Publications by authors named "Santiago Cal"

44Publications

Identification of relevant genetic alterations in cancer using topological data analysis.

Nat Commun 2020 07 30;11(1):3808. Epub 2020 Jul 30.

Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41467-020-17659-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393176PMC
July 2020

New Insights into ADAMTS Metalloproteases in the Central Nervous System.

Biomolecules 2020 03 5;10(3). Epub 2020 Mar 5.

Departamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain.

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http://dx.doi.org/10.3390/biom10030403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175268PMC
March 2020

Novel Associations Within the Tumor Microenvironment: Fibulins Meet ADAMTSs.

Front Oncol 2019 22;9:796. Epub 2019 Aug 22.

Instituto Universitario de Oncología, IUOPA, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.3389/fonc.2019.00796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714394PMC
August 2019

Antitumor Potential of Fibulin-5 in Breast Cancer Cells Depends on Its RGD Cell Adhesion Motif.

Cell Physiol Biochem 2019 ;53(1):87-100

Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Asturias, Spain.

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http://dx.doi.org/10.33594/000000123DOI Listing
June 2019

Assessing the Influence of a Protease in Cell Migration Using the Barrier-Migration Assay.

Methods Mol Biol 2018 ;1731:133-143

Departamento de Biología Funcional, Universidad de Oviedo, Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1007/978-1-4939-7595-2_13DOI Listing
January 2019

Fibulin-5 downregulates Ki-67 and inhibits proliferation and invasion of breast cancer cells.

Int J Oncol 2016 Apr 17;48(4):1447-56. Epub 2016 Feb 17.

Department of Functional Biology-Physiology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.3892/ijo.2016.3394DOI Listing
April 2016

DESC1, a novel tumor suppressor, sensitizes cells to apoptosis by downregulating the EGFR/AKT pathway in esophageal squamous cell carcinoma.

Int J Cancer 2016 Jun 26;138(12):2940-51. Epub 2016 Feb 26.

Department of Clinical Oncology, Faculty of Medicine, University of Hong Kong Li Ka Shing, Pokfulam, Hong Kong, SAR.

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http://dx.doi.org/10.1002/ijc.30034DOI Listing
June 2016

ADAMTS proteases and cancer.

Matrix Biol 2015 May-Jul;44-46:77-85. Epub 2015 Jan 28.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología del Principado de Asturias, IUOPA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1016/j.matbio.2015.01.013DOI Listing
March 2016

Hypernociceptive responses following the intratibial inoculation of RM1 prostate cancer cells in mice.

Prostate 2015 Jan 27;75(1):70-83. Epub 2014 Sep 27.

Laboratorio de Farmacología, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1002/pros.22893DOI Listing
January 2015

Polyserase-1/TMPRSS9 induces pro-tumor effects in pancreatic cancer cells by activation of pro-uPA.

Oncol Rep 2014 Jun 23;31(6):2792-6. Epub 2014 Apr 23.

Department of Biochemistry and Molecular Biology, University of Oviedo, 33006 Oviedo, Asturias, Spain.

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http://dx.doi.org/10.3892/or.2014.3146DOI Listing
June 2014

Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.

Nat Commun 2013 ;4:2531

1] Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo 33006, Spain [2].

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http://dx.doi.org/10.1038/ncomms3531DOI Listing
May 2014

ADAMTS-12 metalloprotease is necessary for normal inflammatory response.

J Biol Chem 2012 Nov 27;287(47):39554-63. Epub 2012 Sep 27.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1074/jbc.M112.408625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501021PMC
November 2012

New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment.

Front Pharmacol 2012 17;3:140. Epub 2012 Jul 17.

Laboratory of Tumor and Development Biology, GIGA-Cancer, University of Liège Liège, Belgium.

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http://dx.doi.org/10.3389/fphar.2012.00140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398411PMC
October 2012

The dual role of fibulins in tumorigenesis.

Cancer Lett 2012 Dec 7;325(2):132-8. Epub 2012 Jul 7.

Departamento de Biología Funcional, Area de Fisiología, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Spain.

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http://dx.doi.org/10.1016/j.canlet.2012.06.019DOI Listing
December 2012

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

Hum Mutat 2011 Jun 24;32(6):E2148-75. Epub 2011 Feb 24.

Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://doi.wiley.com/10.1002/humu.21477
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http://dx.doi.org/10.1002/humu.21477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103704PMC
June 2011

The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities.

J Mol Med (Berl) 2011 Jun 2;89(6):611-9. Epub 2011 Mar 2.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Spain.

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http://dx.doi.org/10.1007/s00109-011-0741-7DOI Listing
June 2011

The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.

J Cell Sci 2009 Aug 28;122(Pt 16):2906-13. Epub 2009 Jul 28.

Departamento de Bioquímica y Biología Molecular, Area de Fisiología, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1242/jcs.050468DOI Listing
August 2009

Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.

Cancer Res 2009 Jun 19;69(11):4926-34. Epub 2009 May 19.

Departamento de Bioquímica y Biología Molecular and Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Servicio de Anatomía Patológica, Hospital Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4155DOI Listing
June 2009

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway.

J Cell Sci 2007 Oct 25;120(Pt 20):3544-52. Epub 2007 Sep 25.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006-Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1242/jcs.005751DOI Listing
October 2007

Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains.

Front Biosci 2007 May 1;12:4661-9. Epub 2007 May 1.

Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Asturias, Spain.

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http://dx.doi.org/10.2741/2415DOI Listing
May 2007

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain.

BMC Biochem 2006 Mar 27;7. Epub 2006 Mar 27.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1186/1471-2091-7-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435904PMC
March 2006

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.

Blood 2005 Dec 1;106(13):4139-45. Epub 2005 Sep 1.

Thrombosis Research Section, Department of Medicine, BCM286, N1319, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2005-05-2029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895231PMC
December 2005

The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer.

Oncogene 2005 Feb;24(6):1098-103

Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Arturo Duperier 4, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1038/sj.onc.1208303DOI Listing
February 2005

Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain.

J Biol Chem 2005 Jan 9;280(3):1953-61. Epub 2004 Nov 9.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1074/jbc.M409139200DOI Listing
January 2005

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

Biochem Biophys Res Commun 2004 Jan;314(1):54-62

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2003.12.050DOI Listing
January 2004

Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.

Proc Natl Acad Sci U S A 2003 Aug 28;100(16):9185-90. Epub 2003 Jul 28.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://dx.doi.org/10.1073/pnas.1633392100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC170893PMC
August 2003

Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.

J Biol Chem 2003 Apr 31;278(15):13382-9. Epub 2003 Jan 31.

Departamento de Bioquíimica y Biologíia Molecular, Facultad de Medicina, Instituto Universitario de Oncologíia, Universidad de Oviedo, 33006-Oviedo, Spain.

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http://www.jbc.org/content/early/2003/01/31/jbc.M211900200.f
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http://www.jbc.org/cgi/doi/10.1074/jbc.M211900200
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http://dx.doi.org/10.1074/jbc.M211900200DOI Listing
April 2003

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.

J Biol Chem 2002 Oct 30;277(40):37637-46. Epub 2002 Jul 30.

Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1074/jbc.M203007200DOI Listing
October 2002

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

Gene 2002 Jan;283(1-2):49-62

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006, Oviedo, Spain.

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http://dx.doi.org/10.1016/s0378-1119(01)00861-7DOI Listing
January 2002