Sangeeta N Bhatia

Sangeeta N Bhatia

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Sangeeta N Bhatia

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Renal clearable catalytic gold nanoclusters for in vivo disease monitoring.

Nat Nanotechnol 2019 Sep 2;14(9):883-890. Epub 2019 Sep 2.

Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, UK.

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http://www.nature.com/articles/s41565-019-0527-6
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http://dx.doi.org/10.1038/s41565-019-0527-6DOI Listing
September 2019

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer.

Oncotarget 2019 Sep 3;10(51):5349-5358. Epub 2019 Sep 3.

HMS Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.oncotarget.com/fulltext/27160
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http://dx.doi.org/10.18632/oncotarget.27160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731108PMC
September 2019

Antimalarial activity of primaquine operates via a two-step biochemical relay.

Nat Commun 2019 Jul 19;10(1):3226. Epub 2019 Jul 19.

Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.

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http://dx.doi.org/10.1038/s41467-019-11239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642103PMC
July 2019

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Gastroenterology 2019 05 12;156(6):1788-1804.e13. Epub 2019 Jan 12.

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Harvard Stem Cell Institute, Cambridge, Massachusetts; Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Divison of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532055PMC
May 2019

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

Cell Metab 2019 Mar;29(3):727-735.e3

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193006
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http://dx.doi.org/10.1016/j.cmet.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408324PMC
March 2019

Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages.

Methods Mol Biol 2018 ;1787:41-52

Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-4939-7847-2_3DOI Listing
February 2019

Protease activity sensors noninvasively classify bacterial infections and antibiotic responses.

EBioMedicine 2018 Dec 29;38:248-256. Epub 2018 Nov 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology Program, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183053
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http://dx.doi.org/10.1016/j.ebiom.2018.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306379PMC
December 2018

Classification of prostate cancer using a protease activity nanosensor library.

Proc Natl Acad Sci U S A 2018 09 20;115(36):8954-8959. Epub 2018 Aug 20.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1805337115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130343PMC
September 2018

Personalized RNA Medicine for Pancreatic Cancer.

Clin Cancer Res 2018 04 12;24(7):1734-1747. Epub 2018 Jan 12.

Harvard Medical School Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2733DOI Listing
April 2018

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

Cell Host Microbe 2018 Mar 22;23(3):395-406.e4. Epub 2018 Feb 22.

Harvard-MIT Department of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Boston, MA 02142, USA; Broad Institute, Boston, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute for Integrative Cancer Research, Boston, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital Boston, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.01.002DOI Listing
March 2018

Engineered Livers for Infectious Diseases.

Cell Mol Gastroenterol Hepatol 2018 22;5(2):131-144. Epub 2017 Nov 22.

Koch Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1016/j.jcmgh.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756057PMC
November 2017

Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas.

Sci Rep 2017 10 10;7(1):12922. Epub 2017 Oct 10.

Eaton Peabody Laboratories, Massachusetts Eye and Ear, 243 Charles Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-13032-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635039PMC
October 2017

Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections.

Adv Mater 2017 Sep 12;29(35). Epub 2017 Jul 12.

Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Harvard-MIT Division of Health Sciences and Technology, Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201701527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765747PMC
September 2017

Ultrasensitive tumour-penetrating nanosensors of protease activity.

Nat Biomed Eng 2017 10;1. Epub 2017 Apr 10.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1038/s41551-017-0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621765PMC
April 2017

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.

Sci Rep 2017 03 31;7:45424. Epub 2017 Mar 31.

Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/srep45424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374446PMC
March 2017

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Int J Parasitol 2016 10 25;46(11):679-83. Epub 2016 Jul 25.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028309PMC
October 2016

Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling.

Nano Lett 2016 Oct 13;16(10):6303-6310. Epub 2016 Sep 13.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.nanolett.6b02670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344125PMC
October 2016

High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro.

J Biomol Screen 2016 Oct 4;21(9):897-911. Epub 2016 Aug 4.

Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA The Broad Institute of MIT and Harvard, Cambridge, MA, USA Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA Howard Hughes Medical Institute, Chevy Chase, MD, USA

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http://dx.doi.org/10.1177/1087057116660277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352718PMC
October 2016

Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide-siRNA Nanocomplexes.

Bioconjug Chem 2016 10 16;27(10):2323-2331. Epub 2016 Sep 16.

Koch Institute for Integrative Cancer Research, MIT , 500 Main Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410868PMC
October 2016

Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.

