Publications by authors named "Santina Bruzzone"

86Publications

eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases.

Int J Mol Sci 2020 Aug 19;21(17). Epub 2020 Aug 19.

Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.

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August 2020

Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter.

Nat Metab 2019 07 12;1(7):662-665. Epub 2019 Jul 12.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.

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July 2019

Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules.

Mol Divers 2020 Aug 25;24(3):655-671. Epub 2019 Jun 25.

Department of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, V.le Benedetto XV 1, 16132, Genoa, Italy.

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August 2020

Slc12a8 is a nicotinamide mononucleotide transporter.

Nat Metab 2019 01 7;1(1):47-57. Epub 2019 Jan 7.

Department of Developmental Biology, Washington University School of Medicine,, St. Louis, MO 63110, USA.

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January 2019

SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells.

FASEB J 2019 03 4;33(3):3704-3717. Epub 2018 Dec 4.

Section of Biochemistry, Department of Experimental Medicine, Center for Excellence in Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

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March 2019

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.

Bioorg Med Chem 2017 10 19;25(20):5849-5858. Epub 2017 Sep 19.

Department of Experimental Medicine, Section of Biochemistry, University of Genoa, V.le Benedetto XV 1, 16132 Genoa, Italy; CEBR, University of Genova, V.le Benedetto XV, 7, 16132 Genoa, Italy. Electronic address:

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October 2017

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.

Eur J Med Chem 2015 Sep 14;102:530-9. Epub 2015 Aug 14.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy; Institute of Organic Synthesis and Photoreactivity (ISOF), National Research Council (CNR), Via P. Gobetti 101, 40129 Bologna, Italy. Electronic address:

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September 2015

Selectivity hot-spots of sirtuin catalytic cores.

Mol Biosyst 2015 Aug;11(8):2263-72

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Alma Mater Studiorum, Via S.Giacomo 14, 40126 Bologna, Italy.

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August 2015

Discovery of novel and selective SIRT6 inhibitors.

J Med Chem 2014 Jun 19;57(11):4796-804. Epub 2014 May 19.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Via S. Giacomo 14, 40126 Bologna, Italy.

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June 2014

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes.

Oncoimmunology 2013 Sep 26;2(9):e26246. Epub 2013 Sep 26.

Laboratory of Immunogenetics; Department of Medical Sciences; University of Torino; Torino, Italy ; Research Center for Experimental Medicine; University of Torino; Torino, Italy ; Transplantation Immunology; "Città della Salute e della Scienza" Hospital; Torino, Italy.

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September 2013

Fluridone as a new anti-inflammatory drug.

Eur J Pharmacol 2013 Nov 6;720(1-3):7-15. Epub 2013 Nov 6.

Department of Experimental Medicine, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy. Electronic address:

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November 2013

The diadenosine homodinucleotide P18 improves in vitro myelination in experimental Charcot-Marie-Tooth type 1A.

J Cell Biochem 2014 Jan;115(1):161-7

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Mother and Child Sciences and CEBR, University of Genova, Genova, Italy.

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January 2014

CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells.

J Biol Chem 2013 Sep 23;288(36):25938-49. Epub 2013 Jul 23.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy.

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September 2013

Cycling assay for determining intracellular cyclic adp-ribose levels.

Cold Spring Harb Protoc 2013 Jun 1;2013(6):564-8. Epub 2013 Jun 1.

Department of Experimental Medicine (DIMES), Section of Biochemistry, University of Genova, 16132 Genova, Italy.

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June 2013

Rejuvenating sirtuins: the rise of a new family of cancer drug targets.

Curr Pharm Des 2013 ;19(4):614-23

Room 221, Department of Internal Medicine, University of Genoa, V.le Benedetto XV 6, 16132 Genoa, Italy.

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July 2013

ABA says NO to UV-B: a universal response?

Trends Plant Sci 2012 Sep 13;17(9):510-7. Epub 2012 Jun 13.

Instituto de Investigaciones Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina.

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September 2012

Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro.

Biochem Biophys Res Commun 2012 May 27;422(1):70-4. Epub 2012 Apr 27.

Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy.

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May 2012

NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.

J Biol Chem 2012 Jun 30;287(25):21067-81. Epub 2012 Apr 30.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy.

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June 2012

Autocrine abscisic acid plays a key role in quartz-induced macrophage activation.

FASEB J 2012 Mar 31;26(3):1261-71. Epub 2011 Oct 31.

DIMES, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1 16132 Genova, Italy.

