Sanjay Asthana

Sanjay Asthana

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Sanjay Asthana

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Predicting Risk for Dementia: Is It Ready for the Clinic?

Am J Psychiatry 2019 Jul;176(7):501-502

The Alzheimer's Disease Research Center at the University of Wisconsin School of Medicine and Public Health, Madison; and the Geriatric Research, Education, and Clinical Center at the William S. Middleton Memorial VA Hospital, Madison.

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http://dx.doi.org/10.1176/appi.ajp.2019.19050520DOI Listing
July 2019

Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer's disease continuum.

Neuroimage Clin 2019 Jun 10;23:101895. Epub 2019 Jun 10.

Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599872PMC
June 2019

Pilot Test of a Computer-Based System to Help Family Caregivers of Dementia Patients.

J Alzheimers Dis 2019 Jun 24. Epub 2019 Jun 24.

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health (SMPH), Madison, WI, USA.

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http://dx.doi.org/10.3233/JAD-190052DOI Listing
June 2019

ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes.

Neurology 2019 Apr 6;92(14):e1567-e1579. Epub 2019 Mar 6.

From the Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.M.F., S.E.S., J.C.M.), Washington University School of Medicine, St. Louis, MO; Florey Institute of Neuroscience and Mental Health (C.F., Q.-X.L., S.J.C., C.L.M.), the University of Melbourne, Australia; Geriatric Research Education and Clinical Center (C.C., S.A., S.J.), Wm. S. Middleton Memorial VA Hospital and Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison; and Center on Aging and Health and Department of Epidemiology (A.L.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

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http://dx.doi.org/10.1212/WNL.0000000000007248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448449PMC
April 2019

heterozygosity attenuates -related amyloid burden in preclinical AD.

Neurology 2019 Apr 13;92(16):e1878-e1889. Epub 2019 Mar 13.

From the Geriatric Research Education and Clinical Center (C.L.G., C.M.C., S.A., S.C.J., O.C.O.), William S. Middleton Memorial VA Hospital; Wisconsin Alzheimer's Disease Research Center (C.M.E., J.M.O., Y.M., C.M.C., B.B.B., S.A., B.P.H., M.A.S., C.D.E., B.T.C., S.C.J., O.C.O.); Departments of Population Health Sciences (B.F.D., C.D.E.), Neurology (C.L.G., B.P.H.), Radiology (M.A.S.), Medical Physics (T.B., B.T.C.), and Biostatistics & Medical Informatics (D.N.), University of Wisconsin School of Medicine and Public Health, Madison; Division of Biology and Biomedical Sciences (S.A.S.), Washington University in St. Louis, MO; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Institute of Neurology (C.L.G., H.Z.), University College London, Queen Square; UK Dementia Research Institute (H.Z.), London; Wisconsin Alzheimer's Institute (C.M.C., B.B.B., S.A., B.P.H., M.A.S., C.D.E., S.C.J., O.C.O.), Madison; and Department of Neurology and Weill Institute for Neurosciences (D.B.D.), University of California, San Francisco.

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http://dx.doi.org/10.1212/WNL.0000000000007323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550504PMC
April 2019

Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife.

Alzheimers Dement 2019 Mar 25;15(3):418-428. Epub 2018 Oct 25.

Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15525260183355
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http://dx.doi.org/10.1016/j.jalz.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408972PMC
March 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Apathy in Preclinical Alzheimer's Disease: Psychometric Validation of the Apathy Evaluation Scale.

Am J Alzheimers Dis Other Demen 2019 Feb 14;34(1):16-22. Epub 2018 Aug 14.

2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

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http://dx.doi.org/10.1177/1533317518794020DOI Listing
February 2019

Cerebrospinal fluid biomarkers of neurofibrillary tangles and synaptic dysfunction are associated with longitudinal decline in white matter connectivity: A multi-resolution graph analysis.