Adv Mater 2016 Sep 6;28(36):7962-7969. Epub 2016 Jul 6.

Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093-0358, USA.

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http://dx.doi.org/10.1002/adma.201600634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274592PMC
September 2016

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.

Angew Chem Int Ed Engl 2016 09 24;55(40):12440-4. Epub 2016 Aug 24.

Institute for Medical Engineering & Science, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201606123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864249PMC
September 2016

Host AMPK Is a Modulator of Plasmodium Liver Infection.

Cell Rep 2016 09 25;16(10):2539-2545. Epub 2016 Aug 25.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014760PMC
September 2016

Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

Nanoscale Horiz 2016 Sep 14;1(5):407-414. Epub 2016 Jun 14.

Department of Chemistry, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1039/C6NH00082GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935492PMC
September 2016

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries.

ACS Nano 2016 08 21;10(8):7926-33. Epub 2016 Jul 21.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsnano.6b03858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896006PMC
August 2016

Synchronized cycles of bacterial lysis for in vivo delivery.

Nature 2016 08 20;536(7614):81-85. Epub 2016 Jul 20.

Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048415PMC
http://dx.doi.org/10.1038/nature18930DOI Listing
August 2016

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Virology 2016 07 27;494:236-47. Epub 2016 Apr 27.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366982PMC
July 2016

Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts.

Adv Funct Mater 2016 May 22;26(17):2919-2928. Epub 2016 Mar 22.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1002/adfm.201505142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914179PMC
May 2016

Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.

Methods 2016 Mar 11;96:6-11. Epub 2015 Dec 11.

The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766037PMC
March 2016

Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.

ACS Nano 2015 Dec 13;9(12):11708-17. Epub 2015 Nov 13.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsnano.5b05946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588683PMC
December 2015

Smart nanosystems: Bio-inspired technologies that interact with the host environment.

Proc Natl Acad Sci U S A 2015 Nov 23;112(47):14460-6. Epub 2015 Nov 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1508522112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664363PMC
November 2015

Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering.

J Biomed Mater Res A 2015 Oct 30;103(10):3331-8. Epub 2015 Apr 30.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139.

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https://pdfs.semanticscholar.org/2c2c/b058b2f48cefcaca3d1bfa
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https://lmrt.mit.edu/sites/default/files/Stevens_JBMR-A_2015
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http://doi.wiley.com/10.1002/jbm.a.35478
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http://dx.doi.org/10.1002/jbm.a.35478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890565PMC
October 2015

Mathematical framework for activity-based cancer biomarkers.

Proc Natl Acad Sci U S A 2015 Oct 28;112(41):12627-32. Epub 2015 Sep 28.

Institute for Medical Engineering and Science, Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Chevy Chase, MD 20815

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http://dx.doi.org/10.1073/pnas.1506925112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611621PMC
October 2015

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

Cancer Res 2015 Aug 29;75(16):3255-67. Epub 2015 Jun 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Howard Hughes Medical Institute, Cambridge, Massachusetts. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. Broad Institute, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833008PMC
August 2015

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.

Sci Rep 2015 Jun 2;5:10833. Epub 2015 Jun 2.

1] Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA [2] Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA [3] Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA [4] Broad Institute, Cambridge, MA 02139, USA [5] Howard Hughes Medical Institute, Cambridge, MA 02139, USA [6] Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep10833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649911PMC
June 2015

Patterning vascular networks in vivo for tissue engineering applications.

Tissue Eng Part C Methods 2015 May 18;21(5):509-17. Epub 2015 Feb 18.

1 Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/ten.TEC.2014.0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410304PMC
May 2015

Programmable probiotics for detection of cancer in urine.

Sci Transl Med 2015 May;7(289):289ra84

Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electrical Engineering and Computer Science and David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa3519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511399PMC
May 2015

Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro.

Stem Cell Reports 2015 Mar 7;4(3):348-59. Epub 2015 Feb 7.

Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Koch Institute, and Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375936PMC
March 2015

Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche.

Cancer Discov 2015 Feb 24;5(2):168-81. Epub 2014 Nov 24.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Howard Hughes Medical Institute, Cambridge, Massachusetts. Division of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-13-0760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367955PMC
February 2015

In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.

Eukaryot Cell 2015 Jan 21;14(1):96-103. Epub 2014 Nov 21.

Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal

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http://dx.doi.org/10.1128/EC.00166-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279013PMC
January 2015

New Methods in Tissue Engineering: Improved Models for Viral Infection.

