Publications by authors named "Sanjay K Nigam"

100Publications

Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.

JCI Insight 2020 04 9;5(7). Epub 2020 Apr 9.

Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1172/jci.insight.133817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205256PMC
April 2020

SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress.

Int J Mol Sci 2020 Mar 15;21(6). Epub 2020 Mar 15.

Department of Pediatrics, University of California San Diego, San Diego, CA 92093, USA.

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http://dx.doi.org/10.3390/ijms21062002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139749PMC
March 2020

Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs.

Int J Mol Sci 2020 Mar 5;21(5). Epub 2020 Mar 5.

Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.

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http://dx.doi.org/10.3390/ijms21051791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084758PMC
March 2020

The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology.

Clin Pharmacol Ther 2020 Jul 11;108(1):40-53. Epub 2020 Apr 11.

Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1002/cpt.1818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292762PMC
July 2020

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.

J Biol Chem 2020 02 2;295(7):1829-1842. Epub 2020 Jan 2.

Department of Pediatrics, University of California San Diego, La Jolla, California 92093-0693

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http://dx.doi.org/10.1074/jbc.RA119.010729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029110PMC
February 2020

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis.

Sci Rep 2019 08 15;9(1):11879. Epub 2019 Aug 15.

Departments of Pediatrics, University of California at San Diego, La Jolla, CA, 92093-0693, USA.

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http://dx.doi.org/10.1038/s41598-019-47798-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695406PMC
August 2019

Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation.

Clin J Am Soc Nephrol 2019 04 18;14(4):540-548. Epub 2019 Mar 18.

Department of Pediatrics and Medicine (Nephrology), School of Medicine, University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.2215/CJN.10350818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450358PMC
April 2019

Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.

Nat Rev Nephrol 2019 05;15(5):301-316

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41581-019-0111-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619437PMC
May 2019

Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development.

Am J Med Genet A 2019 01 13;179(1):71-77. Epub 2018 Nov 13.

Division of Pediatric Cardiology, University of California San Diego School of Medicine, San Diego, California.

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http://dx.doi.org/10.1002/ajmg.a.40481DOI Listing
January 2019

The systems biology of uric acid transporters: the role of remote sensing and signaling.

Curr Opin Nephrol Hypertens 2018 07;27(4):305-313

Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Califonia, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275126PMC
July 2018

Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication.

Expert Opin Drug Metab Toxicol 2018 Jun 4;14(6):561-570. Epub 2018 Jun 4.

b Departments of Pediatrics and Medicine , University of California , San Diego , USA.

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http://dx.doi.org/10.1080/17425255.2018.1473376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277044PMC
June 2018

Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.

Am J Physiol Renal Physiol 2018 08 7;315(2):F386-F394. Epub 2018 Feb 7.

Department of Medicine, University of California and Veterans Affairs San Diego Healthcare System , San Diego, California.

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https://www.physiology.org/doi/10.1152/ajprenal.00503.2017
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http://dx.doi.org/10.1152/ajprenal.00503.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139528PMC
August 2018

The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.

Authors:
Sanjay K Nigam

Annu Rev Pharmacol Toxicol 2018 01;58:663-687

Departments of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093, USA; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010617-052713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225997PMC
January 2018

The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.

J Biol Chem 2017 09 1;292(38):15789-15803. Epub 2017 Aug 1.

From the Departments of Pediatrics,

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http://dx.doi.org/10.1074/jbc.M117.796516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612110PMC
September 2017

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes.

Sci Rep 2017 07 10;7(1):4939. Epub 2017 Jul 10.

Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

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http://www.nature.com/articles/s41598-017-04949-2
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http://dx.doi.org/10.1038/s41598-017-04949-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504054PMC
July 2017

Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

J Pharmacol Exp Ther 2016 10 3;359(1):215-29. Epub 2016 Aug 3.

Departments of Bioengineering (H.C.L.), Pediatrics (A.G., Y.C., C.L., K.T.B., S.K.N.), Medicine (W.W., S.K.N.), Cellular and Molecular Medicine (S.K.N.), and Pharmacology (R.A.), and the San Diego Supercomputer Center (N.B., P.R.), University of California San Diego, La Jolla, California

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034704PMC
http://dx.doi.org/10.1124/jpet.116.232660DOI Listing
October 2016

Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling.

Clin Kidney J 2016 Jun 5;9(3):444-53. Epub 2016 Apr 5.

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA; Department of Medicine (Nephrology), University of California San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1093/ckj/sfw010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886906PMC
June 2016

Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2.

