Publications by authors named "Sanjay Awasthi"

100Publications

Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling.

Aging Cell 2020 Nov 17;19(11):e13261. Epub 2020 Oct 17.

Division of Hematology & Oncology, Department of Internal Medicine, Texas Tech University Medical Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.1111/acel.13261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681049PMC
November 2020

Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.

Microorganisms 2020 Sep 29;8(10). Epub 2020 Sep 29.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.3390/microorganisms8101500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599699PMC
September 2020

Rlip Depletion Suppresses Growth of Breast Cancer.

Cancers (Basel) 2020 Jun 2;12(6). Epub 2020 Jun 2.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.3390/cancers12061446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352702PMC
June 2020

Targeting RLIP with CRISPR/Cas9 controls tumor growth.

Carcinogenesis 2020 May 19. Epub 2020 May 19.

Department of Medical Oncology, City of Hope Comprehensive Cancer Center and National Medical Center, Duarte, CA.

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http://dx.doi.org/10.1093/carcin/bgaa048DOI Listing
May 2020

Therapeutic targeting of miRNA-216b in cancer.

Cancer Lett 2020 Aug 5;484:16-28. Epub 2020 May 5.

Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2020.04.020DOI Listing
August 2020

Association of Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case-Control Studies †.

Cancers (Basel) 2020 Feb 18;12(2). Epub 2020 Feb 18.

Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.3390/cancers12020471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072663PMC
February 2020

SOX9: The master regulator of cell fate in breast cancer.

Biochem Pharmacol 2020 04 3;174:113789. Epub 2020 Jan 3.

Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113789DOI Listing
April 2020

RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis.

Biochim Biophys Acta Rev Cancer 2020 01 2;1873(1):188337. Epub 2020 Jan 2.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Medical Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.1016/j.bbcan.2020.188337DOI Listing
January 2020

Topical 2'-Hydroxyflavanone for Cutaneous Melanoma.

Cancers (Basel) 2019 Oct 14;11(10). Epub 2019 Oct 14.

Division of Hematology & Oncology, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA;.

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http://dx.doi.org/10.3390/cancers11101556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826616PMC
October 2019

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.

Breast Cancer Res 2019 09 6;21(1):104. Epub 2019 Sep 6.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Centre, Lubbock, TX, 79430, USA.

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http://dx.doi.org/10.1186/s13058-019-1192-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729044PMC
September 2019

Notch signaling in breast cancer: From pathway analysis to therapy.

Cancer Lett 2019 10 18;461:123-131. Epub 2019 Jul 18.

Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193040
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http://dx.doi.org/10.1016/j.canlet.2019.07.012DOI Listing
October 2019

Synergistic efficacy of RLIP inhibition and 2'-hydroxyflavanone against DMBA-induced mammary carcinogenesis in SENCAR mice.

Mol Carcinog 2019 08 21;58(8):1438-1449. Epub 2019 Apr 21.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

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http://dx.doi.org/10.1002/mc.23026DOI Listing
August 2019

RLIP: An existential requirement for breast carcinogenesis.

Biochim Biophys Acta Rev Cancer 2019 04 13;1871(2):281-288. Epub 2019 Feb 13.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.1016/j.bbcan.2019.02.001DOI Listing
April 2019

RLIP inhibition suppresses breast-to-lung metastasis.

Cancer Lett 2019 04 23;447:24-32. Epub 2019 Jan 23.

Department of Medical Oncology, City of Hope Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193004
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http://dx.doi.org/10.1016/j.canlet.2019.01.023DOI Listing
April 2019

Anticancer activity of 2'-hydroxyflavanone towards lung cancer.

Oncotarget 2018 Nov 16;9(90):36202-36219. Epub 2018 Nov 16.

Division of Hematology and Oncology, Department of Internal Medicine, Texas Tech Health Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.18632/oncotarget.26329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281421PMC
November 2018

2'-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells.

J Proteomics 2019 02 21;192:233-245. Epub 2018 Sep 21.

Departments of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2018.09.005DOI Listing
February 2019

Metastasis of breast tumor cells to brain is suppressed by targeting RLIP alone and in combination with 2'-Hydroxyflavanone.

