Sanjay K Srivastava

Sanjay K Srivastava

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Sanjay K Srivastava

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Therapeutic Targeting of Vasculature in the Premetastatic and Metastatic Niches Reduces Lung Metastasis.

J Immunol 2020 Jan 3. Epub 2020 Jan 3.

Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601;

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http://dx.doi.org/10.4049/jimmunol.1901208DOI Listing
January 2020

Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala.

Antioxidants (Basel) 2020 Jan 13;9(1). Epub 2020 Jan 13.

Department of Immunotherapeutics and Biotechnology, and Center for Tumor Immunology and Targeted Cancer Therapy, Texas Tech University Health Sciences Center, Abilene, TX 79601, USA.

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http://dx.doi.org/10.3390/antiox9010072DOI Listing
January 2020

CRISPR-Cas9: A multifaceted therapeutic strategy for cancer treatment.

Semin Cell Dev Biol 2019 Dec 4;96:4-12. Epub 2019 May 4.

Department of Immunotherapeutics and Biotechnology and Center for Tumor Immunology and Targeted Cancer Therapy, Texas Tech University Health Sciences Center, Abilene, TX, 79601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829064PMC
December 2019

Atovaquone: An Antiprotozoal Drug Suppresses Primary and Resistant Breast Tumor Growth by Inhibiting HER2/β-Catenin Signaling.

Mol Cancer Ther 2019 10 3;18(10):1708-1720. Epub 2019 Jul 3.

Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905100PMC
October 2019

Role of Phytochemicals in Cancer Prevention.

Int J Mol Sci 2019 Oct 9;20(20). Epub 2019 Oct 9.

Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.3390/ijms20204981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834187PMC
October 2019

Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy.

Semin Cancer Biol 2019 Oct 13. Epub 2019 Oct 13.

Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA; Department of Immunotherapeutics and Biotechnology, and Center for Tumor Immunology and Targeted Cancer Therapy, Texas Tech University Health Sciences Center, Abilene, TX, 79601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.10.007DOI Listing
October 2019

Penfluridol overcomes paclitaxel resistance in metastatic breast cancer.

Sci Rep 2019 Mar 25;9(1):5066. Epub 2019 Mar 25.

Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.

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http://www.nature.com/articles/s41598-019-41632-0
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http://dx.doi.org/10.1038/s41598-019-41632-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434141PMC
March 2019

HER2-mediated GLI2 stabilization promotes anoikis resistance and metastasis of breast cancer cells.

Cancer Lett 2019 02 26;442:68-81. Epub 2018 Oct 26.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA; Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, TX, 79601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311434PMC
February 2019

Cancer cells stemness: A doorstep to targeted therapy.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 26:165424. Epub 2019 Feb 26.

Department of Immunotherapeutics and Biotechnology, and Center for Tumor Immunology and Targeted Cancer Therapy, Texas Tech University Health Sciences Center, Abilene, TX 79601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.02.019DOI Listing
February 2019

AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells.

Mol Cancer Ther 2018 09 11;17(9):1833-1845. Epub 2018 Jun 11.

Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-1023DOI Listing
September 2018

Correction to: Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells.

Arch Toxicol 2018 09;92(9):2979

Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.

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http://dx.doi.org/10.1007/s00204-018-2262-4DOI Listing
September 2018

Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.

Oncogene 2018 07 9;37(27):3715-3728. Epub 2018 Apr 9.

Korean Medicine Tumor Ecosystem Regulation Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1038/s41388-018-0225-0DOI Listing
July 2018

Role of Forkhead Box Class O proteins in cancer progression and metastasis.

Semin Cancer Biol 2018 06 1;50:142-151. Epub 2017 Aug 1.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA; Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, TX 79601, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794649PMC
June 2018

Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells.

Arch Toxicol 2018 Jan 4;92(1):241-257. Epub 2017 Jul 4.

Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.