PLoS One 2016 5;11(4):e0152969. Epub 2016 Apr 5.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152969PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821612PMC
August 2016

Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.

Drug Metab Dispos 2016 07 4;44(7):1050-60. Epub 2016 Apr 4.

Department of Pediatrics (G.M., K.T.B., S.K.N.), Department of Medicine, Division of Nephrology and Hypertension, (S.K.N.), and Department of Cellular and Molecular Medicine (S.K.N.), University of California, San Diego, La Jolla, California

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http://dx.doi.org/10.1124/dmd.115.068254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931883PMC
July 2016

Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters.

Clin J Am Soc Nephrol 2015 Nov 21;10(11):2039-49. Epub 2015 Oct 21.

Division of Family & Preventative Medicine, University of California-San Diego, La Jolla, California;

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http://cjasn.asnjournals.org/cgi/doi/10.2215/CJN.02440314
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http://dx.doi.org/10.2215/CJN.02440314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633783PMC
November 2015

Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors.

Drug Metab Dispos 2015 Dec 10;43(12):1855-63. Epub 2015 Sep 10.

Departments of Pediatrics (K.T.B., S.K.N.), Medicine (Division of Nephrology and Hypertension)(W.W., S.K.N.), Bioengineering (H.C.L.), Biomedical Sciences (C.Z.), School of Pharmacy/Pharmaceutical Science (R.A.), and Cellular and Molecular Medicine (S.K.N.), University of California, San Diego, La Jolla, California

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http://dx.doi.org/10.1124/dmd.115.065250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658493PMC
December 2015

Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways.

Biochem Biophys Rep 2015 Sep;3:51-61

Department of Medicine, University of California, San Diego, La Jolla, CA 92093 ; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 ; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.

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http://dx.doi.org/10.1016/j.bbrep.2015.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522937PMC
September 2015

The organic anion transporter (OAT) family: a systems biology perspective.

Physiol Rev 2015 Jan;95(1):83-123

Departments of Pediatrics, Medicine, Cellular and Molecular Medicine, Bioengineering, and Family and Preventative Medicine, University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1152/physrev.00025.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281586PMC
January 2015

What do drug transporters really do?

Authors:
Sanjay K Nigam

Nat Rev Drug Discov 2015 Jan 5;14(1):29-44. Epub 2014 Dec 5.

Departments of Pediatrics, Medicine, and Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0693, USA.

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http://dx.doi.org/10.1038/nrd4461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750486PMC
January 2015

Cellular and developmental strategies aimed at kidney tissue engineering.

Nephron Exp Nephrol 2014 19;126(2):101. Epub 2014 May 19.

Department of Pediatrics, University of California at San Diego, La Jolla, Calif., USA.

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http://dx.doi.org/10.1159/000360680DOI Listing
March 2015

Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease.

Curr Opin Organ Transplant 2014 Apr;19(2):153-61

aDepartment of Pediatrics bDepartment of Biomedical Sciences cDepartment of Medicine dDepartment of Cellular & Molecular Medicine eDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.

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http://pdfs.journals.lww.com/co-transplantation/2014/04000/R
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOT.0000000000000053DOI Listing
April 2014

Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.

Pediatr Nephrol 2014 Apr 2;29(4):727-35. Epub 2014 Feb 2.

Department of Medicine, University of California, La Jolla, San Diego, CA, 92093-0693, USA,

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http://dx.doi.org/10.1007/s00467-013-2725-zDOI Listing
April 2014

Concise review: can the intrinsic power of branching morphogenesis be used for engineering epithelial tissues and organs?

Authors:
Sanjay K Nigam

Stem Cells Transl Med 2013 Dec 4;2(12):993-1000. Epub 2013 Nov 4.

Departments of Pediatrics, Medicine, Cellular and Molecular Medicine, and Bioengineering, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.5966/sctm.2013-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841094PMC
December 2013

GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling.

Biol Open 2013 30;2(9):952-9. Epub 2013 Jul 30.

Department of Medicine, University of California , San Diego, La Jolla, CA 92093-0693 , USA ; Present address: Department of Pediatrics, University of Calgary and Alberta Children's Hospital, Calgary, AB T3B 6A8, Canada.

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http://dx.doi.org/10.1242/bio.20135595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773342PMC
October 2013

Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters.

Mol Pharmacol 2013 Dec 13;84(6):808-23. Epub 2013 Sep 13.