Cancer Lett 2018 12 15;438:144-153. Epub 2018 Sep 15.

Department of Medical Oncology, City of Hope Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.09.015DOI Listing
December 2018

2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.

Mol Carcinog 2018 12 19;57(12):1751-1762. Epub 2018 Sep 19.

Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, California.

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http://dx.doi.org/10.1002/mc.22894DOI Listing
December 2018

2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer.

Oncotarget 2018 Apr 6;9(26):18053-18068. Epub 2018 Apr 6.

Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.18632/oncotarget.24720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915057PMC
April 2018

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model.

PLoS One 2018 8;13(3):e0193918. Epub 2018 Mar 8.

Texas Tech Health Sciences Center, Division of Hematology & Oncology, Department of Internal Medicine, Lubbock, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193918PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843244PMC
July 2018

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment.

Cancer Lett 2018 01 4;413:122-134. Epub 2017 Nov 4.

Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.11.002DOI Listing
January 2018

2'-Hydroxyflavanone: A novel strategy for targeting breast cancer.

Oncotarget 2017 Sep 24;8(43):75025-75037. Epub 2017 Aug 24.

Department of Molecular Medicine, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.18632/oncotarget.20499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650397PMC
September 2017

Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer.

Int J Cancer 2018 02 28;142(4):658-670. Epub 2017 Nov 28.

Department of Molecular Medicine, City of Hope National Medical Center, Duarte, CA.

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http://dx.doi.org/10.1002/ijc.31085DOI Listing
February 2018

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity.

Sci Rep 2017 06 9;7(1):3182. Epub 2017 Jun 9.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX-77555, USA.

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http://dx.doi.org/10.1038/s41598-017-03284-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466629PMC
June 2017

RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma.

Pharm Res 2017 Aug 6;34(8):1673-1682. Epub 2017 Apr 6.

Department of Molecular Medicine, Comprehensive Cancer Center and National Medical Center, Beckman Research Institute of City of Hope, Duarte, California, 91010, USA.

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http://dx.doi.org/10.1007/s11095-017-2154-yDOI Listing
August 2017

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer.

Biochim Biophys Acta Rev Cancer 2017 Aug 28;1868(1):167-175. Epub 2017 Mar 28.

Department of Molecular Medicine, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, United States.

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http://dx.doi.org/10.1016/j.bbcan.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638116PMC
August 2017

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity.

Free Radic Biol Med 2017 10 26;111:235-243. Epub 2016 Oct 26.

Department of Internal Medicine-Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643026PMC
October 2017

RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.

Biochem Biophys Res Commun 2015 Nov 20;467(4):785-91. Epub 2015 Oct 20.

Department of Anatomy & Cell Biology and The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, United States; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644438PMC
November 2015

Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.

Toxicol Appl Pharmacol 2015 Dec 23;289(3):361-70. Epub 2015 Oct 23.

Department of Medical Oncology, Beckman Research Institute of the City of Hope, Comprehensive Cancer Center, Duarte, CA 91010, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X153010
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http://dx.doi.org/10.1016/j.taap.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852854PMC
December 2015

RLIP76 Targeted Therapy for Kidney Cancer.

Pharm Res 2015 Oct 29;32(10):3123-36. Epub 2015 May 29.

Department of Diabetes & Metabolic Diseases Research, City of Hope, Comprehensive Cancer Center, Duarte, California, 91010, USA.

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http://dx.doi.org/10.1007/s11095-015-1723-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384263PMC
October 2015

2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.

Biochem Pharmacol 2015 Aug 6;96(3):151-8. Epub 2015 May 6.

Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, CA 91010, United States; Department of Medical Oncology, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, CA 91010, United States.

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http://dx.doi.org/10.1016/j.bcp.2015.04.022DOI Listing
August 2015

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells.

Apoptosis 2014 May;19(5):776-88

Departments of Diabetes and Metabolic Diseases Research, Beckman Research Institute of the City of Hope National Medical Center, NCI Designated Comprehensive Cancer Center, Gonda North, RM # 2108, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1007/s10495-014-0974-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169289PMC
May 2014

COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice.

