupta"

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39Publications

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Mouse modeling and structural analysis of the p.G307S mutation in human cystathionine β-synthase () reveal effects on CBS activity but not stability.

J Biol Chem 2018 Sep 20;293(36):13921-13931. Epub 2018 Jul 20.

From the Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 and

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September 2018

S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice.

Mol Genet Metab Rep 2018 Jun 12;15:15-21. Epub 2018 Jan 12.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

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June 2018

The c.797 G>A (p.R266K) cystathionine β-synthase mutation causes homocystinuria by affecting protein stability.

Hum Mutat 2017 07 22;38(7):863-869. Epub 2017 May 22.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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July 2017

The c.797 G>A (p.R266K) cystathionine β-synthase mutation causes homocystinuria by affecting protein stability.

Hum Mutat 2017 07 22;38(7):863-869. Epub 2017 May 22.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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July 2017

Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.

Aging Cell 2017 04 29;16(2):273-280. Epub 2016 Nov 29.

Department of Pharmacology and Center for Translational Medicine, Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.

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April 2017

Lack of global epigenetic methylation defects in CBS deficient mice.

J Inherit Metab Dis 2017 01 21;40(1):113-120. Epub 2016 Jul 21.

Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.

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January 2017

Propensity Score Adjusted Comparison of MIDCAB Versus Full Sternotomy Left Anterior Descending Artery Revascularization.

Innovations (Phila) 2015 May-Jun;10(3):174-8

From the Department of Cardiac Surgery, Harefield Hospital, London, United Kingdom.

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May 2016

Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice.

J Inherit Metab Dis 2016 Jan 1;39(1):39-46. Epub 2015 Aug 1.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.

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January 2016

The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.

Ann N Y Acad Sci 2016 Jan 24;1363:80-90. Epub 2015 Nov 24.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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January 2016

High homocysteine induces betaine depletion.

Biosci Rep 2015 Apr 28;35(4). Epub 2015 Apr 28.

‡Laboratory for Clinical Biochemistry and Metabolism, Department of General Pediatrics, Center for Pediatrics and Adolescent Medicine University Hospital, Freiburg D-79106, Germany.

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April 2015

Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency.

FASEB J 2014 Jun 14;28(6):2686-95. Epub 2014 Feb 14.

Institute for Medicines and Pharmaceutical Sciences (iMed.UL) and Department of Biochemistry and Human Biology, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal;

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June 2014

Cystathionine β-synthase-deficient mice thrive on a low-methionine diet.

FASEB J 2014 Feb 4;28(2):781-90. Epub 2013 Nov 4.

1Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA.

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February 2014

Correction of cystathionine β-synthase deficiency in mice by treatment with proteasome inhibitors.

Hum Mutat 2013 Aug 13;34(8):1085-93. Epub 2013 May 13.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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August 2013

The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis.

PLoS One 2012 7;7(11):e48720. Epub 2012 Nov 7.

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

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May 2013

Cystathionine beta-synthase deficiency causes fat loss in mice.

PLoS One 2011 11;6(11):e27598. Epub 2011 Nov 11.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

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April 2012

Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.

J Nutr Biochem 2011 Nov 28;22(11):1022-9. Epub 2010 Dec 28.

Department of Human Genetics, McGill University-Montreal Children's Hospital, Montreal, Quebec, Canada.

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November 2011

Serum amino acid levels as a biomarker for renal cell carcinoma.

J Urol 2011 Oct 17;186(4):1206-12. Epub 2011 Aug 17.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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October 2011

Huge vulval elephantiasis: Anesthetic management for caesarean delivery.

J Anaesthesiol Clin Pharmacol 2011 Jul;27(3):416-7

Department of Anaesthesiology and Critical Care, R.N.T. Medical College, Udaipur, India.

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July 2011

Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial.

J Cancer Res Ther 2010 Oct-Dec;6(4):492-6

Department of Radiation Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, India.

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June 2011

Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase.

Nutrition 2010 Nov-Dec;26(11-12):1170-5. Epub 2009 Dec 29.

Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.

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February 2011

Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.

Nutr Res 2010 Jul;30(7):492-500

Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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July 2010

Chemoradiation with hyperthermia in the treatment of head and neck cancer.

Int J Hyperthermia 2010 Feb;26(1):21-5

Advanced Centre for Radiation Oncology, Dr Balabhai Nanavati Hospital, Mumbai 400056, India.

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February 2010

Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.

PLoS Genet 2010 Jan 8;6(1):e1000807. Epub 2010 Jan 8.

Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

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January 2010

Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice.

Circulation 2009 Nov 26;120(19):1893-902. Epub 2009 Oct 26.

Department of Pharmacology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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November 2009

Primary pyomyositis in a child.

Int J Infect Dis 2009 Jul 13;13(4):e149-51. Epub 2008 Nov 13.

Department of Pediatrics, Mahatma Gandhi Institute of Medical Science, Sewagram, Wardha, India.

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July 2009

Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.

FASEB J 2009 Jun 9;23(6):1721-7. Epub 2009 Feb 9.

Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, International Center for Public Health, 225 Warren St., Newark, NJ 07101-1709, USA.

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June 2009

Extended spectrum beta-lactamases in Escherichia coli & Klebsiella pneumoniae & associated risk factors.

Indian J Med Res 2009 Jun;129(6):695-700

Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

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June 2009

Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.

J Cell Biochem 2008 Oct;105(2):467-76

Department of Human Genetics, McGill University Health Centre, Montreal Children's Hospital, Montreal, Quebec, Canada.

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October 2008

Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice.

Hum Mutat 2008 Aug;29(8):1048-54

Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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August 2008

Glutathione metabolism of filarial worms: A vulnerable target for the design and synthesis of new antifilarial agents.

Med Sci Monit 2006 Mar 23;12(3):HY1-9. Epub 2006 Feb 23.

Division of Biochemistry, Central Drug Research Institute, Lucknow, India.

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March 2006

Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.

J Assoc Physicians India 2006 Mar;54:183-6

Post Graduate Department of Pharmacology and Therapeutics, Government Medical College, Jammu (J&K) India 180001.

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March 2006

Setaria cervi: kinetic studies of filarial glutathione synthetase by high performance liquid chromatography.

Exp Parasitol 2005 Oct;111(2):137-41

Division of Biochemistry, Central Drug Research Institute, Lucknow 226 001, India.

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October 2005

Direct injection, column switching-liquid chromatographic technique for the estimation of rabeprazole in bioequivalence study.

J Chromatogr B Analyt Technol Biomed Life Sci 2004 Dec;813(1-2):247-54

Zydus Research Centre, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, India.

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December 2004

Liquid chromatography--electrospray ionisation mass spectrometry method for the determination of escitalopram in human plasma and its application in bioequivalence study.

J Chromatogr B Analyt Technol Biomed Life Sci 2004 Nov;811(2):209-15

Biomedical and DMPK Department, Zydus Research Centre, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, India.

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November 2004