Neuroimage Clin 2019 23;21:101586. Epub 2018 Oct 23.

Department of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI, USA; Department of Computer Science, University of Wisconsin - Madison, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.nicl.2018.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411581PMC
October 2018

Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia.

Neurology 2018 Jul 29;91(5):e436-e443. Epub 2018 Jun 29.

From the Department of Medicine (A.P.M., C.M.C., S.C.J., S.A., B.B.B.), Wisconsin Alzheimer's Disease Research Center, and Neuroscience and Public Policy Program (A.P.M.), University of Wisconsin; Geriatric Research Education and Clinical Center (C.M.C., S.C.J., S.A.), William S. Middleton Memorial Veteran's Hospital; Wisconsin Alzheimer's Institute (S.C.J.), Madison; Department of Neurology (S.E.S.), Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Institute of Neurology (H.Z.), University College London, Queen Square; and UK Dementia Research Institute (H.Z.), London.

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http://dx.doi.org/10.1212/WNL.0000000000005901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093766PMC
July 2018

Impact of apolipoprotein E genotypes on vitamin E and memantine treatment outcomes in Alzheimer's disease.

Alzheimers Dement (N Y) 2018 26;4:344-349. Epub 2018 Jul 26.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.trci.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118101PMC
July 2018

The Aging Imperative-Innovations in Research, Education, and Care in Geriatric Medicine.

WMJ 2018 Jun;117(2):92-93

University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

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June 2018

A Pilot Study of Perceived Mouth Dryness, Perceived Swallowing Effort, and Saliva Substitute Effects in Healthy Adults Across the Age Range.

Dysphagia 2018 Apr 6;33(2):200-205. Epub 2017 Sep 6.

Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53705, USA.

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http://dx.doi.org/10.1007/s00455-017-9846-7DOI Listing
April 2018

Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid.

Neurology 2018 Apr 9;90(15):e1306-e1315. Epub 2018 Mar 9.

From the Geriatric Research Education and Clinical Center (L.R.C., S.A., S.C.J., C.M.C.), William S. Middleton Memorial Veterans Hospital, Madison; Alzheimer's Disease Research Center (L.R.C., S.E.B., D.N., B.B.B., S.A., S.C.J., C.M.C.), Wisconsin Alzheimer's Institute (L.R.C., R.L.K., E.J., B.B.B., S.C.J., C.M.C.), Medical Scientist and Neuroscience Training Programs (S.E.B.), and Department of Biostatistics and Medical Informatics (D.N.), University of Wisconsin-Madison School of Medicine and Public Health; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience & Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), University College London, Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000005291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894934PMC
April 2018

Brain structure and cognition 3 years after the end of an early menopausal hormone therapy trial.

Neurology 2018 Apr 21;90(16):e1404-e1412. Epub 2018 Mar 21.

From the Departments of Radiology (K.K., S.M.Z., V.J.L., J.L.G., M.L. Senjem, M.L. Settell, C.R.J.), Health Sciences Research (N.T., T.G.L., K.R.B., W.A.R.), Psychology and Psychiatry (J.A.F.), Internal Medicine (L.T.S.), Neurology (W.A.R.), and Surgery and Physiology and Biomedical Engineering (V.M.M.), Mayo Clinic, Rochester, MN; Department of Medicine (C.E.G., S.A.), School of Medicine and Public Health, University of Wisconsin and Geriatric Research, Education and Clinical Center, William S. Middleton Memorial, Veterans Hospital, Madison, WI; and Department of Biostatistics (N.M.D.), George Washington University, Washington, DC.

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http://dx.doi.org/10.1212/WNL.0000000000005325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902783PMC
April 2018

DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.

J Alzheimers Dis 2018 ;66(3):927-934

Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

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http://dx.doi.org/10.3233/JAD-180592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478383PMC
January 2018

Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts.

Alzheimers Dement 2017 Nov 23;13(11):1217-1225. Epub 2017 May 23.

Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, Madison, Wisconsin, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1016/j.jalz.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810361PMC
November 2017

Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers.

Neurology 2017 Oct 22;89(17):1782-1788. Epub 2017 Sep 22.

From the Memory and Aging Center (K.B.C., F.M.E., J.N., K.Y., J.H.K.), Department of Neurology, University of California, San Francisco; Denver Anschutz Medical Center (B.M.B., C.C.), University of Colorado, Aurora; Wisconsin Alzheimer's Disease Research Center (B.B.B., S.C.J.) and Department of Medicine (S.A.), University of Wisconsin School of Medicine and Public Health; School of Medicine and Public Health (B.B.B., S.C.J.), Wisconsin Alzheimer's Institute; Geriatric Research Education and Clinical Center (S.C.J., C.C.), William S. Middleton Memorial Veterans Hospital, Madison, WI; San Francisco Veterans Affairs Hospital (K.Y.), CA; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (K.B., H.Z.), and Clinical Neurochemistry Laboratory (H.Z.), University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664306PMC
October 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults.

Neurology 2017 Aug 5;89(5):445-453. Epub 2017 Jul 5.

From the Department of Medicine and Neuroscience Training Program (K.E.S.) and Wisconsin Alzheimer's Disease Research Center (C.M.C., O.C.O., M.A.S., S.A., S.C.J., B.B.B.), University of Wisconsin-Madison; Wisconsin Alzheimer's Institute (R.L.K., C.M.C., O.C.O., M.A.S., S.A., S.C.J., B.B.B.); Geriatric Research Education and Clinical Center (C.M.C., O.C.O., S.A., S.C.J., B.B.B.), Wm. S. Middleton Veterans Hospital, Madison, WI; Institute of Neuroscience and Physiology (H.Z., K.B.), University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Department of Psychiatry and Human Behavior (R.M.B.), University of California, Irvine.

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http://dx.doi.org/10.1212/WNL.0000000000004171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539733PMC
August 2017

Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

Neurology 2017 May 3;88(22):2098-2106. Epub 2017 May 3.

From the Geriatric Research Education and Clinical Center (E.A.B., S.A.S., L.R.C., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.C.), William S. Middleton Memorial Veterans Hospital; Wisconsin Alzheimer's Disease Research Center (E.A.B., S.A.S., L.R.C., A.M.R., C.M.C., C.L.G., B.B.B., S.A., M.A.S., B.P.H., B.T.C., S.C.J., O.C.O.), Wisconsin Alzheimer's Institute (L.R.C., R.L.K., C.M.C., K.J.H., B.B.B., S.A., M.A.S., B.P.H., C.D.E., S.C.J., O.C.O.), Department of Population Health Sciences (B.F.D., C.D.E.), Department of Neurology (C.L.G., B.P.H.), Department of Anesthesiology (K.J.H.), Department of Radiology (M.A.S.), and Department of Medical Physics (B.T.C.), University of Wisconsin School of Medicine and Public Health, Madison; and Department of Neurology (D.B.D.), University of California, San Francisco.

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http://dx.doi.org/10.1212/WNL.0000000000003980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447398PMC
May 2017

Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD.

Neurology 2017 Apr 24;88(17):1650-1658. Epub 2017 Mar 24.

From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.

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http://dx.doi.org/10.1212/WNL.0000000000003862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405766PMC
April 2017

Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease.

JAMA Neurol 2017 Jan;74(1):41-49

Alzheimer Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison5Geriatric Research Education and Clinical Center, William S. Middleton Memorial VA Hospital, Madison, Wisconsin.

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http://dx.doi.org/10.1001/jamaneurol.2016.3232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195903PMC
January 2017

Dementia Trends in the United States: Read Up and Weigh In.

JAMA Intern Med 2017 01;177(1):58-60

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison2Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison4Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.