PLoS One 2013 20;8(12):e83801. Epub 2013 Dec 20.

Departments of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869817PMC
March 2015

Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia.

Exp Eye Res 2014 Jan 1;118:125-34. Epub 2013 Nov 1.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835130030
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http://dx.doi.org/10.1016/j.exer.2013.10.018DOI Listing
January 2014

Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression.

Biochem Pharmacol 2013 Dec 4;86(12):1664-72. Epub 2013 Oct 4.

Departments of Diabetes & Metabolic Diseases Research, and Medical Oncology, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186798PMC
December 2013

RLIP76 protein knockdown attenuates obesity due to a high-fat diet.

J Biol Chem 2013 Aug 2;288(32):23394-406. Epub 2013 Jul 2.

Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, California 91010, USA.

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http://dx.doi.org/10.1074/jbc.M113.480194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743508PMC
August 2013

4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway.

J Biol Chem 2013 Jul 3;288(28):20532-46. Epub 2013 Jun 3.

Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.467662
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http://dx.doi.org/10.1074/jbc.M113.467662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711318PMC
July 2013

Role of SMC1 in overcoming drug resistance in triple negative breast cancer.

PLoS One 2013 22;8(5):e64338. Epub 2013 May 22.

Department of Diabetes, Endocrinology and Metabolic Diseases, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661439PMC
January 2014

P300 regulates the human RLIP76 promoter activity and gene expression.

Biochem Pharmacol 2013 Apr 16;85(8):1203-11. Epub 2013 Feb 16.

Department of Molecular Biology & Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.bcp.2013.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822774PMC
April 2013

1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.

Biochem Pharmacol 2012 Dec 28;84(11):1419-27. Epub 2012 Aug 28.

Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, CA 91010, United States.

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http://dx.doi.org/10.1016/j.bcp.2012.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747778PMC
December 2012

RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.

Cancer Res 2012 Oct 17;72(20):5165-73. Epub 2012 Aug 17.

Authors' Affiliations: Department of Anatomy & Cell Biology and The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473090PMC
October 2012

Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane.

Free Radic Biol Med 2012 Jun 1-15;52(11-12):2177-85. Epub 2012 Apr 23.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08915849120021
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http://dx.doi.org/10.1016/j.freeradbiomed.2012.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377772PMC
October 2012

RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer.

PLoS One 2012 3;7(4):e34582. Epub 2012 Apr 3.

Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Comprehensive Cancer Center, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317991PMC
August 2012

Novel anti-cancer compounds for developing combinatorial therapies to target anoikis-resistant tumors.

Pharm Res 2012 Mar 28;29(3):621-36. Epub 2011 Dec 28.

Department of Diabetes and Metabolic Diseases Research Beckman Research Institute, City of Hope, National Medical Center, Duarte, California 91010, USA.

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http://dx.doi.org/10.1007/s11095-011-0645-9DOI Listing
March 2012

Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma.

Cancer Prev Res (Phila) 2012 Mar 15;5(3):473-83. Epub 2011 Dec 15.

Department of Diabetes and Metabolic Disease Research, National Medical Center, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294094PMC
March 2012

Inhibition of mercapturic acid pathway-mediated disposal of 4-hydroxynonenal causes complete and sustained remission of human cancer xenografts in nude mice.

Indian J Exp Biol 2011 Nov;49(11):817-25

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

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November 2011

Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma.

Mol Carcinog 2013 Jan 17;52(1):39-48. Epub 2011 Oct 17.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA.

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http://doi.wiley.com/10.1002/mc.20875
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http://dx.doi.org/10.1002/mc.20875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153352PMC
January 2013

RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.

PLoS One 2011 13;6(9):e24688. Epub 2011 Sep 13.

Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, National Medical Center, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024688PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172288PMC
February 2012

Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer.

Biochem Pharmacol 2011 Nov 23;82(9):1100-9. Epub 2011 Jul 23.

Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, National Medical Center, Duarte, CA 91010, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00062952110053
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http://dx.doi.org/10.1016/j.bcp.2011.07.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252753PMC
November 2011

Inhibition of aldose reductase prevents colon cancer metastasis.