Annu Rev Virol 2014 Nov;1:475-499

Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Cambridge, Massachusetts 02139.

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http://dx.doi.org/10.1146/annurev-virology-031413-085437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398347PMC
November 2014

Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.

J Am Chem Soc 2014 Oct 23;136(39):13709-14. Epub 2014 Sep 23.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Building 76-453, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/ja505676hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183649PMC
October 2014

Drug-induced amplification of nanoparticle targeting to tumors.

Nano Today 2014 Oct 23;9(5):550-559. Epub 2014 Sep 23.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1016/j.nantod.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935498PMC
October 2014

Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology.

Trends Biotechnol 2014 Sep 30;32(9):448-55. Epub 2014 Jul 30.

Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibtech.2014.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295824PMC
September 2014

Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.

ACS Nano 2014 Sep 19;8(9):8776-85. Epub 2014 Aug 19.

Department of Chemical Engineering and ‡Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nn501129qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174090PMC
September 2014

Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes.

Proc Natl Acad Sci U S A 2014 Sep 11;111(38):13948-53. Epub 2014 Sep 11.

Koch Institute for Integrative Cancer Research, Departments of Materials Science and Engineering, Biological Engineering,

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http://dx.doi.org/10.1073/pnas.1400821111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183329PMC
September 2014

Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues.

Tissue Eng Part A 2014 Aug 28;20(15-16):2200-12. Epub 2014 Apr 28.

1 Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.

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http://dx.doi.org/10.1089/ten.tea.2013.0667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137334PMC
August 2014

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.

Proc Natl Acad Sci U S A 2014 Aug 4;111(33):12193-8. Epub 2014 Aug 4.

Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1412631111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143014PMC
August 2014

Microfluidic organs-on-chips.

Nat Biotechnol 2014 Aug;32(8):760-72

1] Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA. [2] Vascular Biology Program, Departments of Pathology &Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nbt.2989
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http://dx.doi.org/10.1038/nbt.2989DOI Listing
August 2014

Cell and tissue engineering for liver disease.

Sci Transl Med 2014 Jul;6(245):245sr2

Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, and McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15224, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374645PMC
July 2014

A Macro-to-Micro Interface for the Control of Cellular Organization.

J Microelectromech Syst 2014 Apr;23(2):391-397

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; the Howard Hughes Medical Institute, Cambridge, MA 02139, USA; and the Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ( ).

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http://dx.doi.org/10.1109/JMEMS.2013.2278813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495972PMC
April 2014

Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics.

Proc Natl Acad Sci U S A 2014 Mar 24;111(10):3671-6. Epub 2014 Feb 24.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1073/pnas.1314651111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956200PMC
March 2014

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.

Dis Model Mech 2014 Feb 28;7(2):215-24. Epub 2013 Nov 28.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.013490
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http://dx.doi.org/10.1242/dmm.013490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917242PMC
February 2014

Weighing nanoparticles in solution at the attogram scale.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):1310-5. Epub 2014 Jan 13.

Departments of Biological Engineering, Materials Science and Engineering, Electrical Engineering and Computer Science, and Mechanical Engineering, Koch Institute for Integrative Cancer Research, Computational and Systems Biology Initiative, Harvard-MIT Health Sciences and Technology, Institute for Medical Engineering and Science, and Microsystems Technology Laboratories, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1073/pnas.1318602111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910582PMC
January 2014

A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors.

Nano Today 2013 Dec;8(6):566-576

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; Division of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA ; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.nantod.2013.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084751PMC
December 2013

Nanotechnology: emerging tools for biology and medicine.

Genes Dev 2013 Nov;27(22):2397-408

Center for Biomedical Engineering, School of Engineering.

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http://dx.doi.org/10.1101/gad.226837.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841729PMC
November 2013

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.

ACS Nano 2013 Oct 12;7(10):9001-9. Epub 2013 Sep 12.

Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nn403550cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807694PMC
October 2013

Nanoparticle amplification photothermal unveiling of cryptic collagen binding sites.

J Mater Chem B 2013 Oct 14;1(39):5235-5240. Epub 2013 Jun 14.

Harvard-MIT Division of Health Sciences and Technology , 77 Massachusetts Ave. 76-453 , Cambridge , MA 02139 , USA . Email:

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http://dx.doi.org/10.1039/c3tb20619jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809612PMC
October 2013

Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source.