Department of Pediatrics (G.M., S.K.N.), Department of Biomedical Sciences (G.M.), Department of Medicine (S.K.N.), and Department of Cellular and Molecular Medicine (S.K.N.), University of California at San Diego, La Jolla, California; and Department of Pediatrics, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada (J.B.T.).

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http://dx.doi.org/10.1124/mol.113.088229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834141PMC
December 2013

Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.

Drug Metab Dispos 2013 Oct 6;41(10):1825-34. Epub 2013 Aug 6.

Departments of Pediatrics (H.C.L., K.T.B., S.K.N.), Medicine, Division of Nephrology and Hypertension (W.W., S.A.E., S.K.N.), Cellular and Molecular Medicine (S.K.N.), and Bioengineering (N.J., B.O.P., S.K.N.), University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1124/dmd.113.052647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781372PMC
October 2013

Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue.

Neurosci Lett 2013 Feb 27;534:133-8. Epub 2012 Nov 27.

Department of Pediatrics, UCSD, La Jolla, CA 92093, United States.

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http://dx.doi.org/10.1016/j.neulet.2012.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591490PMC
February 2013

N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.

J Biol Chem 2012 Dec 11;287(50):42064-70. Epub 2012 Oct 11.

Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA.

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http://www.jbc.org/content/287/50/42064.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M112.423327
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http://dx.doi.org/10.1074/jbc.M112.423327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516752PMC
December 2012

The storytelling brain. Commentary on "On social attribution: implications of recent cognitive neuroscience research for race, law, and politics".

Authors:
Sanjay K Nigam

Sci Eng Ethics 2012 Sep 28;18(3):567-71. Epub 2012 Jul 28.

Deptartment of Pediatrics, Medicine and Cellular and Molecular Medicine, Writer-in-Residence in the Health Sciences, University of California-San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/s11948-012-9378-3DOI Listing
September 2012

In vitro culture of embryonic kidney rudiments and isolated ureteric buds.

Methods Mol Biol 2012 ;886:13-21

Pediatrics Department, University of California, San Diego, CA, USA.

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http://link.springer.com/content/pdf/10.1007/978-1-61779-851
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http://link.springer.com/10.1007/978-1-61779-851-1_2
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http://dx.doi.org/10.1007/978-1-61779-851-1_2DOI Listing
September 2012

A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.

Am J Physiol Renal Physiol 2012 May 15;302(10):F1293-9. Epub 2012 Feb 15.

Depts. of Medicine and Pharmacology, Univ. of California San Diego and VASDHCS, 3350 La Jolla Village Dr. (9151 San Diego, CA 92161, USA.

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http://www.physiology.org/doi/10.1152/ajprenal.00013.2012
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http://dx.doi.org/10.1152/ajprenal.00013.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362066PMC
May 2012

Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury.

J Biol Chem 2011 Jul 7;286(30):26391-5. Epub 2011 Jun 7.

Farmacología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, 2000 Rosario, Argentina.

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http://dx.doi.org/10.1074/jbc.M111.249292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143602PMC
July 2011

Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate.

Dev Biol 2011 Aug 11;356(1):19-27. Epub 2011 May 11.

Department of Medicine (Division of Nephrology and Hypertension), University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130836PMC
August 2011

Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.

Dev Biol 2011 Jul 7;355(2):394-403. Epub 2011 May 7.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118867PMC
July 2011

Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).

Bioorg Med Chem 2011 Jun 28;19(11):3320-40. Epub 2011 Apr 28.

Department of Medicine, Division of Nephrology and Hypertension, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.bmc.2011.04.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310230PMC
June 2011

Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney.

Mol Pharmacol 2011 Jul 14;80(1):147-54. Epub 2011 Apr 14.

Division of Nephrology & Hypertension, Departments of Medicine, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1124/mol.110.070680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127534PMC
July 2011

Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis.

Mol Pharmacol 2011 May 11;79(5):795-805. Epub 2011 Feb 11.

Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1124/mol.110.070607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082935PMC
May 2011

Branching morphogenesis: from individual molecules to a systems biology approach: commentary on "Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney" by Perälä et al.

Differentiation 2011 Feb 17;81(2):79-80. Epub 2010 Dec 17.

Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.diff.2010.11.004DOI Listing
February 2011

Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling.

J Biol Chem 2011 Jan 4;286(1):243-51. Epub 2010 Oct 4.

Department of Pediatrics, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M110.139949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012981PMC
January 2011

Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.

PLoS One 2010 May 18;5(5):e10691. Epub 2010 May 18.

Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872662PMC
May 2010

Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching.

