Sangram S Sisodia

Sangram S Sisodia

UNVERIFIED PROFILE

Are you Sangram S Sisodia?   Register this Author

Register author
Sangram S Sisodia

Sangram S Sisodia

Publications by authors named "Sangram S Sisodia"

Are you Sangram S Sisodia?   Register this Author

73Publications

727Reads

-Profile Views

Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules.

Nat Nanotechnol 2017 12 21;12(12):1183-1189. Epub 2017 Aug 21.

Department of Chemistry, University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nnano.2017.159
Publisher Site
http://dx.doi.org/10.1038/nnano.2017.159DOI Listing
December 2017

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.

Nat Neurosci 2017 Oct 28;20(10):1371-1376. Epub 2017 Aug 28.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.4631DOI Listing
October 2017

Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.

J Biol Chem 2016 Mar 17;291(13):6748-53. Epub 2016 Feb 17.

From the Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637 and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.C115.701649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807262PMC
March 2016

The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.

Mol Neurodegener 2015 Aug 22;10:39. Epub 2015 Aug 22.

Department of Neurobiology, The University of Chicago, 947 E. 58th St. MC0928, Chicago, Il 60637, USA.

View Article

Download full-text PDF

Source
http://www.molecularneurodegeneration.com/content/10/1/39
Publisher Site
http://dx.doi.org/10.1186/s13024-015-0037-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546279PMC
August 2015

Acne inversa caused by missense mutations in NCSTN is not fully compatible with impairments in Notch signaling.

J Invest Dermatol 2015 Feb 11;135(2):618-620. Epub 2014 Sep 11.

Department of Neurobiology, The University of Chicago, Chicago, Illinois, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jid.2014.399DOI Listing
February 2015

Differential release of β-amyloid from dendrite- versus axon-targeted APP.

J Neurosci 2014 Sep;34(37):12313-27

Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2255-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160770PMC
September 2014

Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.

Cell Rep 2014 Aug 14;8(4):1077-92. Epub 2014 Aug 14.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346175PMC
August 2014

Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons.

J Neurosci 2014 Mar;34(10):3668-73

Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, and Department of Neurology, Genetics and Aging Research Unit, Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.5079-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942582PMC
March 2014

Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors.

Mol Neurodegener 2013 Oct 20;8:41. Epub 2013 Oct 20.

Department of Neurobiology, The University of Chicago, 947 E 58th Street, AB 308, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-8-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853710PMC
October 2013

Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.

Proc Natl Acad Sci U S A 2013 May 14;110(22):9148-53. Epub 2013 May 14.

Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1302106110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670351PMC
May 2013

BMS-708,163 targets presenilin and lacks notch-sparing activity.

Biochemistry 2012 Sep 4;51(37):7209-11. Epub 2012 Sep 4.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/bi301137h
Publisher Site
http://dx.doi.org/10.1021/bi301137hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470910PMC
September 2012

Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.

PLoS One 2011 29;6(11):e28179. Epub 2011 Nov 29.

Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028179PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226664PMC
April 2012

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.

Nat Neurosci 2011 Sep 27;14(10):1227-35. Epub 2011 Sep 27.

Department of Neuropathology, University Hospital of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.2923DOI Listing
September 2011

Activation and intrinsic gamma-secretase activity of presenilin 1.

Proc Natl Acad Sci U S A 2010 Dec 29;107(50):21435-40. Epub 2010 Nov 29.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1013246107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003001PMC
December 2010

Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis.

Neurodegener Dis 2010 13;7(1-3):46-9. Epub 2010 Feb 13.

Department of Neurobiology, University of Chicago, 947 E. 58th Street, AB 308, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000283482DOI Listing
July 2010

Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF.

Mol Neurodegener 2009 Dec 21;4:52. Epub 2009 Dec 21.

Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-4-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806355PMC
December 2009

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.

J Biol Chem 2009 Jan 25;284(5):2967-77. Epub 2008 Nov 25.

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M807269200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631949PMC
January 2009

Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.

Mol Neurodegener 2008 Oct 3;3:14. Epub 2008 Oct 3.

Department of Psychiatry, Vanderbilt University, Nashville, TN37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-3-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569036PMC
October 2008

Adult neurogenesis is functionally associated with AD-like neurodegeneration.

Neurobiol Dis 2008 Feb 5;29(2):316-26. Epub 2007 Nov 5.

Department of Psychiatry, The University of Chicago, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2007.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254142PMC
February 2008

Biogenesis of gamma-secretase early in the secretory pathway.

J Cell Biol 2007 Dec;179(5):951-63

Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.200709012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099203PMC
December 2007

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.

J Biol Chem 2007 Aug 5;282(35):25453-63. Epub 2007 Jul 5.

Ben-May Department for Cancer Research, the University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M701590200DOI Listing
August 2007

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

J Neurosci 2007 Jun;27(26):7006-10

Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1919-07.2007DOI Listing
June 2007

Presenilins and Alzheimer disease: the calcium conspiracy.