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March 2012

Binding of abscisic acid to human LANCL2.

Biochem Biophys Res Commun 2011 Nov 20;415(2):390-5. Epub 2011 Oct 20.

Department of Experimental Medicine (DIMES), Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy.

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November 2011

Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.

J Biol Chem 2010 Jul 3;285(27):21165-74. Epub 2010 May 3.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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July 2010

LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.

J Biol Chem 2009 Oct 10;284(41):28045-57. Epub 2009 Aug 10.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 1, Genova 16132, Italy.

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October 2009

P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.

J Biol Chem 2009 Aug 22;284(34):23146-58. Epub 2009 Jun 22.

Department of Neurosciences, Ophthalmology, and Genetics and Center of Excellence for Biomedical Research, University of Genova, Via De Toni 5, 16132 Genova, Italy.

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August 2009

Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis.

J Biol Chem 2009 Jun 30;284(26):17808-18. Epub 2009 Mar 30.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, and Vascular and Endovascular Surgery Unit, San Martino Hospital, Viale Benedetto XV 1, 16132 Genova, Italy.

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June 2009

Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose.

J Biol Chem 2009 May 27;284(22):14777-87. Epub 2009 Mar 27.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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May 2009

Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger.

J Biol Chem 2008 Nov 10;283(47):32188-97. Epub 2008 Sep 10.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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November 2008

Adenylic dinucleotides produced by CD38 are negative endogenous modulators of platelet aggregation.

J Biol Chem 2008 Sep 7;283(36):24460-8. Epub 2008 Jul 7.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 1 16132 Genova, Italy.

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September 2008

NAADP+ is an agonist of the human P2Y11 purinergic receptor.

Cell Calcium 2008 Apr 17;43(4):344-55. Epub 2007 Aug 17.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV/1, Genoa, Italy.

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April 2008

Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger.

Proc Natl Acad Sci U S A 2007 Apr 26;104(14):5759-64. Epub 2007 Mar 26.

Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV/1, 16132 Genoa, Italy.

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April 2007

Emerging functions of extracellular pyridine nucleotides.

Mol Med 2006 Nov-Dec;12(11-12):324-7

DiSCAFF and the DFB Centre, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.

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June 2007

Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR.

J Biol Chem 2007 Feb 8;282(7):5045-52. Epub 2006 Dec 8.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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February 2007

Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line.

J Neurochem 2006 Oct;99(1):165-76

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy.

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October 2006

Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.

J Biol Chem 2006 Oct 22;281(42):31419-29. Epub 2006 Aug 22.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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October 2006

NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.

Biochem Biophys Res Commun 2006 Jun 27;345(2):573-80. Epub 2006 Apr 27.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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June 2006

Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes.

Biochem J 2006 Feb;393(Pt 3):697-704

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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February 2006

ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells.

Proc Natl Acad Sci U S A 2005 Oct 19;102(41):14509-14. Epub 2005 Sep 19.

Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy.

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October 2005

Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system.

Ann N Y Acad Sci 2004 Dec;1028:176-91

Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1-16132 Genova, Italy.

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December 2004

Abscisic acid signaling through cyclic ADP-ribose in hydroid regeneration.

J Biol Chem 2004 Sep 12;279(38):39783-8. Epub 2004 Jul 12.

Dipartimento di Scienze del Mare, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.

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September 2004

Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones.

J Neurochem 2004 Apr;89(1):264-72

Department of Experimental Medicine, Sections of Biochemistry and Pharmacology, University of Genova, Italy.

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April 2004

Concentrative influx of functionally active cyclic ADP-ribose in dimethyl sulfoxide-differentiated HL-60 cells.

J Biol Chem 2004 May 17;279(21):22066-75. Epub 2004 Mar 17.

Department of Experimental Medicine, University of Genova, Viale Benedetto XV/1, Genova, Italy.

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May 2004

Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors.

J Cell Biol 2003 Nov 17;163(4):837-45. Epub 2003 Nov 17.

Department of Experimental Medicine, University of Genova, Italy.

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November 2003

Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells.

Biochem J 2003 Oct;375(Pt 2):395-403

DI.ME.S. (Dipartimento di Medicina Sperimentale), Section of Biochemistry, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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October 2003

Equilibrative and concentrative nucleoside transporters mediate influx of extracellular cyclic ADP-ribose into 3T3 murine fibroblasts.

J Biol Chem 2002 Dec 3;277(49):47097-105. Epub 2002 Oct 3.

Department of Experimental Medicine, Section of Biochemistry, University of Genova, Italy.

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December 2002