ACS Nano 2013 Sep 20;7(9):8089-97. Epub 2013 Aug 20.

Koch Institute for Integrative Cancer Research, ¶Health Sciences and Technology, and #Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology , Cambridge, Massachusetts, United States.

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http://dx.doi.org/10.1021/nn4033757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788585PMC
September 2013

Identification of small molecules for human hepatocyte expansion and iPS differentiation.

Nat Chem Biol 2013 Aug 2;9(8):514-20. Epub 2013 Jun 2.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720805PMC
August 2013

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.

Cell Host Microbe 2013 Jul;14(1):104-15

Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.chom.2013.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780791PMC
July 2013

Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.

Lab Chip 2013 May 5;13(10):1969-78. Epub 2013 Apr 5.

Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1039/c3lc41300dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812960PMC
May 2013

Geometric control of vascular networks to enhance engineered tissue integration and function.

Proc Natl Acad Sci U S A 2013 May 22;110(19):7586-91. Epub 2013 Apr 22.

Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.1217796110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651499PMC
May 2013

Mitochondrial localization and the persistent migration of epithelial cancer cells.

Biophys J 2013 May;104(9):2077-88

Harvard-MIT Division of Health-Science Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.bpj.2013.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647149PMC
May 2013

Bioengineering methods for analysis of cells in vitro.

Annu Rev Cell Dev Biol 2012 ;28:385-410

Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1146/annurev-cellbio-101011-155709DOI Listing
March 2013

Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.

Nat Biotechnol 2013 Jan 16;31(1):63-70. Epub 2012 Dec 16.

Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542405PMC
January 2013

Identification and characterization of receptor-specific peptides for siRNA delivery.

ACS Nano 2012 Oct 27;6(10):8620-31. Epub 2012 Aug 27.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1021/nn301975sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478735PMC
October 2012

Genetic Circuits in Salmonella typhimurium.

ACS Synth Biol 2012 Oct 9;1(10):458-464. Epub 2012 Aug 9.

Department of Bioengineering, University of California, San Diego , San Diego, California, United States.

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http://dx.doi.org/10.1021/sb300060eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477097PMC
October 2012

In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria.

ACS Synth Biol 2012 Oct 21;1(10):465-470. Epub 2012 Sep 21.

Health Sciences and Technology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://pubs.acs.org/doi/10.1021/sb3000639
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http://dx.doi.org/10.1021/sb3000639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477096PMC
October 2012

Modeling hepatitis C virus infection using human induced pluripotent stem cells.

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2544-8. Epub 2012 Jan 30.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1121400109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289320PMC
February 2012

A biophysical indicator of vaso-occlusive risk in sickle cell disease.

Sci Transl Med 2012 Feb;4(123):123ra26

Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633235PMC
February 2012

Bioresponsive mesoporous silica nanoparticles for triggered drug release.

J Am Chem Soc 2011 Dec 18;133(49):19582-5. Epub 2011 Nov 18.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1021/ja206998xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295203PMC
December 2011

In-silico patterning of vascular mesenchymal cells in three dimensions.

PLoS One 2011 25;6(5):e20182. Epub 2011 May 25.

Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020182PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102094PMC
September 2011

DNA-templated assembly of droplet-derived PEG microtissues.

Lab Chip 2011 Sep 21;11(17):2967-75. Epub 2011 Jul 21.

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA.

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http://dx.doi.org/10.1039/c1lc20318eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399244PMC
September 2011

Humanized mice with ectopic artificial liver tissues.

Proc Natl Acad Sci U S A 2011 Jul 11;108(29):11842-7. Epub 2011 Jul 11.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1101791108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142004PMC
July 2011

Nanoparticles that communicate in vivo to amplify tumour targeting.

Nat Mater 2011 Jun 19;10(7):545-52. Epub 2011 Jun 19.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nmat3049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361766PMC
June 2011

Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):745-50. Epub 2010 Dec 27.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1016538108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021044PMC
January 2011

Multiplexed, high-throughput analysis of 3D microtissue suspensions.

Integr Biol (Camb) 2010 Oct 1;2(10):517-27. Epub 2010 Sep 1.

Massachusetts Institute of Technology, Cambridge, 02139, USA.

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http://dx.doi.org/10.1039/c0ib00054jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124885PMC
October 2010

Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting.

Angew Chem Int Ed Engl 2010 Sep;49(40):7266-70

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1002/anie.201003445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412154PMC
September 2010