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http://link.springer.com/10.1007/s00204-017-2021-y
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http://dx.doi.org/10.1007/s00204-017-2021-yDOI Listing
January 2018

Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model.

PLoS One 2013 27;8(6):e67278. Epub 2013 Jun 27.

Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America ; Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067278PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695065PMC
October 2017

Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth.

Oncotarget 2017 Jul;8(29):47632-47641

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.18632/oncotarget.17425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564593PMC
July 2017

Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer.

Tumour Biol 2017 Jun;39(6):1010428317705517

1 Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

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http://dx.doi.org/10.1177/1010428317705517DOI Listing
June 2017

Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1.

Oncotarget 2017 May;8(20):32960-32976

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.18632/oncotarget.16515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464842PMC
May 2017

Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis.

Sci Rep 2016 05 18;6:26165. Epub 2016 May 18.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1038/srep26165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870635PMC
May 2016

Penfluridol: An Antipsychotic Agent Suppresses Metastatic Tumor Growth in Triple-Negative Breast Cancer by Inhibiting Integrin Signaling Axis.

Cancer Res 2016 Feb 1;76(4):877-90. Epub 2015 Dec 1.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755811PMC
February 2016

Nanoemulsion formulations for anti-cancer agent piplartine--Characterization, toxicological, pharmacokinetics and efficacy studies.

Int J Pharm 2016 Feb 28;498(1-2):12-22. Epub 2015 Nov 28.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.11.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718800PMC
February 2016

Poly[μ2-aqua-aqua-[μ3-N-butyl-N-(2-hy-droxy-ethyl)di-thio-carbamato-κ(3) O,O':S]sodium].

Acta Crystallogr E Crystallogr Commun 2016 Feb 20;72(Pt 2):196-8. Epub 2016 Jan 20.

Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.

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http://dx.doi.org/10.1107/S2056989016000657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770959PMC
February 2016

Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.

Oncotarget 2015 Dec;6(38):40535-56

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.5755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747351PMC
December 2015

Modulation of signal transduction pathways by natural compounds in cancer.

Chin J Nat Med 2015 Oct;13(10):730-42

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA; Cancer Preventive Material Development Research Center, College of Korean Medicine, Department of Pathology, Kyunghee University, Seoul 131-701, South Korea. Electronic address:

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http://dx.doi.org/10.1016/S1875-5364(15)30073-XDOI Listing
October 2015

Mechanisms of the Anticancer Effects of Isothiocyanates.

Enzymes 2015;37:111-37. Epub 2015 Jul 7.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Cancer Preventive Material Development Research Center, College of Korean Medicine, Department of Pathology, Kyung Hee University, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1016/bs.enz.2015.06.001DOI Listing
July 2015

Inhibition of β-catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-catenin/TCF-1 complex: critical role of STAT-3.

Oncotarget 2015 May;6(13):11561-74

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://www.oncotarget.com/fulltext/3427
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484476PMC
http://dx.doi.org/10.18632/oncotarget.3427DOI Listing
May 2015

PEITC treatment suppresses myeloid derived tumor suppressor cells to inhibit breast tumor growth.

Oncoimmunology 2015 Feb 6;4(2):e981449. Epub 2015 Mar 6.

Department of Biomedical Sciences and Cancer Biology Center; Texas Tech University Health Sciences Center ; Amarillo, TX USA ; Cancer Preventive Material Development Research Center; College of Korean Medicine; Department of Pathology; Kyunghee University ; Dongdaemun-ku, Seoul, South Korea.

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http://dx.doi.org/10.4161/2162402X.2014.981449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404818PMC
February 2015

Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation.

PLoS One 2014 7;9(5):e94298. Epub 2014 May 7.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America; Cancer Preventive Material Development Research Center, College of Korean Medicine, Department of Pathology, Kyunghee University, Seoul, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094298PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013113PMC
January 2015

Caspase-9 as a therapeutic target for treating cancer.