Carcinogenesis 2011 Aug 3;32(8):1259-67. Epub 2011 Jun 3.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch,Galveston, TX 77555, USA.

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http://dx.doi.org/10.1093/carcin/bgr102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166198PMC
August 2011

Targeting p53-null neuroblastomas through RLIP76.

Cancer Prev Res (Phila) 2011 Jun 16;4(6):879-89. Epub 2011 Mar 16.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107-2699, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107925PMC
June 2011

2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma.

Carcinogenesis 2011 Apr 8;32(4):568-75. Epub 2011 Feb 8.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1093/carcin/bgr021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066423PMC
April 2011

Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells.

Exp Eye Res 2011 Feb 4;92(2):147-54. Epub 2010 Dec 4.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001448351000363
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http://dx.doi.org/10.1016/j.exer.2010.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064457PMC
February 2011

The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors.

Int J Cancer 2011 Feb 7;128(4):743-52. Epub 2010 Dec 7.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1002/ijc.25725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292620PMC
February 2011

Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling.

Biochemistry 2010 Jul;49(29):6263-75

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi100517x
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http://dx.doi.org/10.1021/bi100517xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957295PMC
July 2010

Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent.

Biochemistry 2010 Apr;49(14):3191-202

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902186PMC
April 2010

Physiological and pharmacological significance of glutathione-conjugate transport.

J Toxicol Environ Health B Crit Rev 2009 Aug;12(7):540-51

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.

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August 2009

RLIP76: a versatile transporter and an emerging target for cancer therapy.

Biochem Pharmacol 2010 Jun 25;79(12):1699-705. Epub 2010 Jan 25.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.

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http://dx.doi.org/10.1016/j.bcp.2010.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874070PMC
June 2010

A central role of RLIP76 in regulation of glycemic control.

Diabetes 2010 Mar 10;59(3):714-25. Epub 2009 Dec 10.

Department of Molecular Biology & Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA.

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http://dx.doi.org/10.2337/db09-0911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828645PMC
March 2010

Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.

Int J Cancer 2010 Mar;126(6):1327-38

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1002/ijc.24767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065777PMC
March 2010

hSET1: a novel approach for colon cancer therapy.

Biochem Pharmacol 2009 May 6;77(10):1635-41. Epub 2009 Mar 6.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.bcp.2009.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691870PMC
May 2009

Role of RLIP76 in doxorubicin resistance in lung cancer.

Int J Oncol 2009 Jun;34(6):1505-11

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916676PMC
http://dx.doi.org/10.3892/ijo_00000279DOI Listing
June 2009

RLIP76: a target for kidney cancer therapy.

Cancer Res 2009 May 5;69(10):4244-51. Epub 2009 May 5.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921230PMC
May 2009

Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis.

Cancer Lett 2009 Oct 17;283(2):152-8. Epub 2009 Apr 17.

Department of Molecular Biology and Immunology, 3500 Camp Bowie Blvd., University of North Texas Health Science Center, Fort Worth, TX 76107-2699, United States.

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http://dx.doi.org/10.1016/j.canlet.2009.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721022PMC
October 2009

Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates.

Int J Oncol 2009 Jan;34(1):191-9

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA.

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January 2009

Regression of prostate cancer xenografts by RLIP76 depletion.

Biochem Pharmacol 2009 Mar 25;77(6):1074-83. Epub 2008 Nov 25.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.bcp.2008.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683040PMC
March 2009

4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells.

Arch Biochem Biophys 2008 Dec 7;480(2):85-94. Epub 2008 Oct 7.

Department of Molecular Biology and Immunology, RES 416G, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.abb.2008.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664083PMC
December 2008

The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS.

Anal Bioanal Chem 2008 Dec 25;392(7-8):1325-33. Epub 2008 Sep 25.

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA.

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December 2008

RLIP76 in defense of radiation poisoning.

Int J Radiat Oncol Biol Phys 2008 Oct;72(2):553-61

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2008.06.1497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664086PMC
October 2008

Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76.