Dev Biol 2010 Mar 6;339(2):354-65. Epub 2010 Jan 6.

Department of Medicine, University of California, San Diego, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834281PMC
March 2010

Interaction of organic cations with organic anion transporters.

J Biol Chem 2009 Nov 8;284(45):31422-30. Epub 2009 Sep 8.

Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M109.024489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781538PMC
November 2009

Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy.

Nat Med 2009 Sep 30;15(9):1046-54. Epub 2009 Aug 30.

Biomedical Sciences Program and Departments of Pediatrics and Medicine, University of California-San Diego (UCSD), La Jolla, California, USA.

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http://www.nature.com/articles/nm.2010
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http://dx.doi.org/10.1038/nm.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895985PMC
September 2009

Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis.

Mol Pharmacol 2009 Sep 10;76(3):481-90. Epub 2009 Jun 10.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1124/mol.109.056564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730381PMC
September 2009

Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function.

Am J Physiol Renal Physiol 2009 Jul 13;297(1):F210-7. Epub 2009 May 13.

Department of Pediatrics, University of California, La Jolla, California 92093-0693, USA.

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http://dx.doi.org/10.1152/ajprenal.90260.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711709PMC
July 2009

Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members.

Physiol Genomics 2009 Jul 5;38(2):116-24. Epub 2009 May 5.

Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093-0693, USA.

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http://dx.doi.org/10.1152/physiolgenomics.90309.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712220PMC
July 2009

Organogenesis forum lecture: In vitro kidney development, tissue engineering and systems biology.

Organogenesis 2008 Jul;4(3):137-43

Department of Medicine, School of Medicine; University of California; San Diego, La Jolla, California USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634587PMC
http://dx.doi.org/10.4161/org.4.3.6498DOI Listing
July 2008

Analysis of metagene portraits reveals distinct transitions during kidney organogenesis.

Sci Signal 2008 Dec 9;1(49):ra16. Epub 2008 Dec 9.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0505, USA.

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http://dx.doi.org/10.1126/scisignal.1163630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016920PMC
December 2008

How does the ureteric bud branch?

J Am Soc Nephrol 2009 Jul 3;20(7):1465-9. Epub 2008 Dec 3.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1681/ASN.2008020132DOI Listing
July 2009

Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function.

J Bioinform Comput Biol 2008 Oct;6(5):885-904

San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676871PMC
http://dx.doi.org/10.1142/s0219720008003801DOI Listing
October 2008

Organic anion transporter 3 contributes to the regulation of blood pressure.

J Am Soc Nephrol 2008 Sep 28;19(9):1732-40. Epub 2008 May 28.

Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego and VASDHCS, 3350 La Jolla Village Drive (9151), San Diego, CA 92161, USA.

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http://dx.doi.org/10.1681/ASN.2008020180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518443PMC
September 2008

Multiple organic anion transporters contribute to net renal excretion of uric acid.

Physiol Genomics 2008 Apr 12;33(2):180-92. Epub 2008 Feb 12.

Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00207.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016923PMC
April 2008

Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.

Am J Physiol Renal Physiol 2008 Apr 23;294(4):F867-73. Epub 2008 Jan 23.

Dept. of Medicine, Univ. of California, San Diego and VASDHCS, 3350 La Jolla Village Drive (9151) San Diego, CA 92161, USA.

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http://dx.doi.org/10.1152/ajprenal.00528.2007DOI Listing
April 2008

Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.

J Biol Chem 2008 Mar 3;283(13):8654-63. Epub 2008 Jan 3.

Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1074/jbc.M708615200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2417182PMC
March 2008

Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct.

J Am Soc Nephrol 2007 Dec 14;18(12):3147-55. Epub 2007 Nov 14.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0693, USA.

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http://dx.doi.org/10.1681/ASN.2007060642DOI Listing
December 2007

The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues.

Biomaterials 2007 Nov 15;28(32):4806-17. Epub 2007 Aug 15.

Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive #0693, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2007.07.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700261PMC
November 2007

Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues.

Nat Clin Pract Nephrol 2007 Aug;3(8):443-8

University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1038/ncpneph0558DOI Listing
August 2007

Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development.

Differentiation 2006 Dec;74(9-10):638-47

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1111/j.1432-0436.2006.00102.xDOI Listing
December 2006

The developmental nephrome: systems biology in the developing kidney.

Curr Opin Nephrol Hypertens 2007 Jan;16(1):3-9

Department of Medicine, Nephrology Division, Federal University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1097/MNH.0b013e3280118a5aDOI Listing
January 2007

Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.