Expert Opin Ther Targets 2015 Jan 26;19(1):113-27. Epub 2014 Sep 26.

Kyunghee University, College of Korean Medicine, Cancer Preventive Material Development Research Center , 1 Hoegi-dong, Dongdaemun-ku, Seoul 131-701 , South Korea.

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http://dx.doi.org/10.1517/14728222.2014.961425DOI Listing
January 2015

STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells.

Carcinogenesis 2015 Jan 19;36(1):142-50. Epub 2014 Nov 19.

Department of Biomedical Sciences & Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA

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http://dx.doi.org/10.1093/carcin/bgu233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291051PMC
January 2015

HER2 mediated de novo production of TGFβ leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer.

Mol Oncol 2014 Dec 18;8(8):1532-47. Epub 2014 Jun 18.

Department of Biomedical Sciences Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2014.06.006
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http://dx.doi.org/10.1016/j.molonc.2014.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252481PMC
December 2014

Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.

Biochim Biophys Acta 2014 Dec 23;1846(2):405-24. Epub 2014 Aug 23.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA; Cancer Preventive Material Development Research Center, College of Korean Medicine, Department of Pathology, Kyunghee University, 1 Hoegi-dong, Dongdaemun-ku, Seoul 131-701, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260992PMC
December 2014

Tucaresol down-modulation of MUC1-stimulated human mononuclear cells.

Immunol Invest 2014 4;43(2):160-9. Epub 2013 Dec 4.

Women's Health Research Institute, Department of Internal Medicine, Texas Tech University Health Sciences Center , Amarillo, Texas, 79106 , USA .

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http://dx.doi.org/10.3109/08820139.2013.860161DOI Listing
October 2014

Molecular targets of isothiocyanates in cancer: recent advances.

Mol Nutr Food Res 2014 Aug 10;58(8):1685-707. Epub 2014 Feb 10.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

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http://dx.doi.org/10.1002/mnfr.201300684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122603PMC
August 2014

Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.

Bioorg Med Chem Lett 2014 Aug 4;24(15):3392-7. Epub 2014 Jun 4.

Department of Chemistry, 213 CBC Building, Kansas State University, Manhattan, KS 66506, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.05.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110911PMC
August 2014

Critical role of STAT3 in melanoma metastasis through anoikis resistance.

Oncotarget 2014 Aug;5(16):7051-64

Department of Biomedical Sciences & Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196183PMC
http://dx.doi.org/10.18632/oncotarget.2251DOI Listing
August 2014

TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells.

Oncol Lett 2014 Jun 12;7(6):2113-2117. Epub 2014 Mar 12.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA.

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http://dx.doi.org/10.3892/ol.2014.1969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049764PMC
June 2014

Large area fabrication of vertical silicon nanowire arrays by silver-assisted single-step chemical etching and their formation kinetics.

Nanotechnology 2014 May 9;25(17):175601. Epub 2014 Apr 9.

CSIR-National Physical Laboratory, New Delhi 110012, India. Network of Institutes for Solar Energy (NISE), India. Max Planck Institute for the Science of Light, Erlangen, D-91058, Germany.

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http://dx.doi.org/10.1088/0957-4484/25/17/175601DOI Listing
May 2014

Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression.

Oncotarget 2014 Apr;5(7):1812-28

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039119PMC
http://dx.doi.org/10.18632/oncotarget.1743DOI Listing
April 2014

Tri-phenyl-tellurium chloride.

Acta Crystallogr Sect E Struct Rep Online 2014 Apr 12;70(Pt 4):o421-2. Epub 2014 Mar 12.

Department of Chemistry, Howard University, 525 College Street NW, Washington, DC 20059, USA.

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http://dx.doi.org/10.1107/S160053681400498XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998628PMC
April 2014

CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT.

Mol Cancer Ther 2014 Mar 13;13(3):687-98. Epub 2014 Jan 13.