FEBS Lett 2008 Oct 18;582(23-24):3408-14. Epub 2008 Sep 18.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, EAD RM No. 542, Fort Worth, TX 76107-2699, United States.

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http://dx.doi.org/10.1016/j.febslet.2008.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586942PMC
October 2008

RLIP76 and Cancer.

Clin Cancer Res 2008 Jul;14(14):4372-7

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919285PMC
July 2008

Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1.

J Biol Chem 2008 Jul 12;283(28):19714-29. Epub 2008 May 12.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107-2699, USA.

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http://dx.doi.org/10.1074/jbc.M708703200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443664PMC
July 2008

Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death.

Free Radic Biol Med 2008 Jul 2;45(2):111-8. Epub 2008 May 2.

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664084PMC
July 2008

4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas.

Biochemistry 2008 Jan 11;47(1):143-56. Epub 2007 Dec 11.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA. unt.edu

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http://dx.doi.org/10.1021/bi701559fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564820PMC
January 2008

On the diversity of biological therapeutics.

Authors:
Sanjay Awasthi

Biologics 2007 Sep;1(3):183-4

Professor of Biology and Associate Vice President for Clinical Research at University of North Texas Health Sciences Center; Medical Oncologist, Texas Oncology; Partner, US Oncology.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721317PMC
September 2007

Editorial foreword.

Authors:
Sanjay Awasthi

Biologics 2007 Jun;1(2):75-6

Professor of Biology and Associate, Vice President for Clinical Research, University of North Texas Health Sciences Center, Medical Oncologist, Texas Oncology, Partner, US Oncology.

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June 2007

The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance.

Curr Drug Metab 2007 May;8(4):315-23

Department of Biochemistry and Molecular Biology, 551-Basic Science Bldg., University of Texas Medical Branch at Galveston, Galveston, TX 77555-0647, USA.

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http://dx.doi.org/10.2174/138920007780655414DOI Listing
May 2007

Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).

Cancer Res 2007 May;67(9):4382-9

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4124DOI Listing
May 2007

Editorial.

Authors:
Sanjay Awasthi

Biologics 2007 Mar;1(1):1-2

Professor of Biology and Associate Vice President for Clinical Research at University of North Texas Health Sciences Center; Medical Oncologist, Texas Oncology; Partner, US Oncology.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721343PMC
March 2007

Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer.

Int J Oncol 2007 Mar;30(3):717-25

Department of Chemistry and Biochemistry, University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA.

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March 2007

Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters.

Cancer Metastasis Rev 2007 Mar;26(1):59-69

Department of Chemistry and Biochemistry, University of Texas at Arlington, TX 76019-0065, USA.

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http://dx.doi.org/10.1007/s10555-007-9043-5DOI Listing
March 2007

RALBP1/RLIP76 mediates multidrug resistance.

Int J Oncol 2007 Jan;30(1):139-44

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019-0065, USA.

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January 2007

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells.

Cancer Res 2006 Oct;66(19):9705-13

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0647, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2105DOI Listing
October 2006

Therapeutic resistance in lung cancer.

Expert Opin Drug Metab Toxicol 2006 Oct;2(5):753-77

Department of Chemistry and Biochemistry, University of Texas at Arlington, 700 Planetarium Place, CPB # 351, 76019-0065, USA.

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http://dx.doi.org/10.1517/17425255.2.5.753DOI Listing
October 2006

Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal.

Biochemistry 2006 Oct;45(40):12253-64

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-0647, USA.

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http://dx.doi.org/10.1021/bi060780+DOI Listing
October 2006

Mitogenic and drug-resistance mediating effects of PKCalpha require RLIP76.

Biochem Biophys Res Commun 2006 Sep 28;348(2):722-7. Epub 2006 Jul 28.

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019-0065, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.07.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916682PMC
September 2006

Glutathione S-transferases as antioxidant enzymes: small cell lung cancer (H69) cells transfected with hGSTA1 resist doxorubicin-induced apoptosis.

Arch Biochem Biophys 2006 Aug 5;452(2):165-73. Epub 2006 May 5.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.

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August 2006