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http://dx.doi.org/10.1001/jamainternmed.2016.7073DOI Listing
January 2017

Macrovascular and microvascular cerebral blood flow in adults at risk for Alzheimer's disease.

Alzheimers Dement (Amst) 2017 23;7:48-55. Epub 2017 Jan 23.

Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, William. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.dadm.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318539PMC
January 2017

Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife.

Brain 2016 08 20;139(Pt 8):2261-74. Epub 2016 Jun 20.

1 Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, USA, Madison, WI 53705, USA 4 Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, USA, Madison, WI 53705, USA 5 Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, USA, Madison WI 53705, USA 10 Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, USA, Madison, WI 53705, USA

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http://brain.oxfordjournals.org/content/brain/early/2016/06/
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http://dx.doi.org/10.1093/brain/aww142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958904PMC
August 2016

Effects of hormone therapy on brain structure: A randomized controlled trial.

Neurology 2016 Aug 29;87(9):887-96. Epub 2016 Jul 29.

From the Departments of Radiology (K.K., S.M.Z., J.L.G., P.V., M.L.S., C.R.J.), Health Sciences Research (N.T., T.G.L., K.R.B., W.A.R.), Internal Medicine (L.T.S.), Neurology (W.A.R.), and Surgery and Physiology and Biomedical Engineering (V.M.M.), Mayo Clinic, Rochester, MN; Department of Medicine (C.E.G., S.A.), School of Medicine and Public Health, University of Wisconsin and Geriatric Research, Education and Clinical Center, William S. Middleton Memorial, Veterans' Hospital, Madison, WI; Department of Neurology (W.W.), Emory University, Atlanta, GA; and Department of Biostatistics and Medical Informatics (N.M.D.), University of Wisconsin, Madison.

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http://dx.doi.org/10.1212/WNL.0000000000002970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035155PMC
August 2016

Cognitive variability-A marker for incident MCI and AD: An analysis for the Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (Amst) 2016 26;4:47-55. Epub 2016 May 26.

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.dadm.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961828PMC
August 2016

Cognitive Effects of Soy Isoflavones in Patients with Alzheimer's Disease.

J Alzheimers Dis 2015 ;47(4):1009-19

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.

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http://dx.doi.org/10.3233/JAD-142958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657545PMC
July 2016

Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study.

Alzheimers Dement 2016 07 21;12(7):805-14. Epub 2016 Jan 21.

Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947439PMC
July 2016

Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging.

Neurobiol Aging 2016 07 6;43:79-88. Epub 2016 Apr 6.

Department of Medicine, Wisconsin Alzheimer's Disease Research Center, University of Wisconsin, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893194PMC
July 2016

Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer's Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data.

Arch Clin Neuropsychol 2016 May 8. Epub 2016 May 8.

Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53705, USA Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53705, USA Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA

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http://dx.doi.org/10.1093/arclin/acw024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088607PMC
May 2016

Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation.

Neuroimage Clin 2014 19;4:604-14. Epub 2014 Feb 19.

Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, Madison, WI 53705, USA ; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA ; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA ; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53705, USA.

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http://dx.doi.org/10.1016/j.nicl.2014.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053642PMC
February 2016

Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation.

Alzheimers Dement (Amst) 2016;2:27-38

Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, USA, Madison WI 53705; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, USA, Madison, WI 53705; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, USA, Madison, WI 53705; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, USA, Madison, WI 53705.

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https://linkinghub.elsevier.com/retrieve/pii/S23528729150009
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http://dx.doi.org/10.1016/j.dadm.2015.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778249PMC
January 2016

Intracranial Arterial 4D-Flow is Associated with Metrics of Brain Health and Alzheimer's Disease.

Alzheimers Dement (Amst) 2015 Dec;1(4):420-428

Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 ; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.

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http://dx.doi.org/10.1016/j.dadm.2015.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674833PMC
December 2015

Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease.