Biochem Biophys Res Commun 2006 Dec 2;351(4):872-6. Epub 2006 Nov 2.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810587PMC
December 2006

Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system.

Dev Biol 2006 Oct 12;298(2):571-84. Epub 2006 Jul 12.

Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, and Urological Diseases Research Center, Department of Urology, Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.07.006DOI Listing
October 2006

Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3).

J Hum Genet 2006 29;51(6):575-580. Epub 2006 Apr 29.

Departments of Pediatrics, Medicine, Cellular and Molecular Medicine, Family, Preventative Medicine, and the San Diego Veterans Administration Medical Center, University of California-San Diego, 9500 Gilman Dr., 0693, La Jolla, CA, 92093-0693, USA.

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http://dx.doi.org/10.1007/s10038-006-0398-1DOI Listing
September 2006

Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.

Dev Biol 2006 Jul 27;295(2):473-85. Epub 2006 Apr 27.

Department of Pediatrics, Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.03.011DOI Listing
July 2006

Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.

J Biol Chem 2006 Feb 14;281(8):5072-83. Epub 2005 Dec 14.

Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M508050200DOI Listing
February 2006

Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney.

J Am Soc Nephrol 2006 Jan 7;17(1):188-98. Epub 2005 Dec 7.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1681/ASN.2005040370DOI Listing
January 2006

Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia.

J Biol Chem 2005 Dec 23;280(51):42181-7. Epub 2005 Sep 23.

Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M507962200DOI Listing
December 2005

Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].

Kidney Int 2005 Oct;68(4):1491-9

Department of Pediatrics, Family and Preventative Medicine and San Diego Veterans Administration Medical Center, University of California San Diego, La Jolla, California 92161, USA.

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http://dx.doi.org/10.1111/j.1523-1755.2005.00612.xDOI Listing
October 2005

Implications of gene networks for understanding resilience and vulnerability in the kidney branching program.

Physiology (Bethesda) 2004 Dec;19:339-47

Department of Medicine, School of Medicine, University of California-San Diego, La Jolla, California 92093-0696, USA.

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http://dx.doi.org/10.1152/physiol.00025.2004DOI Listing
December 2004

Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.

Biochem Biophys Res Commun 2004 Oct;323(2):429-36

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.bbrc.2004.08.112DOI Listing
October 2004

Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells.

Biochem Biophys Res Commun 2004 Sep;322(1):223-31

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0401608
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http://dx.doi.org/10.1016/j.bbrc.2004.07.097DOI Listing
September 2004

Complex dynamics of chaperone-protein interactions under cellular stress.

Cell Biochem Biophys 2004 ;40(3):263-76

Department of Chemistry and Biochemistry, and San Diego Supercomputer Center, University ofCalifornia, San Diego, La Jolla, CA, USA.

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http://link.springer.com/10.1385/CBB:40:3:263
Publisher Site
http://dx.doi.org/10.1385/CBB:40:3:263DOI Listing
January 2007

Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice.

Am J Physiol Renal Physiol 2004 May 23;286(5):F972-8. Epub 2003 Dec 23.

Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1152/ajprenal.00356.2003DOI Listing
May 2004

Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters.

Physiol Genomics 2004 Jun 17;18(1):12-24. Epub 2004 Jun 17.

Department of Medicine, University of California, San Diego, La Jolla, California 92093-0693, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00014.2004DOI Listing
June 2004

Branching morphogenesis and kidney disease.

Development 2004 Apr;131(7):1449-62

Department of Pediatrics, University of California, San Diego, CA 92093-0693, USA.

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http://dx.doi.org/10.1242/dev.01089DOI Listing
April 2004

The molecular pharmacology of organic anion transporters: from DNA to FDA?

Mol Pharmacol 2004 Mar;65(3):479-87

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1124/mol.65.3.479DOI Listing
March 2004

TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud.

Dev Biol 2004 Feb;266(2):285-98

Department of Medicine, Pediatrics and Cellular Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.ydbio.2003.10.023DOI Listing
February 2004

Developmental approaches to kidney tissue engineering.

Am J Physiol Renal Physiol 2004 Jan;286(1):F1-7

Department of Medicine, Pediatrics, and Cellular Molecular Medicine, University of California, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1152/ajprenal.00167.2003DOI Listing
January 2004

From the ureteric bud to the penome.

Authors:
Sanjay K Nigam

Kidney Int 2003 Dec;64(6):2320-2

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http://dx.doi.org/10.1046/j.1523-1755.2003.00397.xDOI Listing
December 2003