Nat Neurosci 2006 Nov;9(11):1354-5

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn1106-1354DOI Listing
November 2006

Abeta star: a light onto synaptic dysfunction?

Nat Med 2006 Jul;12(7):760-1; discussion 761

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm0706-760DOI Listing
July 2006

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.

Proc Natl Acad Sci U S A 2006 Feb 31;103(6):1936-40. Epub 2006 Jan 31.

Laboratory of Molecular and Cellular Neuroscience, and Fisher Center for Research on Alzheimer Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0510710103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413666PMC
February 2006

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Proc Natl Acad Sci U S A 2006 Feb 31;103(6):1941-6. Epub 2006 Jan 31.

Laboratory of Molecular and Cellular Neuroscience, and Fisher Center for Research on Alzheimer Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0510708103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413665PMC
February 2006

Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.

J Neurosci 2006 Jan;26(2):429-34

Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3961-05.2006DOI Listing
January 2006

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.

Neurobiol Dis 2005 Dec 11;20(3):969-85. Epub 2005 Jul 11.

Pediatric Center for Neuroscience, Children's Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09699961050016
Publisher Site
http://dx.doi.org/10.1016/j.nbd.2005.06.004DOI Listing
December 2005

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

J Biol Chem 2005 Dec 18;280(51):41953-66. Epub 2005 Oct 18.

Department of Neurobiology, Pharmacology and Physiology, the University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M509070200DOI Listing
December 2005

Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice.

Am J Geriatr Psychiatry 2005 Dec;13(12):1041-51

Department of Psychiatry, University of Pittsburgh School of Medicine, E1453 Biomedical Science Tower, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1176/appi.ajgp.13.12.1041DOI Listing
December 2005

Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice.

J Neurosci 2005 Nov;25(44):10220-9

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2773-05.2005DOI Listing
November 2005

True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice.

Methods 2005 Nov;37(3):261-73

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2005.09.005DOI Listing
November 2005

Spatial segregation of gamma-secretase and substrates in distinct membrane domains.

J Biol Chem 2005 Jul 10;280(27):25892-900. Epub 2005 May 10.

Department of Neurobiology, Pharmacology, and Physiology, the University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M503570200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201532PMC
July 2005

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.

Cell 2005 Mar;120(5):701-13

Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2005.01.015DOI Listing
March 2005

Presenilin attenuates receptor-mediated signaling and synaptic function.

J Neurosci 2005 Feb;25(6):1540-9

Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3850-04.2005DOI Listing
February 2005

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

J Biol Chem 2005 Jan 10;280(3):1992-2001. Epub 2004 Nov 10.

Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M412404200DOI Listing
January 2005

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.

J Biol Chem 2004 Nov 29;279(47):48615-9. Epub 2004 Sep 29.

Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.C400396200
Publisher Site
http://dx.doi.org/10.1074/jbc.C400396200DOI Listing
November 2004

Presenilin 1 in migration and morphogenesis in the central nervous system.

Development 2004 Jul 26;131(13):3093-105. Epub 2004 May 26.

Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 E. 58th Street, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.01191DOI Listing
July 2004

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.

J Biol Chem 2003 Sep 23;278(36):33992-4002. Epub 2003 Jun 23.

Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M305834200DOI Listing
September 2003

Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC).

J Biol Chem 2003 Aug 2;278(33):30425-8. Epub 2003 Jul 2.

Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.C300239200DOI Listing
August 2003

Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules.

Blood Cells Mol Dis 2002 Jan-Feb;28(1):28-38

Department of Pediatrics, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
June 2003

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.

J Biol Chem 2003 Mar 24;278(10):7751-4. Epub 2003 Jan 24.

Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.C200711200DOI Listing
March 2003

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.

J Biol Chem 2003 Jan 14;278(5):3446-54. Epub 2002 Nov 14.

Fisher Center for Research on Alzheimer's Disease and Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M209065200DOI Listing
January 2003

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.

J Neurosci 2002 Nov;22(22):9785-93

Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
November 2002

Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.

Neuromolecular Med 2002 ;1(1):43-54

Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/NMM:1:1:43DOI Listing
June 2002

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Nat Rev Neurosci 2002 Apr;3(4):281-90

Center for Molecular Neurobiology, Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrn785DOI Listing
April 2002

Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.

Neurobiol Aging 2002 Mar-Apr;23(2):171-7

Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Ave., Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
February 2002

Biomedicine. A cargo receptor mystery APParently solved?

Science 2002 Feb;295(5556):805-7

Center for Molecular Neurobiology, Chicago, IL 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1069661DOI Listing
February 2002

Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides.

J Biol Chem 2002 Jan 14;277(3):1872-7. Epub 2001 Nov 14.

Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M108739200DOI Listing
January 2002