Arch Clin Neuropsychol 2015 Nov 8;30(7):634-42. Epub 2015 Jul 8.

Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA

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http://dx.doi.org/10.1093/arclin/acv041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605365PMC
November 2015

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults.

Neurobiol Aging 2015 Sep 14;36(9):2568-76. Epub 2015 May 14.

Wisconsin Center for Sleep Medicine and Research, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523445PMC
September 2015

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease.

JAMA Neurol 2015 Sep;72(9):1013-20

Clinical Science Center, Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison5Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisco.

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http://dx.doi.org/10.1001/jamaneurol.2015.0613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570876PMC
September 2015

Effect of Cognitive Reserve on Age-Related Changes in Cerebrospinal Fluid Biomarkers of Alzheimer Disease.

JAMA Neurol 2015 Jun;72(6):699-706

Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin3Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison4Wisconsin Alzheimer's Disease Rese.

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http://dx.doi.org/10.1001/jamaneurol.2015.0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639566PMC
June 2015

Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study.

PLoS Med 2015 Jun 2;12(6):e1001833; discussion e1001833. Epub 2015 Jun 2.

School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America; Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States of America; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1001833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452757PMC
June 2015

Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Alzheimers Dement (Amst) 2015 Jun;1(2):160-169

Geriatric Research Education and Clinical Center, William S. Middleton Memorial VA Hospital, Madison WI ; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI ; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI.

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http://dx.doi.org/10.1016/j.dadm.2015.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492165PMC
June 2015

Insulin resistance predicts brain amyloid deposition in late middle-aged adults.

Alzheimers Dement 2015 May 17;11(5):504-510.e1. Epub 2014 Jul 17.

Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297592PMC
May 2015

Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD.

Alzheimers Dement (Amst) 2015 Mar;1(1):33-40

Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705 ; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.

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https://linkinghub.elsevier.com/retrieve/pii/S23528729150001
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http://dx.doi.org/10.1016/j.dadm.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412027PMC
March 2015

The KEEPS-Cognitive and Affective Study: baseline associations between vascular risk factors and cognition.

J Alzheimers Dis 2014 ;40(2):331-41

Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veterans Hospital, Madison, WI, USA Wisconsin Alzheimer's Disease Research Center, (ADRC) Madison, WI, USA.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-130245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367860PMC
January 2015

Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease.

Neurobiol Aging 2014 Nov 27;35(11):2486-2494. Epub 2014 May 27.

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Madison VA Geriatric Research, Education and Clinical Center (GRECC), Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170854PMC
November 2014

Physical activity attenuates age-related biomarker alterations in preclinical AD.

Neurology 2014 Nov 8;83(19):1753-60. Epub 2014 Oct 8.

From the Geriatric Research Education and Clinical Center (O.C.O., S.A.S., J.M.O., J.L., D.C., C.L.G., C.M.C., B.B.B., S.A., S.C.J.), William S. Middleton Memorial VA Hospital, Madison WI; Wisconsin Alzheimer's Institute (O.C.O., D.E., R.K., B.B.B., A.L., S.A., B.P.H., S.C.J., M.A.S.), Wisconsin Alzheimer's Disease Research Center (O.C.O., S.A.S., J.M.O., J.L., D.E., C.L.G., N.M.D., C.M.C., B.B.B., H.A.R., B.T.C., S.A., B.P.H., S.C.J., M.A.S.), Departments of Kinesiology (D.E., D.C.), Neurology (C.L.G.), Biostatistics & Medical Informatics (N.M.D., B.P.H.), Radiology (H.A.R.), and Medical Physics (B.T.C.), University of Wisconsin School of Medicine and Public Health, Madison.

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http://www.neurology.org/content/83/19/1753.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000096
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000000964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239838PMC
November 2014

Effects of hormone therapy on cognition and mood.

