Publications by authors named "Sanne B E A Hoeks"

4 Publications

  • Page 1 of 1

TH17 differentiation capacity develops within the first 3 months of life.

J Allergy Clin Immunol 2014 Mar 1;133(3):891-4.e5. Epub 2013 Nov 1.

Center for Molecular and Cellular Intervention, Laboratory for Translational Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.09.022DOI Listing
March 2014

Defective TH17 development in human neonatal T cells involves reduced RORC2 mRNA content.

J Allergy Clin Immunol 2013 Sep 29;132(3):754-756.e3. Epub 2013 May 29.

Department of Pediatric Immunology, Center for Molecular and Cellular Intervention CMCI, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jaci.2013.04.014DOI Listing
September 2013

Toll-like receptor 2 polymorphism is associated with preterm birth.

Pediatr Res 2007 Oct;62(4):474-6

Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB, The Netherlands.

Evidence is increasing for a role of polymorphisms in maternal or fetal innate immune response genes in preterm birth. Toll-like receptors (TLRs) are important receptors in the innate immunity. The genotype distribution of two TLR2 single nucleotide polymorphisms (SNPs) and one TLR4 SNP were determined among 524 neonates and associated with gestational age (GA). Genomic DNA was isolated from prospectively collected blood samples and polymorphisms in TLR2 (T-16934A, RS4696480 and Arg753Gln, RS5743708) and TLR4 (Thr399Ile, RS4986791) were determined using sequence specific primers by PCR. Allele frequencies of two TLR2 SNPs and one TLR4 SNP were analyzed according to prematurity. Analysis among 305 infants, after exclusion of infants born after multiple pregnancy or because of preeclampsia, revealed significantly shorter GAs for infants carrying two polymorphic TLR2 alleles (-16934TA/AA and 753ArgGln/GlnGln) compared with infants carrying one polymorphic and one wild-type allele or two wild-type alleles (median GA 30.6 wk versus 34.1-36.8 wk, respectively, p < 0.02). Carriage of two variant TLR2 alleles potentially leads to aberrant innate immune responses, which may have contributed to very preterm birth.
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http://dx.doi.org/10.1203/PDR.0b013e31813c9401DOI Listing
October 2007