Corresponding Author: Sanjay K. Srivastava, Department of Biomedical Sciences, Suite 1103, Texas Tech University Health Sciences Center, 1406 Coulter Drive, Amarillo, TX 79106.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954235PMC
March 2014

Pancreatic cancer chemoprevention by phytochemicals.

Cancer Lett 2013 Jun 27;334(1):86-94. Epub 2012 Oct 27.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2012.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625461PMC
June 2013

Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.

PLoS One 2012 27;7(8):e43577. Epub 2012 Aug 27.

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043577PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428303PMC
February 2013

Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.

Chem Res Toxicol 2013 Jan 6;26(1):55-66. Epub 2012 Nov 6.

Department of Pharmacology and Toxicology, University of Utah , 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, Utah 84112, United States.

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http://pubs.acs.org/doi/10.1021/tx300366k
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http://dx.doi.org/10.1021/tx300366kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610763PMC
January 2013

DIMming ovarian cancer growth.

Curr Drug Targets 2012 Dec;13(14):1869-75

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA.

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http://dx.doi.org/10.2174/138945012804545650DOI Listing
December 2012

Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis.

Antioxid Redox Signal 2012 Nov 11;17(10):1417-32. Epub 2012 Jun 11.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1089/ars.2011.4369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437051PMC
November 2012

Prevention of human adenocarcinoma with CpG-ODN in a mouse model.

Oncol Lett 2012 Nov 6;4(5):1061-1063. Epub 2012 Aug 6.

Women's Health Research Institute, Department of Internal Medicine;

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http://dx.doi.org/10.3892/ol.2012.849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499539PMC
November 2012

4-Isopropyl-5,5-dimethyl-2-sulfanyl-1,3,2-dioxaphosphinane 2-sulfide.

Acta Crystallogr Sect E Struct Rep Online 2012 Sep 11;68(Pt 9):o2667. Epub 2012 Aug 11.

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http://dx.doi.org/10.1107/S1600536812030188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435691PMC
September 2012

Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo.

J Biol Chem 2012 Aug 6;287(34):28745-54. Epub 2012 Jul 6.

Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA.

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http://dx.doi.org/10.1074/jbc.M112.351379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436512PMC
August 2012

Nanowire arrays in multicrystalline silicon thin films on glass: a promising material for research and applications in nanotechnology.

Nano Lett 2012 Aug 26;12(8):4050-4. Epub 2012 Jul 26.

Max Planck Institute for the Science of Light, Günther-Scharowsky-Strasse 1, 91058 Erlangen, Germany.

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http://dx.doi.org/10.1021/nl301419qDOI Listing
August 2012

Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.

BMC Med 2012 Jul 24;10:80. Epub 2012 Jul 24.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

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http://dx.doi.org/10.1186/1741-7015-10-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412708PMC
July 2012

Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo.

J Pharmacol Exp Ther 2012 Apr 28;341(1):24-32. Epub 2011 Dec 28.

Department of Biomedical Sciences, Cancer Biology Center, Texas Tech University Health Sciences Center, 1406 Coulter, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1124/jpet.111.188706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310701PMC
April 2012

Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.

Oncotarget 2012 Apr;3(4):435-49

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380578PMC
http://dx.doi.org/10.18632/oncotarget.483DOI Listing
April 2012

Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3.

PLoS One 2011 10;6(10):e25799. Epub 2011 Oct 10.

Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025799PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189946PMC
February 2012

Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).

BMC Med 2012 Jan 26;10. Epub 2012 Jan 26.

Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1186/1741-7015-10-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298725PMC
January 2012

Nanoemulsions of cancer chemopreventive agent benzyl isothiocyanate display enhanced solubility, dissolution, and permeability.

J Agric Food Chem 2011 Dec 11;59(23):12396-404. Epub 2011 Nov 11.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, United States.

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http://dx.doi.org/10.1021/jf202612bDOI Listing
December 2011

Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice.

Carcinogenesis 2011 Nov 22;32(11):1689-96. Epub 2011 Aug 22.

Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 6-118, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1093/carcin/bgr191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204349PMC
November 2011

Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells.

PLoS One 2011 25;6(5):e20151. Epub 2011 May 25.

Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102063PMC
September 2011

Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway.

Clin Cancer Res 2011 Apr 24;17(7):1784-95. Epub 2011 Feb 24.

Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076680PMC
April 2011

The role of K-ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.

Cancer Chemother Pharmacol 2011 Feb 17;67(2):481-7. Epub 2010 Sep 17.

Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Suite 1103, 1406 Coulter Drive, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1007/s00280-010-1463-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842667PMC
February 2011

Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells.

Mol Pharmacol 2010 Aug 5;78(2):297-309. Epub 2010 May 5.

Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1124/mol.110.063750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917853PMC
August 2010

Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells.

Mol Cancer Ther 2010 Jun 18;9(6):1596-608. Epub 2010 May 18.

Department of Biomedical Sciences, and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-1146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946330PMC
June 2010

Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach.

Chem Biol Interact 2010 Feb 26;183(3):462-71. Epub 2009 Nov 26.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1406 Coulter Drive, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1016/j.cbi.2009.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821678PMC
February 2010

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells.

Carcinogenesis 2009 Oct 23;30(10):1744-53. Epub 2009 Jun 23.

Department of Biomedical and Pharmaceutical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Suite 1103, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1093/carcin/bgp157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757546PMC
October 2009

RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways.

Proteomics 2009 May;9(10):2776-87

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter Rd., Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1002/pmic.200800847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992961PMC
May 2009

Making a technological choice for disaster management and poverty alleviation in India.

Disasters 2009 Mar 21;33(1):58-81. Epub 2008 May 21.

Scientist, Disaster Management Support Programme, Indian Space Research Organisation, Government of India, India.

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March 2009

Synthesis of quinazolines as tyrosine kinase inhibitors.

Anticancer Agents Med Chem 2009 Mar;9(3):246-75

Dabur Research Foundation, Sahibabad, Ghaziabad, U.P., India.

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http://dx.doi.org/10.2174/1871520610909030246DOI Listing
March 2009

Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.

Bioorg Med Chem Lett 2009 Feb 3;19(3):949-53. Epub 2008 Dec 3.

Medicinal Chemistry, Torrent Research Centre, Torrent Pharmaceuticals Ltd, PO Bhat, Gandhinagar 382428, Gujarat, India.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.099DOI Listing
February 2009

The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.

J Natl Cancer Inst 2009 Feb 27;101(3):176-93. Epub 2009 Jan 27.

Department of Pharmaceutical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djn470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724856PMC
February 2009

In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway.

Apoptosis 2008 Dec;13(12):1465-78

Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://link.springer.com/10.1007/s10495-008-0278-6
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December 2008

Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis.

BMC Cancer 2008 Oct 10;8:294. Epub 2008 Oct 10.

Department of Pharmaceutical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, Texas, USA.

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http://dx.doi.org/10.1186/1471-2407-8-294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576337PMC
October 2008

Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives.

Bioorg Med Chem Lett 2007 Dec 11;17(23):6660-4. Epub 2007 Aug 11.

Division of Medicinal Chemistry, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad, 201 010 UP, India.

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December 2007

Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.

Anticancer Agents Med Chem 2007 Nov;7(6):685-709

Medicinal Chemistry, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad--201 010, U.P. India.

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http://dx.doi.org/10.2174/187152007784111313DOI Listing
November 2007

Cell division cycle 25B phosphatase is essential for benzo(a)pyrene-7,8-Diol-9,10-epoxide induced neoplastic transformation.

Cancer Res 2007 Oct;67(19):9150-7

Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-07-0025DOI Listing
October 2007

Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells.

J Nutr 2006 Nov;136(11):2728-34

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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November 2006

Synthesis of 13-amino costunolide derivatives as anticancer agents.