Fertil Steril 2014 Apr;101(4):898-904

Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Affairs Hospital, Madison, Wisconsin; Wisconsin Alzheimer's Disease Research Center (ADRC), Madison, Wisconsin; Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

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http://dx.doi.org/10.1016/j.fertnstert.2014.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330961PMC
April 2014

Amyloid burden and neural function in people at risk for Alzheimer's Disease.

Neurobiol Aging 2014 Mar 23;35(3):576-84. Epub 2013 Oct 23.

Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial VA Hospital, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018215PMC
March 2014

Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective sub study (KEEPS Cog).

Brain Res 2013 Jun 17;1514:12-7. Epub 2013 Apr 17.

Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53792, USA.

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http://dx.doi.org/10.1016/j.brainres.2013.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731133PMC
June 2013

Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults.

Diabetes Care 2013 Feb 15;36(2):443-9. Epub 2012 Oct 15.

Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

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http://dx.doi.org/10.2337/dc12-0922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554303PMC
February 2013

Neurobiological Underpinnings of the Estrogen - Mood Relationship.

Curr Psychiatry Rev 2012 Aug;8(3):247-256

University of Wisconsin, Alzheimer's Disease Research Center ; University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin ; Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.

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http://dx.doi.org/10.2174/157340012800792957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753111PMC
August 2012

Using predictors of hormone therapy use to model the healthy user bias: how does healthy user status influence cognitive effects of hormone therapy?

Menopause 2012 May;19(5):524-33

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.

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http://dx.doi.org/10.1097/gme.0b013e318238ff2cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326437PMC
May 2012

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Authors:
Trygve E Bakken J Cooper Roddey Srdjan Djurovic Natacha Akshoomoff David G Amaral Cinnamon S Bloss B J Casey Linda Chang Thomas M Ernst Jeffrey R Gruen Terry L Jernigan Walter E Kaufmann Tal Kenet David N Kennedy Joshua M Kuperman Sarah S Murray Elizabeth R Sowell Lars M Rimol Morten Mattingsdal Ingrid Melle Ingrid Agartz Ole A Andreassen Nicholas J Schork Anders M Dale Michael Weiner Paul Aisen Ronald Petersen Clifford R Jack William Jagust John Q Trojanowki Arthur W Toga Laurel Beckett Robert C Green Andrew J Saykin John Morris Enchi Liu Tom Montine Anthony Gamst Ronald G Thomas Michael Donohue Sarah Walter Devon Gessert Tamie Sather Danielle Harvey John Kornak Anders Dale Matthew Bernstein Joel Felmlee Nick Fox Paul Thompson Norbert Schuff Gene Alexander Charles DeCarli Dan Bandy Robert A Koeppe Norm Foster Eric M Reiman Kewei Chen Chet Mathis Nigel J Cairns Lisa Taylor-Reinwald J Q Trojanowki Les Shaw Virginia M Y Lee Magdalena Korecka Karen Crawford Scott Neu Tatiana M Foroud Steven Potkin Li Shen Zaven Kachaturian Richard Frank Peter J Snyder Susan Molchan Jeffrey Kaye Joseph Quinn Betty Lind Sara Dolen Lon S Schneider Sonia Pawluczyk Bryan M Spann James Brewer Helen Vanderswag Judith L Heidebrink Joanne L Lord Kris Johnson Rachelle S Doody Javier Villanueva-Meyer Munir Chowdhury Yaakov Stern Lawrence S Honig Karen L Bell John C Morris Beau Ances Maria Carroll Sue Leon Mark A Mintun Stacy Schneider Daniel Marson Randall Griffith David Clark Hillel Grossman Effie Mitsis Aliza Romirowsky Leyla deToledo-Morrell Raj C Shah Ranjan Duara Daniel Varon Peggy Roberts Marilyn Albert Chiadi Onyike Stephanie Kielb Henry Rusinek Mony J de Leon Lidia Glodzik Susan De Santi P Murali Doraiswamy Jeffrey R Petrella R Edward Coleman Steven E Arnold Jason H Karlawish David Wolk Charles D Smith Greg Jicha Peter Hardy Oscar L Lopez MaryAnn Oakley Donna M Simpson Anton P Porsteinsson Bonnie S Goldstein Kim Martin Kelly M Makino M Saleem Ismail Connie Brand Ruth A Mulnard Gaby Thai Catherine Mc-Adams-Ortiz Kyle Womack Dana Mathews Mary Quiceno Ramon Diaz-Arrastia Richard King Myron Weiner Kristen Martin-Cook Michael DeVous Allan I Levey James J Lah Janet S Cellar Jeffrey M Burns Heather S Anderson Russell H Swerdlow Liana Apostolova Po H Lu George Bartzokis Daniel H S Silverman Neill R Graff-Radford Francine Parfitt Heather Johnson Martin R Farlow Ann Marie Hake Brandy R Matthews Scott Herring Christopher H van Dyck Richard E Carson Martha G MacAvoy Howard Chertkow Howard Bergman Chris Hosein Sandra Black Bojana Stefanovic Curtis Caldwell Ging-Yuek Robin Hsiung Howard Feldman Benita Mudge Michele Assaly Andrew Kertesz John Rogers Dick Trost Charles Bernick Donna Munic Diana Kerwin Marek-Marsel Mesulam Kristina Lipowski Chuang-Kuo Wu Nancy Johnson Carl Sadowsky Walter Martinez Teresa Villena Raymond Scott Turner Kathleen Johnson Brigid Reynolds Reisa A Sperling Keith A Johnson Gad Marshall Meghan Frey Jerome Yesavage Joy L Taylor Barton Lane Allyson Rosen Jared Tinklenberg Marwan Sabbagh Christine Belden Sandra Jacobson Neil Kowall Ronald Killiany Andrew E Budson Alexander Norbash Patricia Lynn Johnson Thomas O Obisesan Saba Wolday Salome K Bwayo Alan Lerner Leon Hudson Paula Ogrocki Evan Fletcher Owen Carmichael John Olichney Smita Kittur Michael Borrie T-Y Lee Rob Bartha Sterling Johnson Sanjay Asthana Cynthia M Carlsson Steven G Potkin Adrian Preda Dana Nguyen Pierre Tariot Adam Fleisher Stephanie Reeder Vernice Bates Horacio Capote Michelle Rainka Douglas W Scharre Maria Kataki Earl A Zimmerman Dzintra Celmins Alice D Brown Godfrey D Pearlson Karen Blank Karen Anderson Robert B Santulli Eben S Schwartz Kaycee M Sink Jeff D Williamson Pradeep Garg Franklin Watkins Brian R Ott Henry Querfurth Geoffrey Tremont Stephen Salloway Paul Malloy Stephen Correia Howard J Rosen Bruce L Miller Jacobo Mintzer Crystal Flynn Longmire Kenneth Spicer Elizabether Finger Irina Rachinsky Dick Drost Terry Jernigan Connor McCabe Ellen Grant Thomas Ernst Josh Kuperman Yoon Chung Sarah Murray Cinnamon Bloss Burcu Darst Lexi Pritchett Ashley Saito David Amaral Mishaela DiNino Bella Eyngorina Elizabeth Sowell Suzanne Houston Lindsay Soderberg Walter Kaufmann Peter van Zijl Hilda Rizzo-Busack Mohsin Javid Natasha Mehta Erika Ruberry Alisa Powers Bruce Rosen Nitzah Gebhard Holly Manigan Jean Frazier David Kennedy Lauren Yakutis Michael Hill Jeffrey Gruen Joan Bosson-Heenan Heatherly Carlson

Proc Natl Acad Sci U S A 2012 Mar 16;109(10):3985-90. Epub 2012 Feb 16.

Medical Scientist Training Program, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1105829109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309762PMC
March 2012