Bioorg Med Chem Lett 2006 Aug 12;16(16):4195-9. Epub 2006 Jun 12.

Divisions of Medicinal Chemistry, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad, India.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X060063
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http://dx.doi.org/10.1016/j.bmcl.2006.05.083DOI Listing
August 2006

Betulinic acid derivatives as anticancer agents: structure activity relationship.

Anticancer Agents Med Chem 2006 May;6(3):271-9

Medicinal Chemistry, Dabur Research Foundation, 22 Site IV, Sahibabad, Ghaziabad 201010, UP, India.

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http://dx.doi.org/10.2174/187152006776930846DOI Listing
May 2006

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

J Biol Chem 2005 May 11;280(20):19911-24. Epub 2005 Mar 11.

Department of Pharmacology and University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA

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http://dx.doi.org/10.1074/jbc.M412443200DOI Listing
May 2005

Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist.

J Med Chem 2005 Mar;48(5):1676-9

Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1021/jm049172nDOI Listing
March 2005

Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells.

Carcinogenesis 2004 Sep 29;25(9):1701-9. Epub 2004 Apr 29.

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1093/carcin/bgh179DOI Listing
September 2004

Synthesis and cytotoxic activity of 3-O-acyl/3-hydrazine /2-bromo/20,29-dibromo betulinic acid derivatives.

Bioorg Med Chem Lett 2004 Aug;14(15):4087-91

Division of Experimental Oncology, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad 201 010, UP, India.

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http://dx.doi.org/10.1016/j.bmcl.2004.05.034DOI Listing
August 2004

Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide.

Biochemistry 2004 Aug;43(30):9708-15

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1021/bi049435fDOI Listing
August 2004

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

J Biol Chem 2004 Jun 8;279(24):25813-22. Epub 2004 Apr 8.

Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1074/jbc.M313538200DOI Listing
June 2004

Synthesis of 3-O-acyl/3-benzylidene/3-hydrazone/3-hydrazine/17-carboxyacryloyl ester derivatives of betulinic acid as anti-angiogenic agents.

Bioorg Med Chem Lett 2004 Jun;14(12):3169-72

Divisions of Experimental Oncology, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad 201 010, UP, India.

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http://dx.doi.org/10.1016/j.bmcl.2004.04.010DOI Listing
June 2004

Betulinic acid and its derivatives as anti-angiogenic agents.

Bioorg Med Chem Lett 2004 May;14(9):2181-4

Divisions of Experimental Oncology, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad 201 010, UP, India.

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http://dx.doi.org/10.1016/j.bmcl.2004.02.044DOI Listing
May 2004

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.

Carcinogenesis 2003 Oct 1;24(10):1665-70. Epub 2003 Aug 1.

Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

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http://carcin.oxfordjournals.org/content/24/10/1665.full.pdf
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http://www.carcin.oupjournals.org/cgi/doi/10.1093/carcin/bgg
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http://dx.doi.org/10.1093/carcin/bgg123DOI Listing
October 2003

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis.

Carcinogenesis 2003 May;24(5):891-7

Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, PA 15213, USA.

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http://dx.doi.org/10.1093/carcin/bgg023DOI Listing
May 2003

Role of glutathione conjugate efflux in cellular protection against benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage.

Mol Carcinog 2002 Mar;33(3):156-62

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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March 2002

Differential expression of glutathione S-transferase isoenzymes in murine small intestine and colon.

Comp Biochem Physiol B Biochem Mol Biol 2002 Mar;131(3):443-52

Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/s1096-4959(01)00515-2DOI Listing
March 2002

Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products.

J Biol Chem 2002 Feb 19;277(6):4232-9. Epub 2001 Nov 19.

Department of Internal Medicine, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109678200
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February 2002

4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity.

J Med Chem 2002 Jan;45(2):537-40

School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.

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http://dx.doi.org/10.1021/jm010841wDOI Listing
January 2002